Reviewed,
UniProtKB/Swiss-Prot P55033 (TYRO_FELCA)
Last modified
October 13, 2009.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tyrosinase EC=1.14.18.1 Alternative name(s): Monophenol monooxygenase | ||
| Gene names |
| ||
| Organism | Felis catus (Cat) (Felis silvestris catus) | ||
| Taxonomic identifier | 9685 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis |
Protein attributes
| Sequence length | 80 AA. |
| Sequence status | Fragment. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. |
| Catalytic activity | L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O. |
| Cofactor | Binds 2 copper ions per subunit. |
| Subcellular location | |
| Sequence similarities | Belongs to the tyrosinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Melanin biosynthesis |
| Cellular component | Membrane |
| Domain | Transmembrane |
| Ligand | Copper |
| Molecular function | Monooxygenase Oxidoreductase |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | melanin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW monophenol monooxygenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| [1] | "Cutaneous malignant melanomas in 57 cats: identification of (amelanotic) signet-ring and balloon cell types and verification of their origin by immunohistochemistry, electron microscopy, and in situ hybridization." van der Linde-Sipman J.S., de Wit M.M., van Garderen E., Molenbeek R.F., van der Velde-Zimmermann D., de Weger R.A. Vet. Pathol. 34:31-38(1997) [PubMed: 9150543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: European shorthair. Tissue: Melanoma. |
Cross-references
Sequence databases | |
|---|---|
| U40716 mRNA. Translation: AAB08729.1. | |
3D structure databases | |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | P55033. |
Enzyme and pathway databases | |
| BRENDA | 1.14.18.1. 273949. |
Family and domain databases | |
| InterPro | IPR002227. Tyrosinase. [Graphical view] |
| PROSITE | PS00497. TYROSINASE_1. Partial match. PS00498. TYROSINASE_2. Partial match. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TYRO_FELCA | ||||||||
| Accession | Primary (citable) accession number: P55033 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Protein Spotlight Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


