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P55026 (TYRO_PELSI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosinase

EC=1.14.18.1
Alternative name(s):
Monophenol monooxygenase
Gene names
Name:TYR
OrganismPelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
Taxonomic identifier13735 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupTestudinesCryptodiraTrionychoideaTrionychidaePelodiscus

Protein attributes

Sequence length273 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

Catalytic activity

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.

L-tyrosine + O2 = dopaquinone + H2O.

Cofactor

Binds 2 copper ions per subunit.

Subcellular location

Melanosome membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the tyrosinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – ›273›255Tyrosinase
PRO_0000035885

Sites

Metal binding1801Copper A By similarity
Metal binding2021Copper A By similarity
Metal binding2111Copper A By similarity

Amino acid modifications

Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation2301N-linked (GlcNAc...) Potential

Experimental info

Non-terminal residue2731

Sequences

Sequence LengthMass (Da)Tools
P55026 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 9365C76EDB26A625

FASTA27331,136
        10         20         30         40         50         60 
MCLLALGFLL GILQPASGQF PRACASSESL LRKECCPLWA GDGSPCGELS GRGSCQEILL 

        70         80         90        100        110        120 
SRAPLGPQFP FTGVDDREDW PAVFYNRTCQ CNSNFMGFNC GECRFGFSGP NCAERRMRMR 

       130        140        150        160        170        180 
RSIFQLSTRE KNKFLAYLNL AKHTPSQDYV IATGTYAQMN NGLTPMFRNI SVYDLFVWMH 

       190        200        210        220        230        240 
YYVSRDTLLG DASVWRDIDF AHEAPGFLPW HRLFLVLWEH EIQKITGDEN FTIPYWDWRD 

       250        260        270 
AEGCDVCTDE LMGDRHPTNP QLLSPASFFS SWQ 

« Hide

References

[1]"Phylogeny of regulatory regions of vertebrate tyrosinase genes."
Yamamoto H., Kudo T., Masuko N., Miura H., Sato S., Tanaka M., Tanaka S., Takeuchi S., Shibahara S., Takeuchi T.
Pigment Cell Res. 5:284-294(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Ssp. Japonicus.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S56789 Genomic DNA. Translation: AAB25511.1.

3D structure databases

ProteinModelPortalP55026.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG003553.

Family and domain databases

Gene3D1.10.1280.10. 1 hit.
InterProIPR002227. Tyrosinase.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSPR00092. TYROSINASE.
SUPFAMSSF48056. SSF48056. 1 hit.
PROSITEPS00497. TYROSINASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRO_PELSI
AccessionPrimary (citable) accession number: P55026
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families