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P55000

- SLUR1_HUMAN

UniProt

P55000 - SLUR1_HUMAN

Protein

Secreted Ly-6/uPAR-related protein 1

Gene

SLURP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin.

    GO - Molecular functioni

    1. cytokine activity Source: UniProtKB

    GO - Biological processi

    1. cell activation Source: UniProtKB
    2. cell adhesion Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secreted Ly-6/uPAR-related protein 1
    Short name:
    SLURP-1
    Alternative name(s):
    ARS component B
    ARS(component B)-81/S
    Anti-neoplastic urinary protein
    Short name:
    ANUP
    Gene namesi
    Name:SLURP1
    Synonyms:ARS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:18746. SLURP1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: UniProtKB-KW
    3. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Mal de Meleda (MDM) [MIM:248300]: A rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities.4 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151W → R in MDM; no expression of the protein. 1 Publication
    VAR_032871
    Natural varianti71 – 711R → H in MDM; reduced expression of the protein. 1 Publication
    VAR_032872
    Natural varianti77 – 771C → R in MDM. 1 Publication
    VAR_032873
    Natural varianti86 – 861G → R in MDM; reduced expression of the protein. 1 Publication
    Corresponds to variant rs28937888 [ dbSNP | Ensembl ].
    VAR_032874
    Natural varianti99 – 991C → Y in MDM. 1 Publication
    VAR_032875

    Keywords - Diseasei

    Disease mutation, Palmoplantar keratoderma

    Organism-specific databases

    MIMi248300. phenotype.
    Orphaneti87503. Mal de Meleda.
    PharmGKBiPA134936818.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 10381Secreted Ly-6/uPAR-related protein 1PRO_0000036167Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 50Sequence Analysis
    Disulfide bondi28 ↔ 37Sequence Analysis
    Disulfide bondi43 ↔ 73Sequence Analysis
    Disulfide bondi77 ↔ 93Sequence Analysis
    Disulfide bondi94 ↔ 99Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP55000.
    PeptideAtlasiP55000.
    PRIDEiP55000.

    PTM databases

    PhosphoSiteiP55000.

    Expressioni

    Tissue specificityi

    Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine.2 Publications

    Inductioni

    Regulated by retinoic acid, EGF and IFNG/IFN-gamma.1 Publication

    Gene expression databases

    BgeeiP55000.
    CleanExiHS_SLURP1.
    GenevestigatoriP55000.

    Organism-specific databases

    HPAiHPA050967.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000246515.

    Structurei

    3D structure databases

    ProteinModelPortaliP55000.
    SMRiP55000. Positions 39-101.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 7350UPAR/Ly6Add
    BLAST

    Sequence similaritiesi

    Contains 1 UPAR/Ly6 domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43367.
    HOGENOMiHOG000035114.
    HOVERGENiHBG094857.
    InParanoidiP55000.
    OMAiTAIMSER.
    OrthoDBiEOG7P8P9W.
    PhylomeDBiP55000.
    TreeFamiTF336080.

    Family and domain databases

    InterProiIPR016054. LY6_UPA_recep-like.
    IPR001526. LY6_UPAR.
    IPR027103. SLURP1.
    [Graphical view]
    PANTHERiPTHR10036:SF4. PTHR10036:SF4. 1 hit.
    PfamiPF00021. UPAR_LY6. 1 hit.
    [Graphical view]
    SMARTiSM00134. LU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55000-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASRWAVQLL LVAAWSMGCG EALKCYTCKE PMTSASCRTI TRCKPEDTAC    50
    MTTLVTVEAE YPFNQSPVVT RSCSSSCVAT DPDSIGAAHL IFCCFRDLCN 100
    SEL 103
    Length:103
    Mass (Da):11,186
    Last modified:July 15, 1998 - v2
    Checksum:i07AAF6BCA8031282
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171M → V in AAT01436. (PubMed:16354194)Curated
    Sequence conflicti22 – 221A → Q AA sequence (PubMed:8742060)Curated
    Sequence conflicti36 – 361S → A AA sequence (PubMed:8742060)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151W → R in MDM; no expression of the protein. 1 Publication
    VAR_032871
    Natural varianti71 – 711R → H in MDM; reduced expression of the protein. 1 Publication
    VAR_032872
    Natural varianti77 – 771C → R in MDM. 1 Publication
    VAR_032873
    Natural varianti86 – 861G → R in MDM; reduced expression of the protein. 1 Publication
    Corresponds to variant rs28937888 [ dbSNP | Ensembl ].
    VAR_032874
    Natural varianti99 – 991C → Y in MDM. 1 Publication
    VAR_032875

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99977 Genomic DNA. Translation: CAA68237.1.
    AY579079 mRNA. Translation: AAT01436.1.
    AY579080 mRNA. Translation: AAT01437.1.
    BC069292 mRNA. Translation: AAH69292.1.
    BC105133 mRNA. Translation: AAI05134.1.
    BC105135 mRNA. Translation: AAI05136.1.
    CCDSiCCDS6387.1.
    PIRiA59031.
    RefSeqiNP_065160.1. NM_020427.2.
    UniGeneiHs.103505.
    Hs.676358.

    Genome annotation databases

    EnsembliENST00000246515; ENSP00000246515; ENSG00000126233.
    GeneIDi57152.
    KEGGihsa:57152.
    UCSCiuc003ywy.3. human.

    Polymorphism databases

    DMDMi3287957.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99977 Genomic DNA. Translation: CAA68237.1 .
    AY579079 mRNA. Translation: AAT01436.1 .
    AY579080 mRNA. Translation: AAT01437.1 .
    BC069292 mRNA. Translation: AAH69292.1 .
    BC105133 mRNA. Translation: AAI05134.1 .
    BC105135 mRNA. Translation: AAI05136.1 .
    CCDSi CCDS6387.1.
    PIRi A59031.
    RefSeqi NP_065160.1. NM_020427.2.
    UniGenei Hs.103505.
    Hs.676358.

    3D structure databases

    ProteinModelPortali P55000.
    SMRi P55000. Positions 39-101.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000246515.

    PTM databases

    PhosphoSitei P55000.

    Polymorphism databases

    DMDMi 3287957.

    Proteomic databases

    PaxDbi P55000.
    PeptideAtlasi P55000.
    PRIDEi P55000.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000246515 ; ENSP00000246515 ; ENSG00000126233 .
    GeneIDi 57152.
    KEGGi hsa:57152.
    UCSCi uc003ywy.3. human.

    Organism-specific databases

    CTDi 57152.
    GeneCardsi GC08M143820.
    HGNCi HGNC:18746. SLURP1.
    HPAi HPA050967.
    MIMi 248300. phenotype.
    606119. gene.
    neXtProti NX_P55000.
    Orphaneti 87503. Mal de Meleda.
    PharmGKBi PA134936818.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43367.
    HOGENOMi HOG000035114.
    HOVERGENi HBG094857.
    InParanoidi P55000.
    OMAi TAIMSER.
    OrthoDBi EOG7P8P9W.
    PhylomeDBi P55000.
    TreeFami TF336080.

    Miscellaneous databases

    GeneWikii SLURP1.
    GenomeRNAii 57152.
    NextBioi 63125.
    PROi P55000.
    SOURCEi Search...

    Gene expression databases

    Bgeei P55000.
    CleanExi HS_SLURP1.
    Genevestigatori P55000.

    Family and domain databases

    InterProi IPR016054. LY6_UPA_recep-like.
    IPR001526. LY6_UPAR.
    IPR027103. SLURP1.
    [Graphical view ]
    PANTHERi PTHR10036:SF4. PTHR10036:SF4. 1 hit.
    Pfami PF00021. UPAR_LY6. 1 hit.
    [Graphical view ]
    SMARTi SM00134. LU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mastrangeli R.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skin.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes."
      Ridge R.J., Sloane N.H.
      Cytokine 8:1-5(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.
      Tissue: Granulocyte.
    5. "Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily."
      Andermann K., Wattler F., Wattler S., Heine G., Meyer M., Forssmann W.-G., Nehls M.
      Protein Sci. 8:810-819(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, SIGNAL SEQUENCE CLEAVAGE SITE.
    6. "ARS component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda."
      Mastrangeli R., Donini S., Kelton C.A., He C., Bressan A., Milazzo F., Ciolli V., Borrelli F., Martelli F., Biffoni M., Serlupi-Crescenzi O., Serani S., Micangeli E., El Tayar N., Vaccaro R., Renda T., Lisciani R., Rossi M., Papoian R.
      Eur. J. Dermatol. 13:560-570(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION, POSSIBLE FUNCTION.
    7. "SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda."
      Favre B., Plantard L., Aeschbach L., Brakch N., Christen-Zaech S., de Viragh P.A., Sergeant A., Huber M., Hohl D.
      J. Invest. Dermatol. 127:301-308(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, POSSIBLE FUNCTION, VARIANT MDM HIS-71, CHARACTERIZATION OF VARIANTS MDM ARG-15 AND ARG-86.
    8. Cited for: INVOLVEMENT IN MDM.
    9. "Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates."
      Eckl K.M., Stevens H.P., Lestringant G.G., Westenberger-Treumann M., Traupe H., Hinz B., Frossard P.M., Stadler R., Leigh I.M., Nuernberg P., Reis A., Hennies H.C.
      Hum. Genet. 112:50-56(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS MDM ARG-15 AND ARG-86.
    10. Cited for: VARIANTS MDM ARG-77 AND TYR-99.

    Entry informationi

    Entry nameiSLUR1_HUMAN
    AccessioniPrimary (citable) accession number: P55000
    Secondary accession number(s): Q53YJ6, Q6PUA6, Q92483
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is not certain that ARS and ANUP are identical proteins.Curated

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3