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P55000 (SLUR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Secreted Ly-6/uPAR-related protein 1

Short name=SLURP-1
Alternative name(s):
ARS component B
ARS(component B)-81/S
Anti-neoplastic urinary protein
Short name=ANUP
Gene names
Name:SLURP1
Synonyms:ARS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length103 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. Ref.6 Ref.7

Subunit structure

Homodimer.

Subcellular location

Secreted.

Tissue specificity

Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine. Ref.6 Ref.7

Induction

Regulated by retinoic acid, EGF and IFNG/IFN-gamma. Ref.6

Involvement in disease

Mal de Meleda (MDM) [MIM:248300]: A rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Ref.8 Ref.9 Ref.10

Sequence similarities

Contains 1 UPAR/Ly6 domain.

Caution

It is not certain that ARS and ANUP are identical proteins.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseDisease mutation
Palmoplantar keratoderma
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcell activation

Non-traceable author statement Ref.8. Source: UniProtKB

cell adhesion

Traceable author statement PubMed 14506129. Source: UniProtKB

   Cellular_componentextracellular region

Non-traceable author statement Ref.6Ref.4. Source: UniProtKB

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncytokine activity

Non-traceable author statement Ref.4. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222
Chain23 – 10381Secreted Ly-6/uPAR-related protein 1
PRO_0000036167

Regions

Domain24 – 7350UPAR/Ly6

Amino acid modifications

Disulfide bond25 ↔ 50 Potential
Disulfide bond28 ↔ 37 Potential
Disulfide bond43 ↔ 73 Potential
Disulfide bond77 ↔ 93 Potential
Disulfide bond94 ↔ 99 Potential

Natural variations

Natural variant151W → R in MDM; no expression of the protein. Ref.7 Ref.9
VAR_032871
Natural variant711R → H in MDM; reduced expression of the protein. Ref.7
VAR_032872
Natural variant771C → R in MDM. Ref.10
VAR_032873
Natural variant861G → R in MDM; reduced expression of the protein. Ref.7 Ref.9
Corresponds to variant rs28937888 [ dbSNP | Ensembl ].
VAR_032874
Natural variant991C → Y in MDM. Ref.10
VAR_032875

Experimental info

Sequence conflict171M → V in AAT01436. Ref.2
Sequence conflict221A → Q AA sequence Ref.4
Sequence conflict361S → A AA sequence Ref.4

Sequences

Sequence LengthMass (Da)Tools
P55000 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 07AAF6BCA8031282

FASTA10311,186
        10         20         30         40         50         60 
MASRWAVQLL LVAAWSMGCG EALKCYTCKE PMTSASCRTI TRCKPEDTAC MTTLVTVEAE 

        70         80         90        100 
YPFNQSPVVT RSCSSSCVAT DPDSIGAAHL IFCCFRDLCN SEL 

« Hide

References

« Hide 'large scale' references
[1]Mastrangeli R.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[2]"Biological effects of SLURP-1 on human keratinocytes."
Arredondo J., Chernyavsky A.I., Webber R.J., Grando S.A.
J. Invest. Dermatol. 125:1236-1241(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skin.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes."
Ridge R.J., Sloane N.H.
Cytokine 8:1-5(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.
Tissue: Granulocyte.
[5]"Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily."
Andermann K., Wattler F., Wattler S., Heine G., Meyer M., Forssmann W.-G., Nehls M.
Protein Sci. 8:810-819(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, SIGNAL SEQUENCE CLEAVAGE SITE.
[6]"ARS component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda."
Mastrangeli R., Donini S., Kelton C.A., He C., Bressan A., Milazzo F., Ciolli V., Borrelli F., Martelli F., Biffoni M., Serlupi-Crescenzi O., Serani S., Micangeli E., El Tayar N., Vaccaro R., Renda T., Lisciani R., Rossi M., Papoian R.
Eur. J. Dermatol. 13:560-570(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INDUCTION, POSSIBLE FUNCTION.
[7]"SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda."
Favre B., Plantard L., Aeschbach L., Brakch N., Christen-Zaech S., de Viragh P.A., Sergeant A., Huber M., Hohl D.
J. Invest. Dermatol. 127:301-308(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, POSSIBLE FUNCTION, VARIANT MDM HIS-71, CHARACTERIZATION OF VARIANTS MDM ARG-15 AND ARG-86.
[8]"Mutations in the gene encoding SLURP-1 in Mal de Meleda."
Fischer J., Bouadjar B., Heilig R., Huber M., Lefevre C., Jobard F., Macari F., Bakija-Konsuo A., Ait-Belkacem F., Weissenbach J., Lathrop M., Hohl D., Prud'homme J.-F.
Hum. Mol. Genet. 10:875-880(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN MDM.
[9]"Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates."
Eckl K.M., Stevens H.P., Lestringant G.G., Westenberger-Treumann M., Traupe H., Hinz B., Frossard P.M., Stadler R., Leigh I.M., Nuernberg P., Reis A., Hennies H.C.
Hum. Genet. 112:50-56(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS MDM ARG-15 AND ARG-86.
[10]"Heterozygous manifestations in female carriers of Mal de Meleda."
Mokni M., Charfeddine C., Ben Mously R., Baccouche D., Kaabi B., Ben Osman A., Dellagi K., Abdelhak S.
Clin. Genet. 65:244-246(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS MDM ARG-77 AND TYR-99.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X99977 Genomic DNA. Translation: CAA68237.1.
AY579079 mRNA. Translation: AAT01436.1.
AY579080 mRNA. Translation: AAT01437.1.
BC069292 mRNA. Translation: AAH69292.1.
BC105133 mRNA. Translation: AAI05134.1.
BC105135 mRNA. Translation: AAI05136.1.
PIRA59031.
RefSeqNP_065160.1. NM_020427.2.
UniGeneHs.103505.
Hs.676358.

3D structure databases

ProteinModelPortalP55000.
SMRP55000. Positions 23-101.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000246515.

PTM databases

PhosphoSiteP55000.

Polymorphism databases

DMDM3287957.

Proteomic databases

PaxDbP55000.
PeptideAtlasP55000.
PRIDEP55000.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000246515; ENSP00000246515; ENSG00000126233.
GeneID57152.
KEGGhsa:57152.
UCSCuc003ywy.3. human.

Organism-specific databases

CTD57152.
GeneCardsGC08M143820.
HGNCHGNC:18746. SLURP1.
HPAHPA050967.
MIM248300. phenotype.
606119. gene.
neXtProtNX_P55000.
Orphanet87503. Mal de Meleda.
PharmGKBPA134936818.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43367.
HOGENOMHOG000035114.
HOVERGENHBG094857.
InParanoidP55000.
OMAMVTRSCS.
OrthoDBEOG7P8P9W.
PhylomeDBP55000.
TreeFamTF336080.

Gene expression databases

BgeeP55000.
CleanExHS_SLURP1.
GenevestigatorP55000.

Family and domain databases

InterProIPR016054. LY6_UPA_recep-like.
IPR001526. LY6_UPAR.
IPR027103. SLURP1.
[Graphical view]
PANTHERPTHR10036:SF1. PTHR10036:SF1. 1 hit.
PfamPF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTSM00134. LU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLURP1.
GenomeRNAi57152.
NextBio63125.
PROP55000.
SOURCESearch...

Entry information

Entry nameSLUR1_HUMAN
AccessionPrimary (citable) accession number: P55000
Secondary accession number(s): Q53YJ6, Q6PUA6, Q92483
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: February 19, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM