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Protein

Bax inhibitor 1

Gene

Tmbim6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation.By similarity

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • autophagy Source: UniProtKB-KW
  • lung development Source: RGD
  • negative regulation of apoptotic process Source: InterPro
  • response to unfolded protein Source: UniProtKB-KW
  • spermatogenesis Source: RGD
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Autophagy, Unfolded protein response

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Bax inhibitor 1
Short name:
BI-1
Alternative name(s):
Testis-enhanced gene transcript protein
Transmembrane BAX inhibitor motif-containing protein 6
Gene namesi
Name:Tmbim6
Synonyms:Bi1, Tegt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi3842. Tmbim6.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 52LumenalSequence analysis2
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 86CytoplasmicSequence analysisAdd BLAST13
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 112LumenalSequence analysis5
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 139CytoplasmicSequence analysis6
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 166LumenalSequence analysis6
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 206CytoplasmicSequence analysisAdd BLAST19
Intramembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 237CytoplasmicSequence analysis10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001790821 – 237Bax inhibitor 1Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP55062.
PRIDEiP55062.

Expressioni

Tissue specificityi

Highly abundant in adult testis.1 Publication

Developmental stagei

During spermatogenesis, it is mainly expressed postmeiotically.1 Publication

Gene expression databases

BgeeiENSRNOG00000016911.
ExpressionAtlasiP55062. baseline.
GenevisibleiP55062. RN.

Interactioni

Subunit structurei

Interacts with BCL2. Interacts with BCL2L1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048834.

Family & Domainsi

Domaini

The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into the cytosol.By similarity

Sequence similaritiesi

Belongs to the BI1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1629. Eukaryota.
ENOG4111GCT. LUCA.
GeneTreeiENSGT00390000006722.
HOGENOMiHOG000238748.
HOVERGENiHBG001192.
InParanoidiP55062.
PhylomeDBiP55062.

Family and domain databases

InterProiIPR006213. Bax_inhbtr1_CS.
IPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PROSITEiPS01243. BI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIFDRKINF DALLKFSHIT PSTQQHLKKV YASFALCMFV AAAGAYVHVV
60 70 80 90 100
TRFIQAGLLS ALGALALMIC LMATPHSHET EQKRLGLLAG FAFLTGVGLG
110 120 130 140 150
PALELCIAIN PSILPTAFMG TAMIFTCFSL SALYARRRSY LFLGGILMSA
160 170 180 190 200
MSLMFVSSLG NLFFGSIWLF QANLYMGLLV MCGFVLFDTQ LIIEKAEHGD
210 220 230
KDYIWHCIDL FLDFVTLFRK LMLILAFNEK DKKKEKK
Length:237
Mass (Da):26,464
Last modified:April 26, 2005 - v2
Checksum:iF04FCDD8877B758B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90 – 91GF → V in CAA53470 (PubMed:8012111).Curated2
Sequence conflicti90 – 91GF → V in CAA53471 (PubMed:8012111).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75855 mRNA. Translation: CAA53470.1.
X75856 mRNA. Translation: CAA53471.1.
BC058478 mRNA. Translation: AAH58478.1.
PIRiS42069.
RefSeqiNP_062254.2. NM_019381.2.
XP_006257385.1. XM_006257323.3.
UniGeneiRn.107678.

Genome annotation databases

EnsembliENSRNOT00000084674; ENSRNOP00000073494; ENSRNOG00000055579.
ENSRNOT00000088176; ENSRNOP00000074493; ENSRNOG00000055579.
GeneIDi24822.
KEGGirno:24822.
UCSCiRGD:3842. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75855 mRNA. Translation: CAA53470.1.
X75856 mRNA. Translation: CAA53471.1.
BC058478 mRNA. Translation: AAH58478.1.
PIRiS42069.
RefSeqiNP_062254.2. NM_019381.2.
XP_006257385.1. XM_006257323.3.
UniGeneiRn.107678.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048834.

Proteomic databases

PaxDbiP55062.
PRIDEiP55062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000084674; ENSRNOP00000073494; ENSRNOG00000055579.
ENSRNOT00000088176; ENSRNOP00000074493; ENSRNOG00000055579.
GeneIDi24822.
KEGGirno:24822.
UCSCiRGD:3842. rat.

Organism-specific databases

CTDi7009.
RGDi3842. Tmbim6.

Phylogenomic databases

eggNOGiKOG1629. Eukaryota.
ENOG4111GCT. LUCA.
GeneTreeiENSGT00390000006722.
HOGENOMiHOG000238748.
HOVERGENiHBG001192.
InParanoidiP55062.
PhylomeDBiP55062.

Miscellaneous databases

PROiP55062.

Gene expression databases

BgeeiENSRNOG00000016911.
ExpressionAtlasiP55062. baseline.
GenevisibleiP55062. RN.

Family and domain databases

InterProiIPR006213. Bax_inhbtr1_CS.
IPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PROSITEiPS01243. BI1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBI1_RAT
AccessioniPrimary (citable) accession number: P55062
Secondary accession number(s): Q64712, Q6PDV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.