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P55025

- TYRO_ORYLA

UniProt

P55025 - TYRO_ORYLA

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Protein

Tyrosinase

Gene
tyr, tyro
Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
L-tyrosine + O2 = dopaquinone + H2O.

Cofactori

Binds 2 copper ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi182 – 1821Copper A By similarity
Metal bindingi205 – 2051Copper A By similarity
Metal bindingi214 – 2141Copper A By similarity
Metal bindingi366 – 3661Copper B By similarity
Metal bindingi370 – 3701Copper B By similarity
Metal bindingi393 – 3931Copper B By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. monophenol monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. melanin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Monophenol monooxygenase
Gene namesi
Name:tyr
Synonyms:tyro
OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
ProteomesiUP000001038: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 480461Lumenal, melanosome Reviewed predictionAdd
BLAST
Transmembranei481 – 50121Helical; Reviewed predictionAdd
BLAST
Topological domaini502 – 54039Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. melanosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 540521TyrosinasePRO_0000035883Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi233 – 2331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi374 – 3741N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP55025.

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG08919.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiP55025.
KOiK00505.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55025-1 [UniParc]FASTAAdd to Basket

« Hide

MKSLFLSAVL LQFFETCWSQ FPRPCANSEG LRTKECCPVW SGDGSPCGAL    50
SGRGFCADVS VSDEPNGPQY PHSGIDDRER WPLAFFNRTC RCAGNYGGFN 100
CGECRFGYWG SNCAEYRESV RRNIMSMSTT EQQKFISYLN LAKNTINPDY 150
VITTGTRAEM GENGESPMFS DINTYDLFVW IHYYVSRDTF LGGPGNVWRD 200
IDFAHESAAF LPWHRVYLLH WEQEIRKITG DFNFTIPYWD WRDAQSCEVC 250
TDNLMGGRNA LNPNLISPAS VFSSWKVICT QQEEYNNQEA LCNATAEGPL 300
LRNPGNHDPN RVPRIPTTAD VEFTISLPEY ETGSMDRFAN NSFRNVLEGF 350
ASPETGMAVQ GQSTMHNALH VFMNGSMSSV QGSANDPIFL LHHAFIDSIF 400
ERWLRTHQPP RSIYPRTNAP IGHNDGYYMV PFLPLYRNGD YLLSNKALGY 450
EYAYLLDPGQ RFVQEFLTPY LQQAQQIWQW LLGAGILGAL IATIVAAVIV 500
FARRKRRRNQ KRKRAPSFGE RQPLLQSSSE EGSSSYQTTL 540
Length:540
Mass (Da):61,254
Last modified:October 1, 1996 - v1
Checksum:i7ADEA02C3870CAE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D29687 mRNA. Translation: BAA06156.1.
D29686 mRNA. Translation: BAA06155.1.
AB010101 Genomic DNA. Translation: BAA31348.1.
RefSeqiNP_001098272.1. NM_001104802.1.
UniGeneiOla.86.

Genome annotation databases

GeneIDi100049427.
KEGGiola:100049427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D29687 mRNA. Translation: BAA06156.1 .
D29686 mRNA. Translation: BAA06155.1 .
AB010101 Genomic DNA. Translation: BAA31348.1 .
RefSeqi NP_001098272.1. NM_001104802.1.
UniGenei Ola.86.

3D structure databases

ProteinModelPortali P55025.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100049427.
KEGGi ola:100049427.

Organism-specific databases

CTDi 7299.

Phylogenomic databases

eggNOGi NOG08919.
HOGENOMi HOG000118376.
HOVERGENi HBG003553.
InParanoidi P55025.
KOi K00505.

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
InterProi IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 1 hit.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of the tyrosinase-encoding gene in a colorless melanophore mutant of the medaka fish, Oryzias latipes."
    Inagaki H., Bessho Y., Koga A., Hori H.
    Gene 150:319-324(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Eye.
  2. "The tyrosinase gene from medaka: transgenic expression rescued albino mutation."
    Inagaki H., Koga A., Bessho Y., Hori H.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiTYRO_ORYLA
AccessioniPrimary (citable) accession number: P55025
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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