P55022 (TYRO_STRGB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosinase
EC=1.14.18.1

Alternative name(s):
Monophenol monooxygenase

Gene names

Name:	melC2
Synonyms:	mel

Organism

Streptomyces galbus

Taxonomic identifier

33898 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
Catalytic activity	2 L-dopa + O2 = 2 dopaquinone + 2 H2O. L-tyrosine + O2 = dopaquinone + H2O.
Cofactor	Binds 2 copper ions per subunit By similarity.
Sequence similarities	Belongs to the tyrosinase family.

Ontologies

Keywords
Biological process	Melanin biosynthesis
Ligand	Copper Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological_process	melanin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW monophenol monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 276	275	Tyrosinase		PRO_0000186736
Sites
	Metal binding	38	1	Copper A By similarity
	Metal binding	56	1	Copper A By similarity
	Metal binding	66	1	Copper A By similarity
	Metal binding	193	1	Copper B By similarity
	Metal binding	197	1	Copper B By similarity
	Metal binding	219	1	Copper B By similarity

Sequences

	Sequence		Length	Mass (Da)
	P55022 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: CE0D48B0D3AA5144	FASTA	276	31,310
	10 20 30 40 50 60 MTVRKNQAAL TADEKRRFVA AVLELKRNGR YDEFVRTHNE FIMSDTRTGR RGGPGHRLPL 70 80 90 100 110 120 PFLPWHRRFL LDFEQALQSV DSSVALPYWD WSTDRTVRAS LWAPDFLGGT GRSSDGRVMD 130 140 150 160 170 180 GPFAASTGNW PVNVRVDGRT FLRRSLGTGV RELPTRAEVD SVLSMATYDM APYNSASDGF 190 200 210 220 230 240 RNHLEGWRGV NLHNRVHVWV GGQMATGVSP NDPVFWLHHA YNRQLWAEWQ RRHPGAGYVP 250 260 270 TGGTPDVVDL NDTMKPWNDV RPADLLTHTA HYTFDV

References

[1]	Wehmeier U.F., Brass N., Roessler C., Piepersberg W. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 14077 / CBS 700.72 / DSM 40480 / NBRC 13399 / VKM Ac-160.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X95705 Genomic DNA. Translation: CAA65005.1.
3D structure databases
ProteinModelPortal	P55022.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.1280.10. 1 hit.
InterPro	IPR002227. Tyrosinase. IPR008922. Unchr_di-copper_centre. [Graphical view]
Pfam	PF00264. Tyrosinase. 1 hit. [Graphical view]
PRINTS	PR00092. TYROSINASE.
SUPFAM	SSF48056. Di-copper_centre. 1 hit.
PROSITE	PS00497. TYROSINASE_1. 1 hit. PS00498. TYROSINASE_2. False negative. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1924.

Entry information

Entry name

TYRO_STRGB

Accession

Primary (citable) accession number: P55022

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	March 6, 2013
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program