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P55000

- SLUR1_HUMAN

UniProt

P55000 - SLUR1_HUMAN

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Protein

Secreted Ly-6/uPAR-related protein 1

Gene

SLURP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin.

GO - Molecular functioni

  1. cytokine activity Source: UniProtKB

GO - Biological processi

  1. cell activation Source: UniProtKB
  2. cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted Ly-6/uPAR-related protein 1
Short name:
SLURP-1
Alternative name(s):
ARS component B
ARS(component B)-81/S
Anti-neoplastic urinary protein
Short name:
ANUP
Gene namesi
Name:SLURP1
Synonyms:ARS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:18746. SLURP1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: UniProtKB-KW
  3. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Mal de Meleda (MDM) [MIM:248300]: A rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities.4 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151W → R in MDM; no expression of the protein. 1 Publication
VAR_032871
Natural varianti71 – 711R → H in MDM; reduced expression of the protein. 1 Publication
VAR_032872
Natural varianti77 – 771C → R in MDM. 1 Publication
VAR_032873
Natural varianti86 – 861G → R in MDM; reduced expression of the protein. 1 Publication
Corresponds to variant rs28937888 [ dbSNP | Ensembl ].
VAR_032874
Natural varianti99 – 991C → Y in MDM. 1 Publication
VAR_032875

Keywords - Diseasei

Disease mutation, Palmoplantar keratoderma

Organism-specific databases

MIMi248300. phenotype.
Orphaneti87503. Mal de Meleda.
PharmGKBiPA134936818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 10381Secreted Ly-6/uPAR-related protein 1PRO_0000036167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 50Sequence Analysis
Disulfide bondi28 ↔ 37Sequence Analysis
Disulfide bondi43 ↔ 73Sequence Analysis
Disulfide bondi77 ↔ 93Sequence Analysis
Disulfide bondi94 ↔ 99Sequence Analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP55000.
PeptideAtlasiP55000.
PRIDEiP55000.

PTM databases

PhosphoSiteiP55000.

Expressioni

Tissue specificityi

Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine.2 Publications

Inductioni

Regulated by retinoic acid, EGF and IFNG/IFN-gamma.1 Publication

Gene expression databases

BgeeiP55000.
CleanExiHS_SLURP1.
GenevestigatoriP55000.

Organism-specific databases

HPAiHPA050967.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9606.ENSP00000246515.

Structurei

3D structure databases

ProteinModelPortaliP55000.
SMRiP55000. Positions 38-101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 7350UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43367.
GeneTreeiENSGT00510000047304.
HOGENOMiHOG000035114.
HOVERGENiHBG094857.
InParanoidiP55000.
OMAiTAIMSER.
OrthoDBiEOG7P8P9W.
PhylomeDBiP55000.
TreeFamiTF336080.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
IPR001526. LY6_UPAR.
IPR027103. SLURP1.
[Graphical view]
PANTHERiPTHR10036:SF4. PTHR10036:SF4. 1 hit.
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55000-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASRWAVQLL LVAAWSMGCG EALKCYTCKE PMTSASCRTI TRCKPEDTAC
60 70 80 90 100
MTTLVTVEAE YPFNQSPVVT RSCSSSCVAT DPDSIGAAHL IFCCFRDLCN

SEL
Length:103
Mass (Da):11,186
Last modified:July 15, 1998 - v2
Checksum:i07AAF6BCA8031282
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171M → V in AAT01436. (PubMed:16354194)Curated
Sequence conflicti22 – 221A → Q AA sequence (PubMed:8742060)Curated
Sequence conflicti36 – 361S → A AA sequence (PubMed:8742060)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151W → R in MDM; no expression of the protein. 1 Publication
VAR_032871
Natural varianti71 – 711R → H in MDM; reduced expression of the protein. 1 Publication
VAR_032872
Natural varianti77 – 771C → R in MDM. 1 Publication
VAR_032873
Natural varianti86 – 861G → R in MDM; reduced expression of the protein. 1 Publication
Corresponds to variant rs28937888 [ dbSNP | Ensembl ].
VAR_032874
Natural varianti99 – 991C → Y in MDM. 1 Publication
VAR_032875

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99977 Genomic DNA. Translation: CAA68237.1.
AY579079 mRNA. Translation: AAT01436.1.
AY579080 mRNA. Translation: AAT01437.1.
BC069292 mRNA. Translation: AAH69292.1.
BC105133 mRNA. Translation: AAI05134.1.
BC105135 mRNA. Translation: AAI05136.1.
CCDSiCCDS6387.1.
PIRiA59031.
RefSeqiNP_065160.1. NM_020427.2.
UniGeneiHs.103505.
Hs.676358.

Genome annotation databases

EnsembliENST00000246515; ENSP00000246515; ENSG00000126233.
GeneIDi57152.
KEGGihsa:57152.
UCSCiuc003ywy.3. human.

Polymorphism databases

DMDMi3287957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99977 Genomic DNA. Translation: CAA68237.1 .
AY579079 mRNA. Translation: AAT01436.1 .
AY579080 mRNA. Translation: AAT01437.1 .
BC069292 mRNA. Translation: AAH69292.1 .
BC105133 mRNA. Translation: AAI05134.1 .
BC105135 mRNA. Translation: AAI05136.1 .
CCDSi CCDS6387.1.
PIRi A59031.
RefSeqi NP_065160.1. NM_020427.2.
UniGenei Hs.103505.
Hs.676358.

3D structure databases

ProteinModelPortali P55000.
SMRi P55000. Positions 38-101.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000246515.

PTM databases

PhosphoSitei P55000.

Polymorphism databases

DMDMi 3287957.

Proteomic databases

PaxDbi P55000.
PeptideAtlasi P55000.
PRIDEi P55000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000246515 ; ENSP00000246515 ; ENSG00000126233 .
GeneIDi 57152.
KEGGi hsa:57152.
UCSCi uc003ywy.3. human.

Organism-specific databases

CTDi 57152.
GeneCardsi GC08M143820.
HGNCi HGNC:18746. SLURP1.
HPAi HPA050967.
MIMi 248300. phenotype.
606119. gene.
neXtProti NX_P55000.
Orphaneti 87503. Mal de Meleda.
PharmGKBi PA134936818.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43367.
GeneTreei ENSGT00510000047304.
HOGENOMi HOG000035114.
HOVERGENi HBG094857.
InParanoidi P55000.
OMAi TAIMSER.
OrthoDBi EOG7P8P9W.
PhylomeDBi P55000.
TreeFami TF336080.

Miscellaneous databases

GeneWikii SLURP1.
GenomeRNAii 57152.
NextBioi 63125.
PROi P55000.
SOURCEi Search...

Gene expression databases

Bgeei P55000.
CleanExi HS_SLURP1.
Genevestigatori P55000.

Family and domain databases

InterProi IPR016054. LY6_UPA_recep-like.
IPR001526. LY6_UPAR.
IPR027103. SLURP1.
[Graphical view ]
PANTHERi PTHR10036:SF4. PTHR10036:SF4. 1 hit.
Pfami PF00021. UPAR_LY6. 1 hit.
[Graphical view ]
SMARTi SM00134. LU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Mastrangeli R.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes."
    Ridge R.J., Sloane N.H.
    Cytokine 8:1-5(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
    Tissue: Granulocyte.
  5. "Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily."
    Andermann K., Wattler F., Wattler S., Heine G., Meyer M., Forssmann W.-G., Nehls M.
    Protein Sci. 8:810-819(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, SIGNAL SEQUENCE CLEAVAGE SITE.
  6. "ARS component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda."
    Mastrangeli R., Donini S., Kelton C.A., He C., Bressan A., Milazzo F., Ciolli V., Borrelli F., Martelli F., Biffoni M., Serlupi-Crescenzi O., Serani S., Micangeli E., El Tayar N., Vaccaro R., Renda T., Lisciani R., Rossi M., Papoian R.
    Eur. J. Dermatol. 13:560-570(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION, POSSIBLE FUNCTION.
  7. "SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda."
    Favre B., Plantard L., Aeschbach L., Brakch N., Christen-Zaech S., de Viragh P.A., Sergeant A., Huber M., Hohl D.
    J. Invest. Dermatol. 127:301-308(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, POSSIBLE FUNCTION, VARIANT MDM HIS-71, CHARACTERIZATION OF VARIANTS MDM ARG-15 AND ARG-86.
  8. Cited for: INVOLVEMENT IN MDM.
  9. "Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates."
    Eckl K.M., Stevens H.P., Lestringant G.G., Westenberger-Treumann M., Traupe H., Hinz B., Frossard P.M., Stadler R., Leigh I.M., Nuernberg P., Reis A., Hennies H.C.
    Hum. Genet. 112:50-56(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS MDM ARG-15 AND ARG-86.
  10. Cited for: VARIANTS MDM ARG-77 AND TYR-99.

Entry informationi

Entry nameiSLUR1_HUMAN
AccessioniPrimary (citable) accession number: P55000
Secondary accession number(s): Q53YJ6, Q6PUA6, Q92483
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is not certain that ARS and ANUP are identical proteins.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3