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P55008

- AIF1_HUMAN

UniProt

P55008 - AIF1_HUMAN

Protein

Allograft inflammatory factor 1

Gene

AIF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi58 – 69121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi94 – 105122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. actin filament binding Source: UniProtKB
    2. calcium ion binding Source: UniProtKB

    GO - Biological processi

    1. actin filament bundle assembly Source: UniProtKB
    2. actin filament polymerization Source: UniProtKB
    3. cellular response to interferon-gamma Source: UniProtKB
    4. inflammatory response Source: UniProtKB
    5. microglial cell activation Source: UniProtKB
    6. negative regulation of smooth muscle cell chemotaxis Source: UniProtKB
    7. negative regulation of smooth muscle cell proliferation Source: UniProtKB
    8. phagocytosis, engulfment Source: UniProtKB
    9. positive regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
    10. positive regulation of monocyte chemotaxis Source: UniProtKB
    11. positive regulation of smooth muscle cell chemotaxis Source: UniProtKB
    12. positive regulation of smooth muscle cell proliferation Source: UniProtKB
    13. positive regulation of T cell migration Source: UniProtKB
    14. positive regulation of T cell proliferation Source: UniProtKB
    15. Rac protein signal transduction Source: UniProtKB
    16. ruffle assembly Source: UniProtKB

    Keywords - Ligandi

    Actin-binding, Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Allograft inflammatory factor 1
    Short name:
    AIF-1
    Alternative name(s):
    Ionized calcium-binding adapter molecule 1
    Protein G1
    Gene namesi
    Name:AIF1
    Synonyms:G1, IBA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:352. AIF1.

    Subcellular locationi

    Cytoplasmcytoskeleton. Cell projectionruffle membrane; Peripheral membrane protein; Cytoplasmic side
    Note: Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.

    GO - Cellular componenti

    1. actin filament Source: Ensembl
    2. cytoplasm Source: UniProtKB
    3. cytosol Source: UniProtKB
    4. lamellipodium Source: UniProtKB
    5. nucleus Source: UniProtKB
    6. perinuclear region of cytoplasm Source: UniProtKB
    7. phagocytic cup Source: UniProtKB
    8. ruffle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24646.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 147146Allograft inflammatory factor 1PRO_0000073865Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei11 – 111N6-acetyllysine1 Publication

    Post-translational modificationi

    Phosphorylated on serine residues.

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP55008.
    PaxDbiP55008.
    PRIDEiP55008.

    PTM databases

    PhosphoSiteiP55008.

    Expressioni

    Tissue specificityi

    Detected in T-lymphocytes and peripheral blood mononuclear cells.1 Publication

    Gene expression databases

    ArrayExpressiP55008.
    BgeeiP55008.
    CleanExiHS_AIF1.
    GenevestigatoriP55008.

    Organism-specific databases

    HPAiHPA049234.

    Interactioni

    Subunit structurei

    Homodimer Potential. Monomer. Interacts with LCP1.2 PublicationsCurated

    Protein-protein interaction databases

    BioGridi106702. 1 interaction.
    IntActiP55008. 2 interactions.
    STRINGi9606.ENSP00000393996.

    Structurei

    Secondary structure

    1
    147
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi10 – 134
    Helixi20 – 3213
    Helixi35 – 373
    Helixi43 – 5412
    Helixi67 – 7610
    Helixi83 – 9311
    Beta strandi95 – 1017
    Helixi103 – 1108
    Beta strandi111 – 1144
    Helixi117 – 1226

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2D58X-ray1.90A17-123[»]
    2G2BNMR-A2-147[»]
    ProteinModelPortaliP55008.
    SMRiP55008. Positions 2-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP55008.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 8036EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini81 – 11535EF-hand 2; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG262998.
    HOGENOMiHOG000231928.
    HOVERGENiHBG004002.
    InParanoidiP55008.
    OrthoDBiEOG73FQPC.
    PhylomeDBiP55008.
    TreeFamiTF320736.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P55008-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQTRDLQGG KAFGLLKAQQ EERLDEINKQ FLDDPKYSSD EDLPSKLEGF    50
    KEKYMEFDLN GNGDIDIMSL KRMLEKLGVP KTHLELKKLI GEVSSGSGET 100
    FSYPDFLRMM LGKRSAILKM ILMYEEKARE KEKPTGPPAK KAISELP 147
    Length:147
    Mass (Da):16,703
    Last modified:October 1, 1996 - v1
    Checksum:i0104CCF092074E8F
    GO
    Isoform 2 (identifier: P55008-2) [UniParc]FASTAAdd to Basket

    Also known as: G1

    The sequence of this isoform differs from the canonical sequence as follows:
         2-54: Missing.

    Show »
    Length:94
    Mass (Da):10,587
    Checksum:iEA6C6C4A7F62EE60
    GO
    Isoform 3 (identifier: P55008-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-65: SQTRDLQGGK...EFDLNGNGDI → MEFDLNGNGD...PSPHPHPLPP
         121-147: Missing.

    Show »
    Length:133
    Mass (Da):14,748
    Checksum:iFC69ACB7F55BC067
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331D → H in AAA92457. (PubMed:8081366)Curated
    Sequence conflicti131 – 14717KEKPT…ISELP → RKTNTPPSQESPI in AAA92457. (PubMed:8081366)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti14 – 141G → R.2 Publications
    Corresponds to variant rs2736182 [ dbSNP | Ensembl ].
    VAR_048665

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 6564SQTRD…GNGDI → MEFDLNGNGDIGEKRVICGG RVVCRPKKTEVSPTCSIPHD LGGGPPTTVGGRRMGMRKWE RRERVSPPSPHPHPLPP in isoform 3. 2 PublicationsVSP_043837Add
    BLAST
    Alternative sequencei2 – 5453Missing in isoform 2. 3 PublicationsVSP_043838Add
    BLAST
    Alternative sequencei121 – 14727Missing in isoform 3. 2 PublicationsVSP_043839Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49392 mRNA. Translation: AAA92457.1.
    U95213 mRNA. Translation: AAC24422.1.
    U19713 mRNA. Translation: AAB05003.1.
    Y14768 Genomic DNA. Translation: CAA75060.1.
    Y14768 Genomic DNA. Translation: CAA75061.1.
    Y14768 Genomic DNA. Translation: CAA75062.1.
    D86438 mRNA. Translation: BAA13088.1.
    AF299327 mRNA. Translation: AAG39110.1.
    EF070982 mRNA. Translation: ABK35646.1.
    AK290771 mRNA. Translation: BAF83460.1.
    CR542153 mRNA. Translation: CAG46950.1.
    AF129756 Genomic DNA. Translation: AAD18087.1.
    BA000025 Genomic DNA. Translation: BAB63392.1.
    AL662847 Genomic DNA. Translation: CAI17694.1.
    AL805934 Genomic DNA. Translation: CAI18495.1.
    AL662801 Genomic DNA. Translation: CAI18308.1.
    AL805934 Genomic DNA. Translation: CAO03652.1.
    CR753892 Genomic DNA. Translation: CAQ06958.1.
    CR759761 Genomic DNA. Translation: CAQ10844.1.
    BX248305 Genomic DNA. Translation: CAM26281.1.
    CH471081 Genomic DNA. Translation: EAX03442.1.
    CH471081 Genomic DNA. Translation: EAX03446.1.
    BC009474 mRNA. Translation: AAH09474.1.
    CCDSiCCDS4706.1. [P55008-1]
    PIRiJC5246.
    RefSeqiNP_001614.3. NM_001623.3. [P55008-1]
    NP_004838.1. NM_004847.3.
    NP_116573.1. NM_032955.1.
    UniGeneiHs.76364.

    Genome annotation databases

    EnsembliENST00000376059; ENSP00000365227; ENSG00000204472. [P55008-1]
    ENST00000383474; ENSP00000372966; ENSG00000206428. [P55008-1]
    ENST00000413349; ENSP00000416061; ENSG00000235985. [P55008-1]
    ENST00000414149; ENSP00000391720; ENSG00000237727. [P55008-1]
    ENST00000425748; ENSP00000398013; ENSG00000234836. [P55008-1]
    ENST00000440907; ENSP00000397842; ENSG00000235588. [P55008-1]
    GeneIDi199.
    KEGGihsa:199.
    UCSCiuc003nuy.3. human. [P55008-1]
    uc010jsy.3. human. [P55008-3]

    Polymorphism databases

    DMDMi1703217.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49392 mRNA. Translation: AAA92457.1 .
    U95213 mRNA. Translation: AAC24422.1 .
    U19713 mRNA. Translation: AAB05003.1 .
    Y14768 Genomic DNA. Translation: CAA75060.1 .
    Y14768 Genomic DNA. Translation: CAA75061.1 .
    Y14768 Genomic DNA. Translation: CAA75062.1 .
    D86438 mRNA. Translation: BAA13088.1 .
    AF299327 mRNA. Translation: AAG39110.1 .
    EF070982 mRNA. Translation: ABK35646.1 .
    AK290771 mRNA. Translation: BAF83460.1 .
    CR542153 mRNA. Translation: CAG46950.1 .
    AF129756 Genomic DNA. Translation: AAD18087.1 .
    BA000025 Genomic DNA. Translation: BAB63392.1 .
    AL662847 Genomic DNA. Translation: CAI17694.1 .
    AL805934 Genomic DNA. Translation: CAI18495.1 .
    AL662801 Genomic DNA. Translation: CAI18308.1 .
    AL805934 Genomic DNA. Translation: CAO03652.1 .
    CR753892 Genomic DNA. Translation: CAQ06958.1 .
    CR759761 Genomic DNA. Translation: CAQ10844.1 .
    BX248305 Genomic DNA. Translation: CAM26281.1 .
    CH471081 Genomic DNA. Translation: EAX03442.1 .
    CH471081 Genomic DNA. Translation: EAX03446.1 .
    BC009474 mRNA. Translation: AAH09474.1 .
    CCDSi CCDS4706.1. [P55008-1 ]
    PIRi JC5246.
    RefSeqi NP_001614.3. NM_001623.3. [P55008-1 ]
    NP_004838.1. NM_004847.3.
    NP_116573.1. NM_032955.1.
    UniGenei Hs.76364.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2D58 X-ray 1.90 A 17-123 [» ]
    2G2B NMR - A 2-147 [» ]
    ProteinModelPortali P55008.
    SMRi P55008. Positions 2-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106702. 1 interaction.
    IntActi P55008. 2 interactions.
    STRINGi 9606.ENSP00000393996.

