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Protein

Phospholipid transfer protein

Gene

Pltp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • flagellated sperm motility Source: MGI
  • high-density lipoprotein particle remodeling Source: MGI
  • lipid metabolic process Source: InterPro
  • lipid transport Source: UniProtKB-KW
  • positive regulation of cholesterol efflux Source: MGI
  • vitamin E biosynthetic process Source: MGI

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-8964058. HDL remodeling.

Chemistry databases

SwissLipidsiSLP:000000471.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid transfer protein
Alternative name(s):
Lipid transfer protein II
Gene namesi
Name:Pltp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:103151. Pltp.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: BHF-UCL

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001716318 – 493Phospholipid transfer proteinAdd BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 185By similarity
Glycosylationi245N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP55065.
PeptideAtlasiP55065.
PRIDEiP55065.

PTM databases

PhosphoSitePlusiP55065.

Expressioni

Tissue specificityi

Highest in lung, adipose tissue, brain, and heart.

Gene expression databases

BgeeiENSMUSG00000017754.
CleanExiMM_PLTP.
ExpressionAtlasiP55065. baseline and differential.
GenevisibleiP55065. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061519.

Structurei

3D structure databases

ProteinModelPortaliP55065.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00730000110583.
HOGENOMiHOG000231006.
HOVERGENiHBG103156.
InParanoidiP55065.
KOiK08761.
OMAiGMRFLLN.
OrthoDBiEOG091G058L.
PhylomeDBiP55065.
TreeFamiTF315617.

Family and domain databases

InterProiView protein in InterPro
IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR030675. BPI/LBP.
IPR032942. BPI/LBP/Plunc.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
IPR030179. PLTP.
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF103. PTHR10504:SF103. 1 hit.
PfamiView protein in Pfam
PF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
PIRSFiPIRSF002417. Lipid_binding_protein. 1 hit.
SMARTiView protein in SMART
SM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
SUPFAMiSSF55394. SSF55394. 2 hits.
PROSITEiView protein in PROSITE
PS00400. LBP_BPI_CETP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLWALFLA LLAGAHAELP GCKIRVTSAA LDLVKQEGLR FLEQELETIT
60 70 80 90 100
IPDVYGAKGH FYYNISDVRV TQLHLISSEL HFQPDQDLLL NISNASLGLH
110 120 130 140 150
FRRQLLYWFL YDGGYINASA EGVSIRTGLQ LSQDSSGRIK VSNVSCEASV
160 170 180 190 200
SKMNMAFGGT FRRMYNFFST FITSGMRFLL NQQICPVLYH AGTVLLNSLL
210 220 230 240 250
DTVPVRSSVD DLVGIDYSLL KDPVVSNGNL DMEFRGAFFP LKEDNWSLPN
260 270 280 290 300
RAVEPQLEDD ERMVYVAFSE FFFDSAMESY FQAGALQLTL VGDKVPSDLD
310 320 330 340 350
MLLRATYFGS IVLLSPTVIN SPLKLKLEAT SPPRCTIKPS GTTISITASV
360 370 380 390 400
TITLAPPMLP EVELSKMIME GRLSAKLTLR GKALRVKLDL RRFQIYSNQS
410 420 430 440 450
ALESLALIPL QAPLKTLLQI GVMPLLNERT WRGVQIPLPE GINFVREVVT
460 470 480 490
NHAGFVTVGA DLHFAKGLRE VIDKNRPADV AASHVPPPSA AAA
Length:493
Mass (Da):54,453
Last modified:October 1, 1996 - v1
Checksum:iE58E2C71142B77B5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16 – 17Missing (PubMed:7615508).Curated2
Sequence conflicti32D → E in AAH03782 (PubMed:15489334).Curated1
Sequence conflicti53 – 54DV → ER in AAA87943 (PubMed:7615508).Curated2
Sequence conflicti103R → S in AAA87943 (PubMed:7615508).Curated1
Sequence conflicti106L → P in AAA87943 (PubMed:7615508).Curated1
Sequence conflicti156A → D in AAA87943 (PubMed:7615508).Curated1
Sequence conflicti242 – 244KED → RRN in AAA87943 (PubMed:7615508).Curated3
Sequence conflicti326K → M in AAA87943 (PubMed:7615508).Curated1
Sequence conflicti464F → L in AAA87943 (PubMed:7615508).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37226 mRNA. Translation: AAA80542.1.
U28960 mRNA. Translation: AAA87943.1.
BC003782 mRNA. Translation: AAH03782.1.
CCDSiCCDS17063.1.
PIRiI49370.
RefSeqiNP_035255.1. NM_011125.2.
UniGeneiMm.6105.

Genome annotation databases

EnsembliENSMUST00000059954; ENSMUSP00000061519; ENSMUSG00000017754.
ENSMUST00000109316; ENSMUSP00000104939; ENSMUSG00000017754.
GeneIDi18830.
KEGGimmu:18830.
UCSCiuc008nwn.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPLTP_MOUSE
AccessioniPrimary (citable) accession number: P55065
Secondary accession number(s): Q99L70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 7, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families