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Protein

Secreted Ly-6/uPAR-related protein 1

Gene

SLURP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca2+ signaling (PubMed:17286989). Seems to have a immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896).By similarity2 Publications4 Publications

GO - Molecular functioni

  • acetylcholine receptor activator activity Source: UniProtKB
  • cytokine activity Source: UniProtKB

GO - Biological processi

  • cell activation Source: GO_Central
  • cell adhesion Source: UniProtKB
  • locomotory behavior Source: Ensembl
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of keratinocyte proliferation Source: Ensembl
  • neuromuscular process controlling posture Source: Ensembl
  • urokinase plasminogen activator signaling pathway Source: UniProtKB

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted Ly-6/uPAR-related protein 1
Short name:
SLURP-1
Alternative name(s):
ARS component B
ARS(component B)-81/S
Anti-neoplastic urinary protein
Short name:
ANUP
Gene namesi
Name:SLURP1
Synonyms:ARS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18746. SLURP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Mal de Meleda (MDM)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities.
See also OMIM:248300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03287115W → R in MDM; no expression of the protein. 4 PublicationsCorresponds to variant dbSNP:rs121908318Ensembl.1
Natural variantiVAR_03287271R → H in MDM; reduced expression of the protein; decreased secretion. 2 Publications1
Natural variantiVAR_07730771R → P in MDM; decreased secretion. 2 Publications1
Natural variantiVAR_03287377C → R in MDM; decreased secretion. 2 PublicationsCorresponds to variant dbSNP:rs121908319Ensembl.1
Natural variantiVAR_07730882P → S in MDM; unknown pathological significance; no effect on secretion. 2 Publications1
Natural variantiVAR_03287486G → R in MDM; reduced expression of the protein. 2 PublicationsCorresponds to variant dbSNP:rs28937888Ensembl.1
Natural variantiVAR_07730994C → S in MDM; decreased secretion. 2 PublicationsCorresponds to variant dbSNP:rs772388665Ensembl.1
Natural variantiVAR_07731098L → P in MDM; decreased secretion. 2 Publications1
Natural variantiVAR_03287599C → Y in MDM. 1 PublicationCorresponds to variant dbSNP:rs121908320Ensembl.1

Keywords - Diseasei

Disease mutation, Palmoplantar keratoderma

Organism-specific databases

DisGeNETi57152.
MalaCardsiSLURP1.
MIMi248300. phenotype.
OpenTargetsiENSG00000126233.
Orphaneti87503. Mal de Meleda.
PharmGKBiPA134936818.

Polymorphism and mutation databases

BioMutaiSLURP1.
DMDMi3287957.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000003616723 – 103Secreted Ly-6/uPAR-related protein 1Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 50Sequence analysisBy similarity1 Publication
Disulfide bondi28 ↔ 37Sequence analysisBy similarity1 Publication
Disulfide bondi43 ↔ 73Sequence analysisBy similarity1 Publication
Disulfide bondi77 ↔ 93Sequence analysisBy similarity1 Publication
Disulfide bondi94 ↔ 99Sequence analysisBy similarity1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP55000.
PeptideAtlasiP55000.
PRIDEiP55000.

PTM databases

iPTMnetiP55000.
PhosphoSitePlusiP55000.

Expressioni

Tissue specificityi

Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine.2 Publications

Inductioni

Regulated by retinoic acid, EGF and IFNG/IFN-gamma (PubMed:14721776). Down-regulated by IL-13 in cultured human bronchial epithelial cells (related to asthmatic condition) (PubMed:20621062).2 Publications

Gene expression databases

BgeeiENSG00000126233.
CleanExiHS_SLURP1.
GenevisibleiP55000. HS.

Organism-specific databases

HPAiHPA050967.

Interactioni

Subunit structurei

Homodimer. Interacts with PLAU (PubMed:25168896). Interacts with CHRNA7 (PubMed:26905431).

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

Protein-protein interaction databases

IntActiP55000. 1 interactor.
STRINGi9606.ENSP00000246515.

Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 26Combined sources3
Beta strandi29 – 31Combined sources3
Beta strandi40 – 42Combined sources3
Beta strandi49 – 54Combined sources6
Beta strandi70 – 76Combined sources7
Beta strandi85 – 87Combined sources3
Beta strandi89 – 96Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MUONMR-A23-103[»]
2MUPNMR-A23-103[»]
ProteinModelPortaliP55000.
SMRiP55000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 73UPAR/Ly6Add BLAST50

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J33S. Eukaryota.
ENOG411196K. LUCA.
GeneTreeiENSGT00510000047304.
HOGENOMiHOG000035114.
HOVERGENiHBG094857.
InParanoidiP55000.
OMAiPMVTRSC.
OrthoDBiEOG091G0UOB.
PhylomeDBiP55000.
TreeFamiTF336080.

Family and domain databases

InterProiView protein in InterPro
IPR016054. LY6_UPA_recep-like.
PfamiView protein in Pfam
PF00021. UPAR_LY6. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRWAVQLL LVAAWSMGCG EALKCYTCKE PMTSASCRTI TRCKPEDTAC
60 70 80 90 100
MTTLVTVEAE YPFNQSPVVT RSCSSSCVAT DPDSIGAAHL IFCCFRDLCN

SEL
Length:103
Mass (Da):11,186
Last modified:July 15, 1998 - v2
Checksum:i07AAF6BCA8031282
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17M → V in AAT01436 (PubMed:16354194).Curated1
Sequence conflicti22A → Q AA sequence (PubMed:8742060).Curated1
Sequence conflicti36S → A AA sequence (PubMed:8742060).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03287115W → R in MDM; no expression of the protein. 4 PublicationsCorresponds to variant dbSNP:rs121908318Ensembl.1
Natural variantiVAR_03287271R → H in MDM; reduced expression of the protein; decreased secretion. 2 Publications1
Natural variantiVAR_07730771R → P in MDM; decreased secretion. 2 Publications1
Natural variantiVAR_03287377C → R in MDM; decreased secretion. 2 PublicationsCorresponds to variant dbSNP:rs121908319Ensembl.1
Natural variantiVAR_07730882P → S in MDM; unknown pathological significance; no effect on secretion. 2 Publications1
Natural variantiVAR_03287486G → R in MDM; reduced expression of the protein. 2 PublicationsCorresponds to variant dbSNP:rs28937888Ensembl.1
Natural variantiVAR_07730994C → S in MDM; decreased secretion. 2 PublicationsCorresponds to variant dbSNP:rs772388665Ensembl.1
Natural variantiVAR_07731098L → P in MDM; decreased secretion. 2 Publications1
Natural variantiVAR_03287599C → Y in MDM. 1 PublicationCorresponds to variant dbSNP:rs121908320Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99977 Genomic DNA. Translation: CAA68237.1.
AY579079 mRNA. Translation: AAT01436.1.
AY579080 mRNA. Translation: AAT01437.1.
BC069292 mRNA. Translation: AAH69292.1.
BC105133 mRNA. Translation: AAI05134.1.
BC105135 mRNA. Translation: AAI05136.1.
CCDSiCCDS6387.1.
PIRiA59031.
RefSeqiNP_065160.1. NM_020427.2.
UniGeneiHs.103505.
Hs.676358.

Genome annotation databases

EnsembliENST00000246515; ENSP00000246515; ENSG00000126233.
GeneIDi57152.
KEGGihsa:57152.
UCSCiuc003ywy.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSLUR1_HUMAN
AccessioniPrimary (citable) accession number: P55000
Secondary accession number(s): Q53YJ6, Q6PUA6, Q92483
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: July 5, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is not certain that ARS and ANUP are identical proteins.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references