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P55060

- XPO2_HUMAN

UniProt

P55060 - XPO2_HUMAN

Protein

Exportin-2

Gene

CSE1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 3 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.1 Publication

    GO - Molecular functioni

    1. importin-alpha export receptor activity Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. cell proliferation Source: ProtInc
    3. protein export from nucleus Source: GOC

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exportin-2
    Short name:
    Exp2
    Alternative name(s):
    Cellular apoptosis susceptibility protein
    Chromosome segregation 1-like protein
    Importin-alpha re-exporter
    Gene namesi
    Name:CSE1L
    Synonyms:CAS, XPO2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:2431. CSE1L.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Shuttles between the nucleus and the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. extracellular vesicular exosome Source: UniProt
    3. membrane Source: UniProtKB
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26933.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 971971Exportin-2PRO_0000117287Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine4 Publications
    Modified residuei574 – 5741N6-acetyllysine1 Publication
    Modified residuei824 – 8241N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP55060.
    PaxDbiP55060.
    PRIDEiP55060.

    PTM databases

    PhosphoSiteiP55060.

    Expressioni

    Tissue specificityi

    Highly expressed in proliferating cells.

    Gene expression databases

    ArrayExpressiP55060.
    BgeeiP55060.
    CleanExiHS_CSE1L.
    GenevestigatoriP55060.

    Organism-specific databases

    HPAiCAB002140.
    HPA038059.

    Interactioni

    Subunit structurei

    Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in the presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TP53P046375EBI-286709,EBI-366083

    Protein-protein interaction databases

    BioGridi107821. 81 interactions.
    DIPiDIP-32573N.
    IntActiP55060. 25 interactions.
    MINTiMINT-5001090.

    Structurei

    3D structure databases

    ProteinModelPortaliP55060.
    SMRiP55060. Positions 6-934.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 10274Importin N-terminalPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the XPO2/CSE1 family.Curated
    Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5657.
    HOVERGENiHBG080050.
    InParanoidiP55060.
    OMAiQFVTAVW.
    OrthoDBiEOG76MK7M.
    PhylomeDBiP55060.
    TreeFamiTF300473.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR005043. CAS_CSE1_C.
    IPR013713. Cse1.
    IPR001494. Importin-beta_N.
    [Graphical view]
    PfamiPF03378. CAS_CSE1. 1 hit.
    PF08506. Cse1. 1 hit.
    PF03810. IBN_N. 1 hit.
    [Graphical view]
    SMARTiSM00913. IBN_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P55060-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELSDANLQT LTEYLKKTLD PDPAIRRPAE KFLESVEGNQ NYPLLLLTLL    50
    EKSQDNVIKV CASVTFKNYI KRNWRIVEDE PNKICEADRV AIKANIVHLM 100
    LSSPEQIQKQ LSDAISIIGR EDFPQKWPDL LTEMVNRFQS GDFHVINGVL 150
    RTAHSLFKRY RHEFKSNELW TEIKLVLDAF ALPLTNLFKA TIELCSTHAN 200
    DASALRILFS SLILISKLFY SLNFQDLPEF FEDNMETWMN NFHTLLTLDN 250
    KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQRYL PRFVTAIWNL 300
    LVTTGQEVKY DLLVSNAIQF LASVCERPHY KNLFEDQNTL TSICEKVIVP 350
    NMEFRAADEE AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP 400
    VTGIFSGYVN SMLQEYAKNP SVNWKHKDAA IYLVTSLASK AQTQKHGITQ 450
    ANELVNLTEF FVNHILPDLK SANVNEFPVL KADGIKYIMI FRNQVPKEHL 500
    LVSIPLLINH LQAESIVVHT YAAHALERLF TMRGPNNATL FTAAEIAPFV 550
    EILLTNLFKA LTLPGSSENE YIMKAIMRSF SLLQEAIIPY IPTLITQLTQ 600
    KLLAVSKNPS KPHFNHYMFE AICLSIRITC KANPAAVVNF EEALFLVFTE 650
    ILQNDVQEFI PYVFQVMSLL LETHKNDIPS SYMALFPHLL QPVLWERTGN 700
    IPALVRLLQA FLERGSNTIA SAAADKIPGL LGVFQKLIAS KANDHQGFYL 750
    LNSIIEHMPP ESVDQYRKQI FILLFQRLQN SKTTKFIKSF LVFINLYCIK 800
    YGALALQEIF DGIQPKMFGM VLEKIIIPEI QKVSGNVEKK ICAVGITKLL 850
    TECPPMMDTE YTKLWTPLLQ SLIGLFELPE DDTIPDEEHF IDIEDTPGYQ 900
    TAFSQLAFAG KKEHDPVGQM VNNPKIHLAQ SLHKLSTACP GRVPSMVSTS 950
    LNAEALQYLQ GYLQAASVTL L 971
    Length:971
    Mass (Da):110,417
    Last modified:March 29, 2005 - v3
    Checksum:i08E837AB5008EBFD
    GO
    Isoform 2 (identifier: P55060-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         190-195: ATIELC → VWNASW
         196-971: Missing.

    Show »
    Length:195
    Mass (Da):22,670
    Checksum:i94798963277F26F5
    GO
    Isoform 3 (identifier: P55060-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         943-945: VPS → TYF
         946-971: Missing.

    Show »
    Length:945
    Mass (Da):107,778
    Checksum:i6E2D39436F2ABDD9
    GO
    Isoform 4 (identifier: P55060-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         257-312: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:915
    Mass (Da):103,879
    Checksum:i6EDE8048022CF7D1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti231 – 2333FED → WEG in AAC50367. (PubMed:7479798)Curated
    Sequence conflicti231 – 2333FED → WEG in AAC35008. (PubMed:10331944)Curated
    Sequence conflicti514 – 5141E → G in AAC50367. (PubMed:7479798)Curated
    Sequence conflicti514 – 5141E → G in AAC35008. (PubMed:10331944)Curated
    Sequence conflicti538 – 5381A → T in ABO15009. (PubMed:11703094)Curated
    Sequence conflicti848 – 8481K → N in AAC50367. (PubMed:7479798)Curated
    Sequence conflicti934 – 9341K → M in AAC50367. (PubMed:7479798)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti754 – 7541I → V.
    Corresponds to variant rs2229042 [ dbSNP | Ensembl ].
    VAR_029327
    Natural varianti842 – 8421C → F in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036558
    Natural varianti968 – 9681V → L.
    Corresponds to variant rs3505 [ dbSNP | Ensembl ].
    VAR_048836

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei190 – 1956ATIELC → VWNASW in isoform 2. 1 PublicationVSP_001222
    Alternative sequencei196 – 971776Missing in isoform 2. 1 PublicationVSP_001223Add
    BLAST
    Alternative sequencei257 – 31256Missing in isoform 4. 1 PublicationVSP_047203Add
    BLAST
    Alternative sequencei943 – 9453VPS → TYF in isoform 3. 1 PublicationVSP_001224
    Alternative sequencei946 – 97126Missing in isoform 3. 1 PublicationVSP_001225Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33286 mRNA. Translation: AAC50367.1.
    AF053640 mRNA. Translation: AAC35007.1.
    AF053641 mRNA. Translation: AAC35008.1.
    AF053642 mRNA. Translation: AAC35009.1.
    AF053651
    , AF053644, AF053645, AF053646, AF053647, AF053648, AF053649, AF053650 Genomic DNA. Translation: AAC35297.1.
    EF426455 mRNA. Translation: ABO15009.1.
    AK312306 mRNA. Translation: BAG35231.1.
    AL121903, AL133174 Genomic DNA. Translation: CAI19615.1.
    AL133174, AL121903 Genomic DNA. Translation: CAI42818.1.
    CH471077 Genomic DNA. Translation: EAW75676.1.
    CH471077 Genomic DNA. Translation: EAW75677.1.
    BC108309 mRNA. Translation: AAI08310.1.
    BC109313 mRNA. Translation: AAI09314.1.
    BC109314 mRNA. Translation: AAI09315.1.
    CCDSiCCDS13412.1. [P55060-1]
    CCDS58773.1. [P55060-4]
    PIRiI39166.
    RefSeqiNP_001243064.1. NM_001256135.1. [P55060-4]
    NP_001307.2. NM_001316.3. [P55060-1]
    UniGeneiHs.90073.

    Genome annotation databases

    EnsembliENST00000262982; ENSP00000262982; ENSG00000124207. [P55060-1]
    ENST00000396192; ENSP00000379495; ENSG00000124207. [P55060-4]
    GeneIDi1434.
    KEGGihsa:1434.
    UCSCiuc002xty.4. human. [P55060-1]
    uc010zyh.3. human. [P55060-3]

    Polymorphism databases

    DMDMi62297557.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33286 mRNA. Translation: AAC50367.1 .
    AF053640 mRNA. Translation: AAC35007.1 .
    AF053641 mRNA. Translation: AAC35008.1 .
    AF053642 mRNA. Translation: AAC35009.1 .
    AF053651
    , AF053644 , AF053645 , AF053646 , AF053647 , AF053648 , AF053649 , AF053650 Genomic DNA. Translation: AAC35297.1 .
    EF426455 mRNA. Translation: ABO15009.1 .
    AK312306 mRNA. Translation: BAG35231.1 .
    AL121903 , AL133174 Genomic DNA. Translation: CAI19615.1 .
    AL133174 , AL121903 Genomic DNA. Translation: CAI42818.1 .
    CH471077 Genomic DNA. Translation: EAW75676.1 .
    CH471077 Genomic DNA. Translation: EAW75677.1 .
    BC108309 mRNA. Translation: AAI08310.1 .
    BC109313 mRNA. Translation: AAI09314.1 .
    BC109314 mRNA. Translation: AAI09315.1 .
    CCDSi CCDS13412.1. [P55060-1 ]
    CCDS58773.1. [P55060-4 ]
    PIRi I39166.
    RefSeqi NP_001243064.1. NM_001256135.1. [P55060-4 ]
    NP_001307.2. NM_001316.3. [P55060-1 ]
    UniGenei Hs.90073.

    3D structure databases

    ProteinModelPortali P55060.
    SMRi P55060. Positions 6-934.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107821. 81 interactions.
    DIPi DIP-32573N.
    IntActi P55060. 25 interactions.
    MINTi MINT-5001090.

    PTM databases

    PhosphoSitei P55060.

    Polymorphism databases

    DMDMi 62297557.

    Proteomic databases

    MaxQBi P55060.
    PaxDbi P55060.
    PRIDEi P55060.

    Protocols and materials databases

    DNASUi 1434.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262982 ; ENSP00000262982 ; ENSG00000124207 . [P55060-1 ]
    ENST00000396192 ; ENSP00000379495 ; ENSG00000124207 . [P55060-4 ]
    GeneIDi 1434.
    KEGGi hsa:1434.
    UCSCi uc002xty.4. human. [P55060-1 ]
    uc010zyh.3. human. [P55060-3 ]

    Organism-specific databases

    CTDi 1434.
    GeneCardsi GC20P047662.
    HGNCi HGNC:2431. CSE1L.
    HPAi CAB002140.
    HPA038059.
    MIMi 601342. gene.
    neXtProti NX_P55060.
    PharmGKBi PA26933.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5657.
    HOVERGENi HBG080050.
    InParanoidi P55060.
    OMAi QFVTAVW.
    OrthoDBi EOG76MK7M.
    PhylomeDBi P55060.
    TreeFami TF300473.

    Miscellaneous databases

    ChiTaRSi CSE1L. human.
    GenomeRNAii 1434.
    NextBioi 5853.
    PROi P55060.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55060.
    Bgeei P55060.
    CleanExi HS_CSE1L.
    Genevestigatori P55060.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR005043. CAS_CSE1_C.
    IPR013713. Cse1.
    IPR001494. Importin-beta_N.
    [Graphical view ]
    Pfami PF03378. CAS_CSE1. 1 hit.
    PF08506. Cse1. 1 hit.
    PF03810. IBN_N. 1 hit.
    [Graphical view ]
    SMARTi SM00913. IBN_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1."
      Brinkmann U., Brinkmann E., Gallo M., Pastan I.
      Proc. Natl. Acad. Sci. U.S.A. 92:10427-10431(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. "Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene."
      Brinkmann U., Brinkmann E., Bera T.K., Wellmann A., Pastan I.
      Genomics 58:41-49(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Brain.
    3. "IRF-1-mediated CAS expression enhances interferon-gamma-induced apoptosis of HT-29 colon adenocarcinoma cells."
      Jiang M.C., Lin T.L., Lee T.L., Huang H.T., Lin C.L., Liao C.F.
      Mol. Cell Biol. Res. Commun. 4:353-358(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cerebellum.
    5. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    8. Bienvenut W.V.
      Submitted (JUN-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 1-16; 18-26; 32-67; 76-83; 94-109; 138-151; 166-217; 252-268; 282-288; 293-309; 332-371; 373-382; 396-418; 428-440; 446-481; 560-574; 698-736; 769-777; 789-816; 825-832 AND 913-934, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.
    9. "Export of importin-alpha from the nucleus is mediated by a specific nuclear transport factor."
      Kutay U., Bischoff F.R., Kostka S., Kraft R., Goerlich D.
      Cell 90:1061-1071(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 356-370, FUNCTION IN PROTEIN NUCLEAR EXPORT, IDENTIFICATION IN A COMPLEX WITH RAN AND KPNA2.
    10. "Determination of the functional domain organization of the importin alpha nuclear import factor."
      Herold A., Truant R., Wiegand H., Cullen B.R.
      J. Cell Biol. 143:309-318(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KPNA2.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-574 AND LYS-824, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-842.

    Entry informationi

    Entry nameiXPO2_HUMAN
    AccessioniPrimary (citable) accession number: P55060
    Secondary accession number(s): A3RLL6
    , B2R5T4, E1P5Y0, F8W904, O75432, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99, Q9UPA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 138 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3