ID   TYRO_TRISI              Reviewed;         273 AA.
AC   P55026;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   05-MAY-2009, entry version 48.
DE   RecName: Full=Tyrosinase;
DE            EC=1.14.18.1;
DE   AltName: Full=Monophenol monooxygenase;
DE   Flags: Precursor; Fragment;
GN   Name=TYR;
OS   Trionyx sinensis (Chinese softshell turtle) (Pelodiscus sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Testudines; Cryptodira; Trionychoidea; Trionychidae; Pelodiscus.
OX   NCBI_TaxID=13735;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Ssp. Japonicus; TISSUE=Testis;
RX   MEDLINE=93181407; PubMed=1292011;
RX   DOI=10.1111/j.1600-0749.1992.tb00551.x;
RA   Yamamoto H., Kudo T., Masuko N., Miura H., Sato S., Tanaka M.,
RA   Tanaka S., Takeuchi S., Shibahara S., Takeuchi T.;
RT   "Phylogeny of regulatory regions of vertebrate tyrosinase genes.";
RL   Pigment Cell Res. 5:284-294(1992).
CC   -!- FUNCTION: This is a copper-containing oxidase that functions in
CC       the formation of pigments such as melanins and other polyphenolic
CC       compounds.
CC   -!- CATALYTIC ACTIVITY: L-tyrosine + L-dopa + O(2) = L-dopa +
CC       dopaquinone + H(2)O.
CC   -!- COFACTOR: Binds 2 copper ions per subunit.
CC   -!- SUBCELLULAR LOCATION: Melanosome membrane; Single-pass type I
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the tyrosinase family.
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DR   EMBL; S56789; AAB25511.1; -; Genomic_DNA.
DR   HOVERGEN; P55026; -.
DR   BRENDA; 1.14.18.1; 39406.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005507; F:copper ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004503; F:monophenol monooxygenase activity; IEA:EC.
DR   GO; GO:0006583; P:melanin biosynthetic process from tyrosine; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR008922; Di-copper_centre.
DR   InterPro; IPR002227; Tyrosinase.
DR   Gene3D; G3DSA:1.10.1280.10; Di-copper_centre; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; PARTIAL.
PE   3: Inferred from homology;
KW   Copper; Glycoprotein; Melanin biosynthesis; Membrane; Metal-binding;
KW   Monooxygenase; Oxidoreductase; Signal; Transmembrane.
FT   SIGNAL        1     18       Potential.
FT   CHAIN        19   >273       Tyrosinase.
FT                                /FTId=PRO_0000035885.
FT   METAL       180    180       Copper A (By similarity).
FT   METAL       202    202       Copper A (By similarity).
FT   METAL       211    211       Copper A (By similarity).
FT   CARBOHYD     86     86       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    169    169       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    230    230       N-linked (GlcNAc...) (Potential).
FT   NON_TER     273    273
SQ   SEQUENCE   273 AA;  31136 MW;  9365C76EDB26A625 CRC64;
     MCLLALGFLL GILQPASGQF PRACASSESL LRKECCPLWA GDGSPCGELS GRGSCQEILL
     SRAPLGPQFP FTGVDDREDW PAVFYNRTCQ CNSNFMGFNC GECRFGFSGP NCAERRMRMR
     RSIFQLSTRE KNKFLAYLNL AKHTPSQDYV IATGTYAQMN NGLTPMFRNI SVYDLFVWMH
     YYVSRDTLLG DASVWRDIDF AHEAPGFLPW HRLFLVLWEH EIQKITGDEN FTIPYWDWRD
     AEGCDVCTDE LMGDRHPTNP QLLSPASFFS SWQ
//