Aquaporin-5 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P55064 (AQP5_HUMAN)

Last modified November 24, 2009. Version 74. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Aquaporin-5
Short name=AQP-5

Gene names

Name:

AQP5

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.
Subcellular location	Membrane; Multi-pass membrane protein.
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

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Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
PTM	Glycoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	carbon dioxide transport Inferred from direct assay. Source: UniProtKB excretion Ref.1 Traceable author statement. Source: ProtInc transmembrane transport Inferred from electronic annotation. Source: InterPro water transport Ref.1 Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from physical interaction. Source: IntAct water channel activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
MDFI	Q99750	2	EBI-746103,EBI-724076

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 265

265

Aquaporin-5

PRO_0000063951

Regions

Topological domain

1 – 12

Cytoplasmic Potential

Transmembrane

13 – 33

Potential

Topological domain

34 – 36

Extracellular Potential

Transmembrane

37 – 57

Potential

Topological domain

58 – 87

Cytoplasmic Potential

Transmembrane

88 – 108

Potential

Topological domain

109 – 126

Extracellular Potential

Transmembrane

127 – 147

Potential

Topological domain

148 – 161

Cytoplasmic Potential

Transmembrane

162 – 182

Potential

Topological domain

183 – 205

Extracellular Potential

Transmembrane

206 – 226

Potential

Topological domain

227 – 265

Cytoplasmic Potential

Motif

69 – 71

NPA 1

Motif

185 – 187

NPA 2

Amino acid modifications

Glycosylation

124

N-linked (GlcNAc...) Potential

Glycosylation

125

N-linked (GlcNAc...) Potential

Secondary structure

265

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P55064-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 053C10E6A17EAFDA
Show »

FASTA

265

28,292

        10         20         30         40         50         60 
MKKEVCSVAF LKAVFAEFLA TLIFVFFGLG SALKWPSALP TILQIALAFG LAIGTLAQAL 

        70         80         90        100        110        120 
GPVSGGHINP AITLALLVGN QISLLRAFFY VAAQLVGAIA GAGILYGVAP LNARGNLAVN 

       130        140        150        160        170        180 
ALNNNTTQGQ AMVVELILTF QLALCIFAST DSRRTSPVGS PALSIGLSVT LGHLVGIYFT 

       190        200        210        220        230        240 
GCSMNPARSF GPAVVMNRFS PAHWVFWVGP IVGAVLAAIL YFYLLFPNSL SLSERVAIIK 

       250        260 
GTYEPDEDWE EQREERKKTM ELTTR

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human aquaporin-5 gene. Molecular characterization and chromosomal localization." Lee M.D., Bhakta K.Y., Raina S., Yonescu R., Griffin C.A., Copeland N.G., Gilbert D.J., Jenkins N.A., Preston G.M., Agre P. J. Biol. Chem. 271:8599-8604(1996) [PubMed: 8621489] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

U46569

U46568 Genomic DNA. Translation: AAC50474.1.
CR541989 mRNA. Translation: CAG46786.1.
CR542022 mRNA. Translation: CAG46819.1.
BC032946 mRNA. Translation: AAH32946.1.

IPI

IPI00022752.

RefSeq

NP_001642.1.

UniGene

Hs.298023

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3D9S	X-ray	2.00	A/B/C/D	2-265	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

P55064. 1 interaction.

STRING

P55064.

PTM databases

PhosphoSite

P55064.

Proteomic databases

PRIDE

P55064.

Genome annotation databases

Ensembl

ENST00000293599; ENSP00000293599; ENSG00000161798; Homo sapiens. [Genome view]

GeneID

362.

KEGG

hsa:362.

UCSC

uc001rvo.2. human.

Organism-specific databases

CTD

362.

GeneCards

GC12P048641.

H-InvDB

HIX0010618.

HGNC

HGNC:638. AQP5.

MIM

600442. gene.

PharmGKB

PA24923.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P55064.

HOVERGEN

P55064.

OMA

RKKTIEL

OrthoDB

EOG9P2SMS

Gene expression databases

ArrayExpress

P55064.

Bgee

P55064.

CleanEx

HS_AQP5.

Genevestigator

P55064.

GermOnline

ENSG00000161798. Homo sapiens.

Family and domain databases

InterPro

IPR012269. Aquaporin.
IPR000425. MIP.
[Graphical view]

Gene3D

G3DSA:1.20.1080.10. MIP. 1 hit.

PANTHER

PTHR19139. MIP. 1 hit.

Pfam

PF00230. MIP. 1 hit.
[Graphical view]

PRINTS

PR00783. MINTRINSICP.

TIGRFAMs

TIGR00861. MIP. 1 hit.

PROSITE

PS00221. MIP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

1515.

SOURCE

Search...

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Entry information

Entry name

AQP5_HUMAN

Accession

Primary (citable) accession number: P55064
Secondary accession number(s): Q6FGW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 24, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents