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Protein

Secreted Ly-6/uPAR-related protein 1

Gene

SLURP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

GO - Biological processi

  • cell activation Source: UniProtKB
  • cell adhesion Source: UniProtKB
  • locomotory behavior Source: Ensembl
  • negative regulation of cell migration Source: Ensembl
  • negative regulation of keratinocyte proliferation Source: Ensembl
  • neuromuscular process controlling posture Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126233-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted Ly-6/uPAR-related protein 1
Short name:
SLURP-1
Alternative name(s):
ARS component B
ARS(component B)-81/S
Anti-neoplastic urinary protein
Short name:
ANUP
Gene namesi
Name:SLURP1
Synonyms:ARS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18746. SLURP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Mal de Meleda (MDM)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities.
See also OMIM:248300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03287115W → R in MDM; no expression of the protein. 2 PublicationsCorresponds to variant rs121908318dbSNPEnsembl.1
Natural variantiVAR_03287271R → H in MDM; reduced expression of the protein. 1 Publication1
Natural variantiVAR_03287377C → R in MDM. 1 PublicationCorresponds to variant rs121908319dbSNPEnsembl.1
Natural variantiVAR_03287486G → R in MDM; reduced expression of the protein. 2 PublicationsCorresponds to variant rs28937888dbSNPEnsembl.1
Natural variantiVAR_03287599C → Y in MDM. 1 PublicationCorresponds to variant rs121908320dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Palmoplantar keratoderma

Organism-specific databases

DisGeNETi57152.
MalaCardsiSLURP1.
MIMi248300. phenotype.
OpenTargetsiENSG00000126233.
Orphaneti87503. Mal de Meleda.
PharmGKBiPA134936818.

Polymorphism and mutation databases

BioMutaiSLURP1.
DMDMi3287957.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000003616723 – 103Secreted Ly-6/uPAR-related protein 1Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 50Sequence analysis
Disulfide bondi28 ↔ 37Sequence analysis
Disulfide bondi43 ↔ 73Sequence analysis
Disulfide bondi77 ↔ 93Sequence analysis
Disulfide bondi94 ↔ 99Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP55000.
PeptideAtlasiP55000.
PRIDEiP55000.

PTM databases

iPTMnetiP55000.
PhosphoSitePlusiP55000.

Expressioni

Tissue specificityi

Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine.2 Publications

Inductioni

Regulated by retinoic acid, EGF and IFNG/IFN-gamma.1 Publication

Gene expression databases

BgeeiENSG00000126233.
CleanExiHS_SLURP1.
GenevisibleiP55000. HS.

Organism-specific databases

HPAiHPA050967.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

Protein-protein interaction databases

IntActiP55000. 1 interactor.
STRINGi9606.ENSP00000246515.

Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 26Combined sources3
Beta strandi29 – 31Combined sources3
Beta strandi40 – 42Combined sources3
Beta strandi49 – 54Combined sources6
Beta strandi70 – 76Combined sources7
Beta strandi85 – 87Combined sources3
Beta strandi89 – 96Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MUONMR-A23-103[»]
2MUPNMR-A23-103[»]
ProteinModelPortaliP55000.
SMRiP55000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 73UPAR/Ly6Add BLAST50

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J33S. Eukaryota.
ENOG411196K. LUCA.
GeneTreeiENSGT00510000047304.
HOGENOMiHOG000035114.
HOVERGENiHBG094857.
InParanoidiP55000.
OMAiPMVTRSC.
OrthoDBiEOG091G0UOB.
PhylomeDBiP55000.
TreeFamiTF336080.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
IPR027103. SLURP1.
[Graphical view]
PANTHERiPTHR10036:SF10. PTHR10036:SF10. 1 hit.
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRWAVQLL LVAAWSMGCG EALKCYTCKE PMTSASCRTI TRCKPEDTAC
60 70 80 90 100
MTTLVTVEAE YPFNQSPVVT RSCSSSCVAT DPDSIGAAHL IFCCFRDLCN

