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P55001

- MFAP2_HUMAN

UniProt

P55001 - MFAP2_HUMAN

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Protein

Microfibrillar-associated protein 2

Gene
MFAP2, MAGP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the elastin-associated microfibrils.

GO - Biological processi

  1. extracellular matrix organization Source: Reactome
  2. platelet formation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_150331. Molecules associated with elastic fibres.
REACT_150366. Elastic fibre formation.
SignaLinkiP55001.

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibrillar-associated protein 2
Short name:
MFAP-2
Alternative name(s):
Microfibril-associated glycoprotein 1
Short name:
MAGP
Short name:
MAGP-1
Gene namesi
Name:MFAP2
Synonyms:MAGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:7033. MFAP2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. microfibril Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Or 19 Reviewed predictionAdd
BLAST
Chaini18 – 183166Microfibrillar-associated protein 2PRO_0000018682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181Pyrrolidone carboxylic acid By similarity
Modified residuei47 – 471Sulfotyrosine Inferred
Modified residuei48 – 481Sulfotyrosine Inferred
Modified residuei50 – 501Sulfotyrosine Inferred
Disulfide bondi153 ↔ 183 By similarity
Disulfide bondi160 ↔ 176 By similarity
Disulfide bondi169 ↔ 180 By similarity

Post-translational modificationi

Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils. May form transglutaminase cross-links.
O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

MaxQBiP55001.
PaxDbiP55001.
PRIDEiP55001.

PTM databases

PhosphoSiteiP55001.

Expressioni

Gene expression databases

BgeeiP55001.
CleanExiHS_MFAP2.
GenevestigatoriP55001.

Organism-specific databases

HPAiHPA007354.

Interactioni

Subunit structurei

Forms a ternary complex with BGN and ELN By similarity.

Protein-protein interaction databases

BioGridi110395. 3 interactions.
MINTiMINT-206062.
STRINGi9606.ENSP00000364685.

Structurei

3D structure databases

ProteinModelPortaliP55001.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini153 – 18331ShKTAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 7315Gln/Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the MFAP family.
Contains 1 ShKT domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42345.
HOGENOMiHOG000231186.
HOVERGENiHBG060871.
InParanoidiP55001.
OMAiMATSGLC.
OrthoDBiEOG7NCV5M.
PhylomeDBiP55001.
TreeFamiTF333418.

Family and domain databases

InterProiIPR008673. MAGP.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERiPTHR16485. PTHR16485. 1 hit.
PfamiPF05507. MAGP. 1 hit.
PF01549. ShK. 1 hit.
[Graphical view]
PROSITEiPS51670. SHKT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P55001-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRAAYLFLLF LPAGLLAQGQ YDLDPLPPFP DHVQYTHYSD QIDNPDYYDY    50
QEVTPRPSEE QFQFQSQQQV QQEVIPAPTP EPGNAELEPT EPGPLDCREE 100
QYPCTRLYSI HRPCKQCLNE VCFYSLRRVY VINKEICVRT VCAHEELLRA 150
DLCRDKFSKC GVMASSGLCQ SVAASCARSC GSC 183
Length:183
Mass (Da):20,826
Last modified:October 1, 1996 - v1
Checksum:iA75BE15DC9629B26
GO
Isoform A' (identifier: P55001-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-13: Missing.

Show »
Length:182
Mass (Da):20,754
Checksum:iF8179D36FF49C25B
GO
Isoform B (identifier: P55001-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-42: Missing.

Show »
Length:153
Mass (Da):17,444
Checksum:i949A4852012F645A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei13 – 4230Missing in isoform B. VSP_042779Add
BLAST
Alternative sequencei13 – 131Missing in isoform A'. VSP_042780

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19718 mRNA. Translation: AAA79920.1.
CR407678 mRNA. Translation: CAG28606.1.
AK222751 mRNA. Translation: BAD96471.1.
AL049569 Genomic DNA. Translation: CAB96824.1.
AL049569 Genomic DNA. Translation: CAI20368.1.
CH471134 Genomic DNA. Translation: EAW94821.1.
BC015039 mRNA. Translation: AAH15039.1.
H27217 mRNA. No translation available.
CCDSiCCDS174.1. [P55001-1]
CCDS44071.1. [P55001-2]
PIRiI38923.
RefSeqiNP_001128719.1. NM_001135247.1. [P55001-2]
NP_001128720.1. NM_001135248.1. [P55001-2]
NP_002394.1. NM_002403.3. [P55001-1]
NP_059453.1. NM_017459.2. [P55001-1]
UniGeneiHs.389137.

Genome annotation databases

EnsembliENST00000375534; ENSP00000364684; ENSG00000117122. [P55001-2]
ENST00000375535; ENSP00000364685; ENSG00000117122. [P55001-1]
ENST00000438542; ENSP00000417029; ENSG00000117122. [P55001-2]
GeneIDi4237.
KEGGihsa:4237.
UCSCiuc001azw.3. human. [P55001-1]
uc001azx.3. human. [P55001-2]

Polymorphism databases

DMDMi1708914.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19718 mRNA. Translation: AAA79920.1 .
CR407678 mRNA. Translation: CAG28606.1 .
AK222751 mRNA. Translation: BAD96471.1 .
AL049569 Genomic DNA. Translation: CAB96824.1 .
AL049569 Genomic DNA. Translation: CAI20368.1 .
CH471134 Genomic DNA. Translation: EAW94821.1 .
BC015039 mRNA. Translation: AAH15039.1 .
H27217 mRNA. No translation available.
CCDSi CCDS174.1. [P55001-1 ]
CCDS44071.1. [P55001-2 ]
PIRi I38923.
RefSeqi NP_001128719.1. NM_001135247.1. [P55001-2 ]
NP_001128720.1. NM_001135248.1. [P55001-2 ]
NP_002394.1. NM_002403.3. [P55001-1 ]
NP_059453.1. NM_017459.2. [P55001-1 ]
UniGenei Hs.389137.

3D structure databases

ProteinModelPortali P55001.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110395. 3 interactions.
MINTi MINT-206062.
STRINGi 9606.ENSP00000364685.

PTM databases

PhosphoSitei P55001.

Polymorphism databases

DMDMi 1708914.

Proteomic databases

MaxQBi P55001.
PaxDbi P55001.
PRIDEi P55001.

Protocols and materials databases

DNASUi 4237.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375534 ; ENSP00000364684 ; ENSG00000117122 . [P55001-2 ]
ENST00000375535 ; ENSP00000364685 ; ENSG00000117122 . [P55001-1 ]
ENST00000438542 ; ENSP00000417029 ; ENSG00000117122 . [P55001-2 ]
GeneIDi 4237.
KEGGi hsa:4237.
UCSCi uc001azw.3. human. [P55001-1 ]
uc001azx.3. human. [P55001-2 ]

Organism-specific databases

CTDi 4237.
GeneCardsi GC01M017300.
HGNCi HGNC:7033. MFAP2.
HPAi HPA007354.
MIMi 156790. gene.
neXtProti NX_P55001.
PharmGKBi PA30769.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42345.
HOGENOMi HOG000231186.
HOVERGENi HBG060871.
InParanoidi P55001.
OMAi MATSGLC.
OrthoDBi EOG7NCV5M.
PhylomeDBi P55001.
TreeFami TF333418.

Enzyme and pathway databases

Reactomei REACT_150331. Molecules associated with elastic fibres.
REACT_150366. Elastic fibre formation.
SignaLinki P55001.

Miscellaneous databases

GeneWikii MFAP2.
GenomeRNAii 4237.
NextBioi 16705.
PROi P55001.
SOURCEi Search...

Gene expression databases

Bgeei P55001.
CleanExi HS_MFAP2.
Genevestigatori P55001.

Family and domain databases

InterProi IPR008673. MAGP.
IPR003582. ShKT_dom.
[Graphical view ]
PANTHERi PTHR16485. PTHR16485. 1 hit.
Pfami PF05507. MAGP. 1 hit.
PF01549. ShK. 1 hit.
[Graphical view ]
PROSITEi PS51670. SHKT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170."
    Faraco J., Bashir M.M., Rosenbloom J., Francke U.
    Genomics 25:630-637(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A').
    Tissue: Dermoid cancer.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Tissue: Uterus.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-99 (ISOFORM B).
  8. "Revised genomic structure of the human MAGP1 gene and identification of alternate transcripts in human and mouse tissues."
    Segade F., Broekelmann T.J., Pierce R.A., Mecham R.P.
    Matrix Biol. 19:671-682(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.

Entry informationi

Entry nameiMFAP2_HUMAN
AccessioniPrimary (citable) accession number: P55001
Secondary accession number(s): Q53X60, Q5JXY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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