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P55055

- NR1H2_HUMAN

UniProt

P55055 - NR1H2_HUMAN

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Protein

Oxysterols receptor LXR-beta

Gene

NR1H2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi84 – 16178Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri87 – 10721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri125 – 14925NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. apolipoprotein A-I receptor binding Source: BHF-UCL
  2. ATPase binding Source: BHF-UCL
  3. DNA binding Source: ProtInc
  4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: ProtInc
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  7. sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity Source: Ensembl
  8. steroid hormone receptor activity Source: InterPro
  9. zinc ion binding Source: InterPro

GO - Biological processi

  1. cellular lipid metabolic process Source: Ensembl
  2. gene expression Source: Reactome
  3. negative regulation of cholesterol storage Source: BHF-UCL
  4. negative regulation of interferon-gamma-mediated signaling pathway Source: BHF-UCL
  5. negative regulation of lipid transport Source: BHF-UCL
  6. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  7. negative regulation of pinocytosis Source: BHF-UCL
  8. negative regulation of transcription, DNA-templated Source: HGNC
  9. positive regulation of cellular protein metabolic process Source: BHF-UCL
  10. positive regulation of cholesterol efflux Source: BHF-UCL
  11. positive regulation of cholesterol transport Source: BHF-UCL
  12. positive regulation of fatty acid biosynthetic process Source: BHF-UCL
  13. positive regulation of lipoprotein lipase activity Source: BHF-UCL
  14. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  15. positive regulation of triglyceride biosynthetic process Source: BHF-UCL
  16. regulation of cholesterol homeostasis Source: UniProtKB
  17. retinoic acid receptor signaling pathway Source: Ensembl
  18. transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
SignaLinkiP55055.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterols receptor LXR-beta
Alternative name(s):
Liver X receptor beta
Nuclear receptor NER
Nuclear receptor subfamily 1 group H member 2
Ubiquitously-expressed nuclear receptor
Gene namesi
Name:NR1H2
Synonyms:LXRB, NER, UNR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:7965. NR1H2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: HGNC
  2. nucleoplasm Source: Reactome
  3. nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Oxysterols receptor LXR-betaPRO_0000053532Add
BLAST

Proteomic databases

MaxQBiP55055.
PaxDbiP55055.
PRIDEiP55055.

PTM databases

PhosphoSiteiP55055.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiP55055.
CleanExiHS_NR1H2.
ExpressionAtlasiP55055. baseline and differential.
GenevestigatoriP55055.

Organism-specific databases

HPAiHPA056838.

Interactioni

Subunit structurei

Forms a heterodimer with RXR.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ABCA1O954772EBI-745354,EBI-784112
MDFIQ997503EBI-745354,EBI-724076

Protein-protein interaction databases

BioGridi113222. 54 interactions.
DIPiDIP-53004N.
IntActiP55055. 28 interactions.
MINTiMINT-1444220.
STRINGi9606.ENSP00000253727.

Structurei

Secondary structure

1
460
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi221 – 24222Combined sources
Helixi245 – 2473Combined sources
Helixi261 – 28626Combined sources
Helixi291 – 2933Combined sources
Helixi296 – 31722Combined sources
Turni321 – 3244Combined sources
Beta strandi325 – 3295Combined sources
Beta strandi332 – 3343Combined sources
Helixi336 – 3416Combined sources
Helixi346 – 36217Combined sources
Helixi366 – 37712Combined sources
Helixi388 – 40922Combined sources
Beta strandi410 – 4123Combined sources
Helixi416 – 44227Combined sources
Turni443 – 4453Combined sources
Helixi450 – 4567Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P8DX-ray2.80A/B213-460[»]
1PQ6X-ray2.40A/B/C/D212-460[»]
1PQ9X-ray2.10A/B/C/D212-460[»]
1PQCX-ray2.80A/B/C/D212-460[»]
1UPVX-ray2.10A208-460[»]
1UPWX-ray2.40A208-460[»]
3KFCX-ray2.40A/B/C/D212-460[»]
3L0EX-ray2.30A212-460[»]
4DK7X-ray2.45A/C218-460[»]
4DK8X-ray2.75A/C218-460[»]
ProteinModelPortaliP55055.
SMRiP55055. Positions 75-459.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55055.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni230 – 460231Ligand-bindingSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi190 – 1956Poly-Ser

