ID   TYRO_FELCA              Reviewed;          80 AA.
AC   P55033;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-MAR-2009, entry version 53.
DE   RecName: Full=Tyrosinase;
DE            EC=1.14.18.1;
DE   AltName: Full=Monophenol monooxygenase;
DE   Flags: Fragment;
GN   Name=TYR;
OS   Felis silvestris catus (Cat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=European shorthair; TISSUE=Melanoma;
RX   MEDLINE=97294870; PubMed=9150543;
RA   van der Linde-Sipman J.S., de Wit M.M., van Garderen E.,
RA   Molenbeek R.F., van der Velde-Zimmermann D., de Weger R.A.;
RT   "Cutaneous malignant melanomas in 57 cats: identification of
RT   (amelanotic) signet-ring and balloon cell types and verification of
RT   their origin by immunohistochemistry, electron microscopy, and in situ
RT   hybridization.";
RL   Vet. Pathol. 34:31-38(1997).
CC   -!- FUNCTION: This is a copper-containing oxidase that functions in
CC       the formation of pigments such as melanins and other polyphenolic
CC       compounds. Catalyzes the rate-limiting conversions of tyrosine to
CC       DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to
CC       indole-5,6 quinone.
CC   -!- CATALYTIC ACTIVITY: L-tyrosine + L-dopa + O(2) = L-dopa +
CC       dopaquinone + H(2)O.
CC   -!- COFACTOR: Binds 2 copper ions per subunit.
CC   -!- SUBCELLULAR LOCATION: Melanosome membrane; Single-pass type I
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the tyrosinase family.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=Snowy stardom - Issue
CC       49 of August 2004;
CC       URL="http://www.expasy.org/spotlight/back_issues/sptlt049.shtml";
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DR   EMBL; U40716; AAB08729.1; -; mRNA.
DR   HOVERGEN; P55033; -.
DR   BRENDA; 1.14.18.1; 273949.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005507; F:copper ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004503; F:monophenol monooxygenase activity; IEA:EC.
DR   GO; GO:0006583; P:melanin biosynthetic process from tyrosine; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002227; Tyrosinase.
DR   PROSITE; PS00497; TYROSINASE_1; PARTIAL.
DR   PROSITE; PS00498; TYROSINASE_2; PARTIAL.
PE   3: Inferred from homology;
KW   Copper; Glycoprotein; Melanin biosynthesis; Membrane; Monooxygenase;
KW   Oxidoreductase; Transmembrane.
FT   CHAIN        <1    >80       Tyrosinase.
FT                                /FTId=PRO_0000186729.
FT   CARBOHYD     59     59       N-linked (GlcNAc...) (Potential).
FT   NON_TER       1      1
FT   NON_TER      80     80
SQ   SEQUENCE   80 AA;  8694 MW;  926D7C99D49B74D3 CRC64;
     LEEYNSRQAL CDGTPEGPLL RNPGNHDKAR TPRLPSSADV EFCLSLTQYE SDSMDKAANF
     SFRNTLEGFA SPLTGIADAS
//