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P55037

- GLTB_SYNY3

UniProt

P55037 - GLTB_SYNY3

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Protein
Ferredoxin-dependent glutamate synthase 1
Gene
gltB, sll1502
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+.

Cofactori

Binds 1 3Fe-4S cluster.
FAD.
FMN.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431For GATase activity By similarity
Metal bindingi1150 – 11501Iron-sulfur (3Fe-4S) By similarity
Metal bindingi1156 – 11561Iron-sulfur (3Fe-4S) By similarity
Metal bindingi1161 – 11611Iron-sulfur (3Fe-4S) By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1097 – 115458FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. glutamate synthase (ferredoxin) activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: IntAct

GO - Biological processi

  1. L-glutamate biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Glutamate biosynthesis

Keywords - Ligandi

3Fe-4S, FAD, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00045.
UPA00634; UER00691.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin-dependent glutamate synthase 1 (EC:1.4.7.1)
Alternative name(s):
Fd-GOGAT
Gene namesi
Name:gltB
Ordered Locus Names:sll1502
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15501550Ferredoxin-dependent glutamate synthase 1
PRO_0000170793Add
BLAST

Proteomic databases

PaxDbiP55037.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
trxAP522312EBI-862093,EBI-862916

Protein-protein interaction databases

IntActiP55037. 3 interactions.
STRINGi1148.sll1502.

Structurei

3D structure databases

ProteinModelPortaliP55037.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 440398Glutamine amidotransferase type-2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0069.
HOGENOMiHOG000031559.
KOiK00284.
OMAiRRYGHAG.
OrthoDBiEOG60W7PX.
PhylomeDBiP55037.

Family and domain databases

Gene3Di2.160.20.60. 1 hit.
3.20.20.70. 2 hits.
3.60.20.10. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR002489. Glu_synth_asu_C.
IPR006982. Glu_synth_centr_N.
IPR002932. Glu_synthdom.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PfamiPF00310. GATase_2. 1 hit.
PF04898. Glu_syn_central. 1 hit.
PF01645. Glu_synthase. 1 hit.
PF01493. GXGXG. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
SSF69336. SSF69336. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55037-1 [UniParc]FASTAAdd to Basket

