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Protein

GTP-binding protein RAD

Gene

Rrad

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca2+ currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104GTPBy similarity8
Nucleotide bindingi201 – 204GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein RAD
Alternative name(s):
RAD1
Ras associated with diabetes
Gene namesi
Name:Rrad
Synonyms:Rad
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69357 Rrad

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224801 – 306GTP-binding protein RADAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Omega-N-methylarginineBy similarity1
Modified residuei25PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiP55043
PRIDEiP55043

Interactioni

Subunit structurei

Interacts with Calmodulin preferentially to the inactive, GDP-form. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016259

Structurei

3D structure databases

ProteinModelPortaliP55043
SMRiP55043
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni276 – 295Calmodulin-bindingBy similarityAdd BLAST20

Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
HOGENOMiHOG000246961
HOVERGENiHBG104899
InParanoidiP55043
PhylomeDBiP55043

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR028869 RAD
IPR017358 RGK
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PTHR24070:SF74 PTHR24070:SF74, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
PIRSFiPIRSF038017 GTP-binding_GEM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

P55043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNGGSGAG GSRSAGRERD RRRGSTPWGP APPLHRRSMP VDERDLQAAL
60 70 80 90 100
TPGSLAATAA GTRTQGQRLD WPEGSSDSLS SGDSGSEDGV YKVHAAGAPG
110 120 130 140 150
VGKSALARIF GGVEDGPEAE AAGHTYDRSI TVDGEEASLM VYDIWEQDGG
160 170 180 190 200
CWLPGHCMAM GDAYVIVYSI TDKGSFEKAS ELRVQLRARR QTDVPIILVG
210 220 230 240 250
NKSDLVRSRE VSVDEGRACA EVFDCKFIET SAALHHNVQA LFEGVVRQIR
260 270 280 290 300
LRRDSKEDNA RRQAGTRRRE SLGKKAKLFL GRIVARNSRK MAFLAKSKSC

HDLSVL
Length:306
Mass (Da):33,038
Last modified:November 7, 2003 - v2
Checksum:i1A900FDD4C23C453
GO

Sequence cautioni

The sequence AAA56719 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12187 mRNA Translation: AAA56719.1 Different initiation.
UniGeneiRn.11189

Genome annotation databases

UCSCiRGD:69357 rat

Similar proteinsi

Entry informationi

Entry nameiRAD_RAT
AccessioniPrimary (citable) accession number: P55043
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 7, 2003
Last modified: May 23, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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