Reviewed, UniProtKB/Swiss-Prot P55056 (APOC4_HUMAN)

Names and origin

Protein names

Recommended name:
    Apolipoprotein C-IV
      Short name=Apo-CIV
      Short name=ApoC-IV

Gene names

Name:

APOC4

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May participate in lipoprotein metabolism.
Subcellular location	Secreted.
Tissue specificity	Expressed by the liver and secreted in plasma.
Sequence similarities	Belongs to the apolipoprotein C4 family.

Ontologies

Keywords
Biological process	Lipid transport Transport
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid metabolic process Ref.1 Traceable author statement. Source: ProtInc lipid transport Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of sequestering of triglyceride Inferred from mutant phenotype. Source: UniProtKB triglyceride homeostasis Inferred from mutant phenotype. Source: UniProtKB
Cellular component	high-density lipoprotein particle Inferred from direct assay. Source: UniProtKB very-low-density lipoprotein particle Inferred from direct assay. Source: UniProtKB
Molecular function	lipid transporter activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 127	101	Apolipoprotein C-IV		PRO_0000002036
Amino acid modifications
	Glycosylation	63	1	N-linked (GlcNAc...) Ref.5
Natural variations
	Natural variant	36	1	L → P: dbSNP rs1132899. Ref.6		VAR_012081
	Natural variant	52	1	G → D		VAR_012082
	Natural variant	75	1	P → Q in a breast cancer sample; somatic mutation. Ref.7		VAR_036540
	Natural variant	96	1	L → R: dbSNP rs5167. Ref.6		VAR_012068
	Natural variant	126	1	Q → L: dbSNP rs5168.		VAR_012069

Sequences

	Sequence		Length	Mass (Da)
	P55056-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: D7C7F6F2CD922775	FASTA	127	14,553
	10 20 30 40 50 60 MSLLRNRLQA LPALCLCVLV LACIGACQPE AQEGTLSPPP KLKMSRWSLV RGRMKELLET 70 80 90 100 110 120 VVNRTRDGWQ WFWSPSTFRG FMQTYYDDHL RDLGPLTKAW FLESKDSLLK KTHSLCPRLV CGDKDQG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus." Allan C.M., Walker D., Segrest J.P., Taylor J.M. Genomics 28:291-300(1995) [PubMed: 8530039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-63, MASS SPECTROMETRY. Tissue: Plasma.
[6]	"DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile." Kamboh M.I., Aston C.E., Hamman R.F. Atherosclerosis 152:193-201(2000) [PubMed: 10996355] [Abstract] Cited for: VARIANTS PRO-36; ASP-52 AND ARG-96.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-75.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U32576 Genomic DNA. Translation: AAA91653.1. AK126257 mRNA. Translation: BAG54298.1. CH471126 Genomic DNA. Translation: EAW57310.1. BC020723 mRNA. Translation: AAH20723.1.
IPI	IPI00022731.
RefSeq	NP_001637.1.
UniGene	Hs.655423
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P55056.
Proteomic databases
PeptideAtlas	P55056.
PRIDE	P55056.
Genome annotation databases
Ensembl	ENST00000436871; ENSP00000412935; ENSG00000224916; Homo sapiens. [Genome view]
GeneID	346.
KEGG	hsa:346.
UCSC	uc002pag.1. human.
Organism-specific databases
CTD	346.
GeneCards	GC19P050137.
H-InvDB	HIX0015217.
HGNC	HGNC:611. APOC4.
MIM	600745. gene.
PharmGKB	PA54.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P55056.
OMA	KTHSLCP
OrthoDB	EOG9THZCD
Gene expression databases
ArrayExpress	P55056.
Bgee	P55056.
CleanEx	HS_APOC4.
Genevestigator	P55056.
GermOnline	ENSG00000130207. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	1427.
SOURCE	Search...

Entry information

Entry name

APOC4_HUMAN

Accession

Primary (citable) accession number: P55056
Secondary accession number(s): B3KWY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 24, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.