P55000 (SLUR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Secreted Ly-6/uPAR-related protein 1
Short name=SLURP-1

Alternative name(s):
ARS component B
ARS(component B)-81/S
Anti-neoplastic urinary protein
Short name=ANUP

Gene names

Name:	SLURP1
Synonyms:	ARS

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. Ref.6 Ref.7
Subunit structure	Homodimer.
Subcellular location	Secreted.
Tissue specificity	Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine. Ref.6 Ref.7
Induction	Regulated by retinoic acid, EGF and IFNG/IFN-gamma. Ref.6
Involvement in disease	Mal de Meleda (MDM) [MIM:248300]: A rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Ref.8 Ref.9 Ref.10
Sequence similarities	Contains 1 UPAR/Ly6 domain.
Caution	It is not certain that ARS and ANUP are identical proteins.

Ontologies

Keywords
Cellular component	Secreted
Disease	Disease mutation Palmoplantar keratoderma
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell activation Non-traceable author statement Ref.8. Source: UniProtKB cell adhesion Traceable author statement PubMed 14506129. Source: UniProtKB
Cellular_component	extracellular region Non-traceable author statement Ref.6Ref.4. Source: UniProtKB extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytokine activity Non-traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22
	Chain	23 – 103	81	Secreted Ly-6/uPAR-related protein 1		PRO_0000036167
Regions
	Domain	24 – 73	50	UPAR/Ly6
Amino acid modifications
	Disulfide bond	25 ↔ 50		Potential
	Disulfide bond	28 ↔ 37		Potential
	Disulfide bond	43 ↔ 73		Potential
	Disulfide bond	77 ↔ 93		Potential
	Disulfide bond	94 ↔ 99		Potential
Natural variations
	Natural variant	15	1	W → R in MDM; no expression of the protein. Ref.7 Ref.9		VAR_032871
	Natural variant	71	1	R → H in MDM; reduced expression of the protein. Ref.7		VAR_032872
	Natural variant	77	1	C → R in MDM. Ref.10		VAR_032873
	Natural variant	86	1	G → R in MDM; reduced expression of the protein. Ref.7 Ref.9 Corresponds to variant rs28937888 [ dbSNP | Ensembl ].		VAR_032874
	Natural variant	99	1	C → Y in MDM. Ref.10		VAR_032875
Experimental info
	Sequence conflict	17	1	M → V in AAT01436. Ref.2
	Sequence conflict	22	1	A → Q AA sequence Ref.4
	Sequence conflict	36	1	S → A AA sequence Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P55000 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 07AAF6BCA8031282	FASTA	103	11,186
	10 20 30 40 50 60 MASRWAVQLL LVAAWSMGCG EALKCYTCKE PMTSASCRTI TRCKPEDTAC MTTLVTVEAE 70 80 90 100 YPFNQSPVVT RSCSSSCVAT DPDSIGAAHL IFCCFRDLCN SEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mastrangeli R. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[2]	"Biological effects of SLURP-1 on human keratinocytes." Arredondo J., Chernyavsky A.I., Webber R.J., Grando S.A. J. Invest. Dermatol. 125:1236-1241(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skin.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes." Ridge R.J., Sloane N.H. Cytokine 8:1-5(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE. Tissue: Granulocyte.
[5]	"Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily." Andermann K., Wattler F., Wattler S., Heine G., Meyer M., Forssmann W.-G., Nehls M. Protein Sci. 8:810-819(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, SIGNAL SEQUENCE CLEAVAGE SITE.
