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P55038

- GLTS_SYNY3

UniProt

P55038 - GLTS_SYNY3

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Protein

Ferredoxin-dependent glutamate synthase 2

Gene

gltS

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+.

Cofactori

Binds 1 3Fe-4S cluster.
FAD.
FMN.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371For GATase activityBy similarity
Metal bindingi1173 – 11731Iron-sulfur (3Fe-4S)By similarity
Metal bindingi1179 – 11791Iron-sulfur (3Fe-4S)By similarity
Metal bindingi1184 – 11841Iron-sulfur (3Fe-4S)By similarity

GO - Molecular functioni

  1. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. glutamate synthase (ferredoxin) activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glutamine metabolic process Source: UniProtKB-KW
  2. L-glutamate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Glutamate biosynthesis

Keywords - Ligandi

3Fe-4S, FAD, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00045.
UPA00634; UER00691.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin-dependent glutamate synthase 2 (EC:1.4.7.1)
Alternative name(s):
FD-GOGAT
Gene namesi
Name:gltS
Ordered Locus Names:sll1499
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15561556Ferredoxin-dependent glutamate synthase 2PRO_0000170794Add
BLAST

Proteomic databases

PaxDbiP55038.

Interactioni

Protein-protein interaction databases

IntActiP55038. 4 interactions.
STRINGi1148.sll1499.

Structurei

Secondary structure

1
1556
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi38 – 436Combined sources
Beta strandi45 – 473Combined sources
Helixi52 – 6312Combined sources
Helixi64 – 674Combined sources
Beta strandi74 – 785Combined sources
Beta strandi80 – 856Combined sources
Helixi88 – 9710Combined sources
Helixi105 – 1073Combined sources
Beta strandi109 – 1157Combined sources
Helixi119 – 13517Combined sources
Beta strandi139 – 1457Combined sources
Helixi150 – 1523Combined sources
Helixi155 – 1606Combined sources
Beta strandi163 – 1708Combined sources
Helixi177 – 19115Combined sources
Helixi192 – 1943Combined sources
Beta strandi199 – 21517Combined sources
Helixi217 – 2193Combined sources
Helixi220 – 2234Combined sources
Helixi225 – 2284Combined sources
Beta strandi234 – 2418Combined sources
Beta strandi245 – 2473Combined sources
Helixi251 – 2533Combined sources
Beta strandi254 – 2563Combined sources
Beta strandi258 – 2647Combined sources
Helixi269 – 27911Combined sources
Helixi280 – 2823Combined sources
Helixi290 – 2967Combined sources
Helixi306 – 31914Combined sources
Helixi324 – 3318Combined sources
Helixi340 – 3423Combined sources
Helixi346 – 35510Combined sources
Turni356 – 3583Combined sources
Beta strandi364 – 3718Combined sources
Beta strandi373 – 3808Combined sources
Beta strandi389 – 3935Combined sources
Beta strandi398 – 4036Combined sources
Helixi411 – 4133Combined sources
Beta strandi414 – 4196Combined sources
Beta strandi425 – 4295Combined sources
Turni430 – 4334Combined sources
Beta strandi434 – 4363Combined sources
Helixi438 – 4469Combined sources
Helixi451 – 4588Combined sources
Beta strandi459 – 4624Combined sources
Helixi476 – 48510Combined sources
Helixi490 – 4956Combined sources
Helixi497 – 5037Combined sources
Turni518 – 5203Combined sources
Helixi527 – 5304Combined sources
Beta strandi531 – 5333Combined sources
Beta strandi538 – 5403Combined sources
Turni545 – 5484Combined sources
Helixi549 – 5513Combined sources
Beta strandi556 – 5594Combined sources
Beta strandi564 – 5663Combined sources
Helixi569 – 5724Combined sources
Beta strandi574 – 5785Combined sources
Helixi584 – 5929Combined sources
Beta strandi593 – 5953Combined sources
Beta strandi597 – 6015Combined sources
Beta strandi603 – 6053Combined sources
Beta strandi607 – 6093Combined sources
Helixi612 – 62817Combined sources
Beta strandi632 – 6398Combined sources
Helixi640 – 6423Combined sources
Beta strandi646 – 6483Combined sources
Beta strandi649 – 6513Combined sources
Helixi654 – 66714Combined sources
Helixi671 – 6733Combined sources
Beta strandi675 – 6795Combined sources
Helixi686 – 6949Combined sources
Beta strandi698 – 7014Combined sources
Helixi703 – 71311Combined sources
Helixi716 – 7227Combined sources
Turni723 – 7253Combined sources
Helixi732 – 75322Combined sources
Helixi759 – 7635Combined sources
Beta strandi768 – 7736Combined sources
Helixi775 – 7817Combined sources
Helixi794 – 80815Combined sources
Beta strandi809 – 8113Combined sources
Beta strandi820 – 8234Combined sources
Beta strandi826 – 8283Combined sources
Helixi835 – 84713Combined sources
Helixi862 – 87110Combined sources
Helixi878 – 8814Combined sources
Beta strandi882 – 8843Combined sources
Helixi893 – 8953Combined sources
Helixi899 – 9035Combined sources
Turni913 – 9153Combined sources
Helixi918 – 93114Combined sources
Helixi944 – 9474Combined sources
Beta strandi960 – 9623Combined sources
Beta strandi977 – 9815Combined sources
Helixi990 – 9956Combined sources
Beta strandi997 – 10026Combined sources
Helixi1017 – 10193Combined sources
Helixi1022 – 10287Combined sources
Helixi1048 – 106114Combined sources
Beta strandi1065 – 10728Combined sources
Helixi1077 – 108610Combined sources
Beta strandi1090 – 10956Combined sources
Beta strandi1102 – 11054Combined sources
Helixi1106 – 11116Combined sources
Helixi1116 – 112914Combined sources
Helixi1133 – 11353Combined sources
Beta strandi1137 – 11437Combined sources
Helixi1147 – 11559Combined sources
Beta strandi1159 – 11624Combined sources
Helixi1165 – 11706Combined sources
Helixi1179 – 11813Combined sources
Beta strandi1187 – 11893Combined sources
Helixi1193 – 11964Combined sources
Helixi1203 – 122422Combined sources
Helixi1229 – 12324Combined sources
Helixi1236 – 12383Combined sources
Beta strandi1239 – 12413Combined sources
Beta strandi1248 – 12514Combined sources
Helixi1256 – 12594Combined sources
Helixi1269 – 12713Combined sources
Helixi1283 – 12897Combined sources
Helixi1291 – 12999Combined sources
Beta strandi1302 – 13098Combined sources
Helixi1318 – 132811Combined sources
Turni1329 – 13313Combined sources
Beta strandi1336 – 134510Combined sources
Turni1347 – 13526Combined sources
Beta strandi1357 – 13659Combined sources
Turni1369 – 13724Combined sources
Beta strandi1375 – 13817Combined sources
Helixi1390 – 13923Combined sources
Turni1400 – 14034Combined sources
Beta strandi1408 – 14147Combined sources
Turni1419 – 14224Combined sources
Beta strandi1427 – 14315Combined sources
Turni1437 – 14404Combined sources
Beta strandi1442 – 14487Combined sources
Beta strandi1454 – 14563Combined sources
Turni1457 – 14593Combined sources
Beta strandi1462 – 14687Combined sources
Beta strandi1470 – 14723Combined sources
Helixi1474 – 14774Combined sources
Turni1480 – 14823Combined sources
Beta strandi1484 – 14863Combined sources
Helixi1491 – 150818Combined sources
Helixi1511 – 15188Combined sources
Helixi1520 – 15245Combined sources
Beta strandi1527 – 15315Combined sources
Turni1533 – 15375Combined sources
Turni1539 – 15413Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LLWX-ray2.70A37-1556[»]
1LLZX-ray3.00A37-1556[»]
1LM1X-ray2.80A37-1556[»]
1OFDX-ray2.00A/B37-1556[»]
1OFEX-ray2.45A/B37-1556[»]
ProteinModelPortaliP55038.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55038.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 431395Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glutamate synthase family.Curated
Contains 1 glutamine amidotransferase type-2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0069.
HOGENOMiHOG000031558.
InParanoidiP55038.
KOiK00284.
OMAiYSVQGVT.
OrthoDBiEOG60W7PX.
PhylomeDBiP55038.

