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P55001

- MFAP2_HUMAN

UniProt

P55001 - MFAP2_HUMAN

Protein

Microfibrillar-associated protein 2

Gene

MFAP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Component of the elastin-associated microfibrils.

    GO - Biological processi

    1. extracellular matrix organization Source: Reactome
    2. platelet formation Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_150331. Molecules associated with elastic fibres.
    REACT_150366. Elastic fibre formation.
    SignaLinkiP55001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microfibrillar-associated protein 2
    Short name:
    MFAP-2
    Alternative name(s):
    Microfibril-associated glycoprotein 1
    Short name:
    MAGP
    Short name:
    MAGP-1
    Gene namesi
    Name:MFAP2
    Synonyms:MAGP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:7033. MFAP2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. microfibril Source: InterPro

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30769.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Or 19Sequence AnalysisAdd
    BLAST
    Chaini18 – 183166Microfibrillar-associated protein 2PRO_0000018682Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei18 – 181Pyrrolidone carboxylic acidBy similarity
    Modified residuei47 – 471SulfotyrosineCurated
    Modified residuei48 – 481SulfotyrosineCurated
    Modified residuei50 – 501SulfotyrosineCurated
    Disulfide bondi153 ↔ 183PROSITE-ProRule annotation
    Disulfide bondi160 ↔ 176PROSITE-ProRule annotation
    Disulfide bondi169 ↔ 180PROSITE-ProRule annotation

    Post-translational modificationi

    Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils. May form transglutaminase cross-links.
    O-glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid, Sulfation

    Proteomic databases

    MaxQBiP55001.
    PaxDbiP55001.
    PRIDEiP55001.

    PTM databases

    PhosphoSiteiP55001.

    Expressioni

    Gene expression databases

    BgeeiP55001.
    CleanExiHS_MFAP2.
    GenevestigatoriP55001.

    Organism-specific databases

    HPAiHPA007354.

    Interactioni

    Subunit structurei

    Forms a ternary complex with BGN and ELN.By similarity

    Protein-protein interaction databases

    BioGridi110395. 3 interactions.
    MINTiMINT-206062.
    STRINGi9606.ENSP00000364685.

    Structurei

    3D structure databases

    ProteinModelPortaliP55001.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini153 – 18331ShKTPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi59 – 7315Gln/Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MFAP family.Curated
    Contains 1 ShKT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42345.
    HOGENOMiHOG000231186.
    HOVERGENiHBG060871.
    InParanoidiP55001.
    OMAiMATSGLC.
    OrthoDBiEOG7NCV5M.
    PhylomeDBiP55001.
    TreeFamiTF333418.

    Family and domain databases

    InterProiIPR008673. MAGP.
    IPR003582. ShKT_dom.
    [Graphical view]
    PANTHERiPTHR16485. PTHR16485. 1 hit.
    PfamiPF05507. MAGP. 1 hit.
    PF01549. ShK. 1 hit.
    [Graphical view]
    PROSITEiPS51670. SHKT. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: P55001-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRAAYLFLLF LPAGLLAQGQ YDLDPLPPFP DHVQYTHYSD QIDNPDYYDY    50
    QEVTPRPSEE QFQFQSQQQV QQEVIPAPTP EPGNAELEPT EPGPLDCREE 100
    QYPCTRLYSI HRPCKQCLNE VCFYSLRRVY VINKEICVRT VCAHEELLRA 150
    DLCRDKFSKC GVMASSGLCQ SVAASCARSC GSC 183
    Length:183
    Mass (Da):20,826
    Last modified:October 1, 1996 - v1
    Checksum:iA75BE15DC9629B26
    GO
    Isoform A' (identifier: P55001-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         13-13: Missing.

    Show »
    Length:182
    Mass (Da):20,754
    Checksum:iF8179D36FF49C25B
    GO
    Isoform B (identifier: P55001-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         13-42: Missing.

    Show »
    Length:153
    Mass (Da):17,444
    Checksum:i949A4852012F645A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei13 – 4230Missing in isoform B. 1 PublicationVSP_042779Add
    BLAST
    Alternative sequencei13 – 131Missing in isoform A'. 1 PublicationVSP_042780

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19718 mRNA. Translation: AAA79920.1.
    CR407678 mRNA. Translation: CAG28606.1.
    AK222751 mRNA. Translation: BAD96471.1.
    AL049569 Genomic DNA. Translation: CAB96824.1.
    AL049569 Genomic DNA. Translation: CAI20368.1.
    CH471134 Genomic DNA. Translation: EAW94821.1.
    BC015039 mRNA. Translation: AAH15039.1.
    H27217 mRNA. No translation available.
    CCDSiCCDS174.1. [P55001-1]
    CCDS44071.1. [P55001-2]
    PIRiI38923.
    RefSeqiNP_001128719.1. NM_001135247.1. [P55001-2]
    NP_001128720.1. NM_001135248.1. [P55001-2]
    NP_002394.1. NM_002403.3. [P55001-1]
    NP_059453.1. NM_017459.2. [P55001-1]
    UniGeneiHs.389137.

