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Protein

Fatty acid-binding protein, brain

Gene

Fabp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers.

GO - Molecular functioni

  • fatty acid binding Source: RGD
  • transporter activity Source: InterPro

GO - Biological processi

  • cell proliferation in forebrain Source: RGD
  • epithelial cell proliferation Source: RGD
  • neurogenesis Source: RGD
  • prepulse inhibition Source: RGD
  • startle response Source: RGD

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-163560. Triglyceride catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, brain
Alternative name(s):
Brain lipid-binding protein
Short name:
BLBP
Brain-type fatty acid-binding protein
Short name:
B-FABP
Fatty acid-binding protein 7
Gene namesi
Name:Fabp7
Synonyms:Blbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi69312. Fabp7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000673751 – 132Fatty acid-binding protein, brainAdd BLAST132

Proteomic databases

PaxDbiP55051.
PRIDEiP55051.

PTM databases

iPTMnetiP55051.
PhosphoSitePlusiP55051.

Expressioni

Tissue specificityi

Expressed in brain and other neural tissues.

Gene expression databases

BgeeiENSRNOG00000000814.
GenevisibleiP55051. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001079.

Structurei

3D structure databases

ProteinModelPortaliP55051.
SMRiP55051.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 129Fatty acid bindingBy similarity3

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP55051.
KOiK08756.
OMAiPTIVISH.
OrthoDBiEOG091G0QSV.
PhylomeDBiP55051.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR012674. Calycin.
IPR000463. Fatty_acid-bd.
IPR031259. ILBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiView protein in PROSITE
PS00214. FABP. 1 hit.

Sequencei

Sequence statusi: Complete.

P55051-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDAFCATWK LTDSQNFDEY MKALGVGFAT RQVGNVTKPT VIISQEGGKV
60 70 80 90 100
VIRTQCTFKN TEISFQLGEE FEETSIDDRN CKSVIRLDGD KLIHVQKWDG
110 120 130
KETNCVREIK DGKMVVTLTF GDVVAVRCYE KA
Length:132
Mass (Da):14,864
Last modified:January 23, 2007 - v2
Checksum:iAB8497FE4E6C6C5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02096 mRNA. Translation: AAA60455.1.
PIRiI56510.
RefSeqiNP_110459.1. NM_030832.2.
UniGeneiRn.10014.

Genome annotation databases

EnsembliENSRNOT00000001079; ENSRNOP00000001079; ENSRNOG00000000814.
GeneIDi80841.
KEGGirno:80841.
UCSCiRGD:69312. rat.

Similar proteinsi

Entry informationi

Entry nameiFABP7_RAT
AccessioniPrimary (citable) accession number: P55051
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families