Reviewed, UniProtKB/Swiss-Prot P55061 (BI1_HUMAN)

Names and origin

Protein names

Recommended name:
    Bax inhibitor 1
      Short name=BI-1
Alternative name(s):
    Testis-enhanced gene transcript protein
    Transmembrane BAX inhibitor motif-containing protein 6

Gene names

Name:	TMBIM6
Synonyms:	BI1, TEGT

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Suppressor of apoptosis.
Subunit structure	Interacts with BCL2 and BCL2L1/BCLX.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Highly abundant in testis.
Sequence similarities	Belongs to the BI1 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane
Domain	Transmembrane
PTM	Isopeptide bond Ubl conjugation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of apoptosis Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum Traceable author statement. Source: ProtInc insoluble fraction Traceable author statement. Source: ProtInc integral to plasma membrane Traceable author statement. Source: ProtInc nucleus Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	Bax inhibitor 1		PRO_0000179078
Regions
	Transmembrane	30 – 50	21	Potential
	Transmembrane	53 – 73	21	Potential
	Transmembrane	87 – 107	21	Potential
	Transmembrane	113 – 133	21	Potential
	Transmembrane	140 – 160	21	Potential
	Transmembrane	167 – 187	21	Potential
Amino acid modifications
	Cross-link	7		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.8
Experimental info
	Sequence conflict	118	1	F → L in AAU29521. Ref.2
	Sequence conflict	169	1	L → P in CAA53472. Ref.1
	Sequence conflict	187	1	F → V in CAA53472. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P55061-1 [UniParc]. Last modified May 15, 2002. Version 2. Checksum: 6567E73A1AD6238E	FASTA	237	26,538
	10 20 30 40 50 60 MNIFDRKINF DALLKFSHIT PSTQQHLKKV YASFALCMFV AAAGAYVHMV THFIQAGLLS 70 80 90 100 110 120 ALGSLILMIW LMATPHSHET EQKRLGLLAG FAFLTGVGLG PALEFCIAVN PSILPTAFMG 130 140 150 160 170 180 TAMIFTCFTL SALYARRRSY LFLGGILMSA LSLLLLSSLG NVFFGSIWLF QANLYVGLVV 190 200 210 220 230 MCGFVLFDTQ LIIEKAEHGD QDYIWHCIDL FLDFITVFRK LMMILAMNEK DKKKEKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel conserved human gene, TEGT." Walter L., Marynen P., Szpirer J., Levan G., Guenther E. Genomics 28:301-304(1995) [PubMed: 8530040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	Cowling R.T., Birnboim H.C. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Eukaryotic homologs of BAX inhibitor-1 (BI-1) suppresses BAX- and hydrogen peroxide-induced cell death in endothelial cell lines." Kim J.-H., Jeong M.-Y., Cho S.-G. Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Testis.
[7]	"Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast." Xu Q., Reed J.C. Mol. Biol. Cell 1:337-346(1998) [PubMed: 9660918] [Abstract] Cited for: CHARACTERIZATION.
[8]	"Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry." Meierhofer D., Wang X., Huang L., Kaiser P. J. Proteome Res. 7:4566-4576(2008) [PubMed: 18781797] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-7, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X75861 mRNA. Translation: CAA53472.1. AF033095 mRNA. Translation: AAB87479.1. AY736129 mRNA. Translation: AAU29521.1. AK312238 mRNA. Translation: BAG35171.1. CH471111 Genomic DNA. Translation: EAW58089.1. BC000916 mRNA. Translation: AAH00916.1. BC036203 mRNA. Translation: AAH36203.2. Different initiation.
IPI	IPI00022748.
PIR	I38334.
RefSeq	NP_001092046.1. NP_003208.2.
UniGene	Hs.35052 Hs.708025
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P55061. 1 interaction.
STRING	P55061.
Protein family/group databases
TCDB	9.B.24.1.1. testis-enhanced gene transfer (TEGT) family.
PTM databases
PhosphoSite	P55061.
Proteomic databases
PRIDE	P55061.
Genome annotation databases
Ensembl	ENST00000267115; ENSP00000267115; ENSG00000139644; Homo sapiens. [Genome view] ENST00000423828; ENSP00000389277; ENSG00000139644; Homo sapiens. [Genome view]
GeneID	7009.
KEGG	hsa:7009.
NMPDR	fig|9606.3.peg.7516.
UCSC	uc001rux.2. human.
Organism-specific databases
CTD	7009.
GeneCards	GC12P048422.
H-InvDB	HIX0010611.
HGNC	HGNC:11723. TMBIM6.
MIM	600748. gene.
PharmGKB	PA36440.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG627476.
HOVERGEN	P55061.
OrthoDB	EOG93XXPG.
Gene expression databases
ArrayExpress	P55061.
Bgee	P55061.
CleanEx	HS_TMBIM6.
Genevestigator	P55061.
GermOnline	ENSG00000139644. Homo sapiens.
Family and domain databases
InterPro	IPR006213. Bax_inhbtr1_CS. IPR006214. UPF0005. [Graphical view]
PANTHER	PTHR23291. UPF0005. 1 hit.
Pfam	PF01027. UPF0005. 1 hit. [Graphical view]
PROSITE	PS01243. BI1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	27378.
SOURCE	Search...

Entry information

Entry name

BI1_HUMAN

Accession

Primary (citable) accession number: P55061
Secondary accession number(s): B2R5M4 , O14938, Q643A7, Q96J50

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	May 15, 2002
Last modified:	December 15, 2009
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.