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Protein

Apolipoprotein C-IV

Gene

APOC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate in lipoprotein metabolism.

GO - Molecular functioni

  • lipid transporter activity Source: ProtInc

GO - Biological processi

  • lipid metabolic process Source: ProtInc
  • positive regulation of sequestering of triglyceride Source: BHF-UCL
  • triglyceride homeostasis Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-IV
Short name:
Apo-CIV
Short name:
ApoC-IV
Alternative name(s):
Apolipoprotein C4
Gene namesi
Name:APOC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:611. APOC4.

Subcellular locationi

GO - Cellular componenti

  • high-density lipoprotein particle Source: BHF-UCL
  • very-low-density lipoprotein particle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA54.

Polymorphism and mutation databases

BioMutaiAPOC4.
DMDMi1703333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 127101Apolipoprotein C-IVPRO_0000002036Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP55056.
PeptideAtlasiP55056.
PRIDEiP55056.

PTM databases

PhosphoSiteiP55056.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiP55056.
CleanExiHS_APOC4.
ExpressionAtlasiP55056. baseline.
GenevisibleiP55056. HS.

Organism-specific databases

HPAiHPA062671.

Interactioni

Protein-protein interaction databases

BioGridi106843. 1 interaction.
STRINGi9606.ENSP00000468236.

Structurei

3D structure databases

ProteinModelPortaliP55056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C4 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39292.
GeneTreeiENSGT00390000007913.
ENSGT00390000015914.
HOGENOMiHOG000034003.
HOVERGENiHBG050550.
InParanoidiP55056.
OMAiWLRSSKD.
OrthoDBiEOG76MKBG.
PhylomeDBiP55056.
TreeFamiTF336879.

Family and domain databases

InterProiIPR028120. APOC4.
[Graphical view]
PANTHERiPTHR32288. PTHR32288. 1 hit.
PfamiPF15119. APOC4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLRNRLQA LPALCLCVLV LACIGACQPE AQEGTLSPPP KLKMSRWSLV
60 70 80 90 100
RGRMKELLET VVNRTRDGWQ WFWSPSTFRG FMQTYYDDHL RDLGPLTKAW
110 120
FLESKDSLLK KTHSLCPRLV CGDKDQG
Length:127
Mass (Da):14,553
Last modified:October 1, 1996 - v1
Checksum:iD7C7F6F2CD922775
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361L → P.2 Publications
Corresponds to variant rs1132899 [ dbSNP | Ensembl ].
VAR_012081
Natural varianti52 – 521G → D.1 Publication
VAR_012082
Natural varianti75 – 751P → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_036540
Natural varianti96 – 961L → R.1 Publication
Corresponds to variant rs5167 [ dbSNP | Ensembl ].
VAR_012068
Natural varianti126 – 1261Q → L.
Corresponds to variant rs5168 [ dbSNP | Ensembl ].
VAR_012069

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32576 Genomic DNA. Translation: AAA91653.1.
AY422953 Genomic DNA. Translation: AAQ91812.1.
AK126257 mRNA. Translation: BAG54298.1.
CH471126 Genomic DNA. Translation: EAW57310.1.
BC020723 mRNA. Translation: AAH20723.1.
CCDSiCCDS12649.1.
RefSeqiNP_001637.1. NM_001646.2.
UniGeneiHs.731599.

Genome annotation databases

EnsembliENST00000592954; ENSP00000468236; ENSG00000267467.
GeneIDi346.
KEGGihsa:346.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32576 Genomic DNA. Translation: AAA91653.1.
AY422953 Genomic DNA. Translation: AAQ91812.1.
AK126257 mRNA. Translation: BAG54298.1.
CH471126 Genomic DNA. Translation: EAW57310.1.
BC020723 mRNA. Translation: AAH20723.1.
CCDSiCCDS12649.1.
RefSeqiNP_001637.1. NM_001646.2.
UniGeneiHs.731599.

3D structure databases

ProteinModelPortaliP55056.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106843. 1 interaction.
STRINGi9606.ENSP00000468236.

PTM databases

PhosphoSiteiP55056.

Polymorphism and mutation databases

BioMutaiAPOC4.
DMDMi1703333.

Proteomic databases

PaxDbiP55056.
PeptideAtlasiP55056.
PRIDEiP55056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000592954; ENSP00000468236; ENSG00000267467.
GeneIDi346.
KEGGihsa:346.

Organism-specific databases

CTDi346.
GeneCardsiGC19P045445.
HGNCiHGNC:611. APOC4.
HPAiHPA062671.
MIMi600745. gene.
neXtProtiNX_P55056.
PharmGKBiPA54.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39292.
GeneTreeiENSGT00390000007913.
ENSGT00390000015914.
HOGENOMiHOG000034003.
HOVERGENiHBG050550.
InParanoidiP55056.
OMAiWLRSSKD.
OrthoDBiEOG76MKBG.
PhylomeDBiP55056.
TreeFamiTF336879.

Miscellaneous databases

ChiTaRSiAPOC4. human.
GeneWikiiApolipoprotein_C4.
GenomeRNAii346.
NextBioi1427.
PROiP55056.
SOURCEiSearch...

Gene expression databases

BgeeiP55056.
CleanExiHS_APOC4.
ExpressionAtlasiP55056. baseline.
GenevisibleiP55056. HS.

Family and domain databases

InterProiIPR028120. APOC4.
[Graphical view]
PANTHERiPTHR32288. PTHR32288. 1 hit.
PfamiPF15119. APOC4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus."
    Allan C.M., Walker D., Segrest J.P., Taylor J.M.
    Genomics 28:291-300(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Nickerson D.A., Smith J.D., Fullerton S.M., Clark A.G., Stengard J.H., Salomaa V., Boerwinkle E., Sing C.F., Weiss K.M.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-36.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-63.
    Tissue: Plasma.
  7. "DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile."
    Kamboh M.I., Aston C.E., Hamman R.F.
    Atherosclerosis 152:193-201(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PRO-36; ASP-52 AND ARG-96.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-75.

Entry informationi

Entry nameiAPOC4_HUMAN
AccessioniPrimary (citable) accession number: P55056
Secondary accession number(s): B3KWY6, Q53YY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.