P55058 (PLTP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospholipid transfer protein

Alternative name(s):
Lipid transfer protein II

Gene names

Name:

PLTP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Converts HDL into larger and smaller particles. May play a key role in extracellular phospholipid transport and modulation of hdl particles.
Subcellular location	Secreted.
Tissue specificity	Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain.
Sequence similarities	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Ontologies

Keywords
Biological process	Lipid transport Transport
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	cellular lipid metabolic process Traceable author statement. Source: Reactome lipid transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Traceable author statement. Source: Reactome
Molecular function	lipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P55058-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P55058-2)

The sequence of this isoform differs from the canonical sequence as follows:
     110-162: FYDGGYINASAEGVSIRTGLELSRDPAGRMKVSNVSCQASVSRMHAAFGGTFK → L

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Ref.1
	Chain	18 – 493	476	Phospholipid transfer protein		PRO_0000017162
Amino acid modifications
	Modified residue	93	1	Phosphothreonine Ref.10
	Modified residue	96	1	Phosphoserine Ref.10
	Glycosylation	64	1	N-linked (GlcNAc...) Ref.9 Ref.11
	Glycosylation	94	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	117	1	N-linked (GlcNAc...) Potential
	Glycosylation	143	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	245	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	398	1	N-linked (GlcNAc...) Ref.9
	Disulfide bond	146 ↔ 185		Ref.8
Natural variations
	Alternative sequence	110 – 162	53	FYDGG…GGTFK → L in isoform 2.		VSP_003050
	Natural variant	124	1	S → Y. Ref.3 Corresponds to variant rs11569636 [ dbSNP | Ensembl ].		VAR_018879
	Natural variant	282	1	R → Q. Ref.12		VAR_017020
	Natural variant	372	1	R → H. Ref.12		VAR_017021
	Natural variant	380	1	R → W. Ref.12 Corresponds to variant rs6065903 [ dbSNP | Ensembl ].		VAR_017022
	Natural variant	425	1	M → I. Ref.3 Corresponds to variant rs11569675 [ dbSNP | Ensembl ].		VAR_018880
	Natural variant	444	1	F → L. Corresponds to variant rs1804161 [ dbSNP | Ensembl ].		VAR_012073
	Natural variant	487	1	T → K. Corresponds to variant rs1056929 [ dbSNP | Ensembl ].		VAR_012074
Experimental info
	Sequence conflict	18	1	E → V in AAH19847. Ref.7
	Sequence conflict	18	1	E → V in AAH19898. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: C6E4852F18E12317	FASTA	493	54,739
	10 20 30 40 50 60 MALFGALFLA LLAGAHAEFP GCKIRVTSKA LELVKQEGLR FLEQELETIT IPDLRGKEGH 70 80 90 100 110 120 FYYNISEVKV TELQLTSSEL DFQPQQELML QITNASLGLR FRRQLLYWFF YDGGYINASA 130 140 150 160 170 180 EGVSIRTGLE LSRDPAGRMK VSNVSCQASV SRMHAAFGGT FKKVYDFLST FITSGMRFLL 190 200 210 220 230 240 NQQICPVLYH AGTVLLNSLL DTVPVRSSVD ELVGIDYSLM KDPVASTSNL DMDFRGAFFP 250 260 270 280 290 300 LTERNWSLPN RAVEPQLQEE ERMVYVAFSE FFFDSAMESY FRAGALQLLL VGDKVPHDLD 310 320 330 340 350 360 MLLRATYFGS IVLLSPAVID SPLKLELRVL APPRCTIKPS GTTISVTASV TIALVPPDQP 370 380 390 400 410 420 EVQLSSMTMD ARLSAKMALR GKALRTQLDL RRFRIYSNHS ALESLALIPL QAPLKTMLQI 430 440 450 460 470 480 GVMPMLNERT WRGVQIPLPE GINFVHEVVT NHAGFLTIGA DLHFAKGLRE VIEKNRPADV 490 RASTAPTPST AAV
	Isoform 2 [UniParc]. Checksum: 4D7435F89F79ABAA	FASTA	441	49,272
	10 20 30 40 50 60 MALFGALFLA LLAGAHAEFP GCKIRVTSKA LELVKQEGLR FLEQELETIT IPDLRGKEGH 70 80 90 100 110 120 FYYNISEVKV TELQLTSSEL DFQPQQELML QITNASLGLR FRRQLLYWFL KVYDFLSTFI 130 140 150 160 170 180 TSGMRFLLNQ QICPVLYHAG TVLLNSLLDT VPVRSSVDEL VGIDYSLMKD PVASTSNLDM 190 200 210 220 230 240 DFRGAFFPLT ERNWSLPNRA VEPQLQEEER MVYVAFSEFF FDSAMESYFR AGALQLLLVG 250 260 270 280 290 300 DKVPHDLDML LRATYFGSIV LLSPAVIDSP LKLELRVLAP PRCTIKPSGT TISVTASVTI 310 320 330 340 350 360 ALVPPDQPEV QLSSMTMDAR LSAKMALRGK ALRTQLDLRR FRIYSNHSAL ESLALIPLQA 370 380 390 400 410 420 PLKTMLQIGV MPMLNERTWR GVQIPLPEGI NFVHEVVTNH AGFLTIGADL HFAKGLREVI 430 440 EKNRPADVRA STAPTPSTAA V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete cDNA encoding human phospholipid transfer protein from human endothelial cells." Day J.R., Albers J.J., Lofton-Day C.E., Gilbert T.L., Ching A.F.T., Grant F.J., O'Hara P.J., Marcovina S.M., Adolphson J.L. J. Biol. Chem. 269:9388-9391(1994) [PubMed: 8132678] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-27 AND 163-184. Tissue: Umbilical vein endothelial cell.
[2]	"Molecular cloning and functional characterization of phospholipid transfer protein from human placenta cDNA library." Kobayashi Y., Ohshiro N., Shibusawa A., Sasaki T., Tokuyama S., Yamamoto T. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[3]	SeattleSNPs variation discovery resource Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-124 AND ILE-425.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Adipose tissue.
[5]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Placenta.
[8]	"Role of cysteine residues in human plasma phospholipid transfer protein." Qu S.J., Fan H.Z., Kilinc C., Pownall H.J. J. Protein Chem. 18:193-198(1999) [PubMed: 10333293] [Abstract] Cited for: DISULFIDE BOND.
[9]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64; ASN-94; ASN-143; ASN-245 AND ASN-398, MASS SPECTROMETRY. Tissue: Plasma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-93 AND SER-96, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64, MASS SPECTROMETRY. Tissue: Liver.
[12]	"Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors." Morabia A., Cayanis E., Costanza M.C., Ross B.M., Flaherty M.S., Alvin G.B., Das K., Gilliam T.C. Hum. Mol. Genet. 12:2733-2743(2003) [PubMed: 12966036] [Abstract] Cited for: VARIANTS GLN-282; HIS-372 AND TRP-380.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	L26232 mRNA. Translation: AAA36443.1. AB076694 mRNA. Translation: BAB79630.1. AL008726 Genomic DNA. Translation: CAA15499.1. AK289371 mRNA. Translation: BAF82060.1. AL008726 Genomic DNA. Translation: CAC36020.1. AY509570 Genomic DNA. Translation: AAR87775.1. CH471077 Genomic DNA. Translation: EAW75782.1. CH471077 Genomic DNA. Translation: EAW75781.1. CH471077 Genomic DNA. Translation: EAW75783.1. CH471077 Genomic DNA. Translation: EAW75785.1. CH471077 Genomic DNA. Translation: EAW75787.1. BC005045 mRNA. Translation: AAH05045.1. BC019847 mRNA. Translation: AAH19847.1. BC019898 mRNA. Translation: AAH19898.1.
IPI	IPI00217778. IPI01010596.
PIR	A53533.
RefSeq	NP_001229850.1. NM_001242921.1. NP_006218.1. NM_006227.3. NP_872617.1. NM_182676.2.
UniGene	Hs.439312.
3D structure databases
ProteinModelPortal	P55058.
SMR	P55058. Positions 18-465.
ModBase	Search...
Protein-protein interaction databases
STRING	P55058.
Protein family/group databases
TCDB	1.C.40.1.4. bactericidal permeability increasing protein (BPIP) family.
PTM databases
PhosphoSite	P55058.
Polymorphism databases
DMDM	1709662.
Proteomic databases
PRIDE	P55058.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372431; ENSP00000361508; ENSG00000100979. ENST00000477313; ENSP00000417138; ENSG00000100979.
GeneID	5360.
KEGG	hsa:5360.
UCSC	uc002xql.1. human. uc002xqo.1. human.
Organism-specific databases
CTD	5360.
GeneCards	GC20M044528.
H-InvDB	HIX0015869.
HGNC	HGNC:9093. PLTP.
HPA	CAB032873.
MIM	172425. gene.
neXtProt	NX_P55058.
PharmGKB	PA273.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16339.
HOVERGEN	HBG103156.
InParanoid	P55058.
OMA	TNHAGFL.
PhylomeDB	P55058.
Enzyme and pathway databases
Reactome	REACT_22258. Metabolism of lipids and lipoproteins.
Gene expression databases
ArrayExpress	P55058.
Bgee	P55058.
CleanEx	HS_PLTP.
Genevestigator	P55058.
GermOnline	ENSG00000100979. Homo sapiens.
Family and domain databases
InterPro	IPR017943. Bactericidal_perm-incr_a/b_dom. IPR001124. Lipid-bd_serum_glycop_C. IPR017954. Lipid-bd_serum_glycop_CS. IPR017942. Lipid-bd_serum_glycop_N. [Graphical view]
KO	K08761.
Pfam	PF01273. LBP_BPI_CETP. 1 hit. PF02886. LBP_BPI_CETP_C. 1 hit. [Graphical view]
SMART	SM00328. BPI1. 1 hit. SM00329. BPI2. 1 hit. [Graphical view]
SUPFAM	SSF55394. Bactericidal_perm-incr_a/b_dom. 2 hits.
PROSITE	PS00400. LBP_BPI_CETP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20778.
PMAP-CutDB	P55058.
SOURCE	Search...

Entry information

Entry name

PLTP_HUMAN

Accession

Primary (citable) accession number: P55058
Secondary accession number(s): A8K006 , E1P5N8, Q8WTT1, Q9BR07, Q9BSH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.