P55039 (DRG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Developmentally-regulated GTP-binding protein 2
Short name=DRG-2

Gene names

Name:

DRG2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in cell proliferation, differentiation and death.
Subunit structure	Interacts with RWDD1 By similarity.
Subcellular location	Cytoplasm.
Tissue specificity	Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen, small intestine, lung and Leukocytes.
Post-translational modification	Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with RWDD1 By similarity.
Sequence similarities	Belongs to the GTP1/OBG family. Contains 1 G (guanine nucleotide-binding) domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	GTP-binding Nucleotide-binding
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA mitochondrion Inferred from electronic annotation. Source: Compara
Molecular_function	GTP binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Developmentally-regulated GTP-binding protein 2		PRO_0000205427
Regions
	Domain	74 – 172	99	G
	Nucleotide binding	69 – 76	8	GTP By similarity
	Nucleotide binding	115 – 119	5	GTP By similarity
	Nucleotide binding	246 – 249	4	GTP By similarity
Amino acid modifications
	Modified residue	199	1	Phosphoserine By similarity
Natural variations
	Natural variant	194	1	T → M. Ref.2 Ref.5 Corresponds to variant rs17855350 [ dbSNP | Ensembl ].		VAR_067452
	Natural variant	224	1	S → T. Corresponds to variant rs61256737 [ dbSNP | Ensembl ].		VAR_067453

Sequences

	Sequence		Length	Mass (Da)
	P55039 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: D1754BEB02671F85	FASTA	364	40,746
	10 20 30 40 50 60 MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSASS KGEGFDVMKS 70 80 90 100 110 120 GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI PGVIEYKGAN IQLLDLPGII 130 140 150 160 170 180 EGAAQGKGRG RQVIAVARTA DVIIMMLDAT KGEVQRSLLE KELESVGIRL NKHKPNIYFK 190 200 210 220 230 240 PKKGGGISFN STVTLTQCSE KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP 250 260 270 280 290 300 CLYVYNKIDQ ISMEEVDRLA RKPNSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR 310 320 330 340 350 360 PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWGTST KYSPQRVGLT HTMEHEDVIQ IVKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts." Schenker T., Lach C., Kessler B., Calderara S., Trueb B. J. Biol. Chem. 269:25447-25453(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-194.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-194. Tissue: Lung.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X80754 mRNA. Translation: CAA56730.1. BT006976 mRNA. Translation: AAP35622.1. AK313362 mRNA. Translation: BAG36162.1. CH471196 Genomic DNA. Translation: EAW55669.1. BC000493 mRNA. Translation: AAH00493.1.
IPI	IPI00022697.
PIR	A55014.
RefSeq	NP_001379.1. NM_001388.4.
UniGene	Hs.78582.
3D structure databases
ProteinModelPortal	P55039.
ModBase	Search...
Protein-protein interaction databases
IntAct	P55039. 2 interactions.
MINT	MINT-1453971.
STRING	9606.ENSP00000225729.
PTM databases
PhosphoSite	P55039.
Polymorphism databases
DMDM	1706518.
Proteomic databases
PaxDb	P55039.
PRIDE	P55039.
Protocols and materials databases
DNASU	1819.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000225729; ENSP00000225729; ENSG00000108591.
GeneID	1819.
KEGG	hsa:1819.
UCSC	uc002gsh.1. human.
Organism-specific databases
CTD	1819.
GeneCards	GC17P017992.
HGNC	HGNC:3030. DRG2.
HPA	HPA007716.
MIM	602986. gene.
neXtProt	NX_P55039.
PharmGKB	PA27484.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1163.
HOGENOM	HOG000112078.
HOVERGEN	HBG000948.
InParanoid	P55039.
KO	K06944.
OMA	LFREDCT.
OrthoDB	EOG4ZKJMH.
PhylomeDB	P55039.
Gene expression databases
ArrayExpress	P55039.
Bgee	P55039.
CleanEx	HS_DRG2.
Genevestigator	P55039.
GermOnline	ENSG00000108591. Homo sapiens.
Family and domain databases
InterPro	IPR006074. GTP1-OBG_CS. IPR006073. GTP_binding_domain. IPR005225. Small_GTP-bd_dom. IPR004095. TGS. IPR012676. TGS-like. [Graphical view]
Pfam	PF01926. MMR_HSR1. 1 hit. PF02824. TGS. 1 hit. [Graphical view]
PRINTS	PR00326. GTP1OBG.
SUPFAM	SSF81271. TGS-like. 1 hit.
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS00905. GTP1_OBG. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1819.
NextBio	7413.
SOURCE	Search...

Entry information

Entry name

DRG2_HUMAN

Accession

Primary (citable) accession number: P55039
Secondary accession number(s): B2R8G5, Q53Y50, Q9BWB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.