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P55026

- TYRO_PELSI

UniProt

P55026 - TYRO_PELSI

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Protein

Tyrosinase

Gene
TYR
Organism
Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
L-tyrosine + O2 = dopaquinone + H2O.

Cofactori

Binds 2 copper ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi180 – 1801Copper A By similarity
Metal bindingi202 – 2021Copper A By similarity
Metal bindingi211 – 2111Copper A By similarity

GO - Molecular functioni

  1. copper ion binding Source: Ensembl
  2. monophenol monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell proliferation Source: Ensembl
  2. melanin biosynthetic process Source: UniProtKB-KW
  3. pigmentation Source: Ensembl
  4. thymus development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Monophenol monooxygenase
Gene namesi
Name:TYR
OrganismiPelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
Taxonomic identifieri13735 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupTestudinesCryptodiraTrionychoideaTrionychidaePelodiscus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. melanosome membrane Source: UniProtKB-SubCell
  3. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – ›273›255TyrosinasePRO_0000035885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi169 – 1691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi230 – 2301N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP55026.

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.

Keywords - Domaini

Signal, Transmembrane

Phylogenomic databases

HOVERGENiHBG003553.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55026-1 [UniParc]FASTAAdd to Basket

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MCLLALGFLL GILQPASGQF PRACASSESL LRKECCPLWA GDGSPCGELS    50
GRGSCQEILL SRAPLGPQFP FTGVDDREDW PAVFYNRTCQ CNSNFMGFNC 100
GECRFGFSGP NCAERRMRMR RSIFQLSTRE KNKFLAYLNL AKHTPSQDYV 150
IATGTYAQMN NGLTPMFRNI SVYDLFVWMH YYVSRDTLLG DASVWRDIDF 200
AHEAPGFLPW HRLFLVLWEH EIQKITGDEN FTIPYWDWRD AEGCDVCTDE 250
LMGDRHPTNP QLLSPASFFS SWQ 273
Length:273
Mass (Da):31,136
Last modified:October 1, 1996 - v1
Checksum:i9365C76EDB26A625
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei273 – 2731

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S56789 Genomic DNA. Translation: AAB25511.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S56789 Genomic DNA. Translation: AAB25511.1 .

3D structure databases

ProteinModelPortali P55026.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG003553.

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
InterProi IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 1 hit.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Ssp. Japonicus.
    Tissue: Testis.

Entry informationi

Entry nameiTYRO_PELSI
AccessioniPrimary (citable) accession number: P55026
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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