    Genome annotation databases

    EnsembliENST00000375534; ENSP00000364684; ENSG00000117122. [P55001-2]
    ENST00000375535; ENSP00000364685; ENSG00000117122. [P55001-1]
    GeneIDi4237.
    KEGGihsa:4237.
    UCSCiuc001azw.3. human. [P55001-1]
    uc001azx.3. human. [P55001-2]

    Polymorphism databases

    DMDMi1708914.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19718 mRNA. Translation: AAA79920.1 .
    CR407678 mRNA. Translation: CAG28606.1 .
    AK222751 mRNA. Translation: BAD96471.1 .
    AL049569 Genomic DNA. Translation: CAB96824.1 .
    AL049569 Genomic DNA. Translation: CAI20368.1 .
    CH471134 Genomic DNA. Translation: EAW94821.1 .
    BC015039 mRNA. Translation: AAH15039.1 .
    H27217 mRNA. No translation available.
    CCDSi CCDS174.1. [P55001-1 ]
    CCDS44071.1. [P55001-2 ]
    PIRi I38923.
    RefSeqi NP_001128719.1. NM_001135247.1. [P55001-2 ]
    NP_001128720.1. NM_001135248.1. [P55001-2 ]
    NP_002394.1. NM_002403.3. [P55001-1 ]
    NP_059453.1. NM_017459.2. [P55001-1 ]
    UniGenei Hs.389137.

    3D structure databases

    ProteinModelPortali P55001.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110395. 3 interactions.
    MINTi MINT-206062.
    STRINGi 9606.ENSP00000364685.

    PTM databases

    PhosphoSitei P55001.

    Polymorphism databases

    DMDMi 1708914.

    Proteomic databases

    MaxQBi P55001.
    PaxDbi P55001.
    PRIDEi P55001.

    Protocols and materials databases

    DNASUi 4237.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375534 ; ENSP00000364684 ; ENSG00000117122 . [P55001-2 ]
    ENST00000375535 ; ENSP00000364685 ; ENSG00000117122 . [P55001-1 ]
    GeneIDi 4237.
    KEGGi hsa:4237.
    UCSCi uc001azw.3. human. [P55001-1 ]
    uc001azx.3. human. [P55001-2 ]

    Organism-specific databases

    CTDi 4237.
    GeneCardsi GC01M017300.
    HGNCi HGNC:7033. MFAP2.
    HPAi HPA007354.
    MIMi 156790. gene.
    neXtProti NX_P55001.
    PharmGKBi PA30769.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42345.
    HOGENOMi HOG000231186.
    HOVERGENi HBG060871.
    InParanoidi P55001.
    OMAi MATSGLC.
    OrthoDBi EOG7NCV5M.
    PhylomeDBi P55001.
    TreeFami TF333418.

    Enzyme and pathway databases

    Reactomei REACT_150331. Molecules associated with elastic fibres.
    REACT_150366. Elastic fibre formation.
    SignaLinki P55001.

    Miscellaneous databases

    GeneWikii MFAP2.
    GenomeRNAii 4237.
    NextBioi 16705.
    PROi P55001.
    SOURCEi Search...

    Gene expression databases

    Bgeei P55001.
    CleanExi HS_MFAP2.
    Genevestigatori P55001.

    Family and domain databases

    InterProi IPR008673. MAGP.
    IPR003582. ShKT_dom.
    [Graphical view ]
    PANTHERi PTHR16485. PTHR16485. 1 hit.
    Pfami PF05507. MAGP. 1 hit.
    PF01549. ShK. 1 hit.
    [Graphical view ]
    PROSITEi PS51670. SHKT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170."
      Faraco J., Bashir M.M., Rosenbloom J., Francke U.
      Genomics 25:630-637(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A').
      Tissue: Dermoid cancer.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Tissue: Uterus.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-99 (ISOFORM B).
    8. "Revised genomic structure of the human MAGP1 gene and identification of alternate transcripts in human and mouse tissues."
      Segade F., Broekelmann T.J., Pierce R.A., Mecham R.P.
      Matrix Biol. 19:671-682(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.

    Entry informationi

    Entry nameiMFAP2_HUMAN
    AccessioniPrimary (citable) accession number: P55001
    Secondary accession number(s): Q53X60, Q5JXY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3