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Protein

Fatty acid-binding protein, epidermal

Gene

Fabp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High specificity for fatty acids. Highest affinity for C18 chain length (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109Fatty acidBy similarity1

GO - Molecular functioni

  • fatty acid binding Source: RGD

GO - Biological processi

  • response to wounding Source: RGD

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, epidermal
Alternative name(s):
Cutaneous fatty acid-binding protein
Short name:
C-FABP
DA11
Epidermal-type fatty acid-binding protein
Short name:
E-FABP
Fatty acid-binding protein 5
Gene namesi
Name:Fabp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi70997 Fabp5

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000673792 – 135Fatty acid-binding protein, epidermalAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineCombined sources1
Disulfide bondi120 ↔ 1271 Publication
Modified residuei131PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP55053
PRIDEiP55053

PTM databases

iPTMnetiP55053
PhosphoSitePlusiP55053

Expressioni

Gene expression databases

BgeeiENSRNOG00000049075
GenevisibleiP55053 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064809

Structurei

3D structure databases

ProteinModelPortaliP55053
SMRiP55053
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 131Fatty acid bindingBy similarity3

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOVERGENiHBG005633
InParanoidiP55053
KOiK08754
OMAiVECDMNG
OrthoDBiEOG091G0QSV
PhylomeDBiP55053

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLKDLEGK WRLVESHGFE DYMKELGVGL ALRKMGAMAK PDCIITLDGN
60 70 80 90 100
NLTVKTESTV KTTVFSCTLG EKFDETTADG RKTETVCTFT DGALVQHQKW
110 120 130
EGKESTITRK LKDGKMVVEC VMNNAICTRV YEKVQ
Length:135
Mass (Da):15,059
Last modified:January 23, 2007 - v3
Checksum:i978392433DF54358
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49G → N in AAA86680 (PubMed:7607553).Curated1
Sequence conflicti112K → N in AAB46848 (PubMed:8723767).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13253 mRNA Translation: AAA86680.1
S69874 mRNA Translation: AAB30574.1
S83247 mRNA Translation: AAB46848.1
PIRiJC2201
RefSeqiNP_665885.1, NM_145878.1
UniGeneiRn.98269

Genome annotation databases

EnsembliENSRNOT00000075493; ENSRNOP00000064809; ENSRNOG00000049075
GeneIDi140868
KEGGirno:140868

Similar proteinsi

Entry informationi

Entry nameiFABP5_RAT
AccessioniPrimary (citable) accession number: P55053
Secondary accession number(s): P97757
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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