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P55001 (MFAP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Microfibrillar-associated protein 2

Short name=MFAP-2
Alternative name(s):
Microfibril-associated glycoprotein 1
Short name=MAGP
Short name=MAGP-1
Gene names
Name:MFAP2
Synonyms:MAGP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the elastin-associated microfibrils.

Subunit structure

Forms a ternary complex with BGN and ELN By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Post-translational modification

Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils. May form transglutaminase cross-links.

O-glycosylated.

Sequence similarities

Belongs to the MFAP family.

Contains 1 ShKT domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: P55001-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform A' (identifier: P55001-2)

The sequence of this isoform differs from the canonical sequence as follows:
     13-13: Missing.
Isoform B (identifier: P55001-3)

The sequence of this isoform differs from the canonical sequence as follows:
     13-42: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717Or 19 Potential
Chain18 – 183166Microfibrillar-associated protein 2
PRO_0000018682

Regions

Domain153 – 18331ShKT
Compositional bias59 – 7315Gln/Glu-rich

Amino acid modifications

Modified residue181Pyrrolidone carboxylic acid By similarity
Modified residue471Sulfotyrosine Probable
Modified residue481Sulfotyrosine Probable
Modified residue501Sulfotyrosine Probable
Disulfide bond153 ↔ 183 By similarity
Disulfide bond160 ↔ 176 By similarity
Disulfide bond169 ↔ 180 By similarity

Natural variations

Alternative sequence13 – 4230Missing in isoform B.
VSP_042779
Alternative sequence131Missing in isoform A'.
VSP_042780

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: A75BE15DC9629B26

FASTA18320,826
        10         20         30         40         50         60 
MRAAYLFLLF LPAGLLAQGQ YDLDPLPPFP DHVQYTHYSD QIDNPDYYDY QEVTPRPSEE 

        70         80         90        100        110        120 
QFQFQSQQQV QQEVIPAPTP EPGNAELEPT EPGPLDCREE QYPCTRLYSI HRPCKQCLNE 

       130        140        150        160        170        180 
VCFYSLRRVY VINKEICVRT VCAHEELLRA DLCRDKFSKC GVMASSGLCQ SVAASCARSC 


GSC 

« Hide

Isoform A' [UniParc].

Checksum: F8179D36FF49C25B
Show »

FASTA18220,754
Isoform B [UniParc].

Checksum: 949A4852012F645A
Show »

FASTA15317,444

References

« Hide 'large scale' references
[1]"Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170."
Faraco J., Bashir M.M., Rosenbloom J., Francke U.
Genomics 25:630-637(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
[3]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A').
Tissue: Dermoid cancer.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Tissue: Uterus.
[7]"The WashU-Merck EST project."
Hillier L., Clark N., Dubuque T., Elliston K., Hawkins M., Holman M., Hultman M., Kucaba T., Le M., Lennon G., Marra M., Parsons J., Rifkin L., Rohlfing T., Soares M., Tan F., Trevaskis E., Waterston R. expand/collapse author list , Williamson A., Wohldmann P., Wilson R.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-99 (ISOFORM B).
[8]"Revised genomic structure of the human MAGP1 gene and identification of alternate transcripts in human and mouse tissues."
Segade F., Broekelmann T.J., Pierce R.A., Mecham R.P.
Matrix Biol. 19:671-682(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19718 mRNA. Translation: AAA79920.1.
CR407678 mRNA. Translation: CAG28606.1.
AK222751 mRNA. Translation: BAD96471.1.
AL049569 Genomic DNA. Translation: CAB96824.1.
AL049569 Genomic DNA. Translation: CAI20368.1.
CH471134 Genomic DNA. Translation: EAW94821.1.
BC015039 mRNA. Translation: AAH15039.1.
H27217 mRNA. No translation available.
CCDSCCDS174.1. [P55001-1]
CCDS44071.1. [P55001-2]
PIRI38923.
RefSeqNP_001128719.1. NM_001135247.1. [P55001-2]
NP_001128720.1. NM_001135248.1. [P55001-2]
NP_002394.1. NM_002403.3. [P55001-1]
NP_059453.1. NM_017459.2. [P55001-1]
UniGeneHs.389137.

3D structure databases

ProteinModelPortalP55001.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110395. 3 interactions.
MINTMINT-206062.
STRING9606.ENSP00000364685.

PTM databases

PhosphoSiteP55001.

Polymorphism databases

DMDM1708914.

Proteomic databases

MaxQBP55001.
PaxDbP55001.
PRIDEP55001.

Protocols and materials databases

DNASU4237.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375534; ENSP00000364684; ENSG00000117122. [P55001-2]
ENST00000375535; ENSP00000364685; ENSG00000117122. [P55001-1]
ENST00000438542; ENSP00000417029; ENSG00000117122. [P55001-2]
GeneID4237.
KEGGhsa:4237.
UCSCuc001azw.3. human. [P55001-1]
uc001azx.3. human. [P55001-2]

Organism-specific databases

CTD4237.
GeneCardsGC01M017300.
HGNCHGNC:7033. MFAP2.
HPAHPA007354.
MIM156790. gene.
neXtProtNX_P55001.
PharmGKBPA30769.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42345.
HOGENOMHOG000231186.
HOVERGENHBG060871.
InParanoidP55001.
OMAMATSGLC.
OrthoDBEOG7NCV5M.
PhylomeDBP55001.
TreeFamTF333418.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.
SignaLinkP55001.

Gene expression databases

BgeeP55001.
CleanExHS_MFAP2.
GenevestigatorP55001.

Family and domain databases

InterProIPR008673. MAGP.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERPTHR16485. PTHR16485. 1 hit.
PfamPF05507. MAGP. 1 hit.
PF01549. ShK. 1 hit.
[Graphical view]
PROSITEPS51670. SHKT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMFAP2.
GenomeRNAi4237.
NextBio16705.
PROP55001.
SOURCESearch...

Entry information

Entry nameMFAP2_HUMAN
AccessionPrimary (citable) accession number: P55001
Secondary accession number(s): Q53X60, Q5JXY0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM