Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Retinol dehydrogenase 7

Gene

Rdh7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts on retinol bound on cellular retinol-binding protein (CRBP).

Catalytic activityi

All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164SubstrateBy similarity1
Active sitei176Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 57NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 7 (EC:1.1.1.105)
Alternative name(s):
Retinol dehydrogenase type III
Short name:
RODH III
Gene namesi
Name:Rdh7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631370. Rdh7.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547621 – 317Retinol dehydrogenase 7Add BLAST317

Proteomic databases

PaxDbiP55006.
PRIDEiP55006.

PTM databases

iPTMnetiP55006.
PhosphoSitePlusiP55006.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005875.

Structurei

3D structure databases

ProteinModelPortaliP55006.
SMRiP55006.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
HOVERGENiHBG005482.
KOiK11154.
PhylomeDBiP55006.
TreeFamiTF325617.

Family and domain databases

InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

P55006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLYLLALVG LWNLLRLFRE RKVVSHLQDK YVFITGCDSG FGNLLARQLD
60 70 80 90 100
RRGMRVLAAC LTEKGAEQLR SKTSDRLETV ILDVTKTESI VAATQWVKER
110 120 130 140 150
VGNRGLWGLV NNAGISVPMG PNEWMRKKDF ASVLDVNLLG VIEVTLNMLP
160 170 180 190 200
LVRKARGRVV NIASTMGRMS LLGGGYCISK YGVEAFSDSL RRELTYFGVK
210 220 230 240 250
VAIIEPGGFK TNVTNMERLS DNLKKLWDQA TEEVKEIYGE KFRDSYMKAM
260 270 280 290 300
ESLVNMCSGD LSLVTDCMEH ALTSCHPRTR YSAGWDAKFF YLPMSYLPTF
310
LSDAVIYWGS VKPARAL
Length:317
Mass (Da):35,737
Last modified:October 1, 1996 - v1
Checksum:i8193672B8576897A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33501 mRNA. Translation: AAB07995.1.
BC088090 mRNA. Translation: AAH88090.1.
BC098650 mRNA. Translation: AAH98650.1.
RefSeqiNP_598227.3. NM_133543.3.
UniGeneiRn.31786.

Genome annotation databases

GeneIDi360420.
KEGGirno:360420.
UCSCiRGD:631370. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33501 mRNA. Translation: AAB07995.1.
BC088090 mRNA. Translation: AAH88090.1.
BC098650 mRNA. Translation: AAH98650.1.
RefSeqiNP_598227.3. NM_133543.3.
UniGeneiRn.31786.

3D structure databases

ProteinModelPortaliP55006.
SMRiP55006.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005875.

PTM databases

iPTMnetiP55006.
PhosphoSitePlusiP55006.

Proteomic databases

PaxDbiP55006.
PRIDEiP55006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi360420.
KEGGirno:360420.
UCSCiRGD:631370. rat.

Organism-specific databases

CTDi54150.
RGDi631370. Rdh7.

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
HOVERGENiHBG005482.
KOiK11154.
PhylomeDBiP55006.
TreeFamiTF325617.

Enzyme and pathway databases

UniPathwayiUPA00912.

Family and domain databases

InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRDH7_RAT
AccessioniPrimary (citable) accession number: P55006
Secondary accession number(s): Q4KMB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 10, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.