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P55002

- MFAP2_MOUSE

UniProt

P55002 - MFAP2_MOUSE

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Protein

Microfibrillar-associated protein 2

Gene
Mfap2, Magp, Magp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the elastin-associated microfibrils.

GO - Molecular functioni

  1. fibrinogen binding Source: MGI
  2. fibronectin binding Source: MGI
  3. protein binding Source: MGI

GO - Biological processi

  1. platelet formation Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198996. Elastic fibre formation.
REACT_198998. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibrillar-associated protein 2
Short name:
MFAP-2
Alternative name(s):
Microfibril-associated glycoprotein 1
Short name:
MAGP
Short name:
MAGP-1
Gene namesi
Name:Mfap2
Synonyms:Magp, Magp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:99559. Mfap2.

Subcellular locationi

GO - Cellular componenti

  1. microfibril Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Or 18 Reviewed predictionAdd
BLAST
Chaini17 – 183167Microfibrillar-associated protein 2PRO_0000018683Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171Pyrrolidone carboxylic acid By similarity
Modified residuei46 – 461Sulfotyrosine Inferred
Modified residuei47 – 471Sulfotyrosine Inferred
Modified residuei49 – 491Sulfotyrosine Inferred
Disulfide bondi153 ↔ 183 By similarity
Disulfide bondi160 ↔ 176 By similarity
Disulfide bondi169 ↔ 180 By similarity

Post-translational modificationi

Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils. May form transglutaminase cross-links.
O-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PRIDEiP55002.

Expressioni

Gene expression databases

ArrayExpressiP55002.
BgeeiP55002.
CleanExiMM_MFAP2.
GenevestigatoriP55002.

Interactioni

Subunit structurei

Forms a ternary complex with BGN and ELN By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini153 – 18331ShKTAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 7013Gln/Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the MFAP family.
Contains 1 ShKT domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42345.
HOGENOMiHOG000231186.
HOVERGENiHBG060871.
InParanoidiP55002.

Family and domain databases

InterProiIPR008673. MAGP.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERiPTHR16485. PTHR16485. 1 hit.
PfamiPF05507. MAGP. 1 hit.
[Graphical view]
PROSITEiPS51670. SHKT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55002-1 [UniParc]FASTAAdd to Basket

« Hide

MRAACLFLLF MPGLLAQGQY DLDPLPPFPD HVQYNHYGDQ IDNADYYDYQ    50
EVSPRTPEEQ FQSQQQVQQE VIPAPTPEPA AAGDLETEPT EPGPLDCREE 100
QYPCTRLYSI HKPCKQCLNE VCFYSLRRVY VVNKEICVRT VCAHEELLRA 150
DLCRDKFSKC GVMAVSGLCQ SVAASCARSC GGC 183
Length:183
Mass (Da):20,578
Last modified:October 1, 1996 - v1
Checksum:i1F193F2BE2EF1D05
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23769 mRNA. Translation: AAA16448.1.
BC035490 mRNA. Translation: AAH35490.1.
PIRiA49313.
UniGeneiMm.7386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23769 mRNA. Translation: AAA16448.1 .
BC035490 mRNA. Translation: AAH35490.1 .
PIRi A49313.
UniGenei Mm.7386.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P55002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:99559. Mfap2.

Phylogenomic databases

eggNOGi NOG42345.
HOGENOMi HOG000231186.
HOVERGENi HBG060871.
InParanoidi P55002.

Enzyme and pathway databases

Reactomei REACT_198996. Elastic fibre formation.
REACT_198998. Molecules associated with elastic fibres.

Miscellaneous databases

ChiTaRSi MFAP2. mouse.
PROi P55002.
SOURCEi Search...

Gene expression databases

ArrayExpressi P55002.
Bgeei P55002.
CleanExi MM_MFAP2.
Genevestigatori P55002.

Family and domain databases

InterProi IPR008673. MAGP.
IPR003582. ShKT_dom.
[Graphical view ]
PANTHERi PTHR16485. PTHR16485. 1 hit.
Pfami PF05507. MAGP. 1 hit.
[Graphical view ]
PROSITEi PS51670. SHKT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, chromosomal localization, and expression pattern of the murine Magp gene."
    Chen Y., Faraco J., Yin W., Germiller J., Francke U., Bonadio J.
    J. Biol. Chem. 268:27381-27389(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiMFAP2_MOUSE
AccessioniPrimary (citable) accession number: P55002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi