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P54996

- G6PD_TAKRU

UniProt

P54996 - G6PD_TAKRU

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
g6pd
Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871NADP 1 By similarity
Binding sitei162 – 1621NADP 1 By similarity
Binding sitei186 – 1861NADP 1; via carbonyl oxygen By similarity
Binding sitei186 – 1861Substrate By similarity
Binding sitei254 – 2541Substrate By similarity
Binding sitei273 – 2731Substrate By similarity
Active sitei278 – 2781Proton acceptor By similarity
Binding sitei372 – 3721NADP 2 By similarity
Binding sitei375 – 3751Substrate By similarity
Binding sitei380 – 3801Substrate By similarity
Binding sitei381 – 3811NADP 2 By similarity
Binding sitei385 – 3851NADP 2 By similarity
Binding sitei408 – 4081NADP 2 By similarity
Binding sitei410 – 4101Substrate By similarity
Binding sitei502 – 5021NADP 2 By similarity
Binding sitei518 – 5181NADP 2 By similarity
Binding sitei524 – 5241NADP 2 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi53 – 608NADP 1 By similarity
Nucleotide bindingi416 – 4183NADP 2 By similarity
Nucleotide bindingi436 – 4383NADP 2 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
  2. NADP binding Source: InterPro

GO - Biological processi

  1. glucose 6-phosphate metabolic process Source: UniProtKB
  2. NADP metabolic process Source: UniProtKB
  3. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:g6pd
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Glucose-6-phosphate 1-dehydrogenaseUniRule annotationPRO_0000068088Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP54996.
SMRiP54996. Positions 43-530.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni216 – 2205Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54996-1 [UniParc]FASTAAdd to Basket

« Hide

MMIILFNCFF CASFREDGQH PTVSLGGVWG AAKELHEDKE FHQSDVHVFI    50
IMGASGDLAK KKIYPTLWWL FRDGLLPEQT YFVGFARSAL TVDAIRTSCM 100
PYLKVTETES DRLSAFFSRN SYISGNYTAG GSFSELNAHI MSLPGASDAN 150
RLFYLALPPT IYHSVTENIK HFCMSAKGWN RVIVEKPFGH DLQSSEELST 200
HLSSLFTEDQ IYRIDHYLGK EMVQNLMVLR FGNRIFGPIW NRDNVACVVL 250
TFKEPFGTQG RGGYFDDFGI IRDVMQNHML QMLCLVAMEK PASTNSDDVR 300
DEKVKVLKCI VPASMSDVVL GQYVGDPEGE GDAKLGYLDD PTVPKGSTQA 350
TFATVVLYVH NERWDGVPFI LRCGKALNER KAEVRLQFTD VPGDIFRNQC 400
YRNELVVRVQ PNEAIYAKMM SKKPGVYFTP EETELDLTYK SRYKDVKLPD 450
AYERLILDVF CGSQMHFVAS DELREAWRIF TPLLHQIEKE KPKPIPYKYG 500
SRGPAEADEL EKRVGFRYEG TYKWVNPHRL 530
Length:530
Mass (Da):60,469
Last modified:October 1, 1996 - v1
Checksum:iFC73FB53D834EF29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83611 Genomic DNA. Translation: CAA58590.2.
PIRiA56841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83611 Genomic DNA. Translation: CAA58590.2 .
PIRi A56841.

3D structure databases

ProteinModelPortali P54996.
SMRi P54996. Positions 43-530.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic structure and sequence of the Fugu rubripes glucose-6-phosphate dehydrogenase gene (G6PD)."
    Mason P.J., Stevens D.J., Luzzatto L., Brenner S., Aparicio S.
    Genomics 26:587-591(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiG6PD_TAKRU
AccessioniPrimary (citable) accession number: P54996
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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