« Hide

MPCHEGLHPL VPNFCTVTSP MNSSHLAPQV QGLYDPQNEH DACGVGFIVQ     50
MKGKVSHDIV EQGLQMLVNL EHRGACGCEP NTGDGAGILI QVPHKFIQKI 100
AGAEGITIPA PGQYAVGNIY GSPDPLARAE ARQKFNDIVA QEGLKVLGWR 150
DIPTQNEPLG ETAIASEPFM QQVYIARPEG LTDDLDFERK LYVIRKLTHG 200
AIRSPKIDTY WYVASLSART LVYKGMLTTA QVGQYYPELH DPDMESALAL 250
VHSRFSTNTF PSWERSHPYR YIAHNGEINT MRGNVNWMQA RQALFESSLF 300
GEDMAKVQPV INIDGSDSTI FDNALELLYL AGRSLPHAVM MMIPEPWSAH 350
ESMSQEKKAF YKYHSCLMEP WDGPASIAFT NGKMMGAVLD RNGLRPSRYY 400
VTKDDLVIMA SEAGVLPIEP ERVAKKGRLQ PGRMFLVDME QGRIIADEEI 450
KQEIVSQHPY GEWLAANLKS LEQLPSPGNV PGTDAESLRQ RQMAFGYTFE 500
ELRILLAPMG RDGVEAIGSM GADTPLAVLS DKPKLLYNYF QQLFAQVTNP 550
PIDSIREEII TSAETTIGGE GNLLDPRPES CRLIELKTPI LTNEDLAKLK 600
ALDDDEFKSV TLDILFDPNQ GEAGLKTALD NLFTEADQAI SQGANLIILS 650
DRQVSAEKAA IPALLAVSGL HHHLIRNGSR TKVGLVLESG EPREVHHFAV 700
LLGYGCGAIN PYLAFETLDG MIAEGLLVNV DHKTACKNYI KAATKGVIKV 750
ASKIGISTIQ SYRGAQIFEA VGLNQSVIDE YFCRTSSRIQ GSDLGVIAQE 800
AILRHQHAFA PRPGDLHTLD VGGEYQWRKD GEEHLFSPQT IHLLQRAVRE 850
GNYELYKQYA ALVNEQNQKF FTLRGLLDFQ DRESIPLEEV EPIEAIMKRF 900
KTGAMSYGSI SKEAHESLAI AMNRIGGKSN TGEGGEDPER FTWTNDQGDS 950
KNSAIKQVAS GRFGVTSLYL SQAKEIQIKM AQGAKPGEGG QLPGKKVYPW 1000
IAKVRHSTPG VGLISPPPHH DIYSIEDLAE LIHDLKNANR EARINVKLVS 1050
EVGVGTIAAG VAKAHADVVL VSGYDGGTGA SPQTSIKHAG LPWELGLAET 1100
HQTLVLNNLR SRIVVETDGQ MKTGRDVAIA ALLGAEEFGF STAPLVSLGC 1150
IMMRACHLNT CPVGIATQNP ELRAKFTGDP AHAVNFMTFI ATELREVMAQ 1200
LGFRTINEMV GRTDILEPKK AVAHWKAKGI DLSTILHQPE VGDDVGRYCQ 1250
IPQDHGLQHS LDITQLLDLC QPAIAKGEKV TATLPITNIN RVVGTIVGNE 1300
ITKRHWEGLP EDTVHLHFQG SAGQSFGAFI PKGMTLELEG DANDYLGKGL 1350
SGGKIIVYPP KGSSFIASEN IIAGNVCLYG ATAGEVYISG MVGERFCVRN 1400
SGVNTVVEAV GDHGCEYMTG GKVVVLGQTG RNFAAGMSGG VAYIFDETGD 1450
FATRCNSAMV GLEKLEDPEE IKDLKELIQN HVNYTDSAKG KAVLADWEAS 1500
IPKFVKVMPR DYKRVLQAIK KALEAGLSGD DALNAAFEEN AKDVARIGGS 1550
Length:1,550
Mass (Da):169,071
Last modified:October 1, 1996 - v1
Checksum:i07AA64D832296943
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80485 Genomic DNA. Translation: CAA56652.1.
BA000022 Genomic DNA. Translation: BAA17018.1.
PIRiS60228.
RefSeqiNP_440338.1. NC_000911.1.
YP_005650395.1. NC_017277.1.
YP_007450221.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17018; BAA17018; BAA17018.
GeneIDi953637.
KEGGisyn:sll1502.
syy:SYNGTS_0442.
syz:MYO_14470.
PATRICi23837822. VBISynSp132158_0480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80485 Genomic DNA. Translation: CAA56652.1 .
BA000022 Genomic DNA. Translation: BAA17018.1 .
PIRi S60228.
RefSeqi NP_440338.1. NC_000911.1.
YP_005650395.1. NC_017277.1.
YP_007450221.1. NC_020286.1.

3D structure databases

ProteinModelPortali P55037.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P55037. 3 interactions.
STRINGi 1148.sll1502.

Proteomic databases

PaxDbi P55037.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA17018 ; BAA17018 ; BAA17018 .
GeneIDi 953637.
KEGGi syn:sll1502.
syy:SYNGTS_0442.
syz:MYO_14470.
PATRICi 23837822. VBISynSp132158_0480.

Phylogenomic databases

eggNOGi COG0069.
HOGENOMi HOG000031559.
KOi K00284.
OMAi RRYGHAG.
OrthoDBi EOG60W7PX.
PhylomeDBi P55037.

Enzyme and pathway databases

UniPathwayi UPA00045 .
UPA00634 ; UER00691 .

Family and domain databases

Gene3Di 2.160.20.60. 1 hit.
3.20.20.70. 2 hits.
3.60.20.10. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR002489. Glu_synth_asu_C.
IPR006982. Glu_synth_centr_N.
IPR002932. Glu_synthdom.
IPR029055. Ntn_hydrolases_N.
[Graphical view ]
Pfami PF00310. GATase_2. 1 hit.
PF04898. Glu_syn_central. 1 hit.
PF01645. Glu_synthase. 1 hit.
PF01493. GXGXG. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
SSF69336. SSF69336. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Existence of two ferredoxin-glutamate synthases in the cyanobacterium Synechocystis sp. PCC 6803. Isolation and insertional inactivation of gltB and gltS genes."
    Navarro F., Chavez S., Candau P., Florencio F.J.
    Plant Mol. Biol. 27:753-767(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiGLTB_SYNY3
AccessioniPrimary (citable) accession number: P55037
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-21 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi