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Reviewed, UniProtKB/Swiss-Prot P54996 (G6PD_TAKRU)

Last modified February 9, 2010. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49
Gene names
Name: g6pd
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifier31033 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaTetraodontiformesTetradontoideaTetraodontidaeTakifugu

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Glucose-6-phosphate 1-dehydrogenase
PRO_0000068088

Sites

Active site2781Proton acceptor By similarity
Binding site551NADP By similarity
Binding site871NADP By similarity
Binding site2161Substrate By similarity
Binding site2201Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P54996-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: FC73FB53D834EF29

FASTA53060,469
        10         20         30         40         50         60 
MMIILFNCFF CASFREDGQH PTVSLGGVWG AAKELHEDKE FHQSDVHVFI IMGASGDLAK 

        70         80         90        100        110        120 
KKIYPTLWWL FRDGLLPEQT YFVGFARSAL TVDAIRTSCM PYLKVTETES DRLSAFFSRN 

       130        140        150        160        170        180 
SYISGNYTAG GSFSELNAHI MSLPGASDAN RLFYLALPPT IYHSVTENIK HFCMSAKGWN 

       190        200        210        220        230        240 
RVIVEKPFGH DLQSSEELST HLSSLFTEDQ IYRIDHYLGK EMVQNLMVLR FGNRIFGPIW 

       250        260        270        280        290        300 
NRDNVACVVL TFKEPFGTQG RGGYFDDFGI IRDVMQNHML QMLCLVAMEK PASTNSDDVR 

       310        320        330        340        350        360 
DEKVKVLKCI VPASMSDVVL GQYVGDPEGE GDAKLGYLDD PTVPKGSTQA TFATVVLYVH 

       370        380        390        400        410        420 
NERWDGVPFI LRCGKALNER KAEVRLQFTD VPGDIFRNQC YRNELVVRVQ PNEAIYAKMM 

       430        440        450        460        470        480 
SKKPGVYFTP EETELDLTYK SRYKDVKLPD AYERLILDVF CGSQMHFVAS DELREAWRIF 

       490        500        510        520        530 
TPLLHQIEKE KPKPIPYKYG SRGPAEADEL EKRVGFRYEG TYKWVNPHRL 

« Hide

References

[1]"Genomic structure and sequence of the Fugu rubripes glucose-6-phosphate dehydrogenase gene (G6PD)."
Mason P.J., Stevens D.J., Luzzatto L., Brenner S., Aparicio S.
Genomics 26:587-591(1995) [PubMed: 7607684] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X83611 Genomic DNA. Translation: CAA58590.2.
PIRA56841.

3D structure databases

SMRP54996. Positions 43-530.
ModBaseSearch...

Protein-protein interaction databases

STRINGP54996.

Genome annotation databases

EnsemblENSTRUT00000003235; ENSTRUP00000003217; ENSTRUG00000001399; Takifugu rubripes. [Genome view]

Phylogenomic databases

HOVERGENP54996.

Enzyme and pathway databases

BRENDA1.1.1.49. 281122.

Family and domain databases

InterProIPR001282. Glc-6-P_DH.
IPR019796. Glc-6-P_DH_AS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR23429. G6PDH. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_TAKRU
AccessionPrimary (citable) accession number: P54996
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 9, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents