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Protein

Tyrosinase

Gene

TYR

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.By similarity

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.By similarity
L-tyrosine + O2 = dopaquinone + H2O.By similarity

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi180Copper ABy similarity1
Metal bindingi202Copper ABy similarity1
Metal bindingi211Copper ABy similarity1
Metal bindingi363Copper BBy similarity1
Metal bindingi367Copper BBy similarity1
Metal bindingi390Copper BBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Monophenol monooxygenase
Gene namesi
Name:TYR
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Melanosome membrane By similarity; Single-pass type I membrane protein By similarity
  • Melanosome By similarity

  • Note: Proper trafficking to melanosome is regulated by SGSM2, ANKRD27,RAB9A, RAB32 and RAB38.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 476Lumenal, melanosomeSequence analysisAdd BLAST458
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21
Topological domaini498 – 529CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003588119 – 529TyrosinaseAdd BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Glycosylationi230N-linked (GlcNAc...)Sequence analysis1
Glycosylationi290N-linked (GlcNAc...)Sequence analysis1
Glycosylationi337N-linked (GlcNAc...)Sequence analysis1
Glycosylationi356N-linked (GlcNAc...)Sequence analysis1
Glycosylationi371N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP55024.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027812.

Structurei

3D structure databases

ProteinModelPortaliP55024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEZU. Eukaryota.
ENOG410Y42I. LUCA.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiP55024.
KOiK00505.
OrthoDBiEOG091G03YR.
PhylomeDBiP55024.
TreeFamiTF315865.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLFAMGLLL VILQPSTGQF PRVCANTQSL LRKECCPPWD GDGTPCGERS
60 70 80 90 100
NRGTCQRILL SQAPLGPQFP FSGVDDREDW PSVFYNRTCR CRGNFMGFNC
110 120 130 140 150
GECKFGFSGQ NCTERRLRTR RNIFQLTISE KDKFLAYLNL AKNIPSKDYV
160 170 180 190 200
IATGTYAQMN NGSNPMFRNI NVYDLFVWMH YYASRDTLLG GSNVWRDIDF
210 220 230 240 250
AHEAPGFLPW HRAFLLLWER EIQKITGDEN FTIPYWDWRD AEDCVICTDE
260 270 280 290 300
YMGGQHPTNP NLLSPASFFS SWQVICTQSE EYNSQQALCN ATSEGPILRN
310 320 330 340 350
PGNNDKSRTP RLPSSSEVEF CLTLTQYESG SMDKMANYSF RNTLEGFADP
360 370 380 390 400
HTAISNISQS GLHNALHIYM NGSMSQVQGS ANDPIFILHH AFVDSIFERW
410 420 430 440 450
LRRHRPMLEV YPAANAPIGH NRENYMVPFI PLYRNGEFFI SSRELGYDYE
460 470 480 490 500
YLQEPALGSF QDFLIPYLKQ AHQIWPWLVG AAVIGGIITA VLSGLILACR
510 520
KKRKGTSPEI QPLLTESEDY NNVSYQSHF
Length:529
Mass (Da):60,357
Last modified:October 1, 1996 - v1
Checksum:i74B464A52C3EFBF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88349 mRNA. Translation: BAA13590.1.
L46805 Genomic DNA. Translation: AAB08441.1.
PIRiPC4153.
RefSeqiNP_989491.1. NM_204160.1.
UniGeneiGga.928.

Genome annotation databases

EnsembliENSGALT00000027865; ENSGALP00000027812; ENSGALG00000017237.
GeneIDi373971.
KEGGigga:373971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88349 mRNA. Translation: BAA13590.1.
L46805 Genomic DNA. Translation: AAB08441.1.
PIRiPC4153.
RefSeqiNP_989491.1. NM_204160.1.
UniGeneiGga.928.

3D structure databases

ProteinModelPortaliP55024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027812.

Proteomic databases

PaxDbiP55024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000027865; ENSGALP00000027812; ENSGALG00000017237.
GeneIDi373971.
KEGGigga:373971.

Organism-specific databases

CTDi7299.

Phylogenomic databases

eggNOGiENOG410IEZU. Eukaryota.
ENOG410Y42I. LUCA.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiP55024.
KOiK00505.
OrthoDBiEOG091G03YR.
PhylomeDBiP55024.
TreeFamiTF315865.

Miscellaneous databases

PROiP55024.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYRO_CHICK
AccessioniPrimary (citable) accession number: P55024
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.