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P55055

- NR1H2_HUMAN

UniProt

P55055 - NR1H2_HUMAN

Protein

Oxysterols receptor LXR-beta

Gene

NR1H2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi84 – 16178Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri87 – 10721NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri125 – 14925NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. apolipoprotein A-I receptor binding Source: BHF-UCL
    2. ATPase binding Source: BHF-UCL
    3. DNA binding Source: ProtInc
    4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: ProtInc
    5. protein binding Source: IntAct
    6. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    7. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    8. sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity Source: Ensembl
    9. steroid hormone receptor activity Source: InterPro
    10. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cellular lipid metabolic process Source: Ensembl
    2. cholesterol homeostasis Source: Ensembl
    3. gene expression Source: Reactome
    4. negative regulation of cholesterol storage Source: BHF-UCL
    5. negative regulation of interferon-gamma-mediated signaling pathway Source: BHF-UCL
    6. negative regulation of lipid transport Source: BHF-UCL
    7. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
    8. negative regulation of pinocytosis Source: BHF-UCL
    9. negative regulation of proteolysis Source: Ensembl
    10. negative regulation of transcription, DNA-templated Source: HGNC
    11. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. positive regulation of cellular protein metabolic process Source: BHF-UCL
    13. positive regulation of cholesterol efflux Source: BHF-UCL
    14. positive regulation of cholesterol transport Source: BHF-UCL
    15. positive regulation of fatty acid biosynthetic process Source: BHF-UCL
    16. positive regulation of high-density lipoprotein particle assembly Source: Ensembl
    17. positive regulation of lipid storage Source: Ensembl
    18. positive regulation of lipoprotein lipase activity Source: BHF-UCL
    19. positive regulation of pancreatic juice secretion Source: Ensembl
    20. positive regulation of secretion of lysosomal enzymes Source: Ensembl
    21. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    22. positive regulation of triglyceride biosynthetic process Source: BHF-UCL
    23. regulation of cholesterol homeostasis Source: UniProtKB
    24. retinoic acid receptor signaling pathway Source: Ensembl
    25. transcription initiation from RNA polymerase II promoter Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
    SignaLinkiP55055.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxysterols receptor LXR-beta
    Alternative name(s):
    Liver X receptor beta
    Nuclear receptor NER
    Nuclear receptor subfamily 1 group H member 2
    Ubiquitously-expressed nuclear receptor
    Gene namesi
    Name:NR1H2
    Synonyms:LXRB, NER, UNR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:7965. NR1H2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: HGNC
    2. nucleoplasm Source: Reactome
    3. nucleus Source: HGNC

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31750.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 460460Oxysterols receptor LXR-betaPRO_0000053532Add
    BLAST

    Proteomic databases

    MaxQBiP55055.
    PaxDbiP55055.
    PRIDEiP55055.

    PTM databases

    PhosphoSiteiP55055.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiP55055.
    BgeeiP55055.
    CleanExiHS_NR1H2.
    GenevestigatoriP55055.

    Organism-specific databases

    HPAiHPA056838.

    Interactioni

    Subunit structurei

    Forms a heterodimer with RXR.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABCA1O954772EBI-745354,EBI-784112
    MDFIQ997503EBI-745354,EBI-724076

    Protein-protein interaction databases

    BioGridi113222. 54 interactions.
    DIPiDIP-53004N.
    IntActiP55055. 28 interactions.
    MINTiMINT-1444220.
    STRINGi9606.ENSP00000253727.

    Structurei

    Secondary structure

    1
    460
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi221 – 24222
    Helixi245 – 2473
    Helixi261 – 28626
    Helixi291 – 2933
    Helixi296 – 31722
    Turni321 – 3244
    Beta strandi325 – 3295
    Beta strandi332 – 3343
    Helixi336 – 3416
    Helixi346 – 36217
    Helixi366 – 37712
    Helixi388 – 40922
    Beta strandi410 – 4123
    Helixi416 – 44227
    Turni443 – 4453
    Helixi450 – 4567

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1P8DX-ray2.80A/B213-460[»]
    1PQ6X-ray2.40A/B/C/D212-460[»]
    1PQ9X-ray2.10A/B/C/D212-460[»]
    1PQCX-ray2.80A/B/C/D212-460[»]
    1UPVX-ray2.10A208-460[»]
    1UPWX-ray2.40A208-460[»]
    3KFCX-ray2.40A/B/C/D212-460[»]
    3L0EX-ray2.30A212-460[»]
    4DK7X-ray2.45A/C218-460[»]
    4DK8X-ray2.75A/C218-460[»]
    ProteinModelPortaliP55055.
    SMRiP55055. Positions 75-459.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP55055.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni230 – 460231Ligand-bindingSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi190 – 1956Poly-Ser

