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Protein

GTP-binding protein RAD

Gene

Rrad

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca2+ currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 1048GTPBy similarity
Nucleotide bindingi201 – 2044GTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of cell growth Source: RGD
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding, GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein RAD
Alternative name(s):
RAD1
Ras associated with diabetes
Gene namesi
Name:Rrad
Synonyms:Rad
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69357. Rrad.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306GTP-binding protein RADPRO_0000122480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP55043.
PRIDEiP55043.

Interactioni

Subunit structurei

Interacts with Calmodulin preferentially to the inactive, GDP-form. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016259.

Structurei

3D structure databases

ProteinModelPortaliP55043.
SMRiP55043. Positions 90-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni276 – 29520Calmodulin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiP55043.
PhylomeDBiP55043.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR028869. RRAD.
IPR001806. Small_GTPase.
IPR017358. Small_GTPase_GEM/REM/Rad.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PTHR24070:SF74. PTHR24070:SF74. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PIRSFiPIRSF038017. GTP-binding_GEM. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNGGSGAG GSRSAGRERD RRRGSTPWGP APPLHRRSMP VDERDLQAAL
60 70 80 90 100
TPGSLAATAA GTRTQGQRLD WPEGSSDSLS SGDSGSEDGV YKVHAAGAPG
110 120 130 140 150
VGKSALARIF GGVEDGPEAE AAGHTYDRSI TVDGEEASLM VYDIWEQDGG
160 170 180 190 200
CWLPGHCMAM GDAYVIVYSI TDKGSFEKAS ELRVQLRARR QTDVPIILVG
210 220 230 240 250
NKSDLVRSRE VSVDEGRACA EVFDCKFIET SAALHHNVQA LFEGVVRQIR
260 270 280 290 300
LRRDSKEDNA RRQAGTRRRE SLGKKAKLFL GRIVARNSRK MAFLAKSKSC

HDLSVL
Length:306
Mass (Da):33,038
Last modified:November 7, 2003 - v2
Checksum:i1A900FDD4C23C453
GO

Sequence cautioni

The sequence AAA56719.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12187 mRNA. Translation: AAA56719.1. Different initiation.
UniGeneiRn.11189.

Genome annotation databases

UCSCiRGD:69357. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12187 mRNA. Translation: AAA56719.1. Different initiation.
UniGeneiRn.11189.

3D structure databases

ProteinModelPortaliP55043.
SMRiP55043. Positions 90-256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016259.

Proteomic databases

PaxDbiP55043.
PRIDEiP55043.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:69357. rat.

Organism-specific databases

RGDi69357. Rrad.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiP55043.
PhylomeDBiP55043.

Miscellaneous databases

NextBioi615995.
PROiP55043.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR028869. RRAD.
IPR001806. Small_GTPase.
IPR017358. Small_GTPase_GEM/REM/Rad.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PTHR24070:SF74. PTHR24070:SF74. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PIRSFiPIRSF038017. GTP-binding_GEM. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Rishi A.K., Gulamhussein A., Steele M.P.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiRAD_RAT
AccessioniPrimary (citable) accession number: P55043
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 7, 2003
Last modified: November 11, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.