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P55002 (MFAP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Microfibrillar-associated protein 2

Short name=MFAP-2
Alternative name(s):
Microfibril-associated glycoprotein 1
Short name=MAGP
Short name=MAGP-1
Gene names
Name:Mfap2
Synonyms:Magp, Magp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the elastin-associated microfibrils.

Subunit structure

Forms a ternary complex with BGN and ELN By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Post-translational modification

Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils. May form transglutaminase cross-links.

O-glycosylated By similarity.

Sequence similarities

Belongs to the MFAP family.

Contains 1 ShKT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616Or 18 Potential
Chain17 – 183167Microfibrillar-associated protein 2
PRO_0000018683

Regions

Domain153 – 18331ShKT
Compositional bias58 – 7013Gln/Glu-rich

Amino acid modifications

Modified residue171Pyrrolidone carboxylic acid By similarity
Modified residue461Sulfotyrosine Probable
Modified residue471Sulfotyrosine Probable
Modified residue491Sulfotyrosine Probable
Disulfide bond153 ↔ 183 By similarity
Disulfide bond160 ↔ 176 By similarity
Disulfide bond169 ↔ 180 By similarity

Sequences

Sequence LengthMass (Da)Tools
P55002 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 1F193F2BE2EF1D05

FASTA18320,578
        10         20         30         40         50         60 
MRAACLFLLF MPGLLAQGQY DLDPLPPFPD HVQYNHYGDQ IDNADYYDYQ EVSPRTPEEQ 

        70         80         90        100        110        120 
FQSQQQVQQE VIPAPTPEPA AAGDLETEPT EPGPLDCREE QYPCTRLYSI HKPCKQCLNE 

       130        140        150        160        170        180 
VCFYSLRRVY VVNKEICVRT VCAHEELLRA DLCRDKFSKC GVMAVSGLCQ SVAASCARSC 


GGC 

« Hide

References

« Hide 'large scale' references
[1]"Structure, chromosomal localization, and expression pattern of the murine Magp gene."
Chen Y., Faraco J., Yin W., Germiller J., Francke U., Bonadio J.
J. Biol. Chem. 268:27381-27389(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L23769 mRNA. Translation: AAA16448.1.
BC035490 mRNA. Translation: AAH35490.1.
PIRA49313.
UniGeneMm.7386.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP55002.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:99559. Mfap2.

Phylogenomic databases

eggNOGNOG42345.
HOGENOMHOG000231186.
HOVERGENHBG060871.
InParanoidP55002.

Gene expression databases

ArrayExpressP55002.
BgeeP55002.
CleanExMM_MFAP2.
GenevestigatorP55002.

Family and domain databases

InterProIPR008673. MAGP.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERPTHR16485. PTHR16485. 1 hit.
PfamPF05507. MAGP. 1 hit.
[Graphical view]
PROSITEPS51670. SHKT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMFAP2. mouse.
PROP55002.
SOURCESearch...

Entry information

Entry nameMFAP2_MOUSE
AccessionPrimary (citable) accession number: P55002
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot