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P55023

- TYRO_STRLN

UniProt

P55023 - TYRO_STRLN

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Protein

Tyrosinase

Gene

melC2

Organism
Streptomyces lincolnensis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
L-tyrosine + O2 = dopaquinone + H2O.

Cofactori

Binds 2 copper ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371Copper ABy similarity
Metal bindingi53 – 531Copper ABy similarity
Metal bindingi62 – 621Copper ABy similarity
Metal bindingi189 – 1891Copper BBy similarity
Metal bindingi193 – 1931Copper BBy similarity
Metal bindingi215 – 2151Copper BBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. monophenol monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. melanin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Monophenol monooxygenase
Gene namesi
Name:melC2
Synonyms:mel
OrganismiStreptomyces lincolnensis
Taxonomic identifieri1915 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 273272TyrosinasePRO_0000186739Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP55023.
SMRiP55023. Positions 2-271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55023-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVRKNQATL TADEKRRFVT AVLSSSAARY DTFVTTHNEF IVADTDNGER
60 70 80 90 100
TGHRSPSFLP WHRRFLLEFE RALQSVDASV ALPYWDWSTD RSARSSLWAP
110 120 130 140 150
DFLGGTGRSR NGRVTDGPFR AATGVWPITV RLDGRTYLRR ALGGAGRELP
160 170 180 190 200
TRAEVDSVLS IPTYDMAPWN SASDGFRNHL EGWRGVNLHN RVHVWVGGQM
210 220 230 240 250
ATGVSPNDPV FWLHHAYIDK LWAQWQRRHR TPAYVPAAGT PDVVDLDETM
260 270
KPWHDSSPAD LLDHTGHYTF DTD
Length:273
Mass (Da):30,854
Last modified:January 23, 2007 - v2
Checksum:iE9D8616C99DD4DB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95703 Genomic DNA. Translation: CAA65000.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95703 Genomic DNA. Translation: CAA65000.1 .

3D structure databases

ProteinModelPortali P55023.
SMRi P55023. Positions 2-271.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
InterProi IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 1 hit.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Zhang H.Z., Piepersberg W.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 78-11.

Entry informationi

Entry nameiTYRO_STRLN
AccessioniPrimary (citable) accession number: P55023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3