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Protein

Tyrosinase

Gene

tyr

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
L-tyrosine + O2 = dopaquinone + H2O.

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi182Copper ABy similarity1
Metal bindingi205Copper ABy similarity1
Metal bindingi214Copper ABy similarity1
Metal bindingi366Copper BBy similarity1
Metal bindingi370Copper BBy similarity1
Metal bindingi393Copper BBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processMelanin biosynthesis
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Monophenol monooxygenase
Gene namesi
Name:tyr
Synonyms:tyro
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
Proteomesi

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 480Lumenal, melanosomeSequence analysisAdd BLAST461
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Topological domaini502 – 540CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003588320 – 540TyrosinaseAdd BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP55025

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000013681

Structurei

3D structure databases

ProteinModelPortaliP55025
SMRiP55025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEZU Eukaryota
ENOG410Y42I LUCA
HOGENOMiHOG000118376
HOVERGENiHBG003553
InParanoidiP55025
KOiK00505

Family and domain databases

Gene3Di1.10.1280.10, 1 hit
InterProiView protein in InterPro
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PfamiView protein in Pfam
PF00264 Tyrosinase, 1 hit
PRINTSiPR00092 TYROSINASE
SUPFAMiSSF48056 SSF48056, 1 hit
PROSITEiView protein in PROSITE
PS00497 TYROSINASE_1, 1 hit
PS00498 TYROSINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLFLSAVL LQFFETCWSQ FPRPCANSEG LRTKECCPVW SGDGSPCGAL
60 70 80 90 100
SGRGFCADVS VSDEPNGPQY PHSGIDDRER WPLAFFNRTC RCAGNYGGFN
110 120 130 140 150
CGECRFGYWG SNCAEYRESV RRNIMSMSTT EQQKFISYLN LAKNTINPDY
160 170 180 190 200
VITTGTRAEM GENGESPMFS DINTYDLFVW IHYYVSRDTF LGGPGNVWRD
210 220 230 240 250
IDFAHESAAF LPWHRVYLLH WEQEIRKITG DFNFTIPYWD WRDAQSCEVC
260 270 280 290 300
TDNLMGGRNA LNPNLISPAS VFSSWKVICT QQEEYNNQEA LCNATAEGPL
310 320 330 340 350
LRNPGNHDPN RVPRIPTTAD VEFTISLPEY ETGSMDRFAN NSFRNVLEGF
360 370 380 390 400
ASPETGMAVQ GQSTMHNALH VFMNGSMSSV QGSANDPIFL LHHAFIDSIF
410 420 430 440 450
ERWLRTHQPP RSIYPRTNAP IGHNDGYYMV PFLPLYRNGD YLLSNKALGY
460 470 480 490 500
EYAYLLDPGQ RFVQEFLTPY LQQAQQIWQW LLGAGILGAL IATIVAAVIV
510 520 530 540
FARRKRRRNQ KRKRAPSFGE RQPLLQSSSE EGSSSYQTTL
Length:540
Mass (Da):61,254
Last modified:October 1, 1996 - v1
Checksum:i7ADEA02C3870CAE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29687 mRNA Translation: BAA06156.1
D29686 mRNA Translation: BAA06155.1
AB010101 Genomic DNA Translation: BAA31348.1
RefSeqiNP_001098272.1, NM_001104802.1
UniGeneiOla.86

Genome annotation databases

GeneIDi100049427
KEGGiola:100049427

Similar proteinsi

Entry informationi

Entry nameiTYRO_ORYLA
AccessioniPrimary (citable) accession number: P55025
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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