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri87 – 10721NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri125 – 14925NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG285805.
    HOGENOMiHOG000220845.
    HOVERGENiHBG108655.
    InParanoidiP55055.
    KOiK08535.
    OMAiRRYACRG.
    PhylomeDBiP55055.
    TreeFamiTF352167.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR023257. Liver_X_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR02034. LIVERXRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P55055-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSPTTSSLD TPLPGNGPPQ PGAPSSSPTV KEEGPEPWPG GPDPDVPGTD    50
    EASSACSTDW VIPDPEEEPE RKRKKGPAPK MLGHELCRVC GDKASGFHYN 100
    VLSCEGCKGF FRRSVVRGGA RRYACRGGGT CQMDAFMRRK CQQCRLRKCK 150
    EAGMREQCVL SEEQIRKKKI RKQQQESQSQ SQSPVGPQGS SSSASGPGAS 200
    PGGSEAGSQG SGEGEGVQLT AAQELMIQQL VAAQLQCNKR SFSDQPKVTP 250
    WPLGADPQSR DARQQRFAHF TELAIISVQE IVDFAKQVPG FLQLGREDQI 300
    ALLKASTIEI MLLETARRYN HETECITFLK DFTYSKDDFH RAGLQVEFIN 350
    PIFEFSRAMR RLGLDDAEYA LLIAINIFSA DRPNVQEPGR VEALQQPYVE 400
    ALLSYTRIKR PQDQLRFPRM LMKLVSLRTL SSVHSEQVFA LRLQDKKLPP 450
    LLSEIWDVHE 460
    Length:460
    Mass (Da):50,974
    Last modified:May 18, 2010 - v2
    Checksum:i9465A6FFB7FCFD2F
    GO
    Isoform 2 (identifier: P55055-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         61-158: VIPDPEEEPE...CKEAGMREQC → G

    Note: No experimental confirmation.

    Show »
    Length:363
    Mass (Da):39,920
    Checksum:iE1F0B75FDA51C249
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti175 – 1751Q → QQ in AAA61783. (PubMed:7926814)Curated
    Sequence conflicti175 – 1751Q → QQ in BAF83544. (PubMed:14702039)Curated
    Sequence conflicti175 – 1751Q → QQ in BAG60288. (PubMed:14702039)Curated
    Sequence conflicti175 – 1751Q → QQ in AAH07790. (PubMed:15489334)Curated
    Sequence conflicti175 – 1751Q → QQ in AAH33500. (PubMed:15489334)Curated
    Sequence conflicti175 – 1751Q → QQ in AAH47750. (PubMed:15489334)Curated
    Sequence conflicti175 – 1751Q → QQ in AAH74500. (PubMed:15489334)Curated
    Sequence conflicti175 – 1751Q → QQ in AAA58594. 1 PublicationCurated
    Sequence conflicti244 – 2441D → G in BAG60288. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21S → F.
    Corresponds to variant rs41379547 [ dbSNP | Ensembl ].
    VAR_050579

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei61 – 15898VIPDP…MREQC → G in isoform 2. 1 PublicationVSP_053789Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07132 mRNA. Translation: AAA61783.1.
    AK290855 mRNA. Translation: BAF83544.1.
    AK297978 mRNA. Translation: BAG60288.1.
    AC008655 Genomic DNA. No translation available.
    BC007790 mRNA. Translation: AAH07790.1.
    BC033500 mRNA. Translation: AAH33500.1.
    BC047750 mRNA. Translation: AAH47750.1.
    BC074500 mRNA. Translation: AAH74500.1.
    U14534 mRNA. Translation: AAA58594.1.
    PIRiJC4014.
    RefSeqiNP_001243576.1. NM_001256647.1.
    NP_009052.3. NM_007121.5.
    UniGeneiHs.432976.

    Genome annotation databases

    EnsembliENST00000253727; ENSP00000253727; ENSG00000131408. [P55055-1]
    ENST00000411902; ENSP00000396151; ENSG00000131408. [P55055-2]
    ENST00000593926; ENSP00000471194; ENSG00000131408. [P55055-1]
    GeneIDi7376.
    KEGGihsa:7376.

