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Protein

Retinol dehydrogenase 7

Gene

Rdh7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts on retinol bound on cellular retinol-binding protein (CRBP).

Catalytic activityi

All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164SubstrateBy similarity1
Active sitei176Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 57NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 7 (EC:1.1.1.105)
Alternative name(s):
Retinol dehydrogenase 3Imported
Retinol dehydrogenase type III
Short name:
RODH III
Gene namesi
Name:Rdh7Imported
Synonyms:Rdh3Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631370. Rdh7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547621 – 317Retinol dehydrogenase 7Add BLAST317

Proteomic databases

PaxDbiP55006.
PRIDEiP55006.

PTM databases

iPTMnetiP55006.
PhosphoSitePlusiP55006.

Interactioni

Protein-protein interaction databases

IntActiP55006. 1 interactor.
STRINGi10116.ENSRNOP00000005875.

Structurei

3D structure databases

ProteinModelPortaliP55006.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
HOVERGENiHBG005482.
KOiK11154.
PhylomeDBiP55006.
TreeFamiTF325617.

Family and domain databases

InterProiView protein in InterPro
IPR036291. NAD(P)-bd_dom_sf.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

P55006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLYLLALVG LWNLLRLFRE RKVVSHLQDK YVFITGCDSG FGNLLARQLD
60 70 80 90 100
RRGMRVLAAC LTEKGAEQLR SKTSDRLETV ILDVTKTESI VAATQWVKER
110 120 130 140 150
VGNRGLWGLV NNAGISVPMG PNEWMRKKDF ASVLDVNLLG VIEVTLNMLP
160 170 180 190 200
LVRKARGRVV NIASTMGRMS LLGGGYCISK YGVEAFSDSL RRELTYFGVK
210 220 230 240 250
VAIIEPGGFK TNVTNMERLS DNLKKLWDQA TEEVKEIYGE KFRDSYMKAM
260 270 280 290 300
ESLVNMCSGD LSLVTDCMEH ALTSCHPRTR YSAGWDAKFF YLPMSYLPTF
310
LSDAVIYWGS VKPARAL
Length:317
Mass (Da):35,737
Last modified:October 1, 1996 - v1
Checksum:i8193672B8576897A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119M → V in AAB07997 (PubMed:7876135).Curated1
Sequence conflicti172L → V in AAB07997 (PubMed:7876135).Curated1
Sequence conflicti230A → T in AAB07997 (PubMed:7876135).Curated1
Sequence conflicti243R → Q in AAB07997 (PubMed:7876135).Curated1
Sequence conflicti256M → T in AAB07997 (PubMed:7876135).Curated1
Sequence conflicti283A → P in AAB07997 (PubMed:7876135).Curated1
Sequence conflicti307Y → H in AAB07997 (PubMed:7876135).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18762 mRNA. Translation: AAB07997.1.
U33501 mRNA. Translation: AAB07995.1.
BC088090 mRNA. Translation: AAH88090.1.
BC098650 mRNA. Translation: AAH98650.1.
PIRiA55884.
RefSeqiNP_598227.3. NM_133543.3.
UniGeneiRn.31786.

Genome annotation databases

GeneIDi360420.
KEGGirno:360420.
UCSCiRGD:631370. rat.

Similar proteinsi

Entry informationi

Entry nameiRDH7_RAT
AccessioniPrimary (citable) accession number: P55006
Secondary accession number(s): P50169, Q4KMB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families