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Protein

Apolipoprotein C-IV

Gene

APOC4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May participate in lipoprotein metabolism.

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-IV
Short name:
Apo-CIV
Short name:
ApoC-IV
Alternative name(s):
Apolipoprotein C4
PARP
Gene namesi
Name:APOC4
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Add BLAST27
ChainiPRO_000000203828 – 124Apolipoprotein C-IVAdd BLAST97

Post-translational modificationi

Glycosylated; contains sialic acid. Present in up to five sialylated isoforms.

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Blood plasma, associated primarily with VLDL and HDL. Expressed mainly in the liver.

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C4 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG050550.
InParanoidiP55057.

Family and domain databases

InterProiView protein in InterPro
IPR028120. APOC4.
PANTHERiPTHR32288. PTHR32288. 1 hit.
PfamiView protein in Pfam
PF15119. APOC4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLPRRGLRT LPSLCLYILV LVWVVACEPE GTPTPLPAPE ESRWSLVPSS
60 70 80 90 100
VKELVGPLLT RTRERWQWFW GPGALQGFVQ TYYDDHLRDL GPRAQAWLTS
110 120
SRDRLLNTAQ GLCPRLLCGD KDQD
Length:124
Mass (Da):14,113
Last modified:October 1, 1996 - v1
Checksum:iD4E42C51F078290C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39356 mRNA. Translation: AAC48513.1.
RefSeqiNP_001075834.1. NM_001082365.2.
UniGeneiOcu.2288.

Genome annotation databases

GeneIDi100009218.
KEGGiocu:100009218.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAPOC4_RABIT
AccessioniPrimary (citable) accession number: P55057
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families