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri87 – 10721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri125 – 14925NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG285805.
GeneTreeiENSGT00760000118837.
HOGENOMiHOG000220845.
HOVERGENiHBG108655.
InParanoidiP55055.
KOiK08535.
OMAiRRYACRG.
PhylomeDBiP55055.
TreeFamiTF352167.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P55055-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSPTTSSLD TPLPGNGPPQ PGAPSSSPTV KEEGPEPWPG GPDPDVPGTD
60 70 80 90 100
EASSACSTDW VIPDPEEEPE RKRKKGPAPK MLGHELCRVC GDKASGFHYN
110 120 130 140 150
VLSCEGCKGF FRRSVVRGGA RRYACRGGGT CQMDAFMRRK CQQCRLRKCK
160 170 180 190 200
EAGMREQCVL SEEQIRKKKI RKQQQESQSQ SQSPVGPQGS SSSASGPGAS
210 220 230 240 250
PGGSEAGSQG SGEGEGVQLT AAQELMIQQL VAAQLQCNKR SFSDQPKVTP
260 270 280 290 300
WPLGADPQSR DARQQRFAHF TELAIISVQE IVDFAKQVPG FLQLGREDQI
310 320 330 340 350
ALLKASTIEI MLLETARRYN HETECITFLK DFTYSKDDFH RAGLQVEFIN
360 370 380 390 400
PIFEFSRAMR RLGLDDAEYA LLIAINIFSA DRPNVQEPGR VEALQQPYVE
410 420 430 440 450
ALLSYTRIKR PQDQLRFPRM LMKLVSLRTL SSVHSEQVFA LRLQDKKLPP
460
LLSEIWDVHE
Length:460
Mass (Da):50,974
Last modified:May 18, 2010 - v2
Checksum:i9465A6FFB7FCFD2F
GO
Isoform 2 (identifier: P55055-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-158: VIPDPEEEPE...CKEAGMREQC → G

Note: No experimental confirmation.

Show »
Length:363
Mass (Da):39,920
Checksum:iE1F0B75FDA51C249
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751Q → QQ in AAA61783. (PubMed:7926814)Curated
Sequence conflicti175 – 1751Q → QQ in BAF83544. (PubMed:14702039)Curated
Sequence conflicti175 – 1751Q → QQ in BAG60288. (PubMed:14702039)Curated
Sequence conflicti175 – 1751Q → QQ in AAH07790. (PubMed:15489334)Curated
Sequence conflicti175 – 1751Q → QQ in AAH33500. (PubMed:15489334)Curated
Sequence conflicti175 – 1751Q → QQ in AAH47750. (PubMed:15489334)Curated
Sequence conflicti175 – 1751Q → QQ in AAH74500. (PubMed:15489334)Curated
Sequence conflicti175 – 1751Q → QQ in AAA58594. 1 PublicationCurated
Sequence conflicti244 – 2441D → G in BAG60288. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21S → F.
Corresponds to variant rs41379547 [ dbSNP | Ensembl ].
VAR_050579

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei61 – 15898VIPDP…MREQC → G in isoform 2. 1 PublicationVSP_053789Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07132 mRNA. Translation: AAA61783.1.
AK290855 mRNA. Translation: BAF83544.1.
AK297978 mRNA. Translation: BAG60288.1.
AC008655 Genomic DNA. No translation available.
BC007790 mRNA. Translation: AAH07790.1.
BC033500 mRNA. Translation: AAH33500.1.
BC047750 mRNA. Translation: AAH47750.1.
BC074500 mRNA. Translation: AAH74500.1.
U14534 mRNA. Translation: AAA58594.1.
PIRiJC4014.
RefSeqiNP_001243576.1. NM_001256647.1.
NP_009052.3. NM_007121.5.
UniGeneiHs.432976.

Genome annotation databases

EnsembliENST00000253727; ENSP00000253727; ENSG00000131408. [P55055-1]
ENST00000411902; ENSP00000396151; ENSG00000131408. [P55055-2]
ENST00000593926; ENSP00000471194; ENSG00000131408. [P55055-1]
GeneIDi7376.
KEGGihsa:7376.

Polymorphism databases

DMDMi296439251.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07132 mRNA. Translation: AAA61783.1 .
AK290855 mRNA. Translation: BAF83544.1 .
AK297978 mRNA. Translation: BAG60288.1 .
AC008655 Genomic DNA. No translation available.
BC007790 mRNA. Translation: AAH07790.1 .
BC033500 mRNA. Translation: AAH33500.1 .
BC047750 mRNA. Translation: AAH47750.1 .
BC074500 mRNA. Translation: AAH74500.1 .
U14534 mRNA. Translation: AAA58594.1 .
PIRi JC4014.
RefSeqi NP_001243576.1. NM_001256647.1.
NP_009052.3. NM_007121.5.
UniGenei Hs.432976.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1P8D X-ray 2.80 A/B 213-460 [» ]
1PQ6 X-ray 2.40 A/B/C/D 212-460 [» ]
1PQ9 X-ray 2.10 A/B/C/D 212-460 [» ]
1PQC X-ray 2.80 A/B/C/D 212-460 [» ]
1UPV X-ray 2.10 A 208-460 [» ]
1UPW X-ray 2.40 A 208-460 [» ]
3KFC X-ray 2.40 A/B/C/D 212-460 [» ]
3L0E X-ray 2.30 A 212-460 [» ]
4DK7 X-ray 2.45 A/C 218-460 [» ]
4DK8 X-ray 2.75 A/C 218-460 [» ]
ProteinModelPortali P55055.
SMRi P55055. Positions 75-459.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113222. 54 interactions.
DIPi DIP-53004N.
IntActi P55055. 28 interactions.
MINTi MINT-1444220.
STRINGi 9606.ENSP00000253727.

Chemistry

BindingDBi P55055.
ChEMBLi CHEMBL4093.
GuidetoPHARMACOLOGYi 601.

PTM databases

PhosphoSitei P55055.

Polymorphism databases

DMDMi 296439251.

Proteomic databases

MaxQBi P55055.
PaxDbi P55055.
PRIDEi P55055.

Protocols and materials databases

DNASUi 7376.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253727 ; ENSP00000253727 ; ENSG00000131408 . [P55055-1 ]
ENST00000411902 ; ENSP00000396151 ; ENSG00000131408 . [P55055-2 ]
ENST00000593926 ; ENSP00000471194 ; ENSG00000131408 . [P55055-1 ]
GeneIDi 7376.
KEGGi hsa:7376.

Organism-specific databases

CTDi 7376.
GeneCardsi GC19P050879.
HGNCi HGNC:7965. NR1H2.
HPAi HPA056838.
MIMi 600380. gene.
neXtProti NX_P55055.
PharmGKBi PA31750.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG285805.
GeneTreei ENSGT00760000118837.
HOGENOMi HOG000220845.
HOVERGENi HBG108655.
InParanoidi P55055.
KOi K08535.
OMAi RRYACRG.
PhylomeDBi P55055.
TreeFami TF352167.

Enzyme and pathway databases

Reactomei REACT_15525. Nuclear Receptor transcription pathway.
SignaLinki P55055.

Miscellaneous databases

ChiTaRSi NR1H2. human.
EvolutionaryTracei P55055.
GeneWikii Liver_X_receptor_beta.
GenomeRNAii 7376.
NextBioi 28886.
PROi P55055.
SOURCEi Search...

Gene expression databases

Bgeei P55055.
CleanExi HS_NR1H2.
ExpressionAtlasi P55055. baseline and differential.
Genevestigatori P55055.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NER, a new member of the gene family encoding the human steroid hormone nuclear receptor."
    Shinar D.M., Endo N., Rutledge S.J., Vogel R., Rodan G.A., Schmidt A.
    Gene 147:273-276(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Osteosarcoma and Skin.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Mammary gland.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Blood, Brain, Placenta and Uterus.
  5. "Ubiquitous receptor: a novel receptor that modulates gene activation by retinoic acid and thyroid hormone receptors."
    Song C., Konkontis J.M., Hiipakka R.A., Liao S.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-460 (ISOFORM 1).
  6. "The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands."
    Farnegardh M., Bonn T., Sun S., Ljunggren J., Ahola H., Wilhelmsson A., Gustafsson J.-A., Carlquist M.
    J. Biol. Chem. 278:38821-38828(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 208-460 IN COMPLEX WITH SYNTHETIC LIGANDS.

Entry informationi

Entry nameiNR1H2_HUMAN
AccessioniPrimary (citable) accession number: P55055
Secondary accession number(s): A8K490
, B4DNM6, E7EWA6, Q12970, Q5I0Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3