Family and domain databases

Gene3Di2.160.20.60. 1 hit.
3.20.20.70. 2 hits.
3.60.20.10. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR002489. Glu_synth_asu_C.
IPR006982. Glu_synth_centr_N.
IPR002932. Glu_synthdom.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PfamiPF00310. GATase_2. 1 hit.
PF04898. Glu_syn_central. 1 hit.
PF01645. Glu_synthase. 1 hit.
PF01493. GXGXG. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
SSF69336. SSF69336. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55038-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFQYPLLAP MTNSSVATNS NQPFLGQPWL VEERDACGVG FIANLRGKPD
60 70 80 90 100
HTLVEQALKA LGCMEHRGGC SADNDSGDGA GVMTAIPREL LAQWFNTRNL
110 120 130 140 150
PMPDGDRLGV GMVFLPQEPS AREVARAYVE EVVRLEKLTV LGWREVPVNS
160 170 180 190 200
DVLGIQAKNN QPHIEQILVT CPEGCAGDEL DRRLYIARSI IGKKLAEDFY
210 220 230 240 250
VCSFSCRTIV YKGMVRSIIL GEFYLDLKNP GYTSNFAVYH RRFSTNTMPK
260 270 280 290 300
WPLAQPMRLL GHNGEINTLL GNINWMAARE KELEVSGWTK AELEALTPIV
310 320 330 340 350
NQANSDSYNL DSALELLVRT GRSPLEAAMI LVPEAYKNQP ALKDYPEISD
360 370 380 390 400
FHDYYSGLQE PWDGPALLVF SDGKIVGAGL DRNGLRPARY CITKDDYIVL
410 420 430 440 450
GSEAGVVDLP EVDIVEKGRL APGQMIAVDL AEQKILKNYQ IKQQAAQKYP
460 470 480 490 500
YGEWIKIQRQ TVASDSFAEK TLFNDAQTVL QQQAAFGYTA EDVEMVVVPM
510 520 530 540 550
ASQGKEPTFC MGDDTPLAVL SHKPRLLYDY FKQRFAQVTN PPIDPLRENL
560 570 580 590 600
VMSLAMFLGK RGNLLEPKAE SARTIKLRSP LVNEVELQAI KTGQLQVAEV
610 620 630 640 650
STLYDLDGVN SLETALDNLV KTAIATVQAG AEILVLTDRP NGAILTENQS
660 670 680 690 700
FIPPLLAVGA VHHHLIRAGL RLKASLIVDT AQCWSTHHFA CLVGYGASAI
710 720 730 740 750
CPYLALESVR QWWLDEKTQK LMENGRLDRI DLPTALKNYR QSVEAGLFKI
760 770 780 790 800
LSKMGISLLA SYHGAQIFEA IGLGAELVEY AFAGTTSRVG GLTIADVAGE
810 820 830 840 850
VMVFHGMAFP EMAKKLENFG FVNYRPGGEY HMNSPEMSKS LHKAVAAYKV
860 870 880 890 900
GGNGNNGEAY DHYELYRQYL KDRPVTALRD LLDFNADQPA ISLEEVESVE
910 920 930 940 950
SIVKRFCTGG MSLGALSREA HETLAIAMNR LGAKSNSGEG GEDVVRYLTL
960 970 980 990 1000
DDVDSEGNSP TLPHLHGLQN GDTANSAIKQ IASGRFGVTP EYLMSGKQLE
1010 1020 1030 1040 1050
IKMAQGAKPG EGGQLPGKKV SEYIAMLRRS KPGVTLISPP PHHDIYSIED
1060 1070 1080 1090 1100
LAQLIYDLHQ INPEAQVSVK LVAEIGIGTI AAGVAKANAD IIQISGHDGG
1110 1120 1130 1140 1150
TGASPLSSIK HAGSPWELGV TEVHRVLMEN QLRDRVLLRA DGGLKTGWDV
1160 1170 1180 1190 1200
VMAALMGAEE YGFGSIAMIA EGCIMARVCH TNNCPVGVAT QQERLRQRFK
1210 1220 1230 1240 1250
GVPGQVVNFF YFIAEEVRSL LAHLGYRSLD DIIGRTDLLK VRSDVQLSKT
1260 1270 1280 1290 1300
QNLTLDCLLN LPDTKQNRQW LNHEPVHSNG PVLDDDILAD PDIQEAINHQ
1310 1320 1330 1340 1350
TTATKTYRLV NTDRTVGTRL SGAIAKKYGN NGFEGNITLN FQGAAGQSFG
1360 1370 1380 1390 1400
AFNLDGMTLH LQGEANDYVG KGMNGGEIVI VPHPQASFAP EDNVIIGNTC
1410 1420 1430 1440 1450
LYGATGGNLY ANGRAGERFA VRNSVGKAVI EGAGDHCCEY MTGGVIVVLG
1460 1470 1480 1490 1500
PVGRNVGAGM TGGLAYFLDE VGDLPEKINP EIITLQRITA SKGEEQLKSL
1510 1520 1530 1540 1550
ITAHVEHTGS PKGKAILANW SDYLGKFWQA VPPSEKDSPE ANGDVSLTGE

