P55002 (MFAP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Microfibrillar-associated protein 2
Short name=MFAP-2

Alternative name(s):
Microfibril-associated glycoprotein 1
Short name=MAGP
Short name=MAGP-1

Gene names

Name:	Mfap2
Synonyms:	Magp, Magp1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the elastin-associated microfibrils.
Subunit structure	Forms a ternary complex with BGN and ELN By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Post-translational modification	Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils. May form transglutaminase cross-links. O-glycosylated By similarity.
Sequence similarities	Belongs to the MFAP family. Contains 1 SXC (ShKT) domain.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Signal
PTM	Disulfide bond Glycoprotein Pyrrolidone carboxylic acid Sulfation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	platelet formation Inferred from mutant phenotype PubMed 18281502. Source: MGI
Cellular_component	microfibril Inferred from electronic annotation. Source: InterPro
Molecular_function	fibrinogen binding Inferred from direct assay PubMed 18281502. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Or 18 Potential
	Chain	17 – 183	167	Microfibrillar-associated protein 2		PRO_0000018683
Regions
	Domain	153 – 183	31	SXC
	Compositional bias	58 – 70	13	Gln/Glu-rich
Amino acid modifications
	Modified residue	17	1	Pyrrolidone carboxylic acid By similarity
	Modified residue	46	1	Sulfotyrosine Probable
	Modified residue	47	1	Sulfotyrosine Probable
	Modified residue	49	1	Sulfotyrosine Probable
	Disulfide bond	153 ↔ 183		By similarity
	Disulfide bond	160 ↔ 176		By similarity
	Disulfide bond	169 ↔ 180		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P55002 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 1F193F2BE2EF1D05	FASTA	183	20,578
	10 20 30 40 50 60 MRAACLFLLF MPGLLAQGQY DLDPLPPFPD HVQYNHYGDQ IDNADYYDYQ EVSPRTPEEQ 70 80 90 100 110 120 FQSQQQVQQE VIPAPTPEPA AAGDLETEPT EPGPLDCREE QYPCTRLYSI HKPCKQCLNE 130 140 150 160 170 180 VCFYSLRRVY VVNKEICVRT VCAHEELLRA DLCRDKFSKC GVMAVSGLCQ SVAASCARSC GGC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure, chromosomal localization, and expression pattern of the murine Magp gene." Chen Y., Faraco J., Yin W., Germiller J., Francke U., Bonadio J. J. Biol. Chem. 268:27381-27389(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L23769 mRNA. Translation: AAA16448.1. BC035490 mRNA. Translation: AAH35490.1.
IPI	IPI00875534.
PIR	A49313.
UniGene	Mm.7386.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P55002.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:99559. Mfap2.
Phylogenomic databases
eggNOG	NOG42345.
HOGENOM	HOG000231186.
HOVERGEN	HBG060871.
InParanoid	P55002.
OrthoDB	EOG4NGGNX.
Gene expression databases
ArrayExpress	P55002.
Bgee	P55002.
CleanEx	MM_MFAP2.
Genevestigator	P55002.
GermOnline	ENSMUSG00000060572. Mus musculus.
Family and domain databases
InterPro	IPR008673. MAGP. [Graphical view]
PANTHER	PTHR16485. PTHR16485. 1 hit.
Pfam	PF05507. MAGP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MFAP2. mouse.
SOURCE	Search...

Entry information

Entry name

MFAP2_MOUSE

Accession

Primary (citable) accession number: P55002

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program