Aquaporin-5 - Homo sapiens (Human)

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P55064 (AQP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Aquaporin-5
Short name=AQP-5

Gene names

Name:

AQP5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.
Subcellular location	Membrane; Multi-pass membrane protein.
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	camera-type eye morphogenesis Inferred from electronic annotation. Source: Compara carbon dioxide transport Inferred from direct assay PubMed 19273840. Source: UniProtKB excretion Traceable author statement Ref.1. Source: ProtInc odontogenesis Inferred from expression pattern PubMed 12522663. Source: UniProtKB pancreatic juice secretion Inferred from expression pattern PubMed 12801959. Source: UniProtKB saliva secretion Inferred from electronic annotation. Source: Compara
Cellular_component	apical plasma membrane Inferred from direct assay PubMed 12801959. Source: UniProtKB basal plasma membrane Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc microvillus Inferred from electronic annotation. Source: Compara
Molecular_function	water channel activity Inferred from direct assay PubMed 12801959. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MDFI	Q99750	3	EBI-746103,EBI-724076

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 265

265

Aquaporin-5

PRO_0000063951

Regions

Topological domain

1 – 12

Cytoplasmic Potential

Transmembrane

13 – 33

Helical; Potential

Topological domain

34 – 36

Extracellular Potential

Transmembrane

37 – 57

Helical; Potential

Topological domain

58 – 87

Cytoplasmic Potential

Transmembrane

88 – 108

Helical; Potential

Topological domain

109 – 126

Extracellular Potential

Transmembrane

127 – 147

Helical; Potential

Topological domain

148 – 161

Cytoplasmic Potential

Transmembrane

162 – 182

Helical; Potential

Topological domain

183 – 205

Extracellular Potential

Transmembrane

206 – 226

Helical; Potential

Topological domain

227 – 265

Cytoplasmic Potential

Motif

69 – 71

NPA 1

Motif

185 – 187

NPA 2

Amino acid modifications

Glycosylation

124

N-linked (GlcNAc...) Potential

Glycosylation

125

N-linked (GlcNAc...) Potential

Secondary structure

265

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P55064 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 053C10E6A17EAFDA
Show »

FASTA

265

28,292

        10         20         30         40         50         60 
MKKEVCSVAF LKAVFAEFLA TLIFVFFGLG SALKWPSALP TILQIALAFG LAIGTLAQAL 

        70         80         90        100        110        120 
GPVSGGHINP AITLALLVGN QISLLRAFFY VAAQLVGAIA GAGILYGVAP LNARGNLAVN 

       130        140        150        160        170        180 
ALNNNTTQGQ AMVVELILTF QLALCIFAST DSRRTSPVGS PALSIGLSVT LGHLVGIYFT 

       190        200        210        220        230        240 
GCSMNPARSF GPAVVMNRFS PAHWVFWVGP IVGAVLAAIL YFYLLFPNSL SLSERVAIIK 

       250        260 
GTYEPDEDWE EQREERKKTM ELTTR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human aquaporin-5 gene. Molecular characterization and chromosomal localization." Lee M.D., Bhakta K.Y., Raina S., Yonescu R., Griffin C.A., Copeland N.G., Gilbert D.J., Jenkins N.A., Preston G.M., Agre P. J. Biol. Chem. 271:8599-8604(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U46569

U46568 Genomic DNA. Translation: AAC50474.1.
CR541989 mRNA. Translation: CAG46786.1.
CR542022 mRNA. Translation: CAG46819.1.
BC032946 mRNA. Translation: AAH32946.1.

IPI

IPI00022752.

RefSeq

NP_001642.1. NM_001651.3.

UniGene

Hs.298023.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3D9S	X-ray	2.00	A/B/C/D	2-265	[»]

ProteinModelPortal

P55064.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-46292N.

IntAct

P55064. 3 interactions.

MINT

MINT-1442891.

STRING

9606.ENSP00000293599.

Protein family/group databases

TCDB

1.A.8.8.9. major intrinsic protein (MIP) family.

PTM databases

PhosphoSite

P55064.

Polymorphism databases

DMDM

1703358.

Proteomic databases

PaxDb

P55064.

PRIDE

P55064.

Protocols and materials databases

DNASU

362.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000293599; ENSP00000293599; ENSG00000161798.

GeneID

362.

KEGG

hsa:362.

UCSC

uc001rvo.2. human.

Organism-specific databases

CTD

362.

GeneCards

GC12P050411.

HGNC

HGNC:638. AQP5.

MIM

600442. gene.

neXtProt

NX_P55064.

PharmGKB

PA24923.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0580.

HOGENOM

HOG000288286.

HOVERGEN

HBG000312.

InParanoid

P55064.

K09867.

OMA

GINIVFF.

OrthoDB

EOG4FJ89M.

PhylomeDB

P55064.

Enzyme and pathway databases

Reactome

REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

Bgee

P55064.

CleanEx

HS_AQP5.

Genevestigator

P55064.

GermOnline

ENSG00000161798. Homo sapiens.

Family and domain databases

Gene3D

1.20.1080.10. 1 hit.

InterPro

IPR023271. Aquaporin-like.
IPR023276. Aquaporin_5.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]

PANTHER

PTHR19139. PTHR19139. 1 hit.

Pfam

PF00230. MIP. 1 hit.
[Graphical view]

PRINTS

PR02017. AQUAPORIN5.
PR00783. MINTRINSICP.

SUPFAM

SSF81338. MIP. 1 hit.

TIGRFAMs

TIGR00861. MIP. 1 hit.

PROSITE

PS00221. MIP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P55064.

GenomeRNAi

362.

NextBio

1515.

SOURCE

Search...

Entry information

Entry name

AQP5_HUMAN

Accession

Primary (citable) accession number: P55064
Secondary accession number(s): Q6FGW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents