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P55024

- TYRO_CHICK

UniProt

P55024 - TYRO_CHICK

Protein

Tyrosinase

Gene

TYR

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.

    Catalytic activityi

    2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
    L-tyrosine + O2 = dopaquinone + H2O.

    Cofactori

    Binds 2 copper ions per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi180 – 1801Copper ABy similarity
    Metal bindingi202 – 2021Copper ABy similarity
    Metal bindingi211 – 2111Copper ABy similarity
    Metal bindingi363 – 3631Copper BBy similarity
    Metal bindingi367 – 3671Copper BBy similarity
    Metal bindingi390 – 3901Copper BBy similarity

    GO - Molecular functioni

    1. copper ion binding Source: Ensembl
    2. monophenol monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell proliferation Source: Ensembl
    2. melanin biosynthetic process Source: UniProtKB-KW
    3. pigmentation Source: Ensembl
    4. thymus development Source: Ensembl

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Melanin biosynthesis

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosinase (EC:1.14.18.1)
    Alternative name(s):
    Monophenol monooxygenase
    Gene namesi
    Name:TYR
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. melanosome membrane Source: UniProtKB-SubCell
    3. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 529511TyrosinasePRO_0000035881Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP55024.

    Structurei

    3D structure databases

    ProteinModelPortaliP55024.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 476458Lumenal, melanosomeSequence AnalysisAdd
    BLAST
    Topological domaini498 – 52932CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei477 – 49721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tyrosinase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG08919.
    HOGENOMiHOG000118376.
    HOVERGENiHBG003553.
    InParanoidiP55024.
    KOiK00505.
    OMAiCLSLTQY.
    OrthoDBiEOG7TJ3HG.
    PhylomeDBiP55024.
    TreeFamiTF315865.

    Family and domain databases

    Gene3Di1.10.1280.10. 1 hit.
    InterProiIPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view]
    PfamiPF00264. Tyrosinase. 1 hit.
    [Graphical view]
    PRINTSiPR00092. TYROSINASE.
    SUPFAMiSSF48056. SSF48056. 1 hit.
    PROSITEiPS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55024-1 [UniParc]FASTAAdd to Basket

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    MFLFAMGLLL VILQPSTGQF PRVCANTQSL LRKECCPPWD GDGTPCGERS    50
    NRGTCQRILL SQAPLGPQFP FSGVDDREDW PSVFYNRTCR CRGNFMGFNC 100
    GECKFGFSGQ NCTERRLRTR RNIFQLTISE KDKFLAYLNL AKNIPSKDYV 150
    IATGTYAQMN NGSNPMFRNI NVYDLFVWMH YYASRDTLLG GSNVWRDIDF 200
    AHEAPGFLPW HRAFLLLWER EIQKITGDEN FTIPYWDWRD AEDCVICTDE 250
    YMGGQHPTNP NLLSPASFFS SWQVICTQSE EYNSQQALCN ATSEGPILRN 300
    PGNNDKSRTP RLPSSSEVEF CLTLTQYESG SMDKMANYSF RNTLEGFADP 350
    HTAISNISQS GLHNALHIYM NGSMSQVQGS ANDPIFILHH AFVDSIFERW 400
    LRRHRPMLEV YPAANAPIGH NRENYMVPFI PLYRNGEFFI SSRELGYDYE 450
    YLQEPALGSF QDFLIPYLKQ AHQIWPWLVG AAVIGGIITA VLSGLILACR 500
    KKRKGTSPEI QPLLTESEDY NNVSYQSHF 529
    Length:529
    Mass (Da):60,357
    Last modified:October 1, 1996 - v1
    Checksum:i74B464A52C3EFBF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88349 mRNA. Translation: BAA13590.1.
    L46805 Genomic DNA. Translation: AAB08441.1.
    PIRiPC4153.
    RefSeqiNP_989491.1. NM_204160.1.
    UniGeneiGga.928.

    Genome annotation databases

    GeneIDi373971.
    KEGGigga:373971.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88349 mRNA. Translation: BAA13590.1 .
    L46805 Genomic DNA. Translation: AAB08441.1 .
    PIRi PC4153.
    RefSeqi NP_989491.1. NM_204160.1.
    UniGenei Gga.928.

    3D structure databases

    ProteinModelPortali P55024.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P55024.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 373971.
    KEGGi gga:373971.

    Organism-specific databases

    CTDi 7299.

    Phylogenomic databases

    eggNOGi NOG08919.
    HOGENOMi HOG000118376.
    HOVERGENi HBG003553.
    InParanoidi P55024.
    KOi K00505.
    OMAi CLSLTQY.
    OrthoDBi EOG7TJ3HG.
    PhylomeDBi P55024.
    TreeFami TF315865.

    Miscellaneous databases

    NextBioi 20813500.
    PROi P55024.

    Family and domain databases

    Gene3Di 1.10.1280.10. 1 hit.
    InterProi IPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view ]
    Pfami PF00264. Tyrosinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00092. TYROSINASE.
    SUPFAMi SSF48056. SSF48056. 1 hit.
    PROSITEi PS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a chicken tyrosinase cDNA."
      Mochii M., Iio A., Yamamoto H., Takeuchi T., Eguchi G.
      Pigment Cell Res. 5:162-167(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: White leghorn.
    2. "Characteristic sequences in the promoter region of the chicken tyrosinase-encoding gene."
      Ferguson C.A., Kidson S.H.
      Gene 169:191-195(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-273.

    Entry informationi

    Entry nameiTYRO_CHICK
    AccessioniPrimary (citable) accession number: P55024
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3