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Protein

Exportin-2

Gene

CSE1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.1 Publication

GO - Molecular functioni

  • nuclear export signal receptor activity Source: ProtInc

GO - Biological processi

  • apoptotic process Source: ProtInc
  • cell proliferation Source: ProtInc
  • protein import into nucleus Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124207-MONOMER.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-2
Short name:
Exp2
Alternative name(s):
Cellular apoptosis susceptibility protein
Chromosome segregation 1-like protein
Importin-alpha re-exporter
Gene namesi
Name:CSE1L
Synonyms:CAS, XPO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:2431. CSE1L.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nuclear envelope Source: GO_Central
  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1434.
OpenTargetsiENSG00000124207.
PharmGKBiPA26933.

Polymorphism and mutation databases

BioMutaiCSE1L.
DMDMi62297557.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001172871 – 971Exportin-2Add BLAST971

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei112PhosphoserineCombined sources1
Modified residuei574N6-acetyllysineCombined sources1
Modified residuei824N6-acetyllysineCombined sources1
Modified residuei931PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP55060.
MaxQBiP55060.
PaxDbiP55060.
PeptideAtlasiP55060.
PRIDEiP55060.

PTM databases

iPTMnetiP55060.
PhosphoSitePlusiP55060.
SwissPalmiP55060.

Expressioni

Tissue specificityi

Highly expressed in proliferating cells.

Gene expression databases

BgeeiENSG00000124207.
CleanExiHS_CSE1L.
GenevisibleiP55060. HS.

Organism-specific databases

HPAiCAB002140.
HPA038059.
HPA038060.

Interactioni

Subunit structurei

Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in the presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TP53P046375EBI-286709,EBI-366083

Protein-protein interaction databases

BioGridi107821. 109 interactors.
DIPiDIP-32573N.
IntActiP55060. 36 interactors.
MINTiMINT-5001090.
STRINGi9606.ENSP00000262982.

Structurei

3D structure databases

ProteinModelPortaliP55060.
SMRiP55060.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 102Importin N-terminalPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the XPO2/CSE1 family.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1992. Eukaryota.
COG5657. LUCA.
GeneTreeiENSGT00550000074884.
HOVERGENiHBG080050.
InParanoidiP55060.
KOiK18423.
OMAiSGQVEKK.
OrthoDBiEOG091G01TH.
PhylomeDBiP55060.
TreeFamiTF300473.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR005043. CAS_CSE1_C.
IPR013713. Cse1.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03378. CAS_CSE1. 1 hit.
PF08506. Cse1. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P55060-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELSDANLQT LTEYLKKTLD PDPAIRRPAE KFLESVEGNQ NYPLLLLTLL
60 70 80 90 100
EKSQDNVIKV CASVTFKNYI KRNWRIVEDE PNKICEADRV AIKANIVHLM
110 120 130 140 150
LSSPEQIQKQ LSDAISIIGR EDFPQKWPDL LTEMVNRFQS GDFHVINGVL
160 170 180 190 200
RTAHSLFKRY RHEFKSNELW TEIKLVLDAF ALPLTNLFKA TIELCSTHAN
210 220 230 240 250
DASALRILFS SLILISKLFY SLNFQDLPEF FEDNMETWMN NFHTLLTLDN
260 270 280 290 300
KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQRYL PRFVTAIWNL
310 320 330 340 350
LVTTGQEVKY DLLVSNAIQF LASVCERPHY KNLFEDQNTL TSICEKVIVP
360 370 380 390 400
NMEFRAADEE AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP
410 420 430 440 450
VTGIFSGYVN SMLQEYAKNP SVNWKHKDAA IYLVTSLASK AQTQKHGITQ
460 470 480 490 500
ANELVNLTEF FVNHILPDLK SANVNEFPVL KADGIKYIMI FRNQVPKEHL
510 520 530 540 550
LVSIPLLINH LQAESIVVHT YAAHALERLF TMRGPNNATL FTAAEIAPFV
560 570 580 590 600
EILLTNLFKA LTLPGSSENE YIMKAIMRSF SLLQEAIIPY IPTLITQLTQ
610 620 630 640 650
KLLAVSKNPS KPHFNHYMFE AICLSIRITC KANPAAVVNF EEALFLVFTE
660 670 680 690 700
ILQNDVQEFI PYVFQVMSLL LETHKNDIPS SYMALFPHLL QPVLWERTGN
710 720 730 740 750
IPALVRLLQA FLERGSNTIA SAAADKIPGL LGVFQKLIAS KANDHQGFYL
760 770 780 790 800
LNSIIEHMPP ESVDQYRKQI FILLFQRLQN SKTTKFIKSF LVFINLYCIK
810 820 830 840 850
YGALALQEIF DGIQPKMFGM VLEKIIIPEI QKVSGNVEKK ICAVGITKLL
860 870 880 890 900
TECPPMMDTE YTKLWTPLLQ SLIGLFELPE DDTIPDEEHF IDIEDTPGYQ
910 920 930 940 950
TAFSQLAFAG KKEHDPVGQM VNNPKIHLAQ SLHKLSTACP GRVPSMVSTS
960 970
LNAEALQYLQ GYLQAASVTL L
Length:971
Mass (Da):110,417
Last modified:March 29, 2005 - v3
Checksum:i08E837AB5008EBFD
GO
Isoform 2 (identifier: P55060-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-195: ATIELC → VWNASW
     196-971: Missing.

Show »
Length:195
Mass (Da):22,670
Checksum:i94798963277F26F5
GO
Isoform 3 (identifier: P55060-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     943-945: VPS → TYF
     946-971: Missing.

Show »
Length:945
Mass (Da):107,778
Checksum:i6E2D39436F2ABDD9
GO
Isoform 4 (identifier: P55060-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-312: Missing.

Note: No experimental confirmation available.
Show »
Length:915
Mass (Da):103,879
Checksum:i6EDE8048022CF7D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231 – 233FED → WEG in AAC50367 (PubMed:7479798).Curated3
Sequence conflicti231 – 233FED → WEG in AAC35008 (PubMed:10331944).Curated3
Sequence conflicti514E → G in AAC50367 (PubMed:7479798).Curated1
Sequence conflicti514E → G in AAC35008 (PubMed:10331944).Curated1
Sequence conflicti538A → T in ABO15009 (PubMed:11703094).Curated1
Sequence conflicti848K → N in AAC50367 (PubMed:7479798).Curated1
Sequence conflicti934K → M in AAC50367 (PubMed:7479798).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029327754I → V.Corresponds to variant rs2229042dbSNPEnsembl.1
Natural variantiVAR_036558842C → F in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_048836968V → L.Corresponds to variant rs3505dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001222190 – 195ATIELC → VWNASW in isoform 2. 1 Publication6
Alternative sequenceiVSP_001223196 – 971Missing in isoform 2. 1 PublicationAdd BLAST776
Alternative sequenceiVSP_047203257 – 312Missing in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_001224943 – 945VPS → TYF in isoform 3. 1 Publication3
Alternative sequenceiVSP_001225946 – 971Missing in isoform 3. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33286 mRNA. Translation: AAC50367.1.
AF053640 mRNA. Translation: AAC35007.1.
AF053641 mRNA. Translation: AAC35008.1.
AF053642 mRNA. Translation: AAC35009.1.
AF053651
, AF053644, AF053645, AF053646, AF053647, AF053648, AF053649, AF053650 Genomic DNA. Translation: AAC35297.1.
EF426455 mRNA. Translation: ABO15009.1.
AK312306 mRNA. Translation: BAG35231.1.
AL121903, AL133174 Genomic DNA. Translation: CAI19615.1.
AL133174, AL121903 Genomic DNA. Translation: CAI42818.1.
CH471077 Genomic DNA. Translation: EAW75676.1.
CH471077 Genomic DNA. Translation: EAW75677.1.
BC108309 mRNA. Translation: AAI08310.1.
BC109313 mRNA. Translation: AAI09314.1.
BC109314 mRNA. Translation: AAI09315.1.
CCDSiCCDS13412.1. [P55060-1]
CCDS58773.1. [P55060-4]
PIRiI39166.
RefSeqiNP_001243064.1. NM_001256135.1. [P55060-4]
NP_001307.2. NM_001316.3. [P55060-1]
XP_011526901.1. XM_011528599.2. [P55060-3]
UniGeneiHs.90073.

Genome annotation databases

EnsembliENST00000262982; ENSP00000262982; ENSG00000124207. [P55060-1]
ENST00000396192; ENSP00000379495; ENSG00000124207. [P55060-4]
GeneIDi1434.
KEGGihsa:1434.
UCSCiuc002xty.5. human. [P55060-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33286 mRNA. Translation: AAC50367.1.
AF053640 mRNA. Translation: AAC35007.1.
AF053641 mRNA. Translation: AAC35008.1.
AF053642 mRNA. Translation: AAC35009.1.
AF053651
, AF053644, AF053645, AF053646, AF053647, AF053648, AF053649, AF053650 Genomic DNA. Translation: AAC35297.1.
EF426455 mRNA. Translation: ABO15009.1.
AK312306 mRNA. Translation: BAG35231.1.
AL121903, AL133174 Genomic DNA. Translation: CAI19615.1.
AL133174, AL121903 Genomic DNA. Translation: CAI42818.1.
CH471077 Genomic DNA. Translation: EAW75676.1.
CH471077 Genomic DNA. Translation: EAW75677.1.
BC108309 mRNA. Translation: AAI08310.1.
BC109313 mRNA. Translation: AAI09314.1.
BC109314 mRNA. Translation: AAI09315.1.
CCDSiCCDS13412.1. [P55060-1]
CCDS58773.1. [P55060-4]
PIRiI39166.
RefSeqiNP_001243064.1. NM_001256135.1. [P55060-4]
NP_001307.2. NM_001316.3. [P55060-1]
XP_011526901.1. XM_011528599.2. [P55060-3]
UniGeneiHs.90073.

3D structure databases

ProteinModelPortaliP55060.
SMRiP55060.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107821. 109 interactors.
DIPiDIP-32573N.
IntActiP55060. 36 interactors.
MINTiMINT-5001090.
STRINGi9606.ENSP00000262982.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiP55060.
PhosphoSitePlusiP55060.
SwissPalmiP55060.

Polymorphism and mutation databases

BioMutaiCSE1L.
DMDMi62297557.

Proteomic databases

EPDiP55060.
MaxQBiP55060.
PaxDbiP55060.
PeptideAtlasiP55060.
PRIDEiP55060.

Protocols and materials databases

DNASUi1434.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262982; ENSP00000262982; ENSG00000124207. [P55060-1]
ENST00000396192; ENSP00000379495; ENSG00000124207. [P55060-4]
GeneIDi1434.
KEGGihsa:1434.
UCSCiuc002xty.5. human. [P55060-1]

Organism-specific databases

CTDi1434.
DisGeNETi1434.
GeneCardsiCSE1L.
HGNCiHGNC:2431. CSE1L.
HPAiCAB002140.
HPA038059.
HPA038060.
MIMi601342. gene.
neXtProtiNX_P55060.
OpenTargetsiENSG00000124207.
PharmGKBiPA26933.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1992. Eukaryota.
COG5657. LUCA.
GeneTreeiENSGT00550000074884.
HOVERGENiHBG080050.
InParanoidiP55060.
KOiK18423.
OMAiSGQVEKK.
OrthoDBiEOG091G01TH.
PhylomeDBiP55060.
TreeFamiTF300473.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124207-MONOMER.

Miscellaneous databases

ChiTaRSiCSE1L. human.
GenomeRNAii1434.
PROiP55060.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124207.
CleanExiHS_CSE1L.
GenevisibleiP55060. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR005043. CAS_CSE1_C.
IPR013713. Cse1.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03378. CAS_CSE1. 1 hit.
PF08506. Cse1. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXPO2_HUMAN
AccessioniPrimary (citable) accession number: P55060
Secondary accession number(s): A3RLL6
, B2R5T4, E1P5Y0, F8W904, O75432, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99, Q9UPA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 29, 2005
Last modified: November 30, 2016
This is version 161 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.