    PTM databases

    PhosphoSitei P55008.

    Polymorphism databases

    DMDMi 1703217.

    Proteomic databases

    MaxQBi P55008.
    PaxDbi P55008.
    PRIDEi P55008.

    Protocols and materials databases

    DNASUi 199.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376059 ; ENSP00000365227 ; ENSG00000204472 . [P55008-1 ]
    ENST00000383474 ; ENSP00000372966 ; ENSG00000206428 . [P55008-1 ]
    ENST00000413349 ; ENSP00000416061 ; ENSG00000235985 . [P55008-1 ]
    ENST00000414149 ; ENSP00000391720 ; ENSG00000237727 . [P55008-1 ]
    ENST00000425748 ; ENSP00000398013 ; ENSG00000234836 . [P55008-1 ]
    ENST00000440907 ; ENSP00000397842 ; ENSG00000235588 . [P55008-1 ]
    GeneIDi 199.
    KEGGi hsa:199.
    UCSCi uc003nuy.3. human. [P55008-1 ]
    uc010jsy.3. human. [P55008-3 ]

    Organism-specific databases

    CTDi 199.
    GeneCardsi GC06P031582.
    GC06Pj31570.
    GC06Pk31565.
    GC06Pm31659.
    GC06Pn31573.
    GC06Po31572.
    HGNCi HGNC:352. AIF1.
    HPAi HPA049234.
    MIMi 601833. gene.
    neXtProti NX_P55008.
    PharmGKBi PA24646.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262998.
    HOGENOMi HOG000231928.
    HOVERGENi HBG004002.
    InParanoidi P55008.
    OrthoDBi EOG73FQPC.
    PhylomeDBi P55008.
    TreeFami TF320736.

    Miscellaneous databases

    ChiTaRSi AIF1. human.
    EvolutionaryTracei P55008.
    GeneWikii AIF1.
    GenomeRNAii 199.
    NextBioi 796.
    PROi P55008.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55008.
    Bgeei P55008.
    CleanExi HS_AIF1.
    Genevestigatori P55008.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins."
      Albertella M.R., Campbell D.R.
      Hum. Mol. Genet. 3:793-799(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3).
    2. "Cloning and genomic characterization of LST1: a new gene in the human TNF region."
      Holzinger I., de Baey A., Messer G., Kick G., Zwierzina H., Weiss E.H.
      Immunogenetics 42:315-322(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
    3. "cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries."
      Autieri M.V.
      Biochem. Biophys. Res. Commun. 228:29-37(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
      Tissue: Lymphocyte.
    4. "Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts."
      Utans U., Quist W.C., McManus B.M., Wilson J.E., Arceci R.J., Wallace A.F., Russell M.E.
      Transplantation 61:1387-1392(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing."
      de Baey A., Fellerhoff B., Maier S., Martinozzi S., Weidle U., Weiss E.H.
      Genomics 45:591-600(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3), ALTERNATIVE SPLICING.
    6. "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."
      Neville M.J., Campbell R.D.
      J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
    7. "Novel calcium binding protein, Iba1 (ionized calcium binding adapter molecule 1), which is phosphorylated on serine."
      Imai Y., Ohsawa K., Kohsaka S.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    8. "Upregulation of Allograft inflammatory factor (AIF) is induced by Ab-stimulation in vitro and in human Alzheimer's disease brain."
      Deininger M.H., Trautmann K.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Glial tumor.
    9. Del Galdo F., Artlett C., Jimenez S.A.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    10. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-14.
    11. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    12. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-14.
    13. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    14. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    15. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    16. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Prostate.
    17. "AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF."
      Chen X., Kelemen S.E., Autieri M.V.
      Arterioscler. Thromb. Vasc. Biol. 24:1217-1222(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    18. "Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies."
      Kelemen S.E., Autieri M.V.
      Am. J. Pathol. 167:619-626(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ACTIN, TISSUE SPECIFICITY.
    19. Cited for: FUNCTION, SUBUNIT.
    20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding."
      Yamada M., Ohsawa K., Imai Y., Kohsaka S., Kamitori S.
      J. Mol. Biol. 364:449-457(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 17-123 OF APOPROTEIN.
    22. "NMR structure of the human allograft inflammatory factor 1."
      Center for eukaryotic structural genomics (CESG)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 2-147.

    Entry informationi

    Entry nameiAIF1_HUMAN
    AccessioniPrimary (citable) accession number: P55008
    Secondary accession number(s): A8K406
    , O43904, Q9UIV4, Q9UKS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3