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P55002

- MFAP2_MOUSE

UniProt

P55002 - MFAP2_MOUSE

Protein

Microfibrillar-associated protein 2

Gene

Mfap2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Component of the elastin-associated microfibrils.

    GO - Molecular functioni

    1. fibrinogen binding Source: MGI
    2. fibronectin binding Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. platelet formation Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_198996. Elastic fibre formation.
    REACT_198998. Molecules associated with elastic fibres.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microfibrillar-associated protein 2
    Short name:
    MFAP-2
    Alternative name(s):
    Microfibril-associated glycoprotein 1
    Short name:
    MAGP
    Short name:
    MAGP-1
    Gene namesi
    Name:Mfap2
    Synonyms:Magp, Magp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:99559. Mfap2.

    Subcellular locationi

    GO - Cellular componenti

    1. microfibril Source: InterPro

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Or 18Sequence AnalysisAdd
    BLAST
    Chaini17 – 183167Microfibrillar-associated protein 2PRO_0000018683Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei17 – 171Pyrrolidone carboxylic acidBy similarity
    Modified residuei46 – 461SulfotyrosineCurated
    Modified residuei47 – 471SulfotyrosineCurated
    Modified residuei49 – 491SulfotyrosineCurated
    Disulfide bondi153 ↔ 183PROSITE-ProRule annotation
    Disulfide bondi160 ↔ 176PROSITE-ProRule annotation
    Disulfide bondi169 ↔ 180PROSITE-ProRule annotation

    Post-translational modificationi

    Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils. May form transglutaminase cross-links.
    O-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid, Sulfation

    Proteomic databases

    PRIDEiP55002.

    Expressioni

    Gene expression databases

    ArrayExpressiP55002.
    BgeeiP55002.
    CleanExiMM_MFAP2.
    GenevestigatoriP55002.

    Interactioni

    Subunit structurei

    Forms a ternary complex with BGN and ELN.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini153 – 18331ShKTPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi58 – 7013Gln/Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MFAP family.Curated
    Contains 1 ShKT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42345.
    HOGENOMiHOG000231186.
    HOVERGENiHBG060871.
    InParanoidiP55002.

    Family and domain databases

    InterProiIPR008673. MAGP.
    IPR003582. ShKT_dom.
    [Graphical view]
    PANTHERiPTHR16485. PTHR16485. 1 hit.
    PfamiPF05507. MAGP. 1 hit.
    [Graphical view]
    PROSITEiPS51670. SHKT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55002-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAACLFLLF MPGLLAQGQY DLDPLPPFPD HVQYNHYGDQ IDNADYYDYQ    50
    EVSPRTPEEQ FQSQQQVQQE VIPAPTPEPA AAGDLETEPT EPGPLDCREE 100
    QYPCTRLYSI HKPCKQCLNE VCFYSLRRVY VVNKEICVRT VCAHEELLRA 150
    DLCRDKFSKC GVMAVSGLCQ SVAASCARSC GGC 183
    Length:183
    Mass (Da):20,578
    Last modified:October 1, 1996 - v1
    Checksum:i1F193F2BE2EF1D05
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23769 mRNA. Translation: AAA16448.1.
    BC035490 mRNA. Translation: AAH35490.1.
    PIRiA49313.
    UniGeneiMm.7386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23769 mRNA. Translation: AAA16448.1 .
    BC035490 mRNA. Translation: AAH35490.1 .
    PIRi A49313.
    UniGenei Mm.7386.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P55002.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:99559. Mfap2.

    Phylogenomic databases

    eggNOGi NOG42345.
    HOGENOMi HOG000231186.
    HOVERGENi HBG060871.
    InParanoidi P55002.

    Enzyme and pathway databases

    Reactomei REACT_198996. Elastic fibre formation.
    REACT_198998. Molecules associated with elastic fibres.

    Miscellaneous databases

    ChiTaRSi MFAP2. mouse.
    PROi P55002.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55002.
    Bgeei P55002.
    CleanExi MM_MFAP2.
    Genevestigatori P55002.

    Family and domain databases

    InterProi IPR008673. MAGP.
    IPR003582. ShKT_dom.
    [Graphical view ]
    PANTHERi PTHR16485. PTHR16485. 1 hit.
    Pfami PF05507. MAGP. 1 hit.
    [Graphical view ]
    PROSITEi PS51670. SHKT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, chromosomal localization, and expression pattern of the murine Magp gene."
      Chen Y., Faraco J., Yin W., Germiller J., Francke U., Bonadio J.
      J. Biol. Chem. 268:27381-27389(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiMFAP2_MOUSE
    AccessioniPrimary (citable) accession number: P55002
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3