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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

g6pd

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (g6pd), Glucose-6-phosphate 1-dehydrogenase (LOC101071498), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (LOC101071498), Glucose-6-phosphate 1-dehydrogenase (G6PD (1 of many))
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (pgd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87NADP 1By similarity1
Binding sitei162NADP 1By similarity1
Binding sitei186NADP 1; via carbonyl oxygenBy similarity1
Binding sitei186SubstrateBy similarity1
Binding sitei254SubstrateBy similarity1
Binding sitei273SubstrateBy similarity1
Active sitei278Proton acceptorBy similarity1
Binding sitei372NADP 2By similarity1
Binding sitei375SubstrateBy similarity1
Binding sitei380SubstrateBy similarity1
Binding sitei381NADP 2By similarity1
Binding sitei385NADP 2By similarity1
Binding sitei408NADP 2By similarity1
Binding sitei410SubstrateBy similarity1
Binding sitei502NADP 2By similarity1
Binding sitei518NADP 2By similarity1
Binding sitei524NADP 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi53 – 60NADP 1By similarity8
Nucleotide bindingi416 – 418NADP 2By similarity3
Nucleotide bindingi436 – 438NADP 2By similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:g6pd
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000680881 – 530Glucose-6-phosphate 1-dehydrogenaseAdd BLAST530

Structurei

3D structure databases

ProteinModelPortaliP54996.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni216 – 220Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

InParanoidiP54996.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54996-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMIILFNCFF CASFREDGQH PTVSLGGVWG AAKELHEDKE FHQSDVHVFI
60 70 80 90 100
IMGASGDLAK KKIYPTLWWL FRDGLLPEQT YFVGFARSAL TVDAIRTSCM
110 120 130 140 150
PYLKVTETES DRLSAFFSRN SYISGNYTAG GSFSELNAHI MSLPGASDAN
160 170 180 190 200
RLFYLALPPT IYHSVTENIK HFCMSAKGWN RVIVEKPFGH DLQSSEELST
210 220 230 240 250
HLSSLFTEDQ IYRIDHYLGK EMVQNLMVLR FGNRIFGPIW NRDNVACVVL
260 270 280 290 300
TFKEPFGTQG RGGYFDDFGI IRDVMQNHML QMLCLVAMEK PASTNSDDVR
310 320 330 340 350
DEKVKVLKCI VPASMSDVVL GQYVGDPEGE GDAKLGYLDD PTVPKGSTQA
360 370 380 390 400
TFATVVLYVH NERWDGVPFI LRCGKALNER KAEVRLQFTD VPGDIFRNQC
410 420 430 440 450
YRNELVVRVQ PNEAIYAKMM SKKPGVYFTP EETELDLTYK SRYKDVKLPD
460 470 480 490 500
AYERLILDVF CGSQMHFVAS DELREAWRIF TPLLHQIEKE KPKPIPYKYG
510 520 530
SRGPAEADEL EKRVGFRYEG TYKWVNPHRL
Length:530
Mass (Da):60,469
Last modified:October 1, 1996 - v1
Checksum:iFC73FB53D834EF29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83611 Genomic DNA. Translation: CAA58590.2.
PIRiA56841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83611 Genomic DNA. Translation: CAA58590.2.
PIRiA56841.

3D structure databases

ProteinModelPortaliP54996.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiP54996.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PD_TAKRU
AccessioniPrimary (citable) accession number: P54996
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.