SEL
Length:103
Mass (Da):11,186
Last modified:July 15, 1998 - v2
Checksum:i07AAF6BCA8031282
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17M → V in AAT01436 (PubMed:16354194).Curated1
Sequence conflicti22A → Q AA sequence (PubMed:8742060).Curated1
Sequence conflicti36S → A AA sequence (PubMed:8742060).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03287115W → R in MDM; no expression of the protein. 2 PublicationsCorresponds to variant rs121908318dbSNPEnsembl.1
Natural variantiVAR_03287271R → H in MDM; reduced expression of the protein. 1 Publication1
Natural variantiVAR_03287377C → R in MDM. 1 PublicationCorresponds to variant rs121908319dbSNPEnsembl.1
Natural variantiVAR_03287486G → R in MDM; reduced expression of the protein. 2 PublicationsCorresponds to variant rs28937888dbSNPEnsembl.1
Natural variantiVAR_03287599C → Y in MDM. 1 PublicationCorresponds to variant rs121908320dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99977 Genomic DNA. Translation: CAA68237.1.
AY579079 mRNA. Translation: AAT01436.1.
AY579080 mRNA. Translation: AAT01437.1.
BC069292 mRNA. Translation: AAH69292.1.
BC105133 mRNA. Translation: AAI05134.1.
BC105135 mRNA. Translation: AAI05136.1.
CCDSiCCDS6387.1.
PIRiA59031.
RefSeqiNP_065160.1. NM_020427.2.
UniGeneiHs.103505.
Hs.676358.

Genome annotation databases

EnsembliENST00000246515; ENSP00000246515; ENSG00000126233.
GeneIDi57152.
KEGGihsa:57152.
UCSCiuc003ywy.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99977 Genomic DNA. Translation: CAA68237.1.
AY579079 mRNA. Translation: AAT01436.1.
AY579080 mRNA. Translation: AAT01437.1.
BC069292 mRNA. Translation: AAH69292.1.
BC105133 mRNA. Translation: AAI05134.1.
BC105135 mRNA. Translation: AAI05136.1.
CCDSiCCDS6387.1.
PIRiA59031.
RefSeqiNP_065160.1. NM_020427.2.
UniGeneiHs.103505.
Hs.676358.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MUONMR-A23-103[»]
2MUPNMR-A23-103[»]
ProteinModelPortaliP55000.
SMRiP55000.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP55000. 1 interactor.
STRINGi9606.ENSP00000246515.

PTM databases

iPTMnetiP55000.
PhosphoSitePlusiP55000.

Polymorphism and mutation databases

BioMutaiSLURP1.
DMDMi3287957.

Proteomic databases

PaxDbiP55000.
PeptideAtlasiP55000.
PRIDEiP55000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246515; ENSP00000246515; ENSG00000126233.
GeneIDi57152.
KEGGihsa:57152.
UCSCiuc003ywy.3. human.

Organism-specific databases

CTDi57152.
DisGeNETi57152.
GeneCardsiSLURP1.
HGNCiHGNC:18746. SLURP1.
HPAiHPA050967.
MalaCardsiSLURP1.
MIMi248300. phenotype.
606119. gene.
neXtProtiNX_P55000.
OpenTargetsiENSG00000126233.
Orphaneti87503. Mal de Meleda.
PharmGKBiPA134936818.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J33S. Eukaryota.
ENOG411196K. LUCA.
GeneTreeiENSGT00510000047304.
HOGENOMiHOG000035114.
HOVERGENiHBG094857.
InParanoidiP55000.
OMAiPMVTRSC.
OrthoDBiEOG091G0UOB.
PhylomeDBiP55000.
TreeFamiTF336080.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126233-MONOMER.

Miscellaneous databases

GeneWikiiSLURP1.
GenomeRNAii57152.
PROiP55000.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126233.
CleanExiHS_SLURP1.
GenevisibleiP55000. HS.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
IPR027103. SLURP1.
[Graphical view]
PANTHERiPTHR10036:SF10. PTHR10036:SF10. 1 hit.
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLUR1_HUMAN
AccessioniPrimary (citable) accession number: P55000
Secondary accession number(s): Q53YJ6, Q6PUA6, Q92483
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is not certain that ARS and ANUP are identical proteins.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.