[6]	"ARS component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda." Mastrangeli R., Donini S., Kelton C.A., He C., Bressan A., Milazzo F., Ciolli V., Borrelli F., Martelli F., Biffoni M., Serlupi-Crescenzi O., Serani S., Micangeli E., El Tayar N., Vaccaro R., Renda T., Lisciani R., Rossi M., Papoian R. Eur. J. Dermatol. 13:560-570(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INDUCTION, POSSIBLE FUNCTION.
[7]	"SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda." Favre B., Plantard L., Aeschbach L., Brakch N., Christen-Zaech S., de Viragh P.A., Sergeant A., Huber M., Hohl D. J. Invest. Dermatol. 127:301-308(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, POSSIBLE FUNCTION, VARIANT MDM HIS-71, CHARACTERIZATION OF VARIANTS MDM ARG-15 AND ARG-86.
[8]	"Mutations in the gene encoding SLURP-1 in Mal de Meleda." Fischer J., Bouadjar B., Heilig R., Huber M., Lefevre C., Jobard F., Macari F., Bakija-Konsuo A., Ait-Belkacem F., Weissenbach J., Lathrop M., Hohl D., Prud'homme J.-F. Hum. Mol. Genet. 10:875-880(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN MDM.
[9]	"Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates." Eckl K.M., Stevens H.P., Lestringant G.G., Westenberger-Treumann M., Traupe H., Hinz B., Frossard P.M., Stadler R., Leigh I.M., Nuernberg P., Reis A., Hennies H.C. Hum. Genet. 112:50-56(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MDM ARG-15 AND ARG-86.
[10]	"Heterozygous manifestations in female carriers of Mal de Meleda." Mokni M., Charfeddine C., Ben Mously R., Baccouche D., Kaabi B., Ben Osman A., Dellagi K., Abdelhak S. Clin. Genet. 65:244-246(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MDM ARG-77 AND TYR-99.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X99977 Genomic DNA. Translation: CAA68237.1. AY579079 mRNA. Translation: AAT01436.1. AY579080 mRNA. Translation: AAT01437.1. BC069292 mRNA. Translation: AAH69292.1. BC105133 mRNA. Translation: AAI05134.1. BC105135 mRNA. Translation: AAI05136.1.
IPI	IPI00022620.
PIR	A59031.
RefSeq	NP_065160.1. NM_020427.2.
UniGene	Hs.103505. Hs.676358.
3D structure databases
ProteinModelPortal	P55000.
SMR	P55000. Positions 23-100.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000246515.
PTM databases
PhosphoSite	P55000.
Polymorphism databases
DMDM	3287957.
Proteomic databases
PaxDb	P55000.
PeptideAtlas	P55000.
PRIDE	P55000.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000246515; ENSP00000246515; ENSG00000126233.
GeneID	57152.
KEGG	hsa:57152.
UCSC	uc003ywy.3. human.
Organism-specific databases
CTD	57152.
GeneCards	GC08M143820.
HGNC	HGNC:18746. SLURP1.
HPA	HPA050967.
MIM	248300. phenotype. 606119. gene.
neXtProt	NX_P55000.
Orphanet	87503. Mal de Meleda.
PharmGKB	PA134936818.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43367.
HOGENOM	HOG000035114.
HOVERGEN	HBG094857.
InParanoid	P55000.
OMA	MVTRSCS.
OrthoDB	EOG437RGG.
PhylomeDB	P55000.
Gene expression databases
Bgee	P55000.
CleanEx	HS_SLURP1.
Genevestigator	P55000.
GermOnline	ENSG00000126233. Homo sapiens.
Family and domain databases
InterPro	IPR016054. LY6_UPA_recep-like. IPR001526. LY6_UPAR. IPR027103. SLURP1. [Graphical view]
PANTHER	PTHR10036:SF1. PTHR10036:SF1. 1 hit.
Pfam	PF00021. UPAR_LY6. 1 hit. [Graphical view]
SMART	SM00134. LU. 1 hit. [Graphical view]
PROSITE	PS00983. LY6_UPAR. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57152.
NextBio	63125.
SOURCE	Search...

Entry information

Entry name

SLUR1_HUMAN

Accession

Primary (citable) accession number: P55000
Secondary accession number(s): Q53YJ6, Q6PUA6, Q92483

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 15, 1998
Last modified:	May 1, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.