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Protein

Apolipoprotein C-IV

Gene

APOC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate in lipoprotein metabolism.

GO - Molecular functioni

  • lipid transporter activity Source: ProtInc

GO - Biological processi

  • lipid metabolic process Source: ProtInc
  • positive regulation of sequestering of triglyceride Source: BHF-UCL
  • triglyceride homeostasis Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-33177-MONOMER.
ReactomeiR-HSA-8855121. VLDL interactions.
R-HSA-8866423. VLDL biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-IV
Short name:
Apo-CIV
Short name:
ApoC-IV
Alternative name(s):
Apolipoprotein C4
Gene namesi
Name:APOC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:611. APOC4.

Subcellular locationi

GO - Cellular componenti

  • high-density lipoprotein particle Source: BHF-UCL
  • very-low-density lipoprotein particle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi346.
OpenTargetsiENSG00000224916.
ENSG00000267467.
PharmGKBiPA54.

Polymorphism and mutation databases

BioMutaiAPOC4.
DMDMi1703333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000203630 – 127Apolipoprotein C-IVAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP55056.
PeptideAtlasiP55056.
PRIDEiP55056.

PTM databases

PhosphoSitePlusiP55056.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

CleanExiHS_APOC4.
ExpressionAtlasiP55056. differential.
GenevisibleiP55056. HS.

Organism-specific databases

HPAiHPA062671.

Interactioni

Protein-protein interaction databases

BioGridi106843. 1 interactor.
STRINGi9606.ENSP00000468236.

Structurei

3D structure databases

ProteinModelPortaliP55056.
SMRiP55056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C4 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JGNY. Eukaryota.
ENOG41118WT. LUCA.
GeneTreeiENSGT00390000007913.
ENSGT00390000015914.
HOGENOMiHOG000034003.
HOVERGENiHBG050550.
InParanoidiP55056.
OMAiKTHSLCP.
OrthoDBiEOG091G12IF.
PhylomeDBiP55056.
TreeFamiTF336879.

Family and domain databases

InterProiIPR028120. APOC4.
[Graphical view]
PANTHERiPTHR32288. PTHR32288. 1 hit.
PfamiPF15119. APOC4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLRNRLQA LPALCLCVLV LACIGACQPE AQEGTLSPPP KLKMSRWSLV
60 70 80 90 100
RGRMKELLET VVNRTRDGWQ WFWSPSTFRG FMQTYYDDHL RDLGPLTKAW
110 120
FLESKDSLLK KTHSLCPRLV CGDKDQG
Length:127
Mass (Da):14,553
Last modified:October 1, 1996 - v1
Checksum:iD7C7F6F2CD922775
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01208136L → P.2 PublicationsCorresponds to variant rs1132899dbSNPEnsembl.1
Natural variantiVAR_01208252G → D.1 PublicationCorresponds to variant rs12691089dbSNPEnsembl.1
Natural variantiVAR_03654075P → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_01206896L → R.1 PublicationCorresponds to variant rs5167dbSNPEnsembl.1
Natural variantiVAR_012069126Q → L.Corresponds to variant rs5168dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32576 Genomic DNA. Translation: AAA91653.1.
AY422953 Genomic DNA. Translation: AAQ91812.1.
AK126257 mRNA. Translation: BAG54298.1.
CH471126 Genomic DNA. Translation: EAW57310.1.
BC020723 mRNA. Translation: AAH20723.1.
CCDSiCCDS12649.1.
RefSeqiNP_001637.1. NM_001646.2.
UniGeneiHs.731599.

Genome annotation databases

EnsembliENST00000592954; ENSP00000468236; ENSG00000267467.
GeneIDi346.
KEGGihsa:346.
UCSCiuc060zuq.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32576 Genomic DNA. Translation: AAA91653.1.
AY422953 Genomic DNA. Translation: AAQ91812.1.
AK126257 mRNA. Translation: BAG54298.1.
CH471126 Genomic DNA. Translation: EAW57310.1.
BC020723 mRNA. Translation: AAH20723.1.
CCDSiCCDS12649.1.
RefSeqiNP_001637.1. NM_001646.2.
UniGeneiHs.731599.

3D structure databases

ProteinModelPortaliP55056.
SMRiP55056.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106843. 1 interactor.
STRINGi9606.ENSP00000468236.

PTM databases

PhosphoSitePlusiP55056.

Polymorphism and mutation databases

BioMutaiAPOC4.
DMDMi1703333.

Proteomic databases

PaxDbiP55056.
PeptideAtlasiP55056.
PRIDEiP55056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000592954; ENSP00000468236; ENSG00000267467.
GeneIDi346.
KEGGihsa:346.
UCSCiuc060zuq.1. human.

Organism-specific databases

CTDi346.
DisGeNETi346.
GeneCardsiAPOC4.
HGNCiHGNC:611. APOC4.
HPAiHPA062671.
MIMi600745. gene.
neXtProtiNX_P55056.
OpenTargetsiENSG00000224916.
ENSG00000267467.
PharmGKBiPA54.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JGNY. Eukaryota.
ENOG41118WT. LUCA.
GeneTreeiENSGT00390000007913.
ENSGT00390000015914.
HOGENOMiHOG000034003.
HOVERGENiHBG050550.
InParanoidiP55056.
OMAiKTHSLCP.
OrthoDBiEOG091G12IF.
PhylomeDBiP55056.
TreeFamiTF336879.

Enzyme and pathway databases

BioCyciZFISH:G66-33177-MONOMER.
ReactomeiR-HSA-8855121. VLDL interactions.
R-HSA-8866423. VLDL biosynthesis.

Miscellaneous databases

ChiTaRSiAPOC4. human.
GeneWikiiApolipoprotein_C4.
GenomeRNAii346.
PROiP55056.
SOURCEiSearch...

Gene expression databases

CleanExiHS_APOC4.
ExpressionAtlasiP55056. differential.
GenevisibleiP55056. HS.

Family and domain databases

InterProiIPR028120. APOC4.
[Graphical view]
PANTHERiPTHR32288. PTHR32288. 1 hit.
PfamiPF15119. APOC4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPOC4_HUMAN
AccessioniPrimary (citable) accession number: P55056
Secondary accession number(s): B3KWY6, Q53YY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.