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Protein

Fatty acid-binding protein, brain

Gene

Fabp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers.

GO - Molecular functioni

  • fatty acid binding Source: RGD

GO - Biological processi

  • cell proliferation in forebrain Source: Ensembl
  • epithelial cell proliferation Source: RGD
  • neurogenesis Source: Ensembl
  • prepulse inhibition Source: Ensembl

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-163560 Triglyceride catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, brain
Alternative name(s):
Brain lipid-binding protein
Short name:
BLBP
Brain-type fatty acid-binding protein
Short name:
B-FABP
Fatty acid-binding protein 7
Gene namesi
Name:Fabp7
Synonyms:Blbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi69312 Fabp7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000673752 – 132Fatty acid-binding protein, brainAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvalineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP55051
PRIDEiP55051

PTM databases

iPTMnetiP55051
PhosphoSitePlusiP55051

Expressioni

Tissue specificityi

Expressed in brain and other neural tissues.

Gene expression databases

BgeeiENSRNOG00000000814
GenevisibleiP55051 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001079

Structurei

3D structure databases

ProteinModelPortaliP55051
SMRiP55051
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 129Fatty acid bindingBy similarity3

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP55051
KOiK08756
OMAiICRREFV
OrthoDBiEOG091G0QSV
PhylomeDBiP55051
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55051-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDAFCATWK LTDSQNFDEY MKALGVGFAT RQVGNVTKPT VIISQEGGKV
60 70 80 90 100
VIRTQCTFKN TEISFQLGEE FEETSIDDRN CKSVIRLDGD KLIHVQKWDG
110 120 130
KETNCVREIK DGKMVVTLTF GDVVAVRCYE KA
Length:132
Mass (Da):14,864
Last modified:January 23, 2007 - v2
Checksum:iAB8497FE4E6C6C5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02096 mRNA Translation: AAA60455.1
PIRiI56510
RefSeqiNP_110459.1, NM_030832.2
UniGeneiRn.10014

Genome annotation databases

EnsembliENSRNOT00000001079; ENSRNOP00000001079; ENSRNOG00000000814
GeneIDi80841
KEGGirno:80841
UCSCiRGD:69312 rat

Similar proteinsi

Entry informationi

Entry nameiFABP7_RAT
AccessioniPrimary (citable) accession number: P55051
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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