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P55056 (APOC4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein C-IV

Short name=Apo-CIV
Short name=ApoC-IV
Alternative name(s):
Apolipoprotein C4
Gene names
Name:APOC4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length127 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May participate in lipoprotein metabolism.

Subcellular location

Secreted.

Tissue specificity

Expressed by the liver and secreted in plasma.

Sequence similarities

Belongs to the apolipoprotein C4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 127101Apolipoprotein C-IV
PRO_0000002036

Amino acid modifications

Glycosylation631N-linked (GlcNAc...) Ref.6

Natural variations

Natural variant361L → P. Ref.2 Ref.7
Corresponds to variant rs1132899 [ dbSNP | Ensembl ].
VAR_012081
Natural variant521G → D. Ref.7
VAR_012082
Natural variant751P → Q in a breast cancer sample; somatic mutation. Ref.8
VAR_036540
Natural variant961L → R. Ref.7
Corresponds to variant rs5167 [ dbSNP | Ensembl ].
VAR_012068
Natural variant1261Q → L.
Corresponds to variant rs5168 [ dbSNP | Ensembl ].
VAR_012069

Sequences

Sequence LengthMass (Da)Tools
P55056 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D7C7F6F2CD922775

FASTA12714,553
        10         20         30         40         50         60 
MSLLRNRLQA LPALCLCVLV LACIGACQPE AQEGTLSPPP KLKMSRWSLV RGRMKELLET 

        70         80         90        100        110        120 
VVNRTRDGWQ WFWSPSTFRG FMQTYYDDHL RDLGPLTKAW FLESKDSLLK KTHSLCPRLV 


CGDKDQG 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus."
Allan C.M., Walker D., Segrest J.P., Taylor J.M.
Genomics 28:291-300(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Nickerson D.A., Smith J.D., Fullerton S.M., Clark A.G., Stengard J.H., Salomaa V., Boerwinkle E., Sing C.F., Weiss K.M.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-36.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[6]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-63.
Tissue: Plasma.
[7]"DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile."
Kamboh M.I., Aston C.E., Hamman R.F.
Atherosclerosis 152:193-201(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PRO-36; ASP-52 AND ARG-96.
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-75.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U32576 Genomic DNA. Translation: AAA91653.1.
AY422953 Genomic DNA. Translation: AAQ91812.1.
AK126257 mRNA. Translation: BAG54298.1.
CH471126 Genomic DNA. Translation: EAW57310.1.
BC020723 mRNA. Translation: AAH20723.1.
CCDSCCDS12649.1.
RefSeqNP_001637.1. NM_001646.2.
UniGeneHs.731599.

3D structure databases

ProteinModelPortalP55056.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106843. 1 interaction.
STRING9606.ENSP00000412935.

PTM databases

PhosphoSiteP55056.

Polymorphism databases

DMDM1703333.

Proteomic databases

PaxDbP55056.
PeptideAtlasP55056.
PRIDEP55056.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000419266; ENSP00000406381; ENSG00000267467.
ENST00000592954; ENSP00000468236; ENSG00000267467.
GeneID346.
KEGGhsa:346.

Organism-specific databases

CTD346.
GeneCardsGC19P045445.
HGNCHGNC:611. APOC4.
MIM600745. gene.
neXtProtNX_P55056.
PharmGKBPA54.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39292.
HOGENOMHOG000034003.
HOVERGENHBG050550.
InParanoidP55056.
OMAKTHSLCP.
OrthoDBEOG76MKBG.
PhylomeDBP55056.
TreeFamTF336879.

Gene expression databases

BgeeP55056.
CleanExHS_APOC4.
GenevestigatorP55056.

Family and domain databases

InterProIPR028120. APOC4.
[Graphical view]
PANTHERPTHR32288. PTHR32288. 1 hit.
PfamPF15119. APOC4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAPOC4. human.
GeneWikiApolipoprotein_C4.
GenomeRNAi346.
NextBio1427.
PROP55056.
SOURCESearch...

Entry information

Entry nameAPOC4_HUMAN
AccessionPrimary (citable) accession number: P55056
Secondary accession number(s): B3KWY6, Q53YY8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM