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P55022

- TYRO_STRGB

UniProt

P55022 - TYRO_STRGB

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Protein
Tyrosinase
Gene
melC2, mel
Organism
Streptomyces galbus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
L-tyrosine + O2 = dopaquinone + H2O.

Cofactori

Binds 2 copper ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Copper A By similarity
Metal bindingi56 – 561Copper A By similarity
Metal bindingi66 – 661Copper A By similarity
Metal bindingi193 – 1931Copper B By similarity
Metal bindingi197 – 1971Copper B By similarity
Metal bindingi219 – 2191Copper B By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. monophenol monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. melanin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Monophenol monooxygenase
Gene namesi
Name:melC2
Synonyms:mel
OrganismiStreptomyces galbus
Taxonomic identifieri33898 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 276275Tyrosinase
PRO_0000186736Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP55022.

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55022-1 [UniParc]FASTAAdd to Basket

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MTVRKNQAAL TADEKRRFVA AVLELKRNGR YDEFVRTHNE FIMSDTRTGR    50
RGGPGHRLPL PFLPWHRRFL LDFEQALQSV DSSVALPYWD WSTDRTVRAS 100
LWAPDFLGGT GRSSDGRVMD GPFAASTGNW PVNVRVDGRT FLRRSLGTGV 150
RELPTRAEVD SVLSMATYDM APYNSASDGF RNHLEGWRGV NLHNRVHVWV 200
GGQMATGVSP NDPVFWLHHA YNRQLWAEWQ RRHPGAGYVP TGGTPDVVDL 250
NDTMKPWNDV RPADLLTHTA HYTFDV 276
Length:276
Mass (Da):31,310
Last modified:January 23, 2007 - v2
Checksum:iCE0D48B0D3AA5144
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95705 Genomic DNA. Translation: CAA65005.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95705 Genomic DNA. Translation: CAA65005.1 .

3D structure databases

ProteinModelPortali P55022.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
InterProi IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 1 hit.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Wehmeier U.F., Brass N., Roessler C., Piepersberg W.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 14077 / CBS 700.72 / DSM 40480 / NBRC 13399 / VKM Ac-160.

Entry informationi

Entry nameiTYRO_STRGB
AccessioniPrimary (citable) accession number: P55022
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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