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P55008 (AIF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Allograft inflammatory factor 1

Short name=AIF-1
Alternative name(s):
Ionized calcium-binding adapter molecule 1
Protein G1
Gene names
Name:AIF1
Synonyms:G1, IBA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length147 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. Ref.17 Ref.18 Ref.19

Subunit structure

Homodimer Potential. Monomer. Interacts with LCP1. Ref.18 Ref.19

Subcellular location

Cytoplasmcytoskeleton. Cell projectionruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note: Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.

Tissue specificity

Detected in T-lymphocytes and peripheral blood mononuclear cells. Ref.18

Post-translational modification

Phosphorylated on serine residues.

Sequence similarities

Contains 2 EF-hand domains.

Ontologies

Keywords
   Cellular componentCell membrane
Cell projection
Cytoplasm
Cytoskeleton
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   LigandActin-binding
Calcium
Metal-binding
   PTMAcetylation
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRac protein signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

actin filament bundle assembly

Inferred from direct assay Ref.19. Source: UniProtKB

actin filament polymerization

Inferred from direct assay Ref.18. Source: UniProtKB

cellular response to interferon-gamma

Inferred from expression pattern PubMed 9614071. Source: UniProtKB

inflammatory response

Inferred from sequence or structural similarity. Source: UniProtKB

microglial cell activation

Non-traceable author statement Ref.21. Source: UniProtKB

negative regulation of smooth muscle cell chemotaxis

Inferred from direct assay PubMed 22116621. Source: UniProtKB

negative regulation of smooth muscle cell proliferation

Inferred from direct assay PubMed 22116621PubMed 9614071. Source: UniProtKB

phagocytosis, engulfment

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of G1/S transition of mitotic cell cycle

Inferred from direct assay PubMed 11557666Ref.17. Source: UniProtKB

positive regulation of T cell migration

Inferred from direct assay Ref.18. Source: UniProtKB

positive regulation of T cell proliferation

Inferred from direct assay Ref.18. Source: UniProtKB

positive regulation of monocyte chemotaxis

Inferred from direct assay Ref.17. Source: UniProtKB

positive regulation of smooth muscle cell chemotaxis

Inferred from direct assay PubMed 22116621. Source: UniProtKB

positive regulation of smooth muscle cell proliferation

Inferred from direct assay Ref.17PubMed 22116621. Source: UniProtKB

ruffle assembly

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentactin filament

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

cytosol

Inferred from direct assay PubMed 22116621. Source: UniProtKB

lamellipodium

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from direct assay PubMed 22116621. Source: UniProtKB

perinuclear region of cytoplasm

Inferred from direct assay PubMed 9614071. Source: UniProtKB

phagocytic cup

Inferred from sequence or structural similarity. Source: UniProtKB

ruffle membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionactin filament binding

Inferred from direct assay Ref.18Ref.19. Source: UniProtKB

calcium ion binding

Inferred from sequence or structural similarity Ref.21. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P55008-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P55008-2)

Also known as: G1;

The sequence of this isoform differs from the canonical sequence as follows:
     2-54: Missing.
Isoform 3 (identifier: P55008-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2-65: SQTRDLQGGK...EFDLNGNGDI → MEFDLNGNGD...PSPHPHPLPP
     121-147: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 147146Allograft inflammatory factor 1
PRO_0000073865

Regions

Domain45 – 8036EF-hand 1
Domain81 – 11535EF-hand 2; degenerate
Calcium binding58 – 69121 Potential
Calcium binding94 – 105122 By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue111N6-acetyllysine Ref.20

Natural variations

Alternative sequence2 – 6564SQTRD…GNGDI → MEFDLNGNGDIGEKRVICGG RVVCRPKKTEVSPTCSIPHD LGGGPPTTVGGRRMGMRKWE RRERVSPPSPHPHPLPP in isoform 3.
VSP_043837
Alternative sequence2 – 5453Missing in isoform 2.
VSP_043838
Alternative sequence121 – 14727Missing in isoform 3.
VSP_043839
Natural variant141G → R. Ref.10 Ref.12
Corresponds to variant rs2736182 [ dbSNP | Ensembl ].
VAR_048665

Experimental info

Sequence conflict331D → H in AAA92457. Ref.1
Sequence conflict131 – 14717KEKPT…ISELP → RKTNTPPSQESPI in AAA92457. Ref.1

Secondary structure

.................... 147
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 0104CCF092074E8F

FASTA14716,703
        10         20         30         40         50         60 
MSQTRDLQGG KAFGLLKAQQ EERLDEINKQ FLDDPKYSSD EDLPSKLEGF KEKYMEFDLN 

        70         80         90        100        110        120 
GNGDIDIMSL KRMLEKLGVP KTHLELKKLI GEVSSGSGET FSYPDFLRMM LGKRSAILKM 

       130        140 
ILMYEEKARE KEKPTGPPAK KAISELP 

« Hide

Isoform 2 (G1) [UniParc].

Checksum: EA6C6C4A7F62EE60
Show »

FASTA9410,587
Isoform 3 [UniParc].

Checksum: FC69ACB7F55BC067
Show »

FASTA13314,748

References

« Hide 'large scale' references
[1]"Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins."
Albertella M.R., Campbell D.R.
Hum. Mol. Genet. 3:793-799(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3).
[2]"Cloning and genomic characterization of LST1: a new gene in the human TNF region."
Holzinger I., de Baey A., Messer G., Kick G., Zwierzina H., Weiss E.H.
Immunogenetics 42:315-322(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
[3]"cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries."
Autieri M.V.
Biochem. Biophys. Res. Commun. 228:29-37(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
Tissue: Lymphocyte.
[4]"Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts."
Utans U., Quist W.C., McManus B.M., Wilson J.E., Arceci R.J., Wallace A.F., Russell M.E.
Transplantation 61:1387-1392(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing."
de Baey A., Fellerhoff B., Maier S., Martinozzi S., Weidle U., Weiss E.H.
Genomics 45:591-600(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3), ALTERNATIVE SPLICING.
[6]"A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."
Neville M.J., Campbell R.D.
J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
[7]"Novel calcium binding protein, Iba1 (ionized calcium binding adapter molecule 1), which is phosphorylated on serine."
Imai Y., Ohsawa K., Kohsaka S.
Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[8]"Upregulation of Allograft inflammatory factor (AIF) is induced by Ab-stimulation in vitro and in human Alzheimer's disease brain."
Deininger M.H., Trautmann K.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Glial tumor.
[9]Del Galdo F., Artlett C., Jimenez S.A.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[10]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-14.
[11]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[12]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-14.
[13]"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S., Tamiya G., Oka A., Inoko H.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[14]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[15]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[16]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Prostate.
[17]"AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF."
Chen X., Kelemen S.E., Autieri M.V.
Arterioscler. Thromb. Vasc. Biol. 24:1217-1222(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[18]"Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies."
Kelemen S.E., Autieri M.V.
Am. J. Pathol. 167:619-626(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ACTIN, TISSUE SPECIFICITY.
[19]"Structural and functional characterization of human Iba proteins."
Schulze J.O., Quedenau C., Roske Y., Adam T., Schueler H., Behlke J., Turnbull A.P., Sievert V., Scheich C., Mueller U., Heinemann U., Buessow K.
FEBS J. 275:4627-4640(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[20]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[21]"X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding."
Yamada M., Ohsawa K., Imai Y., Kohsaka S., Kamitori S.
J. Mol. Biol. 364:449-457(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 17-123 OF APOPROTEIN.
[22]"NMR structure of the human allograft inflammatory factor 1."
Center for eukaryotic structural genomics (CESG)
Submitted (FEB-2009) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 2-147.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U49392 mRNA. Translation: AAA92457.1.
U95213 mRNA. Translation: AAC24422.1.
U19713 mRNA. Translation: AAB05003.1.
Y14768 Genomic DNA. Translation: CAA75060.1.
Y14768 Genomic DNA. Translation: CAA75061.1.
Y14768 Genomic DNA. Translation: CAA75062.1.
D86438 mRNA. Translation: BAA13088.1.
AF299327 mRNA. Translation: AAG39110.1.
EF070982 mRNA. Translation: ABK35646.1.
AK290771 mRNA. Translation: BAF83460.1.
CR542153 mRNA. Translation: CAG46950.1.
AF129756 Genomic DNA. Translation: AAD18087.1.
BA000025 Genomic DNA. Translation: BAB63392.1.
AL662847 Genomic DNA. Translation: CAI17694.1.
AL805934 Genomic DNA. Translation: CAI18495.1.
AL662801 Genomic DNA. Translation: CAI18308.1.
AL805934 Genomic DNA. Translation: CAO03652.1.
CR753892 Genomic DNA. Translation: CAQ06958.1.
CR759761 Genomic DNA. Translation: CAQ10844.1.
BX248305 Genomic DNA. Translation: CAM26281.1.
CH471081 Genomic DNA. Translation: EAX03442.1.
CH471081 Genomic DNA. Translation: EAX03446.1.
BC009474 mRNA. Translation: AAH09474.1.
CCDSCCDS34398.1. [P55008-2]
CCDS4706.1. [P55008-1]
PIRJC5246.
RefSeqNP_001614.3. NM_001623.3. [P55008-1]
NP_004838.1. NM_004847.3.
NP_116573.1. NM_032955.1.
UniGeneHs.76364.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2D58X-ray1.90A17-123[»]
2G2BNMR-A2-147[»]
ProteinModelPortalP55008.
SMRP55008. Positions 2-147.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106702. 1 interaction.
IntActP55008. 1 interaction.
STRING9606.ENSP00000393996.

PTM databases

PhosphoSiteP55008.

Polymorphism databases

DMDM1703217.

Proteomic databases

MaxQBP55008.
PaxDbP55008.
PRIDEP55008.

Protocols and materials databases

DNASU199.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376049; ENSP00000365217; ENSG00000204472. [P55008-2]
ENST00000376059; ENSP00000365227; ENSG00000204472. [P55008-1]
ENST00000383473; ENSP00000372965; ENSG00000206428. [P55008-2]
ENST00000383474; ENSP00000372966; ENSG00000206428. [P55008-1]
ENST00000413349; ENSP00000416061; ENSG00000235985. [P55008-1]
ENST00000414149; ENSP00000391720; ENSG00000237727. [P55008-1]
ENST00000415830; ENSP00000413709; ENSG00000235985. [P55008-2]
ENST00000416422; ENSP00000399901; ENSG00000234836. [P55008-2]
ENST00000419376; ENSP00000401433; ENSG00000237727. [P55008-2]
ENST00000424944; ENSP00000399621; ENSG00000235588. [P55008-2]
ENST00000425748; ENSP00000398013; ENSG00000234836. [P55008-1]
ENST00000440907; ENSP00000397842; ENSG00000235588. [P55008-1]
ENST00000549432; ENSP00000447578; ENSG00000235588. [P55008-2]
GeneID199.
KEGGhsa:199.
UCSCuc003nuy.3. human. [P55008-1]
uc010jsy.3. human. [P55008-3]

Organism-specific databases

CTD199.
GeneCardsGC06P031582.
GC06Pj31570.
GC06Pk31565.
GC06Pm31659.
GC06Pn31573.
GC06Po31572.
HGNCHGNC:352. AIF1.
HPAHPA049234.
MIM601833. gene.
neXtProtNX_P55008.
PharmGKBPA24646.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG262998.
HOGENOMHOG000231928.
HOVERGENHBG004002.
InParanoidP55008.
OrthoDBEOG73FQPC.
PhylomeDBP55008.
TreeFamTF320736.

Gene expression databases

ArrayExpressP55008.
BgeeP55008.
CleanExHS_AIF1.
GenevestigatorP55008.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PROSITEPS50222. EF_HAND_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAIF1. human.
EvolutionaryTraceP55008.
GeneWikiAIF1.
GenomeRNAi199.
NextBio796.
PROP55008.
SOURCESearch...

Entry information

Entry nameAIF1_HUMAN
AccessionPrimary (citable) accession number: P55008
Secondary accession number(s): A8K406 expand/collapse secondary AC list , O43904, Q9UIV4, Q9UKS9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM