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Protein

Fatty acid-binding protein, epidermal

Gene

Fabp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High specificity for fatty acids. Highest affinity for C18 chain length (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109Fatty acidBy similarity1

GO - Molecular functioni

  • fatty acid binding Source: RGD
  • transporter activity Source: InterPro

GO - Biological processi

  • response to wounding Source: RGD

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-163560. Triglyceride catabolism.
R-RNO-5362517. Signaling by Retinoic Acid.
R-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, epidermal
Alternative name(s):
Cutaneous fatty acid-binding protein
Short name:
C-FABP
DA11
Epidermal-type fatty acid-binding protein
Short name:
E-FABP
Fatty acid-binding protein 5
Gene namesi
Name:Fabp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi70997. Fabp5.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000673792 – 135Fatty acid-binding protein, epidermalAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineCombined sources1
Disulfide bondi120 ↔ 1271 Publication
Modified residuei131PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP55053.
PRIDEiP55053.

PTM databases

iPTMnetiP55053.
PhosphoSitePlusiP55053.

Expressioni

Gene expression databases

BgeeiENSRNOG00000049075.
GenevisibleiP55053. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064809.

Structurei

3D structure databases

ProteinModelPortaliP55053.
SMRiP55053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 131Fatty acid bindingBy similarity3

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOVERGENiHBG005633.
InParanoidiP55053.
KOiK08754.
OMAiVECDMNG.
OrthoDBiEOG091G0QSV.
PhylomeDBiP55053.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR012674. Calycin.
IPR000463. Fatty_acid-bd.
IPR031259. ILBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiView protein in PROSITE
PS00214. FABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLKDLEGK WRLVESHGFE DYMKELGVGL ALRKMGAMAK PDCIITLDGN
60 70 80 90 100
NLTVKTESTV KTTVFSCTLG EKFDETTADG RKTETVCTFT DGALVQHQKW
110 120 130
EGKESTITRK LKDGKMVVEC VMNNAICTRV YEKVQ
Length:135
Mass (Da):15,059
Last modified:January 23, 2007 - v3
Checksum:i978392433DF54358
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49G → N in AAA86680 (PubMed:7607553).Curated1
Sequence conflicti112K → N in AAB46848 (PubMed:8723767).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13253 mRNA. Translation: AAA86680.1.
S69874 mRNA. Translation: AAB30574.1.
S83247 mRNA. Translation: AAB46848.1.
PIRiJC2201.
RefSeqiNP_665885.1. NM_145878.1.
UniGeneiRn.98269.

Genome annotation databases

EnsembliENSRNOT00000075493; ENSRNOP00000064809; ENSRNOG00000049075.
GeneIDi140868.
KEGGirno:140868.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFABP5_RAT
AccessioniPrimary (citable) accession number: P55053
Secondary accession number(s): P97757
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: July 5, 2017
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families