Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P55050

- FABPI_MOUSE

UniProt

P55050 - FABPI_MOUSE

Protein

Fatty acid-binding protein, intestinal

Gene

Fabp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei83 – 831Fatty acidBy similarity
    Binding sitei107 – 1071Fatty acidBy similarity

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW
    2. transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fatty acid-binding protein, intestinal
    Alternative name(s):
    Fatty acid-binding protein 2
    Intestinal-type fatty acid-binding protein
    Short name:
    I-FABP
    Gene namesi
    Name:Fabp2
    Synonyms:Fabpi
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:95478. Fabp2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. intracellular Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 132131Fatty acid-binding protein, intestinalPRO_0000067329Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP55050.
    PaxDbiP55050.
    PRIDEiP55050.

    PTM databases

    PhosphoSiteiP55050.

    Expressioni

    Tissue specificityi

    Expressed in the small intestine. Highest expression levels in the proximal ileum.1 Publication

    Gene expression databases

    BgeeiP55050.
    CleanExiMM_FABP2.
    GenevestigatoriP55050.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000023820.

    Structurei

    3D structure databases

    ProteinModelPortaliP55050.
    SMRiP55050. Positions 2-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG295259.
    HOGENOMiHOG000004829.
    HOVERGENiHBG005633.
    InParanoidiP55050.
    KOiK08751.
    OMAiNMVKRKL.
    OrthoDBiEOG7NW6BZ.
    PhylomeDBiP55050.
    TreeFamiTF316894.

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view]
    PfamiPF00061. Lipocalin. 1 hit.
    [Graphical view]
    PRINTSiPR00178. FATTYACIDBP.
    SUPFAMiSSF50814. SSF50814. 1 hit.
    PROSITEiPS00214. FABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55050-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFDGTWKVD RNENYEKFME KMGINVMKRK LGAHDNLKLT ITQDGNKFTV    50
    KESSNFRNID VVFELGVNFP YSLADGTELT GAWTIEGNKL IGKFTRVDNG 100
    KELIAVREVS GNELIQTYTY EGVEAKRFFK KE 132
    Length:132
    Mass (Da):15,126
    Last modified:January 23, 2007 - v2
    Checksum:iE02001EE47267456
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65034 mRNA. Translation: AAA37589.1.
    AK007995 mRNA. Translation: BAB25397.1.
    BC013457 mRNA. Translation: AAH13457.1.
    CCDSiCCDS17813.1.
    RefSeqiNP_032006.1. NM_007980.3.
    UniGeneiMm.28398.

    Genome annotation databases

    EnsembliENSMUST00000023820; ENSMUSP00000023820; ENSMUSG00000023057.
    GeneIDi14079.
    KEGGimmu:14079.
    UCSCiuc008rex.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65034 mRNA. Translation: AAA37589.1 .
    AK007995 mRNA. Translation: BAB25397.1 .
    BC013457 mRNA. Translation: AAH13457.1 .
    CCDSi CCDS17813.1.
    RefSeqi NP_032006.1. NM_007980.3.
    UniGenei Mm.28398.

    3D structure databases

    ProteinModelPortali P55050.
    SMRi P55050. Positions 2-132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000023820.

    PTM databases

    PhosphoSitei P55050.

    Proteomic databases

    MaxQBi P55050.
    PaxDbi P55050.
    PRIDEi P55050.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023820 ; ENSMUSP00000023820 ; ENSMUSG00000023057 .
    GeneIDi 14079.
    KEGGi mmu:14079.
    UCSCi uc008rex.1. mouse.

    Organism-specific databases

    CTDi 2169.
    MGIi MGI:95478. Fabp2.

    Phylogenomic databases

    eggNOGi NOG295259.
    HOGENOMi HOG000004829.
    HOVERGENi HBG005633.
    InParanoidi P55050.
    KOi K08751.
    OMAi NMVKRKL.
    OrthoDBi EOG7NW6BZ.
    PhylomeDBi P55050.
    TreeFami TF316894.

    Miscellaneous databases

    NextBioi 285084.
    PROi P55050.
    SOURCEi Search...

    Gene expression databases

    Bgeei P55050.
    CleanExi MM_FABP2.
    Genevestigatori P55050.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view ]
    Pfami PF00061. Lipocalin. 1 hit.
    [Graphical view ]
    PRINTSi PR00178. FATTYACIDBP.
    SUPFAMi SSF50814. SSF50814. 1 hit.
    PROSITEi PS00214. FABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse intestinal fatty acid binding protein gene: nucleotide sequence, pattern of developmental and regional expression, and proposed structure of its protein product."
      Green R.P., Sacchettini J.C., Jackson K.E., Cohn S.M., Gordon J.I.
      DNA Cell Biol. 11:31-41(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Small intestine.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    4. "The intestinal fatty acid binding protein is not essential for dietary fat absorption in mice."
      Vassileva G., Huwyler L., Poirier K., Agellon L.B., Toth M.J.
      FASEB J. 14:2040-2046(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Fatty acid regulation of fatty acid-binding protein expression in the small intestine."
      Poirier H., Niot I., Degrace P., Monnot M.C., Bernard A., Besnard P.
      Am. J. Physiol. 273:G289-G295(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFABPI_MOUSE
    AccessioniPrimary (citable) accession number: P55050
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3