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P55050

- FABPI_MOUSE

UniProt

P55050 - FABPI_MOUSE

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Protein

Fatty acid-binding protein, intestinal

Gene

Fabp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831Fatty acidBy similarity
Binding sitei107 – 1071Fatty acidBy similarity

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW
  2. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, intestinal
Alternative name(s):
Fatty acid-binding protein 2
Intestinal-type fatty acid-binding protein
Short name:
I-FABP
Gene namesi
Name:Fabp2
Synonyms:Fabpi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:95478. Fabp2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. intracellular Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 132131Fatty acid-binding protein, intestinalPRO_0000067329Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP55050.
PaxDbiP55050.
PRIDEiP55050.

PTM databases

PhosphoSiteiP55050.

Expressioni

Tissue specificityi

Expressed in the small intestine. Highest expression levels in the proximal ileum.1 Publication

Gene expression databases

BgeeiP55050.
CleanExiMM_FABP2.
ExpressionAtlasiP55050. baseline and differential.
GenevestigatoriP55050.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023820.

Structurei

3D structure databases

ProteinModelPortaliP55050.
SMRiP55050. Positions 2-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG295259.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP55050.
KOiK08751.
OMAiNMVKRKL.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP55050.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55050-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFDGTWKVD RNENYEKFME KMGINVMKRK LGAHDNLKLT ITQDGNKFTV
60 70 80 90 100
KESSNFRNID VVFELGVNFP YSLADGTELT GAWTIEGNKL IGKFTRVDNG
110 120 130
KELIAVREVS GNELIQTYTY EGVEAKRFFK KE
Length:132
Mass (Da):15,126
Last modified:January 23, 2007 - v2
Checksum:iE02001EE47267456
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65034 mRNA. Translation: AAA37589.1.
AK007995 mRNA. Translation: BAB25397.1.
BC013457 mRNA. Translation: AAH13457.1.
CCDSiCCDS17813.1.
RefSeqiNP_032006.1. NM_007980.3.
UniGeneiMm.28398.

Genome annotation databases

EnsembliENSMUST00000023820; ENSMUSP00000023820; ENSMUSG00000023057.
GeneIDi14079.
KEGGimmu:14079.
UCSCiuc008rex.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65034 mRNA. Translation: AAA37589.1 .
AK007995 mRNA. Translation: BAB25397.1 .
BC013457 mRNA. Translation: AAH13457.1 .
CCDSi CCDS17813.1.
RefSeqi NP_032006.1. NM_007980.3.
UniGenei Mm.28398.

3D structure databases

ProteinModelPortali P55050.
SMRi P55050. Positions 2-132.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000023820.

PTM databases

PhosphoSitei P55050.

Proteomic databases

MaxQBi P55050.
PaxDbi P55050.
PRIDEi P55050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023820 ; ENSMUSP00000023820 ; ENSMUSG00000023057 .
GeneIDi 14079.
KEGGi mmu:14079.
UCSCi uc008rex.1. mouse.

Organism-specific databases

CTDi 2169.
MGIi MGI:95478. Fabp2.

Phylogenomic databases

eggNOGi NOG295259.
HOGENOMi HOG000004829.
HOVERGENi HBG005633.
InParanoidi P55050.
KOi K08751.
OMAi NMVKRKL.
OrthoDBi EOG7NW6BZ.
PhylomeDBi P55050.
TreeFami TF316894.

Miscellaneous databases

NextBioi 285084.
PROi P55050.
SOURCEi Search...

Gene expression databases

Bgeei P55050.
CleanExi MM_FABP2.
ExpressionAtlasi P55050. baseline and differential.
Genevestigatori P55050.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view ]
Pfami PF00061. Lipocalin. 1 hit.
[Graphical view ]
PRINTSi PR00178. FATTYACIDBP.
SUPFAMi SSF50814. SSF50814. 1 hit.
PROSITEi PS00214. FABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse intestinal fatty acid binding protein gene: nucleotide sequence, pattern of developmental and regional expression, and proposed structure of its protein product."
    Green R.P., Sacchettini J.C., Jackson K.E., Cohn S.M., Gordon J.I.
    DNA Cell Biol. 11:31-41(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Small intestine.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. "The intestinal fatty acid binding protein is not essential for dietary fat absorption in mice."
    Vassileva G., Huwyler L., Poirier K., Agellon L.B., Toth M.J.
    FASEB J. 14:2040-2046(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Fatty acid regulation of fatty acid-binding protein expression in the small intestine."
    Poirier H., Niot I., Degrace P., Monnot M.C., Bernard A., Besnard P.
    Am. J. Physiol. 273:G289-G295(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFABPI_MOUSE
AccessioniPrimary (citable) accession number: P55050
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3