ID   APOC4_HUMAN             Reviewed;         127 AA.
AC   P55056; B3KWY6; Q53YY8;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   11-NOV-2015, entry version 125.
DE   RecName: Full=Apolipoprotein C-IV;
DE            Short=Apo-CIV;
DE            Short=ApoC-IV;
DE   AltName: Full=Apolipoprotein C4;
DE   Flags: Precursor;
GN   Name=APOC4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8530039; DOI=10.1006/geno.1995.1144;
RA   Allan C.M., Walker D., Segrest J.P., Taylor J.M.;
RT   "Identification and characterization of a new human gene (APOC4) in
RT   the apolipoprotein E, C-I, and C-II gene locus.";
RL   Genomics 28:291-300(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PRO-36.
RA   Nickerson D.A., Smith J.D., Fullerton S.M., Clark A.G., Stengard J.H.,
RA   Salomaa V., Boerwinkle E., Sing C.F., Weiss K.M.;
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-63.
RC   TISSUE=Plasma;
RX   PubMed=16335952; DOI=10.1021/pr0502065;
RA   Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,
RA   Moore R.J., Smith R.D.;
RT   "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT   hydrazide chemistry, and mass spectrometry.";
RL   J. Proteome Res. 4:2070-2080(2005).
RN   [7]
RP   VARIANTS PRO-36; ASP-52 AND ARG-96.
RX   PubMed=10996355; DOI=10.1016/S0021-9150(99)00459-1;
RA   Kamboh M.I., Aston C.E., Hamman R.F.;
RT   "DNA sequence variation in human apolipoprotein C4 gene and its effect
RT   on plasma lipid profile.";
RL   Atherosclerosis 152:193-201(2000).
RN   [8]
RP   VARIANT [LARGE SCALE ANALYSIS] GLN-75.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA   Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA   Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA   Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA   Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal
RT   cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May participate in lipoprotein metabolism.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
CC   -!- SIMILARITY: Belongs to the apolipoprotein C4 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U32576; AAA91653.1; -; Genomic_DNA.
DR   EMBL; AY422953; AAQ91812.1; -; Genomic_DNA.
DR   EMBL; AK126257; BAG54298.1; -; mRNA.
DR   EMBL; CH471126; EAW57310.1; -; Genomic_DNA.
DR   EMBL; BC020723; AAH20723.1; -; mRNA.
DR   CCDS; CCDS12649.1; -.
DR   RefSeq; NP_001637.1; NM_001646.2.
DR   UniGene; Hs.731599; -.
DR   ProteinModelPortal; P55056; -.
DR   BioGrid; 106843; 1.
DR   STRING; 9606.ENSP00000468236; -.
DR   PhosphoSite; P55056; -.
DR   BioMuta; APOC4; -.
DR   DMDM; 1703333; -.
DR   PaxDb; P55056; -.
DR   PeptideAtlas; P55056; -.
DR   PRIDE; P55056; -.
DR   Ensembl; ENST00000592954; ENSP00000468236; ENSG00000267467.
DR   GeneID; 346; -.
DR   KEGG; hsa:346; -.
DR   CTD; 346; -.
DR   GeneCards; APOC4; -.
DR   HGNC; HGNC:611; APOC4.
DR   HPA; HPA062671; -.
DR   MIM; 600745; gene.
DR   neXtProt; NX_P55056; -.
DR   PharmGKB; PA54; -.
DR   eggNOG; ENOG410JGNY; Eukaryota.
DR   eggNOG; ENOG41118WT; LUCA.
DR   GeneTree; ENSGT00390000007913; -.
DR   GeneTree; ENSGT00390000015914; -.
DR   HOGENOM; HOG000034003; -.
DR   HOVERGEN; HBG050550; -.
DR   InParanoid; P55056; -.
DR   OMA; KTHSLCP; -.
DR   OrthoDB; EOG76MKBG; -.
DR   PhylomeDB; P55056; -.
DR   TreeFam; TF336879; -.
DR   ChiTaRS; APOC4; human.
DR   GeneWiki; Apolipoprotein_C4; -.
DR   GenomeRNAi; 346; -.
DR   NextBio; 1427; -.
DR   PRO; PR:P55056; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; P55056; -.
DR   CleanEx; HS_APOC4; -.
DR   ExpressionAtlas; P55056; baseline.
DR   Genevisible; P55056; HS.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IDA:BHF-UCL.
DR   GO; GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL.
DR   GO; GO:0005319; F:lipid transporter activity; TAS:ProtInc.
DR   GO; GO:0006629; P:lipid metabolic process; TAS:ProtInc.
DR   GO; GO:0010890; P:positive regulation of sequestering of triglyceride; IMP:BHF-UCL.
DR   GO; GO:0070328; P:triglyceride homeostasis; IMP:BHF-UCL.
DR   InterPro; IPR028120; APOC4.
DR   PANTHER; PTHR32288; PTHR32288; 1.
DR   Pfam; PF15119; APOC4; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Glycoprotein; Lipid transport; Polymorphism;
KW   Reference proteome; Secreted; Signal; Transport.
FT   SIGNAL        1     26       {ECO:0000255}.
FT   CHAIN        27    127       Apolipoprotein C-IV.
FT                                /FTId=PRO_0000002036.
FT   CARBOHYD     63     63       N-linked (GlcNAc...).
FT                                {ECO:0000269|PubMed:16335952}.
FT   VARIANT      36     36       L -> P (in dbSNP:rs1132899).
FT                                {ECO:0000269|PubMed:10996355,
FT                                ECO:0000269|Ref.2}.
FT                                /FTId=VAR_012081.
FT   VARIANT      52     52       G -> D. {ECO:0000269|PubMed:10996355}.
FT                                /FTId=VAR_012082.
FT   VARIANT      75     75       P -> Q (in a breast cancer sample;
FT                                somatic mutation).
FT                                {ECO:0000269|PubMed:16959974}.
FT                                /FTId=VAR_036540.
FT   VARIANT      96     96       L -> R (in dbSNP:rs5167).
FT                                {ECO:0000269|PubMed:10996355}.
FT                                /FTId=VAR_012068.
FT   VARIANT     126    126       Q -> L (in dbSNP:rs5168).
FT                                /FTId=VAR_012069.
SQ   SEQUENCE   127 AA;  14553 MW;  D7C7F6F2CD922775 CRC64;
     MSLLRNRLQA LPALCLCVLV LACIGACQPE AQEGTLSPPP KLKMSRWSLV RGRMKELLET
     VVNRTRDGWQ WFWSPSTFRG FMQTYYDDHL RDLGPLTKAW FLESKDSLLK KTHSLCPRLV
     CGDKDQG
//