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Protein

Microfibrillar-associated protein 2

Gene

MFAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the elastin-associated microfibrils.

GO - Biological processi

  • embryonic eye morphogenesis Source: UniProtKB
  • extracellular matrix organization Source: Reactome
  • post-embryonic eye morphogenesis Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117122-MONOMER.
ReactomeiR-HSA-1566948. Elastic fibre formation.
R-HSA-2129379. Molecules associated with elastic fibres.
SignaLinkiP55001.

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibrillar-associated protein 2
Short name:
MFAP-2
Alternative name(s):
Microfibril-associated glycoprotein 1
Short name:
MAGP
Short name:
MAGP-1
Gene namesi
Name:MFAP2
Synonyms:MAGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7033. MFAP2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • microfibril Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4237.
OpenTargetsiENSG00000117122.
PharmGKBiPA30769.

Polymorphism and mutation databases

BioMutaiMFAP2.
DMDMi1708914.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Or 19Sequence analysisAdd BLAST17
ChainiPRO_000001868218 – 183Microfibrillar-associated protein 2Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Pyrrolidone carboxylic acidBy similarity1
Modified residuei47SulfotyrosineCurated1
Modified residuei48SulfotyrosineCurated1
Modified residuei50SulfotyrosineCurated1
Disulfide bondi153 ↔ 183PROSITE-ProRule annotation
Disulfide bondi160 ↔ 176PROSITE-ProRule annotation
Disulfide bondi169 ↔ 180PROSITE-ProRule annotation

Post-translational modificationi

Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils. May form transglutaminase cross-links.
O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

MaxQBiP55001.
PaxDbiP55001.
PeptideAtlasiP55001.
PRIDEiP55001.

PTM databases

iPTMnetiP55001.
PhosphoSitePlusiP55001.

Expressioni

Gene expression databases

BgeeiENSG00000117122.
CleanExiHS_MFAP2.
ExpressionAtlasiP55001. baseline and differential.
GenevisibleiP55001. HS.

Organism-specific databases

HPAiHPA007354.

Interactioni

Subunit structurei

Forms a ternary complex with BGN and ELN. Interacts with FBN1 (via N-terminal domain) and FBN2.By similarity

Protein-protein interaction databases

BioGridi110395. 4 interactors.
MINTiMINT-206062.
STRINGi9606.ENSP00000364685.

Structurei

3D structure databases

ProteinModelPortaliP55001.
SMRiP55001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 183ShKTPROSITE-ProRule annotationAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 73Gln/Glu-richAdd BLAST15

Sequence similaritiesi

Belongs to the MFAP family.Curated
Contains 1 ShKT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFBN. Eukaryota.
ENOG410YIKT. LUCA.
GeneTreeiENSGT00390000017736.
HOGENOMiHOG000231186.
HOVERGENiHBG060871.
InParanoidiP55001.
OMAiMATSGLC.
OrthoDBiEOG091G0UQX.
PhylomeDBiP55001.
TreeFamiTF333418.

Family and domain databases

InterProiIPR008673. MAGP.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERiPTHR16485. PTHR16485. 1 hit.
PfamiPF05507. MAGP. 1 hit.
PF01549. ShK. 1 hit.
[Graphical view]
PROSITEiPS51670. SHKT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P55001-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAAYLFLLF LPAGLLAQGQ YDLDPLPPFP DHVQYTHYSD QIDNPDYYDY
60 70 80 90 100
QEVTPRPSEE QFQFQSQQQV QQEVIPAPTP EPGNAELEPT EPGPLDCREE
110 120 130 140 150
QYPCTRLYSI HRPCKQCLNE VCFYSLRRVY VINKEICVRT VCAHEELLRA
160 170 180
DLCRDKFSKC GVMASSGLCQ SVAASCARSC GSC
Length:183
Mass (Da):20,826
Last modified:October 1, 1996 - v1
Checksum:iA75BE15DC9629B26
GO
Isoform A' (identifier: P55001-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-13: Missing.

Show »
Length:182
Mass (Da):20,754
Checksum:iF8179D36FF49C25B
GO
Isoform B (identifier: P55001-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-42: Missing.

Show »
Length:153
Mass (Da):17,444
Checksum:i949A4852012F645A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04277913 – 42Missing in isoform B. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_04278013Missing in isoform A'. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19718 mRNA. Translation: AAA79920.1.
CR407678 mRNA. Translation: CAG28606.1.
AK222751 mRNA. Translation: BAD96471.1.
AL049569 Genomic DNA. Translation: CAB96824.1.
AL049569 Genomic DNA. Translation: CAI20368.1.
CH471134 Genomic DNA. Translation: EAW94821.1.
BC015039 mRNA. Translation: AAH15039.1.
H27217 mRNA. No translation available.
CCDSiCCDS174.1. [P55001-1]
CCDS44071.1. [P55001-2]
PIRiI38923.
RefSeqiNP_001128719.1. NM_001135247.1. [P55001-2]
NP_001128720.1. NM_001135248.1. [P55001-2]
NP_002394.1. NM_002403.3. [P55001-1]
NP_059453.1. NM_017459.2. [P55001-1]
XP_011539778.1. XM_011541476.2. [P55001-1]
UniGeneiHs.389137.

Genome annotation databases

EnsembliENST00000375534; ENSP00000364684; ENSG00000117122. [P55001-2]
ENST00000375535; ENSP00000364685; ENSG00000117122. [P55001-1]
GeneIDi4237.
KEGGihsa:4237.
UCSCiuc001azw.4. human. [P55001-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19718 mRNA. Translation: AAA79920.1.
CR407678 mRNA. Translation: CAG28606.1.
AK222751 mRNA. Translation: BAD96471.1.
AL049569 Genomic DNA. Translation: CAB96824.1.
AL049569 Genomic DNA. Translation: CAI20368.1.
CH471134 Genomic DNA. Translation: EAW94821.1.
BC015039 mRNA. Translation: AAH15039.1.
H27217 mRNA. No translation available.
CCDSiCCDS174.1. [P55001-1]
CCDS44071.1. [P55001-2]
PIRiI38923.
RefSeqiNP_001128719.1. NM_001135247.1. [P55001-2]
NP_001128720.1. NM_001135248.1. [P55001-2]
NP_002394.1. NM_002403.3. [P55001-1]
NP_059453.1. NM_017459.2. [P55001-1]
XP_011539778.1. XM_011541476.2. [P55001-1]
UniGeneiHs.389137.

3D structure databases

ProteinModelPortaliP55001.
SMRiP55001.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110395. 4 interactors.
MINTiMINT-206062.
STRINGi9606.ENSP00000364685.

PTM databases

iPTMnetiP55001.
PhosphoSitePlusiP55001.

Polymorphism and mutation databases

BioMutaiMFAP2.
DMDMi1708914.

Proteomic databases

MaxQBiP55001.
PaxDbiP55001.
PeptideAtlasiP55001.
PRIDEiP55001.

Protocols and materials databases

DNASUi4237.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375534; ENSP00000364684; ENSG00000117122. [P55001-2]
ENST00000375535; ENSP00000364685; ENSG00000117122. [P55001-1]
GeneIDi4237.
KEGGihsa:4237.
UCSCiuc001azw.4. human. [P55001-1]

Organism-specific databases

CTDi4237.
DisGeNETi4237.
GeneCardsiMFAP2.
HGNCiHGNC:7033. MFAP2.
HPAiHPA007354.
MIMi156790. gene.
neXtProtiNX_P55001.
OpenTargetsiENSG00000117122.
PharmGKBiPA30769.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFBN. Eukaryota.
ENOG410YIKT. LUCA.
GeneTreeiENSGT00390000017736.
HOGENOMiHOG000231186.
HOVERGENiHBG060871.
InParanoidiP55001.
OMAiMATSGLC.
OrthoDBiEOG091G0UQX.
PhylomeDBiP55001.
TreeFamiTF333418.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117122-MONOMER.
ReactomeiR-HSA-1566948. Elastic fibre formation.
R-HSA-2129379. Molecules associated with elastic fibres.
SignaLinkiP55001.

Miscellaneous databases

GeneWikiiMFAP2.
GenomeRNAii4237.
PROiP55001.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117122.
CleanExiHS_MFAP2.
ExpressionAtlasiP55001. baseline and differential.
GenevisibleiP55001. HS.

Family and domain databases

InterProiIPR008673. MAGP.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERiPTHR16485. PTHR16485. 1 hit.
PfamiPF05507. MAGP. 1 hit.
PF01549. ShK. 1 hit.
[Graphical view]
PROSITEiPS51670. SHKT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMFAP2_HUMAN
AccessioniPrimary (citable) accession number: P55001
Secondary accession number(s): Q53X60, Q5JXY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.