KTLTSV
Length:1,556
Mass (Da):169,499
Last modified:November 1, 1997 - v2
Checksum:i4BDAD5F9A4064D9D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti491 – 4911E → Q in CAA63218. (PubMed:7727752)Curated
Sequence conflicti570 – 5723ESA → NPR in CAA63218. (PubMed:7727752)Curated
Sequence conflicti642 – 6509GAILTENQS → RRNIGLRIKV in CAA63218. (PubMed:7727752)Curated
Sequence conflicti659 – 6591G → E in CAA63218. (PubMed:7727752)Curated
Sequence conflicti940 – 9412GG → PP in CAA63218. (PubMed:7727752)Curated
Sequence conflicti1059 – 10591H → L in CAA63218. (PubMed:7727752)Curated
Sequence conflicti1295 – 12951E → RK in CAA63218. (PubMed:7727752)Curated
Sequence conflicti1310 – 13101V → D in CAA63218. (PubMed:7727752)Curated
Sequence conflicti1323 – 13231A → S in CAA63218. (PubMed:7727752)Curated
Sequence conflicti1531 – 15311Missing in CAA63218. (PubMed:7727752)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92480 Genomic DNA. Translation: CAA63218.1.
D78371 Genomic DNA. Translation: BAA11379.1.
BA000022 Genomic DNA. Translation: BAA18693.1.
PIRiS76781.
RefSeqiNP_442881.1. NC_000911.1.
YP_005652942.1. NC_017277.1.
YP_007452757.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18693; BAA18693; BAA18693.
GeneIDi952019.
KEGGisyn:sll1499.
syy:SYNGTS_2989.
syz:MYO_130230.
PATRICi23843556. VBISynSp132158_3309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92480 Genomic DNA. Translation: CAA63218.1 .
D78371 Genomic DNA. Translation: BAA11379.1 .
BA000022 Genomic DNA. Translation: BAA18693.1 .
PIRi S76781.
RefSeqi NP_442881.1. NC_000911.1.
YP_005652942.1. NC_017277.1.
YP_007452757.1. NC_020286.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LLW X-ray 2.70 A 37-1556 [» ]
1LLZ X-ray 3.00 A 37-1556 [» ]
1LM1 X-ray 2.80 A 37-1556 [» ]
1OFD X-ray 2.00 A/B 37-1556 [» ]
1OFE X-ray 2.45 A/B 37-1556 [» ]
ProteinModelPortali P55038.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P55038. 4 interactions.
STRINGi 1148.sll1499.

Proteomic databases

PaxDbi P55038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18693 ; BAA18693 ; BAA18693 .
GeneIDi 952019.
KEGGi syn:sll1499.
syy:SYNGTS_2989.
syz:MYO_130230.
PATRICi 23843556. VBISynSp132158_3309.

Phylogenomic databases

eggNOGi COG0069.
HOGENOMi HOG000031558.
InParanoidi P55038.
KOi K00284.
OMAi YSVQGVT.
OrthoDBi EOG60W7PX.
PhylomeDBi P55038.

Enzyme and pathway databases

UniPathwayi UPA00045 .
UPA00634 ; UER00691 .

Miscellaneous databases

EvolutionaryTracei P55038.

Family and domain databases

Gene3Di 2.160.20.60. 1 hit.
3.20.20.70. 2 hits.
3.60.20.10. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR002489. Glu_synth_asu_C.
IPR006982. Glu_synth_centr_N.
IPR002932. Glu_synthdom.
IPR029055. Ntn_hydrolases_N.
[Graphical view ]
Pfami PF00310. GATase_2. 1 hit.
PF04898. Glu_syn_central. 1 hit.
PF01645. Glu_synthase. 1 hit.
PF01493. GXGXG. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
SSF69336. SSF69336. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Existence of two ferredoxin-glutamate synthases in the cyanobacterium Synechocystis sp. PCC 6803. Isolation and insertional inactivation of gltB and gltS genes."
    Navarro F., Chavez S., Candau P., Florencio F.J.
    Plant Mol. Biol. 27:753-767(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Terauchi K., Ikeuchi M., Ohmori M.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiGLTS_SYNY3
AccessioniPrimary (citable) accession number: P55038
Secondary accession number(s): Q59980
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3