ID   TYRO_STRGB              Reviewed;         276 AA.
AC   P55022;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   20-JAN-2009, entry version 40.
DE   RecName: Full=Tyrosinase;
DE            EC=1.14.18.1;
DE   AltName: Full=Monophenol monooxygenase;
GN   Name=melC2; Synonyms=mel;
OS   Streptomyces galbus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=33898;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 14077 / CBS 700.72 / DSM 40480 / IFO 13399;
RA   Wehmeier U.F., Brass N., Roessler C., Piepersberg W.;
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This is a copper-containing oxidase that functions in
CC       the formation of pigments such as melanins and other polyphenolic
CC       compounds.
CC   -!- CATALYTIC ACTIVITY: L-tyrosine + L-dopa + O(2) = L-dopa +
CC       dopaquinone + H(2)O.
CC   -!- COFACTOR: Binds 2 copper ions per subunit (By similarity).
CC   -!- SIMILARITY: Belongs to the tyrosinase family.
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DR   EMBL; X95705; CAA65005.1; -; Genomic_DNA.
DR   HSSP; O61363; 1JS8.
DR   BRENDA; 1.14.18.1; 66978.
DR   GO; GO:0005507; F:copper ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004503; F:monophenol monooxygenase activity; IEA:EC.
DR   GO; GO:0006583; P:melanin biosynthetic process from tyrosine; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR008922; Di-copper_centre.
DR   InterPro; IPR002227; Tyrosinase.
DR   Gene3D; G3DSA:1.10.1280.10; Di-copper_centre; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; FALSE_NEG.
PE   3: Inferred from homology;
KW   Copper; Melanin biosynthesis; Metal-binding; Monooxygenase;
KW   Oxidoreductase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    276       Tyrosinase.
FT                                /FTId=PRO_0000186736.
FT   METAL        38     38       Copper A (By similarity).
FT   METAL        56     56       Copper A (By similarity).
FT   METAL        66     66       Copper A (By similarity).
FT   METAL       193    193       Copper B (By similarity).
FT   METAL       197    197       Copper B (By similarity).
FT   METAL       219    219       Copper B (By similarity).
SQ   SEQUENCE   276 AA;  31310 MW;  CE0D48B0D3AA5144 CRC64;
     MTVRKNQAAL TADEKRRFVA AVLELKRNGR YDEFVRTHNE FIMSDTRTGR RGGPGHRLPL
     PFLPWHRRFL LDFEQALQSV DSSVALPYWD WSTDRTVRAS LWAPDFLGGT GRSSDGRVMD
     GPFAASTGNW PVNVRVDGRT FLRRSLGTGV RELPTRAEVD SVLSMATYDM APYNSASDGF
     RNHLEGWRGV NLHNRVHVWV GGQMATGVSP NDPVFWLHHA YNRQLWAEWQ RRHPGAGYVP
     TGGTPDVVDL NDTMKPWNDV RPADLLTHTA HYTFDV
//