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Protein

Phospholipid transfer protein

Gene

Pltp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability (By similarity).By similarity

GO - Molecular functioni

  1. lipid binding Source: InterPro

GO - Biological processi

  1. lipid metabolic process Source: InterPro
  2. lipid transport Source: UniProtKB-KW
  3. sperm motility Source: MGI
  4. vitamin E biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_213857. HDL-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid transfer protein
Alternative name(s):
Lipid transfer protein II
Gene namesi
Name:Pltp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:103151. Pltp.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 493476Phospholipid transfer proteinPRO_0000017163Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)1 Publication
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi146 ↔ 185By similarity
Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP55065.
PaxDbiP55065.
PRIDEiP55065.

PTM databases

PhosphoSiteiP55065.

Expressioni

Tissue specificityi

Highest in lung, adipose tissue, brain, and heart.

Gene expression databases

BgeeiP55065.
CleanExiMM_PLTP.
ExpressionAtlasiP55065. baseline and differential.
GenevestigatoriP55065.

Structurei

3D structure databases

ProteinModelPortaliP55065.
SMRiP55065. Positions 20-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG290011.
HOGENOMiHOG000231006.
HOVERGENiHBG103156.
InParanoidiP55065.
KOiK08761.
OMAiEVQLSSM.
OrthoDBiEOG76739B.
PhylomeDBiP55065.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
IPR030179. PLTP.
[Graphical view]
PANTHERiPTHR10504:SF16. PTHR10504:SF16. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLWALFLA LLAGAHAELP GCKIRVTSAA LDLVKQEGLR FLEQELETIT
60 70 80 90 100
IPDVYGAKGH FYYNISDVRV TQLHLISSEL HFQPDQDLLL NISNASLGLH
110 120 130 140 150
FRRQLLYWFL YDGGYINASA EGVSIRTGLQ LSQDSSGRIK VSNVSCEASV
160 170 180 190 200
SKMNMAFGGT FRRMYNFFST FITSGMRFLL NQQICPVLYH AGTVLLNSLL
210 220 230 240 250
DTVPVRSSVD DLVGIDYSLL KDPVVSNGNL DMEFRGAFFP LKEDNWSLPN
260 270 280 290 300
RAVEPQLEDD ERMVYVAFSE FFFDSAMESY FQAGALQLTL VGDKVPSDLD
310 320 330 340 350
MLLRATYFGS IVLLSPTVIN SPLKLKLEAT SPPRCTIKPS GTTISITASV
360 370 380 390 400
TITLAPPMLP EVELSKMIME GRLSAKLTLR GKALRVKLDL RRFQIYSNQS
410 420 430 440 450
ALESLALIPL QAPLKTLLQI GVMPLLNERT WRGVQIPLPE GINFVREVVT
460 470 480 490
NHAGFVTVGA DLHFAKGLRE VIDKNRPADV AASHVPPPSA AAA
Length:493
Mass (Da):54,453
Last modified:October 1, 1996 - v1
Checksum:iE58E2C71142B77B5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 172Missing (PubMed:7615508).Curated
Sequence conflicti32 – 321D → E in AAH03782 (PubMed:15489334).Curated
Sequence conflicti53 – 542DV → ER in AAA87943 (PubMed:7615508).Curated
Sequence conflicti103 – 1031R → S in AAA87943 (PubMed:7615508).Curated
Sequence conflicti106 – 1061L → P in AAA87943 (PubMed:7615508).Curated
Sequence conflicti156 – 1561A → D in AAA87943 (PubMed:7615508).Curated
Sequence conflicti242 – 2443KED → RRN in AAA87943 (PubMed:7615508).Curated
Sequence conflicti326 – 3261K → M in AAA87943 (PubMed:7615508).Curated
Sequence conflicti464 – 4641F → L in AAA87943 (PubMed:7615508).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37226 mRNA. Translation: AAA80542.1.
U28960 mRNA. Translation: AAA87943.1.
BC003782 mRNA. Translation: AAH03782.1.
CCDSiCCDS17063.1.
PIRiI49370.
RefSeqiNP_035255.1. NM_011125.2.
XP_006499015.1. XM_006498952.1.
UniGeneiMm.6105.

Genome annotation databases

EnsembliENSMUST00000059954; ENSMUSP00000061519; ENSMUSG00000017754.
ENSMUST00000109316; ENSMUSP00000104939; ENSMUSG00000017754.
GeneIDi18830.
KEGGimmu:18830.
UCSCiuc008nwn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37226 mRNA. Translation: AAA80542.1.
U28960 mRNA. Translation: AAA87943.1.
BC003782 mRNA. Translation: AAH03782.1.
CCDSiCCDS17063.1.
PIRiI49370.
RefSeqiNP_035255.1. NM_011125.2.
XP_006499015.1. XM_006498952.1.
UniGeneiMm.6105.

3D structure databases

ProteinModelPortaliP55065.
SMRiP55065. Positions 20-466.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP55065.

Proteomic databases

MaxQBiP55065.
PaxDbiP55065.
PRIDEiP55065.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059954; ENSMUSP00000061519; ENSMUSG00000017754.
ENSMUST00000109316; ENSMUSP00000104939; ENSMUSG00000017754.
GeneIDi18830.
KEGGimmu:18830.
UCSCiuc008nwn.1. mouse.

Organism-specific databases

CTDi5360.
MGIiMGI:103151. Pltp.

Phylogenomic databases

eggNOGiNOG290011.
HOGENOMiHOG000231006.
HOVERGENiHBG103156.
InParanoidiP55065.
KOiK08761.
OMAiEVQLSSM.
OrthoDBiEOG76739B.
PhylomeDBiP55065.
TreeFamiTF315617.

Enzyme and pathway databases

ReactomeiREACT_213857. HDL-mediated lipid transport.

Miscellaneous databases

NextBioi295208.
PROiP55065.
SOURCEiSearch...

Gene expression databases

BgeeiP55065.
CleanExiMM_PLTP.
ExpressionAtlasiP55065. baseline and differential.
GenevestigatoriP55065.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
IPR030179. PLTP.
[Graphical view]
PANTHERiPTHR10504:SF16. PTHR10504:SF16. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies."
    Albers J.J., Wolfbauer G., Cheung M.C., Day J.R., Ching A.F.T., Lok S., Tu A.-Y.
    Biochim. Biophys. Acta 1258:27-34(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet."
    Jiang X.-C., Bruce C.
    J. Biol. Chem. 270:17133-17138(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  4. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiPLTP_MOUSE
AccessioniPrimary (citable) accession number: P55065
Secondary accession number(s): Q99L70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 4, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.