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P55025

- TYRO_ORYLA

UniProt

P55025 - TYRO_ORYLA

Protein

Tyrosinase

Gene

tyr

Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

    Catalytic activityi

    2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
    L-tyrosine + O2 = dopaquinone + H2O.

    Cofactori

    Binds 2 copper ions per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi182 – 1821Copper ABy similarity
    Metal bindingi205 – 2051Copper ABy similarity
    Metal bindingi214 – 2141Copper ABy similarity
    Metal bindingi366 – 3661Copper BBy similarity
    Metal bindingi370 – 3701Copper BBy similarity
    Metal bindingi393 – 3931Copper BBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. monophenol monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. melanin biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Melanin biosynthesis

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosinase (EC:1.14.18.1)
    Alternative name(s):
    Monophenol monooxygenase
    Gene namesi
    Name:tyr
    Synonyms:tyro
    OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
    Taxonomic identifieri8090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
    ProteomesiUP000001038: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. melanosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 540521TyrosinasePRO_0000035883Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP55025.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 480461Lumenal, melanosomeSequence AnalysisAdd
    BLAST
    Topological domaini502 – 54039CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei481 – 50121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tyrosinase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG08919.
    HOGENOMiHOG000118376.
    HOVERGENiHBG003553.
    InParanoidiP55025.
    KOiK00505.

    Family and domain databases

    Gene3Di1.10.1280.10. 1 hit.
    InterProiIPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view]
    PfamiPF00264. Tyrosinase. 1 hit.
    [Graphical view]
    PRINTSiPR00092. TYROSINASE.
    SUPFAMiSSF48056. SSF48056. 1 hit.
    PROSITEiPS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55025-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSLFLSAVL LQFFETCWSQ FPRPCANSEG LRTKECCPVW SGDGSPCGAL    50
    SGRGFCADVS VSDEPNGPQY PHSGIDDRER WPLAFFNRTC RCAGNYGGFN 100
    CGECRFGYWG SNCAEYRESV RRNIMSMSTT EQQKFISYLN LAKNTINPDY 150
    VITTGTRAEM GENGESPMFS DINTYDLFVW IHYYVSRDTF LGGPGNVWRD 200
    IDFAHESAAF LPWHRVYLLH WEQEIRKITG DFNFTIPYWD WRDAQSCEVC 250
    TDNLMGGRNA LNPNLISPAS VFSSWKVICT QQEEYNNQEA LCNATAEGPL 300
    LRNPGNHDPN RVPRIPTTAD VEFTISLPEY ETGSMDRFAN NSFRNVLEGF 350
    ASPETGMAVQ GQSTMHNALH VFMNGSMSSV QGSANDPIFL LHHAFIDSIF 400
    ERWLRTHQPP RSIYPRTNAP IGHNDGYYMV PFLPLYRNGD YLLSNKALGY 450
    EYAYLLDPGQ RFVQEFLTPY LQQAQQIWQW LLGAGILGAL IATIVAAVIV 500
    FARRKRRRNQ KRKRAPSFGE RQPLLQSSSE EGSSSYQTTL 540
    Length:540
    Mass (Da):61,254
    Last modified:October 1, 1996 - v1
    Checksum:i7ADEA02C3870CAE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D29687 mRNA. Translation: BAA06156.1.
    D29686 mRNA. Translation: BAA06155.1.
    AB010101 Genomic DNA. Translation: BAA31348.1.
    RefSeqiNP_001098272.1. NM_001104802.1.
    UniGeneiOla.86.

    Genome annotation databases

    GeneIDi100049427.
    KEGGiola:100049427.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D29687 mRNA. Translation: BAA06156.1 .
    D29686 mRNA. Translation: BAA06155.1 .
    AB010101 Genomic DNA. Translation: BAA31348.1 .
    RefSeqi NP_001098272.1. NM_001104802.1.
    UniGenei Ola.86.

    3D structure databases

    ProteinModelPortali P55025.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100049427.
    KEGGi ola:100049427.

    Organism-specific databases

    CTDi 7299.

    Phylogenomic databases

    eggNOGi NOG08919.
    HOGENOMi HOG000118376.
    HOVERGENi HBG003553.
    InParanoidi P55025.
    KOi K00505.

    Family and domain databases

    Gene3Di 1.10.1280.10. 1 hit.
    InterProi IPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view ]
    Pfami PF00264. Tyrosinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00092. TYROSINASE.
    SUPFAMi SSF48056. SSF48056. 1 hit.
    PROSITEi PS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of the tyrosinase-encoding gene in a colorless melanophore mutant of the medaka fish, Oryzias latipes."
      Inagaki H., Bessho Y., Koga A., Hori H.
      Gene 150:319-324(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Eye.
    2. "The tyrosinase gene from medaka: transgenic expression rescued albino mutation."
      Inagaki H., Koga A., Bessho Y., Hori H.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiTYRO_ORYLA
    AccessioniPrimary (citable) accession number: P55025
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3