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P55024 (TYRO_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosinase
EC=1.14.18.1
Alternative name(s):
Monophenol monooxygenase
Gene names
Name:TYR
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.

Catalytic activity

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.

L-tyrosine + O2 = dopaquinone + H2O.

Cofactor

Binds 2 copper ions per subunit.

Subcellular location

Melanosome membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the tyrosinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 529511Tyrosinase
PRO_0000035881

Regions

Topological domain19 – 476458Lumenal, melanosome Potential
Transmembrane477 – 49721Helical; Potential
Topological domain498 – 52932Cytoplasmic Potential

Sites

Metal binding1801Copper A By similarity
Metal binding2021Copper A By similarity
Metal binding2111Copper A By similarity
Metal binding3631Copper B By similarity
Metal binding3671Copper B By similarity
Metal binding3901Copper B By similarity

Amino acid modifications

Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation2301N-linked (GlcNAc...) Potential
Glycosylation2901N-linked (GlcNAc...) Potential
Glycosylation3371N-linked (GlcNAc...) Potential
Glycosylation3561N-linked (GlcNAc...) Potential
Glycosylation3711N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P55024 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 74B464A52C3EFBF5

FASTA52960,357
        10         20         30         40         50         60 
MFLFAMGLLL VILQPSTGQF PRVCANTQSL LRKECCPPWD GDGTPCGERS NRGTCQRILL 

        70         80         90        100        110        120 
SQAPLGPQFP FSGVDDREDW PSVFYNRTCR CRGNFMGFNC GECKFGFSGQ NCTERRLRTR 

       130        140        150        160        170        180 
RNIFQLTISE KDKFLAYLNL AKNIPSKDYV IATGTYAQMN NGSNPMFRNI NVYDLFVWMH 

       190        200        210        220        230        240 
YYASRDTLLG GSNVWRDIDF AHEAPGFLPW HRAFLLLWER EIQKITGDEN FTIPYWDWRD 

       250        260        270        280        290        300 
AEDCVICTDE YMGGQHPTNP NLLSPASFFS SWQVICTQSE EYNSQQALCN ATSEGPILRN 

       310        320        330        340        350        360 
PGNNDKSRTP RLPSSSEVEF CLTLTQYESG SMDKMANYSF RNTLEGFADP HTAISNISQS 

       370        380        390        400        410        420 
GLHNALHIYM NGSMSQVQGS ANDPIFILHH AFVDSIFERW LRRHRPMLEV YPAANAPIGH 

       430        440        450        460        470        480 
NRENYMVPFI PLYRNGEFFI SSRELGYDYE YLQEPALGSF QDFLIPYLKQ AHQIWPWLVG 

       490        500        510        520 
AAVIGGIITA VLSGLILACR KKRKGTSPEI QPLLTESEDY NNVSYQSHF

« Hide

References

[1]"Isolation and characterization of a chicken tyrosinase cDNA."
Mochii M., Iio A., Yamamoto H., Takeuchi T., Eguchi G.
Pigment Cell Res. 5:162-167(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: White leghorn.
[2]"Characteristic sequences in the promoter region of the chicken tyrosinase-encoding gene."
Ferguson C.A., Kidson S.H.
Gene 169:191-195(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-273.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D88349 mRNA. Translation: BAA13590.1.
L46805 Genomic DNA. Translation: AAB08441.1.
IPIIPI00584287.
PIRPC4153.
RefSeqNP_989491.1. NM_204160.1.
UniGeneGga.928.

3D structure databases

ProteinModelPortalP55024.
ModBaseSearch...

Proteomic databases

PaxDbP55024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000027865; ENSGALP00000027812; ENSGALG00000017237.
GeneID373971.
KEGGgga:373971.

Organism-specific databases

CTD7299.

Phylogenomic databases

eggNOGNOG08919.
GeneTreeENSGT00500000044790.
HOGENOMHOG000118376.
HOVERGENHBG003553.
InParanoidP55024.
KOK00505.
OMACLSLTQY.
OrthoDBEOG4D26PK.

Family and domain databases

Gene3D1.10.1280.10. 1 hit.
InterProIPR002227. Tyrosinase.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSPR00092. TYROSINASE.
SUPFAMSSF48056. Di-copper_centre. 1 hit.
PROSITEPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813500.

Entry information

Entry nameTYRO_CHICK
AccessionPrimary (citable) accession number: P55024
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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