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Protein

Fatty acid-binding protein, brain

Gene

Fabp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers.

GO - Molecular functioni

  • fatty acid binding Source: RGD
  • transporter activity Source: InterPro

GO - Biological processi

  • cell proliferation in forebrain Source: Ensembl
  • epithelial cell proliferation Source: RGD
  • neurogenesis Source: Ensembl
  • prepulse inhibition Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, brain
Alternative name(s):
Brain lipid-binding protein
Short name:
BLBP
Brain-type fatty acid-binding protein
Short name:
B-FABP
Fatty acid-binding protein 7
Gene namesi
Name:Fabp7
Synonyms:Blbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi69312. Fabp7.

Subcellular locationi

GO - Cellular componenti

  • cell-cell junction Source: Ensembl
  • cell periphery Source: Ensembl
  • cell projection Source: Ensembl
  • cytoplasm Source: RGD
  • neuronal cell body Source: Ensembl
  • nucleoplasm Source: Ensembl
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000673752 – 132Fatty acid-binding protein, brainAdd BLAST131

Proteomic databases

PaxDbiP55051.
PRIDEiP55051.

PTM databases

iPTMnetiP55051.
PhosphoSitePlusiP55051.

Expressioni

Tissue specificityi

Expressed in brain and other neural tissues.

Gene expression databases

BgeeiENSRNOG00000000814.
GenevisibleiP55051. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001079.

Structurei

3D structure databases

ProteinModelPortaliP55051.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 129Fatty acid bindingBy similarity3

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP55051.
KOiK08756.
OMAiADDRSCK.
OrthoDBiEOG091G0QSV.
PhylomeDBiP55051.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55051-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDAFCATWK LTDSQNFDEY MKALGVGFAT RQVGNVTKPT VIISQEGGKV
60 70 80 90 100
VIRTQCTFKN TEISFQLGEE FEETSIDDRN CKSVIRLDGD KLIHVQKWDG
110 120 130
KETNCVREIK DGKMVVTLTF GDVVAVRCYE KA
Length:132
Mass (Da):14,864
Last modified:January 23, 2007 - v2
Checksum:iAB8497FE4E6C6C5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02096 mRNA. Translation: AAA60455.1.
PIRiI56510.
RefSeqiNP_110459.1. NM_030832.2.
UniGeneiRn.10014.

Genome annotation databases

EnsembliENSRNOT00000001079; ENSRNOP00000001079; ENSRNOG00000000814.
GeneIDi80841.
KEGGirno:80841.
UCSCiRGD:69312. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02096 mRNA. Translation: AAA60455.1.
PIRiI56510.
RefSeqiNP_110459.1. NM_030832.2.
UniGeneiRn.10014.

3D structure databases

ProteinModelPortaliP55051.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001079.

PTM databases

iPTMnetiP55051.
PhosphoSitePlusiP55051.

Proteomic databases

PaxDbiP55051.
PRIDEiP55051.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001079; ENSRNOP00000001079; ENSRNOG00000000814.
GeneIDi80841.
KEGGirno:80841.
UCSCiRGD:69312. rat.

Organism-specific databases

CTDi2173.
RGDi69312. Fabp7.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP55051.
KOiK08756.
OMAiADDRSCK.
OrthoDBiEOG091G0QSV.
PhylomeDBiP55051.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiR-RNO-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

PROiP55051.

Gene expression databases

BgeeiENSRNOG00000000814.
GenevisibleiP55051. RN.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABP7_RAT
AccessioniPrimary (citable) accession number: P55051
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.