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P54996 (G6PD_TAKRU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966
PRO_0000068088

Regions

Nucleotide binding53 – 608NADP 1 By similarity
Nucleotide binding416 – 4183NADP 2 By similarity
Nucleotide binding436 – 4383NADP 2 By similarity
Region216 – 2205Substrate binding By similarity

Sites

Active site2781Proton acceptor By similarity
Binding site871NADP 1 By similarity
Binding site1621NADP 1 By similarity
Binding site1861NADP 1; via carbonyl oxygen By similarity
Binding site1861Substrate By similarity
Binding site2541Substrate By similarity
Binding site2731Substrate By similarity
Binding site3721NADP 2 By similarity
Binding site3751Substrate By similarity
Binding site3801Substrate By similarity
Binding site3811NADP 2 By similarity
Binding site3851NADP 2 By similarity
Binding site4081NADP 2 By similarity
Binding site4101Substrate By similarity
Binding site5021NADP 2 By similarity
Binding site5181NADP 2 By similarity
Binding site5241NADP 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P54996 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: FC73FB53D834EF29

FASTA53060,469
        10         20         30         40         50         60 
MMIILFNCFF CASFREDGQH PTVSLGGVWG AAKELHEDKE FHQSDVHVFI IMGASGDLAK 

        70         80         90        100        110        120 
KKIYPTLWWL FRDGLLPEQT YFVGFARSAL TVDAIRTSCM PYLKVTETES DRLSAFFSRN 

       130        140        150        160        170        180 
SYISGNYTAG GSFSELNAHI MSLPGASDAN RLFYLALPPT IYHSVTENIK HFCMSAKGWN 

       190        200        210        220        230        240 
RVIVEKPFGH DLQSSEELST HLSSLFTEDQ IYRIDHYLGK EMVQNLMVLR FGNRIFGPIW 

       250        260        270        280        290        300 
NRDNVACVVL TFKEPFGTQG RGGYFDDFGI IRDVMQNHML QMLCLVAMEK PASTNSDDVR 

       310        320        330        340        350        360 
DEKVKVLKCI VPASMSDVVL GQYVGDPEGE GDAKLGYLDD PTVPKGSTQA TFATVVLYVH 

       370        380        390        400        410        420 
NERWDGVPFI LRCGKALNER KAEVRLQFTD VPGDIFRNQC YRNELVVRVQ PNEAIYAKMM 

       430        440        450        460        470        480 
SKKPGVYFTP EETELDLTYK SRYKDVKLPD AYERLILDVF CGSQMHFVAS DELREAWRIF 

       490        500        510        520        530 
TPLLHQIEKE KPKPIPYKYG SRGPAEADEL EKRVGFRYEG TYKWVNPHRL 

« Hide

References

[1]"Genomic structure and sequence of the Fugu rubripes glucose-6-phosphate dehydrogenase gene (G6PD)."
Mason P.J., Stevens D.J., Luzzatto L., Brenner S., Aparicio S.
Genomics 26:587-591(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X83611 Genomic DNA. Translation: CAA58590.2.
PIRA56841.

3D structure databases

ProteinModelPortalP54996.
SMRP54996. Positions 43-530.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_TAKRU
AccessionPrimary (citable) accession number: P54996
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways