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Protein

Retinol dehydrogenase 7

Gene

Rdh7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts on retinol bound on cellular retinol-binding protein (CRBP).

Catalytic activityi

All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei164 – 1641SubstrateBy similarity
Active sitei176 – 1761Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 5725NADPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 7 (EC:1.1.1.105)
Alternative name(s):
Retinol dehydrogenase type III
Short name:
RODH III
Gene namesi
Name:Rdh7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631370. Rdh7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Retinol dehydrogenase 7PRO_0000054762Add
BLAST

Proteomic databases

PaxDbiP55006.
PRIDEiP55006.

PTM databases

iPTMnetiP55006.
PhosphoSiteiP55006.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005875.

Structurei

3D structure databases

ProteinModelPortaliP55006.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
HOVERGENiHBG005482.
KOiK11154.
OrthoDBiEOG7FXZZX.
PhylomeDBiP55006.
TreeFamiTF325617.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLYLLALVG LWNLLRLFRE RKVVSHLQDK YVFITGCDSG FGNLLARQLD
60 70 80 90 100
RRGMRVLAAC LTEKGAEQLR SKTSDRLETV ILDVTKTESI VAATQWVKER
110 120 130 140 150
VGNRGLWGLV NNAGISVPMG PNEWMRKKDF ASVLDVNLLG VIEVTLNMLP
160 170 180 190 200
LVRKARGRVV NIASTMGRMS LLGGGYCISK YGVEAFSDSL RRELTYFGVK
210 220 230 240 250
VAIIEPGGFK TNVTNMERLS DNLKKLWDQA TEEVKEIYGE KFRDSYMKAM
260 270 280 290 300
ESLVNMCSGD LSLVTDCMEH ALTSCHPRTR YSAGWDAKFF YLPMSYLPTF
310
LSDAVIYWGS VKPARAL
Length:317
Mass (Da):35,737
Last modified:October 1, 1996 - v1
Checksum:i8193672B8576897A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33501 mRNA. Translation: AAB07995.1.
BC088090 mRNA. Translation: AAH88090.1.
BC098650 mRNA. Translation: AAH98650.1.
RefSeqiNP_598227.3. NM_133543.3.
UniGeneiRn.31786.

Genome annotation databases

GeneIDi360420.
KEGGirno:360420.
UCSCiRGD:631370. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33501 mRNA. Translation: AAB07995.1.
BC088090 mRNA. Translation: AAH88090.1.
BC098650 mRNA. Translation: AAH98650.1.
RefSeqiNP_598227.3. NM_133543.3.
UniGeneiRn.31786.

3D structure databases

ProteinModelPortaliP55006.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005875.

PTM databases

iPTMnetiP55006.
PhosphoSiteiP55006.

Proteomic databases

PaxDbiP55006.
PRIDEiP55006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi360420.
KEGGirno:360420.
UCSCiRGD:631370. rat.

Organism-specific databases

CTDi54150.
RGDi631370. Rdh7.

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
HOVERGENiHBG005482.
KOiK11154.
OrthoDBiEOG7FXZZX.
PhylomeDBiP55006.
TreeFamiTF325617.

Enzyme and pathway databases

UniPathwayiUPA00912.

Miscellaneous databases

NextBioi672807.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a rat cDNA encoding retinol dehydrogenase isozyme type III."
    Chai X., Zhai Y., Napoli J.L.
    Gene 169:219-222(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver and Spleen.

Entry informationi

Entry nameiRDH7_RAT
AccessioniPrimary (citable) accession number: P55006
Secondary accession number(s): Q4KMB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 13, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.