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P55060

- XPO2_HUMAN

UniProt

P55060 - XPO2_HUMAN

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Protein

Exportin-2

Gene

CSE1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.1 Publication

GO - Molecular functioni

  1. importin-alpha export receptor activity Source: ProtInc

GO - Biological processi

  1. apoptotic process Source: ProtInc
  2. cell proliferation Source: ProtInc
  3. protein export from nucleus Source: GOC
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-2
Short name:
Exp2
Alternative name(s):
Cellular apoptosis susceptibility protein
Chromosome segregation 1-like protein
Importin-alpha re-exporter
Gene namesi
Name:CSE1L
Synonyms:CAS, XPO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:2431. CSE1L.

Subcellular locationi

Cytoplasm. Nucleus
Note: Shuttles between the nucleus and the cytoplasm.

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. extracellular vesicular exosome Source: UniProt
  3. membrane Source: UniProtKB
  4. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 971971Exportin-2PRO_0000117287Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine4 Publications
Modified residuei574 – 5741N6-acetyllysine1 Publication
Modified residuei824 – 8241N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP55060.
PaxDbiP55060.
PRIDEiP55060.

PTM databases

PhosphoSiteiP55060.

Expressioni

Tissue specificityi

Highly expressed in proliferating cells.

Gene expression databases

BgeeiP55060.
CleanExiHS_CSE1L.
GenevestigatoriP55060.

Organism-specific databases

HPAiCAB002140.
HPA038059.

Interactioni

Subunit structurei

Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in the presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TP53P046375EBI-286709,EBI-366083

Protein-protein interaction databases

BioGridi107821. 85 interactions.
DIPiDIP-32573N.
IntActiP55060. 25 interactions.
MINTiMINT-5001090.

Structurei

3D structure databases

ProteinModelPortaliP55060.
SMRiP55060. Positions 6-934.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 10274Importin N-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the XPO2/CSE1 family.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5657.
GeneTreeiENSGT00550000074884.
HOVERGENiHBG080050.
InParanoidiP55060.
KOiK18423.
OMAiQFVTAVW.
OrthoDBiEOG76MK7M.
PhylomeDBiP55060.
TreeFamiTF300473.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR005043. CAS_CSE1_C.
IPR013713. Cse1.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03378. CAS_CSE1. 1 hit.
PF08506. Cse1. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P55060-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELSDANLQT LTEYLKKTLD PDPAIRRPAE KFLESVEGNQ NYPLLLLTLL
60 70 80 90 100
EKSQDNVIKV CASVTFKNYI KRNWRIVEDE PNKICEADRV AIKANIVHLM
110 120 130 140 150
LSSPEQIQKQ LSDAISIIGR EDFPQKWPDL LTEMVNRFQS GDFHVINGVL
160 170 180 190 200
RTAHSLFKRY RHEFKSNELW TEIKLVLDAF ALPLTNLFKA TIELCSTHAN
210 220 230 240 250
DASALRILFS SLILISKLFY SLNFQDLPEF FEDNMETWMN NFHTLLTLDN
260 270 280 290 300
KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQRYL PRFVTAIWNL
310 320 330 340 350
LVTTGQEVKY DLLVSNAIQF LASVCERPHY KNLFEDQNTL TSICEKVIVP
360 370 380 390 400
NMEFRAADEE AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP
410 420 430 440 450
VTGIFSGYVN SMLQEYAKNP SVNWKHKDAA IYLVTSLASK AQTQKHGITQ
460 470 480 490 500
ANELVNLTEF FVNHILPDLK SANVNEFPVL KADGIKYIMI FRNQVPKEHL
510 520 530 540 550
LVSIPLLINH LQAESIVVHT YAAHALERLF TMRGPNNATL FTAAEIAPFV
560 570 580 590 600
EILLTNLFKA LTLPGSSENE YIMKAIMRSF SLLQEAIIPY IPTLITQLTQ
610 620 630 640 650
KLLAVSKNPS KPHFNHYMFE AICLSIRITC KANPAAVVNF EEALFLVFTE
660 670 680 690 700
ILQNDVQEFI PYVFQVMSLL LETHKNDIPS SYMALFPHLL QPVLWERTGN
710 720 730 740 750
IPALVRLLQA FLERGSNTIA SAAADKIPGL LGVFQKLIAS KANDHQGFYL
760 770 780 790 800
LNSIIEHMPP ESVDQYRKQI FILLFQRLQN SKTTKFIKSF LVFINLYCIK
810 820 830 840 850
YGALALQEIF DGIQPKMFGM VLEKIIIPEI QKVSGNVEKK ICAVGITKLL
860 870 880 890 900
TECPPMMDTE YTKLWTPLLQ SLIGLFELPE DDTIPDEEHF IDIEDTPGYQ
910 920 930 940 950
TAFSQLAFAG KKEHDPVGQM VNNPKIHLAQ SLHKLSTACP GRVPSMVSTS
960 970
LNAEALQYLQ GYLQAASVTL L
Length:971
Mass (Da):110,417
Last modified:March 29, 2005 - v3
Checksum:i08E837AB5008EBFD
GO
Isoform 2 (identifier: P55060-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-195: ATIELC → VWNASW
     196-971: Missing.

