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P55056

- APOC4_HUMAN

UniProt

P55056 - APOC4_HUMAN

Protein

Apolipoprotein C-IV

Gene

APOC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May participate in lipoprotein metabolism.

    GO - Molecular functioni

    1. lipid transporter activity Source: ProtInc

    GO - Biological processi

    1. lipid metabolic process Source: ProtInc
    2. positive regulation of sequestering of triglyceride Source: BHF-UCL
    3. triglyceride homeostasis Source: BHF-UCL

    Keywords - Biological processi

    Lipid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein C-IV
    Short name:
    Apo-CIV
    Short name:
    ApoC-IV
    Alternative name(s):
    Apolipoprotein C4
    Gene namesi
    Name:APOC4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:611. APOC4.

    Subcellular locationi

    GO - Cellular componenti

    1. high-density lipoprotein particle Source: BHF-UCL
    2. very-low-density lipoprotein particle Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA54.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 127101Apolipoprotein C-IVPRO_0000002036Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi63 – 631N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP55056.
    PeptideAtlasiP55056.
    PRIDEiP55056.

    PTM databases

    PhosphoSiteiP55056.

    Expressioni

    Tissue specificityi

    Expressed by the liver and secreted in plasma.

    Gene expression databases

    BgeeiP55056.
    CleanExiHS_APOC4.
    GenevestigatoriP55056.

    Interactioni

    Protein-protein interaction databases

    BioGridi106843. 1 interaction.
    STRINGi9606.ENSP00000412935.

    Structurei

    3D structure databases

    ProteinModelPortaliP55056.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the apolipoprotein C4 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39292.
    HOGENOMiHOG000034003.
    HOVERGENiHBG050550.
    InParanoidiP55056.
    OMAiKTHSLCP.
    OrthoDBiEOG76MKBG.
    PhylomeDBiP55056.
    TreeFamiTF336879.

    Family and domain databases

    InterProiIPR028120. APOC4.
    [Graphical view]
    PANTHERiPTHR32288. PTHR32288. 1 hit.
    PfamiPF15119. APOC4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55056-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLLRNRLQA LPALCLCVLV LACIGACQPE AQEGTLSPPP KLKMSRWSLV    50
    RGRMKELLET VVNRTRDGWQ WFWSPSTFRG FMQTYYDDHL RDLGPLTKAW 100
    FLESKDSLLK KTHSLCPRLV CGDKDQG 127
    Length:127
    Mass (Da):14,553
    Last modified:October 1, 1996 - v1
    Checksum:iD7C7F6F2CD922775
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti36 – 361L → P.2 Publications
    Corresponds to variant rs1132899 [ dbSNP | Ensembl ].
    VAR_012081
    Natural varianti52 – 521G → D.1 Publication
    VAR_012082
    Natural varianti75 – 751P → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036540
    Natural varianti96 – 961L → R.1 Publication
    Corresponds to variant rs5167 [ dbSNP | Ensembl ].
    VAR_012068
    Natural varianti126 – 1261Q → L.
    Corresponds to variant rs5168 [ dbSNP | Ensembl ].
    VAR_012069

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32576 Genomic DNA. Translation: AAA91653.1.
    AY422953 Genomic DNA. Translation: AAQ91812.1.
    AK126257 mRNA. Translation: BAG54298.1.
    CH471126 Genomic DNA. Translation: EAW57310.1.
    BC020723 mRNA. Translation: AAH20723.1.
    CCDSiCCDS12649.1.
    RefSeqiNP_001637.1. NM_001646.2.
    UniGeneiHs.731599.

    Genome annotation databases

    EnsembliENST00000592954; ENSP00000468236; ENSG00000267467.
    GeneIDi346.
    KEGGihsa:346.

    Polymorphism databases

    DMDMi1703333.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32576 Genomic DNA. Translation: AAA91653.1 .
    AY422953 Genomic DNA. Translation: AAQ91812.1 .
    AK126257 mRNA. Translation: BAG54298.1 .
    CH471126 Genomic DNA. Translation: EAW57310.1 .
    BC020723 mRNA. Translation: AAH20723.1 .
    CCDSi CCDS12649.1.
    RefSeqi NP_001637.1. NM_001646.2.
    UniGenei Hs.731599.

    3D structure databases

    ProteinModelPortali P55056.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106843. 1 interaction.
    STRINGi 9606.ENSP00000412935.

    PTM databases

    PhosphoSitei P55056.

    Polymorphism databases

    DMDMi 1703333.

    Proteomic databases

    PaxDbi P55056.
    PeptideAtlasi P55056.
    PRIDEi P55056.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000592954 ; ENSP00000468236 ; ENSG00000267467 .
    GeneIDi 346.
    KEGGi hsa:346.

    Organism-specific databases

    CTDi 346.
    GeneCardsi GC19P045445.
    HGNCi HGNC:611. APOC4.
    MIMi 600745. gene.
    neXtProti NX_P55056.
    PharmGKBi PA54.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39292.
    HOGENOMi HOG000034003.
    HOVERGENi HBG050550.
    InParanoidi P55056.
    OMAi KTHSLCP.
    OrthoDBi EOG76MKBG.
    PhylomeDBi P55056.
    TreeFami TF336879.

    Miscellaneous databases

    ChiTaRSi APOC4. human.
    GeneWikii Apolipoprotein_C4.
    GenomeRNAii 346.
    NextBioi 1427.
    PROi P55056.
    SOURCEi Search...

    Gene expression databases

    Bgeei P55056.
    CleanExi HS_APOC4.
    Genevestigatori P55056.

    Family and domain databases

    InterProi IPR028120. APOC4.
    [Graphical view ]
    PANTHERi PTHR32288. PTHR32288. 1 hit.
    Pfami PF15119. APOC4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus."
      Allan C.M., Walker D., Segrest J.P., Taylor J.M.
      Genomics 28:291-300(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Nickerson D.A., Smith J.D., Fullerton S.M., Clark A.G., Stengard J.H., Salomaa V., Boerwinkle E., Sing C.F., Weiss K.M.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-36.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-63.
      Tissue: Plasma.
    7. "DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile."
      Kamboh M.I., Aston C.E., Hamman R.F.
      Atherosclerosis 152:193-201(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PRO-36; ASP-52 AND ARG-96.
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-75.

    Entry informationi

    Entry nameiAPOC4_HUMAN
    AccessioniPrimary (citable) accession number: P55056
    Secondary accession number(s): B3KWY6, Q53YY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3