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P55039

- DRG2_HUMAN

UniProt

P55039 - DRG2_HUMAN

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Protein
Developmentally-regulated GTP-binding protein 2
Gene
DRG2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in cell proliferation, differentiation and death.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 768GTP By similarity
Nucleotide bindingi115 – 1195GTP By similarity
Nucleotide bindingi246 – 2494GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: ProtInc

GO - Biological processi

  1. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated GTP-binding protein 2
Short name:
DRG-2
Gene namesi
Name:DRG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:3030. DRG2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27484.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Developmentally-regulated GTP-binding protein 2
PRO_0000205427Add
BLAST

Post-translational modificationi

Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with RWDD1 By similarity.

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiP55039.
PaxDbiP55039.
PRIDEiP55039.

PTM databases

PhosphoSiteiP55039.

Expressioni

Tissue specificityi

Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen, small intestine, lung and Leukocytes.

Gene expression databases

ArrayExpressiP55039.
BgeeiP55039.
CleanExiHS_DRG2.
GenevestigatoriP55039.

Organism-specific databases

HPAiHPA007716.

Interactioni

Subunit structurei

Interacts with RWDD1 By similarity.

Protein-protein interaction databases

BioGridi108153. 9 interactions.
IntActiP55039. 2 interactions.
MINTiMINT-1453971.
STRINGi9606.ENSP00000225729.

Structurei

3D structure databases

ProteinModelPortaliP55039.
SMRiP55039. Positions 4-364.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 288226OBG-type G
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1163.
HOGENOMiHOG000112078.
HOVERGENiHBG000948.
InParanoidiP55039.
KOiK06944.
OMAiIRIYTKR.
OrthoDBiEOG7PZRXJ.
PhylomeDBiP55039.
TreeFamiTF105706.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55039-1 [UniParc]FASTAAdd to Basket

« Hide

MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSASS    50
KGEGFDVMKS GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI 100
PGVIEYKGAN IQLLDLPGII EGAAQGKGRG RQVIAVARTA DVIIMMLDAT 150
KGEVQRSLLE KELESVGIRL NKHKPNIYFK PKKGGGISFN STVTLTQCSE 200
KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP CLYVYNKIDQ 250
ISMEEVDRLA RKPNSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR 300
PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWGTST KYSPQRVGLT 350
HTMEHEDVIQ IVKK 364
Length:364
Mass (Da):40,746
Last modified:October 1, 1996 - v1
Checksum:iD1754BEB02671F85
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti194 – 1941T → M.2 Publications
Corresponds to variant rs17855350 [ dbSNP | Ensembl ].
VAR_067452
Natural varianti224 – 2241S → T.
Corresponds to variant rs61256737 [ dbSNP | Ensembl ].
VAR_067453

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80754 mRNA. Translation: CAA56730.1.
BT006976 mRNA. Translation: AAP35622.1.
AK313362 mRNA. Translation: BAG36162.1.
CH471196 Genomic DNA. Translation: EAW55669.1.
BC000493 mRNA. Translation: AAH00493.1.
CCDSiCCDS11191.1.
PIRiA55014.
RefSeqiNP_001379.1. NM_001388.4.
UniGeneiHs.78582.

Genome annotation databases

EnsembliENST00000225729; ENSP00000225729; ENSG00000108591.
GeneIDi1819.
KEGGihsa:1819.
UCSCiuc002gsh.2. human.

Polymorphism databases

DMDMi1706518.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80754 mRNA. Translation: CAA56730.1 .
BT006976 mRNA. Translation: AAP35622.1 .
AK313362 mRNA. Translation: BAG36162.1 .
CH471196 Genomic DNA. Translation: EAW55669.1 .
BC000493 mRNA. Translation: AAH00493.1 .
CCDSi CCDS11191.1.
PIRi A55014.
RefSeqi NP_001379.1. NM_001388.4.
UniGenei Hs.78582.

3D structure databases

ProteinModelPortali P55039.
SMRi P55039. Positions 4-364.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108153. 9 interactions.
IntActi P55039. 2 interactions.
MINTi MINT-1453971.
STRINGi 9606.ENSP00000225729.

PTM databases

PhosphoSitei P55039.

Polymorphism databases

DMDMi 1706518.

Proteomic databases

MaxQBi P55039.
PaxDbi P55039.
PRIDEi P55039.

Protocols and materials databases

DNASUi 1819.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225729 ; ENSP00000225729 ; ENSG00000108591 .
GeneIDi 1819.
KEGGi hsa:1819.
UCSCi uc002gsh.2. human.

Organism-specific databases

CTDi 1819.
GeneCardsi GC17P017992.
HGNCi HGNC:3030. DRG2.
HPAi HPA007716.
MIMi 602986. gene.
neXtProti NX_P55039.
PharmGKBi PA27484.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1163.
HOGENOMi HOG000112078.
HOVERGENi HBG000948.
InParanoidi P55039.
KOi K06944.
OMAi IRIYTKR.
OrthoDBi EOG7PZRXJ.
PhylomeDBi P55039.
TreeFami TF105706.

Miscellaneous databases

GeneWikii DRG2.
GenomeRNAii 1819.
NextBioi 7413.
PROi P55039.
SOURCEi Search...

Gene expression databases

ArrayExpressi P55039.
Bgeei P55039.
CleanExi HS_DRG2.
Genevestigatori P55039.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01926. MMR_HSR1. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
PRINTSi PR00326. GTP1OBG.
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts."
    Schenker T., Lach C., Kessler B., Calderara S., Trueb B.
    J. Biol. Chem. 269:25447-25453(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-194.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-194.
    Tissue: Lung.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDRG2_HUMAN
AccessioniPrimary (citable) accession number: P55039
Secondary accession number(s): B2R8G5, Q53Y50, Q9BWB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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