P55056 (APOC4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apolipoprotein C-IV
Short name=Apo-CIV
Short name=ApoC-IV

Alternative name(s):
Apolipoprotein C4

Gene names

Name:

APOC4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May participate in lipoprotein metabolism.
Subcellular location	Secreted.
Tissue specificity	Expressed by the liver and secreted in plasma.
Sequence similarities	Belongs to the apolipoprotein C4 family.

Ontologies

Keywords
Biological process	Lipid transport Transport
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid metabolic process Traceable author statement Ref.1. Source: ProtInc positive regulation of sequestering of triglyceride Inferred from mutant phenotype PubMed 18809223. Source: BHF-UCL triglyceride homeostasis Inferred from mutant phenotype PubMed 8827523. Source: BHF-UCL
Cellular_component	high-density lipoprotein particle Inferred from direct assay PubMed 12700345. Source: BHF-UCL very-low-density lipoprotein particle Inferred from direct assay PubMed 12700345PubMed 17154273. Source: BHF-UCL
Molecular_function	lipid transporter activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 127	101	Apolipoprotein C-IV		PRO_0000002036
Amino acid modifications
	Glycosylation	63	1	N-linked (GlcNAc...) Ref.6
Natural variations
	Natural variant	36	1	L → P. Ref.2 Ref.7 Corresponds to variant rs1132899 [ dbSNP | Ensembl ].		VAR_012081
	Natural variant	52	1	G → D. Ref.7		VAR_012082
	Natural variant	75	1	P → Q in a breast cancer sample; somatic mutation. Ref.8		VAR_036540
	Natural variant	96	1	L → R. Ref.7 Corresponds to variant rs5167 [ dbSNP | Ensembl ].		VAR_012068
	Natural variant	126	1	Q → L. Corresponds to variant rs5168 [ dbSNP | Ensembl ].		VAR_012069

Sequences

	Sequence		Length	Mass (Da)
	P55056 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: D7C7F6F2CD922775	FASTA	127	14,553
	10 20 30 40 50 60 MSLLRNRLQA LPALCLCVLV LACIGACQPE AQEGTLSPPP KLKMSRWSLV RGRMKELLET 70 80 90 100 110 120 VVNRTRDGWQ WFWSPSTFRG FMQTYYDDHL RDLGPLTKAW FLESKDSLLK KTHSLCPRLV CGDKDQG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus." Allan C.M., Walker D., Segrest J.P., Taylor J.M. Genomics 28:291-300(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Nickerson D.A., Smith J.D., Fullerton S.M., Clark A.G., Stengard J.H., Salomaa V., Boerwinkle E., Sing C.F., Weiss K.M. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-36.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[6]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-63, MASS SPECTROMETRY. Tissue: Plasma.
[7]	"DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile." Kamboh M.I., Aston C.E., Hamman R.F. Atherosclerosis 152:193-201(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PRO-36; ASP-52 AND ARG-96.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-75.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U32576 Genomic DNA. Translation: AAA91653.1. AY422953 Genomic DNA. Translation: AAQ91812.1. AK126257 mRNA. Translation: BAG54298.1. CH471126 Genomic DNA. Translation: EAW57310.1. BC020723 mRNA. Translation: AAH20723.1.
IPI	IPI00022731.
RefSeq	NP_001637.1. NM_001646.2.
UniGene	Hs.731599.
3D structure databases
ProteinModelPortal	P55056.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000412935.
PTM databases
PhosphoSite	P55056.
Polymorphism databases
DMDM	1703333.
Proteomic databases
PaxDb	P55056.
PeptideAtlas	P55056.
PRIDE	P55056.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000592954; ENSP00000468236; ENSG00000267467.
GeneID	346.
KEGG	hsa:346.
Organism-specific databases
CTD	346.
GeneCards	GC19P045445.
HGNC	HGNC:611. APOC4.
MIM	600745. gene.
neXtProt	NX_P55056.
PharmGKB	PA54.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39292.
HOGENOM	HOG000034003.
HOVERGEN	HBG050550.
InParanoid	P55056.
OMA	TYYDDHL.
OrthoDB	EOG4JQ402.
PhylomeDB	P55056.
Gene expression databases
ArrayExpress	P55056.
Bgee	P55056.
CleanEx	HS_APOC4.
Genevestigator	P55056.
GermOnline	ENSG00000130207. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	APOC4. human.
GenomeRNAi	346.
NextBio	1427.
SOURCE	Search...

Entry information

Entry name

APOC4_HUMAN

Accession

Primary (citable) accession number: P55056
Secondary accession number(s): B3KWY6, Q53YY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.