    Polymorphism databases

    DMDMi296439251.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07132 mRNA. Translation: AAA61783.1 .
    AK290855 mRNA. Translation: BAF83544.1 .
    AK297978 mRNA. Translation: BAG60288.1 .
    AC008655 Genomic DNA. No translation available.
    BC007790 mRNA. Translation: AAH07790.1 .
    BC033500 mRNA. Translation: AAH33500.1 .
    BC047750 mRNA. Translation: AAH47750.1 .
    BC074500 mRNA. Translation: AAH74500.1 .
    U14534 mRNA. Translation: AAA58594.1 .
    PIRi JC4014.
    RefSeqi NP_001243576.1. NM_001256647.1.
    NP_009052.3. NM_007121.5.
    UniGenei Hs.432976.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1P8D X-ray 2.80 A/B 213-460 [» ]
    1PQ6 X-ray 2.40 A/B/C/D 212-460 [» ]
    1PQ9 X-ray 2.10 A/B/C/D 212-460 [» ]
    1PQC X-ray 2.80 A/B/C/D 212-460 [» ]
    1UPV X-ray 2.10 A 208-460 [» ]
    1UPW X-ray 2.40 A 208-460 [» ]
    3KFC X-ray 2.40 A/B/C/D 212-460 [» ]
    3L0E X-ray 2.30 A 212-460 [» ]
    4DK7 X-ray 2.45 A/C 218-460 [» ]
    4DK8 X-ray 2.75 A/C 218-460 [» ]
    ProteinModelPortali P55055.
    SMRi P55055. Positions 75-459.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113222. 54 interactions.
    DIPi DIP-53004N.
    IntActi P55055. 28 interactions.
    MINTi MINT-1444220.
    STRINGi 9606.ENSP00000253727.

    Chemistry

    BindingDBi P55055.
    ChEMBLi CHEMBL4093.
    GuidetoPHARMACOLOGYi 601.

    PTM databases

    PhosphoSitei P55055.

    Polymorphism databases

    DMDMi 296439251.

    Proteomic databases

    MaxQBi P55055.
    PaxDbi P55055.
    PRIDEi P55055.

    Protocols and materials databases

    DNASUi 7376.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253727 ; ENSP00000253727 ; ENSG00000131408 . [P55055-1 ]
    ENST00000411902 ; ENSP00000396151 ; ENSG00000131408 . [P55055-2 ]
    ENST00000593926 ; ENSP00000471194 ; ENSG00000131408 . [P55055-1 ]
    GeneIDi 7376.
    KEGGi hsa:7376.

    Organism-specific databases

    CTDi 7376.
    GeneCardsi GC19P050879.
    HGNCi HGNC:7965. NR1H2.
    HPAi HPA056838.
    MIMi 600380. gene.
    neXtProti NX_P55055.
    PharmGKBi PA31750.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285805.
    HOGENOMi HOG000220845.
    HOVERGENi HBG108655.
    InParanoidi P55055.
    KOi K08535.
    OMAi RRYACRG.
    PhylomeDBi P55055.
    TreeFami TF352167.

    Enzyme and pathway databases

    Reactomei REACT_15525. Nuclear Receptor transcription pathway.
    SignaLinki P55055.

    Miscellaneous databases

    ChiTaRSi NR1H2. human.
    EvolutionaryTracei P55055.
    GeneWikii Liver_X_receptor_beta.
    GenomeRNAii 7376.
    NextBioi 28886.
    PROi P55055.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55055.
    Bgeei P55055.
    CleanExi HS_NR1H2.
    Genevestigatori P55055.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR023257. Liver_X_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR02034. LIVERXRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NER, a new member of the gene family encoding the human steroid hormone nuclear receptor."
      Shinar D.M., Endo N., Rutledge S.J., Vogel R., Rodan G.A., Schmidt A.
      Gene 147:273-276(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Osteosarcoma and Skin.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Mammary gland.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Blood, Brain, Placenta and Uterus.
    5. "Ubiquitous receptor: a novel receptor that modulates gene activation by retinoic acid and thyroid hormone receptors."
      Song C., Konkontis J.M., Hiipakka R.A., Liao S.
      Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-460 (ISOFORM 1).
    6. "The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands."
      Farnegardh M., Bonn T., Sun S., Ljunggren J., Ahola H., Wilhelmsson A., Gustafsson J.-A., Carlquist M.
      J. Biol. Chem. 278:38821-38828(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 208-460 IN COMPLEX WITH SYNTHETIC LIGANDS.

    Entry informationi

    Entry nameiNR1H2_HUMAN
    AccessioniPrimary (citable) accession number: P55055
    Secondary accession number(s): A8K490
    , B4DNM6, E7EWA6, Q12970, Q5I0Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 159 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3