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P54996

- G6PD_TAKRU

UniProt

P54996 - G6PD_TAKRU

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

g6pd

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871NADP 1By similarity
Binding sitei162 – 1621NADP 1By similarity
Binding sitei186 – 1861NADP 1; via carbonyl oxygenBy similarity
Binding sitei186 – 1861SubstrateBy similarity
Binding sitei254 – 2541SubstrateBy similarity
Binding sitei273 – 2731SubstrateBy similarity
Active sitei278 – 2781Proton acceptorBy similarity
Binding sitei372 – 3721NADP 2By similarity
Binding sitei375 – 3751SubstrateBy similarity
Binding sitei380 – 3801SubstrateBy similarity
Binding sitei381 – 3811NADP 2By similarity
Binding sitei385 – 3851NADP 2By similarity
Binding sitei408 – 4081NADP 2By similarity
Binding sitei410 – 4101SubstrateBy similarity
Binding sitei502 – 5021NADP 2By similarity
Binding sitei518 – 5181NADP 2By similarity
Binding sitei524 – 5241NADP 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi53 – 608NADP 1By similarity
Nucleotide bindingi416 – 4183NADP 2By similarity
Nucleotide bindingi436 – 4383NADP 2By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
  2. NADP binding Source: InterPro

GO - Biological processi

  1. glucose 6-phosphate metabolic process Source: UniProtKB
  2. NADP metabolic process Source: UniProtKB
  3. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:g6pd
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Glucose-6-phosphate 1-dehydrogenasePRO_0000068088Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP54996.
SMRiP54996. Positions 43-530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni216 – 2205Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

InParanoidiP54996.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54996-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMIILFNCFF CASFREDGQH PTVSLGGVWG AAKELHEDKE FHQSDVHVFI
60 70 80 90 100
IMGASGDLAK KKIYPTLWWL FRDGLLPEQT YFVGFARSAL TVDAIRTSCM
110 120 130 140 150
PYLKVTETES DRLSAFFSRN SYISGNYTAG GSFSELNAHI MSLPGASDAN
160 170 180 190 200
RLFYLALPPT IYHSVTENIK HFCMSAKGWN RVIVEKPFGH DLQSSEELST
210 220 230 240 250
HLSSLFTEDQ IYRIDHYLGK EMVQNLMVLR FGNRIFGPIW NRDNVACVVL
260 270 280 290 300
TFKEPFGTQG RGGYFDDFGI IRDVMQNHML QMLCLVAMEK PASTNSDDVR
310 320 330 340 350
DEKVKVLKCI VPASMSDVVL GQYVGDPEGE GDAKLGYLDD PTVPKGSTQA
360 370 380 390 400
TFATVVLYVH NERWDGVPFI LRCGKALNER KAEVRLQFTD VPGDIFRNQC
410 420 430 440 450
YRNELVVRVQ PNEAIYAKMM SKKPGVYFTP EETELDLTYK SRYKDVKLPD
460 470 480 490 500
AYERLILDVF CGSQMHFVAS DELREAWRIF TPLLHQIEKE KPKPIPYKYG
510 520 530
SRGPAEADEL EKRVGFRYEG TYKWVNPHRL
Length:530
Mass (Da):60,469
Last modified:October 1, 1996 - v1
Checksum:iFC73FB53D834EF29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83611 Genomic DNA. Translation: CAA58590.2.
PIRiA56841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83611 Genomic DNA. Translation: CAA58590.2 .
PIRi A56841.

3D structure databases

ProteinModelPortali P54996.
SMRi P54996. Positions 43-530.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

InParanoidi P54996.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic structure and sequence of the Fugu rubripes glucose-6-phosphate dehydrogenase gene (G6PD)."
    Mason P.J., Stevens D.J., Luzzatto L., Brenner S., Aparicio S.
    Genomics 26:587-591(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiG6PD_TAKRU
AccessioniPrimary (citable) accession number: P54996
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3