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Protein

2'-hydroxybiphenyl-2-sulfinate desulfinase

Gene

soxB

Organism
Rhodococcus sp. (strain IGTS8)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of a pathway to remove covalently bound sulfur from dibenzothiophene (DBT) without breaking carbon-carbon bonds. This enzyme metabolizes DBT-sulfone (DBTO2 or DBT 5,5-dioxide) to 2-hydroxybiphenyl (2-HBP).

Catalytic activityi

2'-hydroxybiphenyl-2-sulfinate + H2O = 2-hydroxybiphenyl + sulfite.

Cofactori

FMNCurated

Pathwayi: dibenzothiophene degradation

This protein is involved in the pathway dibenzothiophene degradation, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway dibenzothiophene degradation and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Monooxygenase, Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-266.
BRENDAi3.13.1.3. 5389.
UniPathwayiUPA00346.

Names & Taxonomyi

Protein namesi
Recommended name:
2'-hydroxybiphenyl-2-sulfinate desulfinase (EC:3.13.1.3)
Alternative name(s):
Dibenzothiophene desulfurization enzyme B
Gene namesi
Name:soxB
Synonyms:dszB
Encoded oniPlasmid unnamed1 Publication
OrganismiRhodococcus sp. (strain IGTS8)
Taxonomic identifieri54064 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720471 – 3652'-hydroxybiphenyl-2-sulfinate desulfinaseAdd BLAST365

Interactioni

Subunit structurei

Heterodimer of two subunits, SoxA and SoxB.

Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 26Combined sources6
Helixi32 – 38Combined sources7
Helixi41 – 44Combined sources4
Beta strandi48 – 51Combined sources4
Helixi54 – 58Combined sources5
Helixi59 – 62Combined sources4
Beta strandi68 – 72Combined sources5
Helixi75 – 82Combined sources8
Beta strandi88 – 97Combined sources10
Beta strandi100 – 106Combined sources7
Helixi114 – 117Combined sources4
Beta strandi121 – 124Combined sources4
Helixi126 – 133Combined sources8
Helixi139 – 141Combined sources3
Helixi144 – 151Combined sources8
Helixi154 – 166Combined sources13
Helixi171 – 173Combined sources3
Beta strandi174 – 178Combined sources5
Turni182 – 184Combined sources3
Helixi188 – 193Combined sources6
Beta strandi194 – 198Combined sources5
Helixi199 – 202Combined sources4
Helixi206 – 215Combined sources10
Beta strandi216 – 218Combined sources3
Beta strandi220 – 225Combined sources6
Helixi226 – 234Combined sources9
Beta strandi237 – 241Combined sources5
Helixi243 – 245Combined sources3
Helixi247 – 249Combined sources3
Beta strandi251 – 258Combined sources8
Helixi259 – 264Combined sources6
Helixi266 – 283Combined sources18
Helixi287 – 298Combined sources12
Helixi302 – 309Combined sources8
Helixi313 – 315Combined sources3
Helixi323 – 338Combined sources16
Helixi348 – 351Combined sources4
Helixi355 – 361Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DE2X-ray1.80A1-365[»]
2DE3X-ray1.60A/B1-365[»]
2DE4X-ray1.80A/B1-365[»]
ProteinModelPortaliP54997.
SMRiP54997.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54997.

Family & Domainsi

Sequence similaritiesi

Sequencei

Sequence statusi: Complete.

P54997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRVDPANP GSELDSAIRD TLTYSNCPVP NALLTASESG FLDAAGIELD
60 70 80 90 100
VLSGQQGTVH FTYDQPAYTR FGGEIPPLLS EGLRAPGRTR LLGITPLLGR
110 120 130 140 150
QGFFVRDDSP ITAAADLAGR RIGVSASAIR ILRGQLGDYL ELDPWRQTLV
160 170 180 190 200
ALGSWEARAL LHTLEHGELG VDDVELVPIS SPGVDVPAEQ LEESATVKGA
210 220 230 240 250
DLFPDVARGQ AAVLASGDVD ALYSWLPWAG ELQATGARPV VDLGLDERNA
260 270 280 290 300
YASVWTVSSG LVRQRPGLVQ RLVDAAVDAG LWARDHSDAV TSLHAANLGV
310 320 330 340 350
STGAVGQGFG ADFQQRLVPR LDHDALALLE RTQQFLLTNN LLQEPVALDQ
360
WAAPEFLNNS LNRHR
Length:365
Mass (Da):39,045
Last modified:October 1, 1996 - v1
Checksum:iDA6A867756DA23D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08850 Genomic DNA. Translation: AAA56672.1.
L37363 Genomic DNA. Translation: AAA99483.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08850 Genomic DNA. Translation: AAA56672.1.
L37363 Genomic DNA. Translation: AAA99483.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DE2X-ray1.80A1-365[»]
2DE3X-ray1.60A/B1-365[»]
2DE4X-ray1.80A/B1-365[»]
ProteinModelPortaliP54997.
SMRiP54997.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00346.
BioCyciMetaCyc:MONOMER-266.
BRENDAi3.13.1.3. 5389.

Miscellaneous databases

EvolutionaryTraceiP54997.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSOXB_RHOSG
AccessioniPrimary (citable) accession number: P54997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Encoded on an unnamed 120 kb plasmid.1 Publication

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.