Show »
Length:195
Mass (Da):22,670
Checksum:i94798963277F26F5
GO
Isoform 3 (identifier: P55060-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     943-945: VPS → TYF
     946-971: Missing.

Show »
Length:945
Mass (Da):107,778
Checksum:i6E2D39436F2ABDD9
GO
Isoform 4 (identifier: P55060-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-312: Missing.

Note: No experimental confirmation available.

Show »
Length:915
Mass (Da):103,879
Checksum:i6EDE8048022CF7D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti231 – 2333FED → WEG in AAC50367. (PubMed:7479798)Curated
Sequence conflicti231 – 2333FED → WEG in AAC35008. (PubMed:10331944)Curated
Sequence conflicti514 – 5141E → G in AAC50367. (PubMed:7479798)Curated
Sequence conflicti514 – 5141E → G in AAC35008. (PubMed:10331944)Curated
Sequence conflicti538 – 5381A → T in ABO15009. (PubMed:11703094)Curated
Sequence conflicti848 – 8481K → N in AAC50367. (PubMed:7479798)Curated
Sequence conflicti934 – 9341K → M in AAC50367. (PubMed:7479798)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti754 – 7541I → V.
Corresponds to variant rs2229042 [ dbSNP | Ensembl ].
VAR_029327
Natural varianti842 – 8421C → F in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036558
Natural varianti968 – 9681V → L.
Corresponds to variant rs3505 [ dbSNP | Ensembl ].
VAR_048836

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei190 – 1956ATIELC → VWNASW in isoform 2. 1 PublicationVSP_001222
Alternative sequencei196 – 971776Missing in isoform 2. 1 PublicationVSP_001223Add
BLAST
Alternative sequencei257 – 31256Missing in isoform 4. 1 PublicationVSP_047203Add
BLAST
Alternative sequencei943 – 9453VPS → TYF in isoform 3. 1 PublicationVSP_001224
Alternative sequencei946 – 97126Missing in isoform 3. 1 PublicationVSP_001225Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33286 mRNA. Translation: AAC50367.1.
AF053640 mRNA. Translation: AAC35007.1.
AF053641 mRNA. Translation: AAC35008.1.
AF053642 mRNA. Translation: AAC35009.1.
AF053651
, AF053644, AF053645, AF053646, AF053647, AF053648, AF053649, AF053650 Genomic DNA. Translation: AAC35297.1.
EF426455 mRNA. Translation: ABO15009.1.
AK312306 mRNA. Translation: BAG35231.1.
AL121903, AL133174 Genomic DNA. Translation: CAI19615.1.
AL133174, AL121903 Genomic DNA. Translation: CAI42818.1.
CH471077 Genomic DNA. Translation: EAW75676.1.
CH471077 Genomic DNA. Translation: EAW75677.1.
BC108309 mRNA. Translation: AAI08310.1.
BC109313 mRNA. Translation: AAI09314.1.
BC109314 mRNA. Translation: AAI09315.1.
CCDSiCCDS13412.1. [P55060-1]
CCDS58773.1. [P55060-4]
PIRiI39166.
RefSeqiNP_001243064.1. NM_001256135.1. [P55060-4]
NP_001307.2. NM_001316.3. [P55060-1]
UniGeneiHs.90073.

Genome annotation databases

EnsembliENST00000262982; ENSP00000262982; ENSG00000124207. [P55060-1]
ENST00000396192; ENSP00000379495; ENSG00000124207. [P55060-4]
GeneIDi1434.
KEGGihsa:1434.
UCSCiuc002xty.4. human. [P55060-1]
uc010zyh.3. human. [P55060-3]

Polymorphism databases

DMDMi62297557.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33286 mRNA. Translation: AAC50367.1 .
AF053640 mRNA. Translation: AAC35007.1 .
AF053641 mRNA. Translation: AAC35008.1 .
AF053642 mRNA. Translation: AAC35009.1 .
AF053651
, AF053644 , AF053645 , AF053646 , AF053647 , AF053648 , AF053649 , AF053650 Genomic DNA. Translation: AAC35297.1 .
EF426455 mRNA. Translation: ABO15009.1 .
AK312306 mRNA. Translation: BAG35231.1 .
AL121903 , AL133174 Genomic DNA. Translation: CAI19615.1 .
AL133174 , AL121903 Genomic DNA. Translation: CAI42818.1 .
CH471077 Genomic DNA. Translation: EAW75676.1 .
CH471077 Genomic DNA. Translation: EAW75677.1 .
BC108309 mRNA. Translation: AAI08310.1 .
BC109313 mRNA. Translation: AAI09314.1 .
BC109314 mRNA. Translation: AAI09315.1 .
CCDSi CCDS13412.1. [P55060-1 ]
CCDS58773.1. [P55060-4 ]
PIRi I39166.
RefSeqi NP_001243064.1. NM_001256135.1. [P55060-4 ]
NP_001307.2. NM_001316.3. [P55060-1 ]
UniGenei Hs.90073.

3D structure databases

ProteinModelPortali P55060.
SMRi P55060. Positions 6-934.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107821. 85 interactions.
DIPi DIP-32573N.
IntActi P55060. 25 interactions.
MINTi MINT-5001090.

PTM databases

PhosphoSitei P55060.

Polymorphism databases

DMDMi 62297557.

Proteomic databases

MaxQBi P55060.
PaxDbi P55060.
PRIDEi P55060.

Protocols and materials databases

DNASUi 1434.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262982 ; ENSP00000262982 ; ENSG00000124207 . [P55060-1 ]
ENST00000396192 ; ENSP00000379495 ; ENSG00000124207 . [P55060-4 ]
GeneIDi 1434.
KEGGi hsa:1434.
UCSCi uc002xty.4. human. [P55060-1 ]
uc010zyh.3. human. [P55060-3 ]

Organism-specific databases

CTDi 1434.
GeneCardsi GC20P047662.
HGNCi HGNC:2431. CSE1L.
HPAi CAB002140.
HPA038059.
MIMi 601342. gene.
neXtProti NX_P55060.
PharmGKBi PA26933.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5657.
GeneTreei ENSGT00550000074884.
HOVERGENi HBG080050.
InParanoidi P55060.
KOi K18423.
OMAi QFVTAVW.
OrthoDBi EOG76MK7M.
PhylomeDBi P55060.
TreeFami TF300473.

Miscellaneous databases

ChiTaRSi CSE1L. human.
GenomeRNAii 1434.
NextBioi 5853.
PROi P55060.
SOURCEi Search...

Gene expression databases

Bgeei P55060.
CleanExi HS_CSE1L.
Genevestigatori P55060.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR005043. CAS_CSE1_C.
IPR013713. Cse1.
IPR001494. Importin-beta_N.
[Graphical view ]
Pfami PF03378. CAS_CSE1. 1 hit.
PF08506. Cse1. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view ]
SMARTi SM00913. IBN_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1."
    Brinkmann U., Brinkmann E., Gallo M., Pastan I.
    Proc. Natl. Acad. Sci. U.S.A. 92:10427-10431(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene."
    Brinkmann U., Brinkmann E., Bera T.K., Wellmann A., Pastan I.
    Genomics 58:41-49(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain.
  3. "IRF-1-mediated CAS expression enhances interferon-gamma-induced apoptosis of HT-29 colon adenocarcinoma cells."
    Jiang M.C., Lin T.L., Lee T.L., Huang H.T., Lin C.L., Liao C.F.
    Mol. Cell Biol. Res. Commun. 4:353-358(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cerebellum.
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  8. Bienvenut W.V.
    Submitted (JUN-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-16; 18-26; 32-67; 76-83; 94-109; 138-151; 166-217; 252-268; 282-288; 293-309; 332-371; 373-382; 396-418; 428-440; 446-481; 560-574; 698-736; 769-777; 789-816; 825-832 AND 913-934, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  9. "Export of importin-alpha from the nucleus is mediated by a specific nuclear transport factor."
    Kutay U., Bischoff F.R., Kostka S., Kraft R., Goerlich D.
    Cell 90:1061-1071(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 356-370, FUNCTION IN PROTEIN NUCLEAR EXPORT, IDENTIFICATION IN A COMPLEX WITH RAN AND KPNA2.
  10. "Determination of the functional domain organization of the importin alpha nuclear import factor."
    Herold A., Truant R., Wiegand H., Cullen B.R.
    J. Cell Biol. 143:309-318(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KPNA2.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-574 AND LYS-824, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-842.

Entry informationi

Entry nameiXPO2_HUMAN
AccessioniPrimary (citable) accession number: P55060
Secondary accession number(s): A3RLL6
, B2R5T4, E1P5Y0, F8W904, O75432, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99, Q9UPA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 29, 2005
Last modified: October 29, 2014
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3