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P54977

- CRTB_STRGR

UniProt

P54977 - CRTB_STRGR

Protein

Phytoene synthase

Gene

crtB

Organism
Streptomyces griseus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene By similarity.By similarity

    Cofactori

    ATP. ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction By similarity.By similarity
    Manganese or magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. carotenoid biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00799.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phytoene synthase (EC:2.5.1.-)
    Short name:
    PSase
    Gene namesi
    Name:crtB
    Synonyms:crtI
    OrganismiStreptomyces griseus
    Taxonomic identifieri1911 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Phytoene synthasePRO_0000067435Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP54977.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phytoene/squalene synthase family.Curated

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54977-1 [UniParc]FASTAAdd to Basket

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    MTVHELDAAG IHDPALRAAY TRCRGLNARH GKTYFLATRL LPVDRRPAVH    50
    ALYGFARWAD DIVDDLDTPA TPGERARALL GLEAQLEAGL RGARAAEPVI 100
    RALADTAARY TIDHRHFTDF LSSMRSDLTV GGYASYEELG RYMHGSAAVI 150
    GLQMLPVLGT VVAREEAAPH AAALGVAFQL TNFLRDVGED LDRGRLYLPT 200
    ELLAAHGADR DRFEWSRSTG MPDSRITDVL RAAAAHNRAV YRAALPGIAM 250
    LAPVSRPCIR TAFVLYSGIL DAIEADGYAV LHRRAVVPRR RRAAVALDGL 300
    VRAVAVRTVC RRRADAVDAS RSAELSRPRT AGGPAPVRRE AV 342
    Length:342
    Mass (Da):37,137
    Last modified:October 1, 1996 - v1
    Checksum:i3685F999CBC0227C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37405 Genomic DNA. Translation: AAA91951.1.
    X95596 Genomic DNA. Translation: CAA64851.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37405 Genomic DNA. Translation: AAA91951.1 .
    X95596 Genomic DNA. Translation: CAA64851.1 .

    3D structure databases

    ProteinModelPortali P54977.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00799 .

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Activation and analysis of cryptic crt genes for carotenoid biosynthesis from Streptomyces griseus."
      Schumann G., Nurnberger H., Sandmann G., Kruegel H.J.
      Mol. Gen. Genet. 252:658-666(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: JA 3933.

    Entry informationi

    Entry nameiCRTB_STRGR
    AccessioniPrimary (citable) accession number: P54977
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3