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P55065 (PLTP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospholipid transfer protein
Alternative name(s):
Lipid transfer protein II
Gene names
Name:Pltp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability By similarity.

Subcellular location

Secreted.

Tissue specificity

Highest in lung, adipose tissue, brain, and heart.

Sequence similarities

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Ontologies

Keywords
   Biological processLipid transport
Transport
   Cellular componentSecreted
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipid transport

Inferred from electronic annotation. Source: UniProtKB-KW

sperm motility

Inferred from mutant phenotype PubMed 16467369. Source: MGI

vitamin E biosynthetic process

Inferred from mutant phenotype PubMed 16467369. Source: MGI

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 493476Phospholipid transfer protein
PRO_0000017163

Amino acid modifications

Glycosylation641N-linked (GlcNAc...) Ref.4
Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation2451N-linked (GlcNAc...) Potential
Glycosylation3981N-linked (GlcNAc...) Potential
Disulfide bond146 ↔ 185 By similarity

Experimental info

Sequence conflict16 – 172Missing Ref.2
Sequence conflict321D → E in AAH03782. Ref.3
Sequence conflict53 – 542DV → ER in AAA87943. Ref.2
Sequence conflict1031R → S in AAA87943. Ref.2
Sequence conflict1061L → P in AAA87943. Ref.2
Sequence conflict1561A → D in AAA87943. Ref.2
Sequence conflict242 – 2443KED → RRN in AAA87943. Ref.2
Sequence conflict3261K → M in AAA87943. Ref.2
Sequence conflict4641F → L in AAA87943. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P55065 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E58E2C71142B77B5

FASTA49354,453
        10         20         30         40         50         60 
MVLLWALFLA LLAGAHAELP GCKIRVTSAA LDLVKQEGLR FLEQELETIT IPDVYGAKGH 

        70         80         90        100        110        120 
FYYNISDVRV TQLHLISSEL HFQPDQDLLL NISNASLGLH FRRQLLYWFL YDGGYINASA 

       130        140        150        160        170        180 
EGVSIRTGLQ LSQDSSGRIK VSNVSCEASV SKMNMAFGGT FRRMYNFFST FITSGMRFLL 

       190        200        210        220        230        240 
NQQICPVLYH AGTVLLNSLL DTVPVRSSVD DLVGIDYSLL KDPVVSNGNL DMEFRGAFFP 

       250        260        270        280        290        300 
LKEDNWSLPN RAVEPQLEDD ERMVYVAFSE FFFDSAMESY FQAGALQLTL VGDKVPSDLD 

       310        320        330        340        350        360 
MLLRATYFGS IVLLSPTVIN SPLKLKLEAT SPPRCTIKPS GTTISITASV TITLAPPMLP 

       370        380        390        400        410        420 
EVELSKMIME GRLSAKLTLR GKALRVKLDL RRFQIYSNQS ALESLALIPL QAPLKTLLQI 

       430        440        450        460        470        480 
GVMPLLNERT WRGVQIPLPE GINFVREVVT NHAGFVTVGA DLHFAKGLRE VIDKNRPADV 

       490 
AASHVPPPSA AAA 

« Hide

References

« Hide 'large scale' references
[1]"Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies."
Albers J.J., Wolfbauer G., Cheung M.C., Day J.R., Ching A.F.T., Lok S., Tu A.-Y.
Biochim. Biophys. Acta 1258:27-34(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet."
Jiang X.-C., Bruce C.
J. Biol. Chem. 270:17133-17138(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[4]"Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64.
Strain: C57BL/6.
Tissue: Plasma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U37226 mRNA. Translation: AAA80542.1.
U28960 mRNA. Translation: AAA87943.1.
BC003782 mRNA. Translation: AAH03782.1.
CCDSCCDS17063.1.
PIRI49370.
RefSeqNP_035255.1. NM_011125.2.
XP_006499015.1. XM_006498952.1.
UniGeneMm.6105.

3D structure databases

ProteinModelPortalP55065.
SMRP55065. Positions 20-466.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP55065.

Proteomic databases

MaxQBP55065.
PaxDbP55065.
PRIDEP55065.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000059954; ENSMUSP00000061519; ENSMUSG00000017754.
ENSMUST00000109316; ENSMUSP00000104939; ENSMUSG00000017754.
GeneID18830.
KEGGmmu:18830.
UCSCuc008nwn.1. mouse.

Organism-specific databases

CTD5360.
MGIMGI:103151. Pltp.

Phylogenomic databases

eggNOGNOG290011.
HOGENOMHOG000231006.
HOVERGENHBG103156.
InParanoidP55065.
KOK08761.
OMAAPPRCTI.
OrthoDBEOG76739B.
PhylomeDBP55065.
TreeFamTF315617.

Gene expression databases

ArrayExpressP55065.
BgeeP55065.
CleanExMM_PLTP.
GenevestigatorP55065.

Family and domain databases

InterProIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMSSF55394. SSF55394. 2 hits.
PROSITEPS00400. LBP_BPI_CETP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295208.
PROP55065.
SOURCESearch...

Entry information

Entry namePLTP_MOUSE
AccessionPrimary (citable) accession number: P55065
Secondary accession number(s): Q99L70
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot