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Protein

Phospholipid transfer protein

Gene

Pltp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • ceramide transport Source: MGI
  • flagellated sperm motility Source: MGI
  • high-density lipoprotein particle remodeling Source: MGI
  • lipid metabolic process Source: InterPro
  • lipid transport Source: MGI
  • phospholipid transport Source: MGI
  • positive regulation of cholesterol efflux Source: MGI
  • vitamin E biosynthetic process Source: MGI

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-8964058 HDL remodeling

Chemistry databases

SwissLipidsiSLP:000000471

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid transfer protein
Alternative name(s):
Lipid transfer protein II
Gene namesi
Name:Pltp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:103151 Pltp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001716318 – 493Phospholipid transfer proteinAdd BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 185By similarity
Glycosylationi245N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP55065
PeptideAtlasiP55065
PRIDEiP55065

PTM databases

iPTMnetiP55065
PhosphoSitePlusiP55065

Expressioni

Tissue specificityi

Highest in lung, adipose tissue, brain, and heart.

Gene expression databases

BgeeiENSMUSG00000017754
CleanExiMM_PLTP
ExpressionAtlasiP55065 baseline and differential
GenevisibleiP55065 MM

Interactioni

Protein-protein interaction databases

BioGridi202259, 1 interactor
STRINGi10090.ENSMUSP00000061519

Structurei

3D structure databases

ProteinModelPortaliP55065
SMRiP55065
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00730000110583
HOGENOMiHOG000231006
HOVERGENiHBG103156
InParanoidiP55065
KOiK08761
OMAiRGVQIPL
OrthoDBiEOG091G058L
PhylomeDBiP55065
TreeFamiTF315617

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR030675 BPI/LBP
IPR032942 BPI/LBP/Plunc
IPR001124 Lipid-bd_serum_glycop_C
IPR017954 Lipid-bd_serum_glycop_CS
IPR017942 Lipid-bd_serum_glycop_N
IPR030179 PLTP
PANTHERiPTHR10504 PTHR10504, 1 hit
PTHR10504:SF16 PTHR10504:SF16, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
PIRSFiPIRSF002417 Lipid_binding_protein, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits
PROSITEiView protein in PROSITE
PS00400 LBP_BPI_CETP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLWALFLA LLAGAHAELP GCKIRVTSAA LDLVKQEGLR FLEQELETIT
60 70 80 90 100
IPDVYGAKGH FYYNISDVRV TQLHLISSEL HFQPDQDLLL NISNASLGLH
110 120 130 140 150
FRRQLLYWFL YDGGYINASA EGVSIRTGLQ LSQDSSGRIK VSNVSCEASV
160 170 180 190 200
SKMNMAFGGT FRRMYNFFST FITSGMRFLL NQQICPVLYH AGTVLLNSLL
210 220 230 240 250
DTVPVRSSVD DLVGIDYSLL KDPVVSNGNL DMEFRGAFFP LKEDNWSLPN
260 270 280 290 300
RAVEPQLEDD ERMVYVAFSE FFFDSAMESY FQAGALQLTL VGDKVPSDLD
310 320 330 340 350
MLLRATYFGS IVLLSPTVIN SPLKLKLEAT SPPRCTIKPS GTTISITASV
360 370 380 390 400
TITLAPPMLP EVELSKMIME GRLSAKLTLR GKALRVKLDL RRFQIYSNQS
410 420 430 440 450
ALESLALIPL QAPLKTLLQI GVMPLLNERT WRGVQIPLPE GINFVREVVT
460 470 480 490
NHAGFVTVGA DLHFAKGLRE VIDKNRPADV AASHVPPPSA AAA
Length:493
Mass (Da):54,453
Last modified:October 1, 1996 - v1
Checksum:iE58E2C71142B77B5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16 – 17Missing (PubMed:7615508).Curated2
Sequence conflicti32D → E in AAH03782 (PubMed:15489334).Curated1
Sequence conflicti53 – 54DV → ER in AAA87943 (PubMed:7615508).Curated2
Sequence conflicti103R → S in AAA87943 (PubMed:7615508).Curated1
Sequence conflicti106L → P in AAA87943 (PubMed:7615508).Curated1
Sequence conflicti156A → D in AAA87943 (PubMed:7615508).Curated1
Sequence conflicti242 – 244KED → RRN in AAA87943 (PubMed:7615508).Curated3
Sequence conflicti326K → M in AAA87943 (PubMed:7615508).Curated1
Sequence conflicti464F → L in AAA87943 (PubMed:7615508).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37226 mRNA Translation: AAA80542.1
U28960 mRNA Translation: AAA87943.1
BC003782 mRNA Translation: AAH03782.1
CCDSiCCDS17063.1
PIRiI49370
RefSeqiNP_035255.1, NM_011125.2
UniGeneiMm.6105

Genome annotation databases

EnsembliENSMUST00000059954; ENSMUSP00000061519; ENSMUSG00000017754
ENSMUST00000109316; ENSMUSP00000104939; ENSMUSG00000017754
GeneIDi18830
KEGGimmu:18830
UCSCiuc008nwn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPLTP_MOUSE
AccessioniPrimary (citable) accession number: P55065
Secondary accession number(s): Q99L70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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