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P54977

- CRTB_STRGR

UniProt

P54977 - CRTB_STRGR

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Protein
Phytoene synthase
Gene
crtB, crtI
Organism
Streptomyces griseus
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene By similarity.

Cofactori

ATP. ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction By similarity.
Manganese or magnesium By similarity.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00799.

Names & Taxonomyi

Protein namesi
Recommended name:
Phytoene synthase (EC:2.5.1.-)
Short name:
PSase
Gene namesi
Name:crtB
Synonyms:crtI
OrganismiStreptomyces griseus
Taxonomic identifieri1911 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Phytoene synthase
PRO_0000067435Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP54977.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54977-1 [UniParc]FASTAAdd to Basket

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MTVHELDAAG IHDPALRAAY TRCRGLNARH GKTYFLATRL LPVDRRPAVH    50
ALYGFARWAD DIVDDLDTPA TPGERARALL GLEAQLEAGL RGARAAEPVI 100
RALADTAARY TIDHRHFTDF LSSMRSDLTV GGYASYEELG RYMHGSAAVI 150
GLQMLPVLGT VVAREEAAPH AAALGVAFQL TNFLRDVGED LDRGRLYLPT 200
ELLAAHGADR DRFEWSRSTG MPDSRITDVL RAAAAHNRAV YRAALPGIAM 250
LAPVSRPCIR TAFVLYSGIL DAIEADGYAV LHRRAVVPRR RRAAVALDGL 300
VRAVAVRTVC RRRADAVDAS RSAELSRPRT AGGPAPVRRE AV 342
Length:342
Mass (Da):37,137
Last modified:October 1, 1996 - v1
Checksum:i3685F999CBC0227C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37405 Genomic DNA. Translation: AAA91951.1.
X95596 Genomic DNA. Translation: CAA64851.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37405 Genomic DNA. Translation: AAA91951.1 .
X95596 Genomic DNA. Translation: CAA64851.1 .

3D structure databases

ProteinModelPortali P54977.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00799 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Activation and analysis of cryptic crt genes for carotenoid biosynthesis from Streptomyces griseus."
    Schumann G., Nurnberger H., Sandmann G., Kruegel H.J.
    Mol. Gen. Genet. 252:658-666(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: JA 3933.

Entry informationi

Entry nameiCRTB_STRGR
AccessioniPrimary (citable) accession number: P54977
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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