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P55022 (TYRO_STRGB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosinase

EC=1.14.18.1
Alternative name(s):
Monophenol monooxygenase
Gene names
Name:melC2
Synonyms:mel
OrganismStreptomyces galbus
Taxonomic identifier33898 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

Catalytic activity

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.

L-tyrosine + O2 = dopaquinone + H2O.

Cofactor

Binds 2 copper ions per subunit By similarity.

Sequence similarities

Belongs to the tyrosinase family.

Ontologies

Keywords
   Biological processMelanin biosynthesis
   LigandCopper
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Biological_processmelanin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

monophenol monooxygenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 276275Tyrosinase
PRO_0000186736

Sites

Metal binding381Copper A By similarity
Metal binding561Copper A By similarity
Metal binding661Copper A By similarity
Metal binding1931Copper B By similarity
Metal binding1971Copper B By similarity
Metal binding2191Copper B By similarity

Sequences

Sequence LengthMass (Da)Tools
P55022 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: CE0D48B0D3AA5144

FASTA27631,310
        10         20         30         40         50         60 
MTVRKNQAAL TADEKRRFVA AVLELKRNGR YDEFVRTHNE FIMSDTRTGR RGGPGHRLPL 

        70         80         90        100        110        120 
PFLPWHRRFL LDFEQALQSV DSSVALPYWD WSTDRTVRAS LWAPDFLGGT GRSSDGRVMD 

       130        140        150        160        170        180 
GPFAASTGNW PVNVRVDGRT FLRRSLGTGV RELPTRAEVD SVLSMATYDM APYNSASDGF 

       190        200        210        220        230        240 
RNHLEGWRGV NLHNRVHVWV GGQMATGVSP NDPVFWLHHA YNRQLWAEWQ RRHPGAGYVP 

       250        260        270 
TGGTPDVVDL NDTMKPWNDV RPADLLTHTA HYTFDV 

« Hide

References

[1]Wehmeier U.F., Brass N., Roessler C., Piepersberg W.
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 14077 / CBS 700.72 / DSM 40480 / NBRC 13399 / VKM Ac-160.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X95705 Genomic DNA. Translation: CAA65005.1.

3D structure databases

ProteinModelPortalP55022.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1280.10. 1 hit.
InterProIPR002227. Tyrosinase.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSPR00092. TYROSINASE.
SUPFAMSSF48056. SSF48056. 1 hit.
PROSITEPS00497. TYROSINASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRO_STRGB
AccessionPrimary (citable) accession number: P55022
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families