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P55039

- DRG2_HUMAN

UniProt

P55039 - DRG2_HUMAN

Protein

Developmentally-regulated GTP-binding protein 2

Gene

DRG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May play a role in cell proliferation, differentiation and death.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi69 – 768GTPPROSITE-ProRule annotation
    Nucleotide bindingi115 – 1195GTPPROSITE-ProRule annotation
    Nucleotide bindingi246 – 2494GTPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. GTP binding Source: ProtInc

    GO - Biological processi

    1. signal transduction Source: ProtInc

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Developmentally-regulated GTP-binding protein 2
    Short name:
    DRG-2
    Gene namesi
    Name:DRG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:3030. DRG2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. membrane Source: UniProtKB
    3. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27484.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Developmentally-regulated GTP-binding protein 2PRO_0000205427Add
    BLAST

    Post-translational modificationi

    Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with RWDD1.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiP55039.
    PaxDbiP55039.
    PRIDEiP55039.

    PTM databases

    PhosphoSiteiP55039.

    Expressioni

    Tissue specificityi

    Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen, small intestine, lung and Leukocytes.

    Gene expression databases

    ArrayExpressiP55039.
    BgeeiP55039.
    CleanExiHS_DRG2.
    GenevestigatoriP55039.

    Organism-specific databases

    HPAiHPA007716.

    Interactioni

    Subunit structurei

    Interacts with RWDD1.By similarity

    Protein-protein interaction databases

    BioGridi108153. 9 interactions.
    IntActiP55039. 2 interactions.
    MINTiMINT-1453971.
    STRINGi9606.ENSP00000225729.

    Structurei

    3D structure databases

    ProteinModelPortaliP55039.
    SMRiP55039. Positions 4-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 288226OBG-type GPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
    Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1163.
    HOGENOMiHOG000112078.
    HOVERGENiHBG000948.
    InParanoidiP55039.
    KOiK06944.
    OMAiIRIYTKR.
    OrthoDBiEOG7PZRXJ.
    PhylomeDBiP55039.
    TreeFamiTF105706.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR006074. GTP1-OBG_CS.
    IPR006073. GTP_binding_domain.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view]
    PfamiPF01926. MMR_HSR1. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view]
    PRINTSiPR00326. GTP1OBG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51710. G_OBG. 1 hit.
    PS00905. GTP1_OBG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55039-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSASS    50
    KGEGFDVMKS GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI 100
    PGVIEYKGAN IQLLDLPGII EGAAQGKGRG RQVIAVARTA DVIIMMLDAT 150
    KGEVQRSLLE KELESVGIRL NKHKPNIYFK PKKGGGISFN STVTLTQCSE 200
    KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP CLYVYNKIDQ 250
    ISMEEVDRLA RKPNSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR 300
    PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWGTST KYSPQRVGLT 350
    HTMEHEDVIQ IVKK 364
    Length:364
    Mass (Da):40,746
    Last modified:October 1, 1996 - v1
    Checksum:iD1754BEB02671F85
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti194 – 1941T → M.2 Publications
    Corresponds to variant rs17855350 [ dbSNP | Ensembl ].
    VAR_067452
    Natural varianti224 – 2241S → T.
    Corresponds to variant rs61256737 [ dbSNP | Ensembl ].
    VAR_067453

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80754 mRNA. Translation: CAA56730.1.
    BT006976 mRNA. Translation: AAP35622.1.
    AK313362 mRNA. Translation: BAG36162.1.
    CH471196 Genomic DNA. Translation: EAW55669.1.
    BC000493 mRNA. Translation: AAH00493.1.
    CCDSiCCDS11191.1.
    PIRiA55014.
    RefSeqiNP_001379.1. NM_001388.4.
    UniGeneiHs.78582.

    Genome annotation databases

    EnsembliENST00000225729; ENSP00000225729; ENSG00000108591.
    GeneIDi1819.
    KEGGihsa:1819.
    UCSCiuc002gsh.2. human.

    Polymorphism databases

    DMDMi1706518.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80754 mRNA. Translation: CAA56730.1 .
    BT006976 mRNA. Translation: AAP35622.1 .
    AK313362 mRNA. Translation: BAG36162.1 .
    CH471196 Genomic DNA. Translation: EAW55669.1 .
    BC000493 mRNA. Translation: AAH00493.1 .
    CCDSi CCDS11191.1.
    PIRi A55014.
    RefSeqi NP_001379.1. NM_001388.4.
    UniGenei Hs.78582.

    3D structure databases

    ProteinModelPortali P55039.
    SMRi P55039. Positions 4-364.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108153. 9 interactions.
    IntActi P55039. 2 interactions.
    MINTi MINT-1453971.
    STRINGi 9606.ENSP00000225729.

    PTM databases

    PhosphoSitei P55039.

    Polymorphism databases

    DMDMi 1706518.

    Proteomic databases

    MaxQBi P55039.
    PaxDbi P55039.
    PRIDEi P55039.

    Protocols and materials databases

    DNASUi 1819.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225729 ; ENSP00000225729 ; ENSG00000108591 .
    GeneIDi 1819.
    KEGGi hsa:1819.
    UCSCi uc002gsh.2. human.

    Organism-specific databases

    CTDi 1819.
    GeneCardsi GC17P017992.
    HGNCi HGNC:3030. DRG2.
    HPAi HPA007716.
    MIMi 602986. gene.
    neXtProti NX_P55039.
    PharmGKBi PA27484.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1163.
    HOGENOMi HOG000112078.
    HOVERGENi HBG000948.
    InParanoidi P55039.
    KOi K06944.
    OMAi IRIYTKR.
    OrthoDBi EOG7PZRXJ.
    PhylomeDBi P55039.
    TreeFami TF105706.

    Miscellaneous databases

    GeneWikii DRG2.
    GenomeRNAii 1819.
    NextBioi 7413.
    PROi P55039.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55039.
    Bgeei P55039.
    CleanExi HS_DRG2.
    Genevestigatori P55039.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR006074. GTP1-OBG_CS.
    IPR006073. GTP_binding_domain.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view ]
    Pfami PF01926. MMR_HSR1. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view ]
    PRINTSi PR00326. GTP1OBG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51710. G_OBG. 1 hit.
    PS00905. GTP1_OBG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts."
      Schenker T., Lach C., Kessler B., Calderara S., Trueb B.
      J. Biol. Chem. 269:25447-25453(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-194.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-194.
      Tissue: Lung.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDRG2_HUMAN
    AccessioniPrimary (citable) accession number: P55039
    Secondary accession number(s): B2R8G5, Q53Y50, Q9BWB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3