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P55065

- PLTP_MOUSE

UniProt

P55065 - PLTP_MOUSE

Protein

Phospholipid transfer protein

Gene

Pltp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability By similarity.By similarity

    GO - Molecular functioni

    1. lipid binding Source: InterPro

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW
    2. sperm motility Source: MGI
    3. vitamin E biosynthetic process Source: MGI

    Keywords - Biological processi

    Lipid transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_213857. HDL-mediated lipid transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospholipid transfer protein
    Alternative name(s):
    Lipid transfer protein II
    Gene namesi
    Name:Pltp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:103151. Pltp.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 493476Phospholipid transfer proteinPRO_0000017163Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)1 Publication
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi146 ↔ 185By similarity
    Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP55065.
    PaxDbiP55065.
    PRIDEiP55065.

    PTM databases

    PhosphoSiteiP55065.

    Expressioni

    Tissue specificityi

    Highest in lung, adipose tissue, brain, and heart.

    Gene expression databases

    ArrayExpressiP55065.
    BgeeiP55065.
    CleanExiMM_PLTP.
    GenevestigatoriP55065.

    Structurei

    3D structure databases

    ProteinModelPortaliP55065.
    SMRiP55065. Positions 20-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG290011.
    HOGENOMiHOG000231006.
    HOVERGENiHBG103156.
    InParanoidiP55065.
    KOiK08761.
    OMAiAPPRCTI.
    OrthoDBiEOG76739B.
    PhylomeDBiP55065.
    TreeFamiTF315617.

    Family and domain databases

    InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017954. Lipid-bd_serum_glycop_CS.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view]
    PfamiPF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view]
    SMARTiSM00328. BPI1. 1 hit.
    SM00329. BPI2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55394. SSF55394. 2 hits.
    PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55065-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLLWALFLA LLAGAHAELP GCKIRVTSAA LDLVKQEGLR FLEQELETIT    50
    IPDVYGAKGH FYYNISDVRV TQLHLISSEL HFQPDQDLLL NISNASLGLH 100
    FRRQLLYWFL YDGGYINASA EGVSIRTGLQ LSQDSSGRIK VSNVSCEASV 150
    SKMNMAFGGT FRRMYNFFST FITSGMRFLL NQQICPVLYH AGTVLLNSLL 200
    DTVPVRSSVD DLVGIDYSLL KDPVVSNGNL DMEFRGAFFP LKEDNWSLPN 250
    RAVEPQLEDD ERMVYVAFSE FFFDSAMESY FQAGALQLTL VGDKVPSDLD 300
    MLLRATYFGS IVLLSPTVIN SPLKLKLEAT SPPRCTIKPS GTTISITASV 350
    TITLAPPMLP EVELSKMIME GRLSAKLTLR GKALRVKLDL RRFQIYSNQS 400
    ALESLALIPL QAPLKTLLQI GVMPLLNERT WRGVQIPLPE GINFVREVVT 450
    NHAGFVTVGA DLHFAKGLRE VIDKNRPADV AASHVPPPSA AAA 493
    Length:493
    Mass (Da):54,453
    Last modified:October 1, 1996 - v1
    Checksum:iE58E2C71142B77B5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 172Missing(PubMed:7615508)Curated
    Sequence conflicti32 – 321D → E in AAH03782. (PubMed:15489334)Curated
    Sequence conflicti53 – 542DV → ER in AAA87943. (PubMed:7615508)Curated
    Sequence conflicti103 – 1031R → S in AAA87943. (PubMed:7615508)Curated
    Sequence conflicti106 – 1061L → P in AAA87943. (PubMed:7615508)Curated
    Sequence conflicti156 – 1561A → D in AAA87943. (PubMed:7615508)Curated
    Sequence conflicti242 – 2443KED → RRN in AAA87943. (PubMed:7615508)Curated
    Sequence conflicti326 – 3261K → M in AAA87943. (PubMed:7615508)Curated
    Sequence conflicti464 – 4641F → L in AAA87943. (PubMed:7615508)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37226 mRNA. Translation: AAA80542.1.
    U28960 mRNA. Translation: AAA87943.1.
    BC003782 mRNA. Translation: AAH03782.1.
    CCDSiCCDS17063.1.
    PIRiI49370.
    RefSeqiNP_035255.1. NM_011125.2.
    XP_006499015.1. XM_006498952.1.
    UniGeneiMm.6105.

    Genome annotation databases

    EnsembliENSMUST00000059954; ENSMUSP00000061519; ENSMUSG00000017754.
    ENSMUST00000109316; ENSMUSP00000104939; ENSMUSG00000017754.
    GeneIDi18830.
    KEGGimmu:18830.
    UCSCiuc008nwn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37226 mRNA. Translation: AAA80542.1 .
    U28960 mRNA. Translation: AAA87943.1 .
    BC003782 mRNA. Translation: AAH03782.1 .
    CCDSi CCDS17063.1.
    PIRi I49370.
    RefSeqi NP_035255.1. NM_011125.2.
    XP_006499015.1. XM_006498952.1.
    UniGenei Mm.6105.

    3D structure databases

    ProteinModelPortali P55065.
    SMRi P55065. Positions 20-466.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P55065.

    Proteomic databases

    MaxQBi P55065.
    PaxDbi P55065.
    PRIDEi P55065.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059954 ; ENSMUSP00000061519 ; ENSMUSG00000017754 .
    ENSMUST00000109316 ; ENSMUSP00000104939 ; ENSMUSG00000017754 .
    GeneIDi 18830.
    KEGGi mmu:18830.
    UCSCi uc008nwn.1. mouse.

    Organism-specific databases

    CTDi 5360.
    MGIi MGI:103151. Pltp.

    Phylogenomic databases

    eggNOGi NOG290011.
    HOGENOMi HOG000231006.
    HOVERGENi HBG103156.
    InParanoidi P55065.
    KOi K08761.
    OMAi APPRCTI.
    OrthoDBi EOG76739B.
    PhylomeDBi P55065.
    TreeFami TF315617.

    Enzyme and pathway databases

    Reactomei REACT_213857. HDL-mediated lipid transport.

    Miscellaneous databases

    NextBioi 295208.
    PROi P55065.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55065.
    Bgeei P55065.
    CleanExi MM_PLTP.
    Genevestigatori P55065.

    Family and domain databases

    InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017954. Lipid-bd_serum_glycop_CS.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view ]
    Pfami PF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00328. BPI1. 1 hit.
    SM00329. BPI2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55394. SSF55394. 2 hits.
    PROSITEi PS00400. LBP_BPI_CETP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies."
      Albers J.J., Wolfbauer G., Cheung M.C., Day J.R., Ching A.F.T., Lok S., Tu A.-Y.
      Biochim. Biophys. Acta 1258:27-34(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet."
      Jiang X.-C., Bruce C.
      J. Biol. Chem. 270:17133-17138(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    4. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
      Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
      J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiPLTP_MOUSE
    AccessioniPrimary (citable) accession number: P55065
    Secondary accession number(s): Q99L70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3