Geranylgeranyl pyrophosphate synthetase - Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

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Reviewed, UniProtKB/Swiss-Prot P54976 (CRTE_RHOS4)

Last modified November 3, 2009. Version 55. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Geranylgeranyl pyrophosphate synthetase
      Short name=GGPP synthetase
    EC=2.5.1.29
Alternative name(s):
    Farnesyltranstransferase

Gene names

Name:	crtE
Ordered Locus Names:	RHOS4_18710
ORF Names:	RSP_0265

Organism

Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) [Complete proteome] [HAMAP]

Taxonomic identifier

272943 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

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Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Catalytic activity	Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Cofactor	Binds 3 magnesium ions per subunit By similarity.
Pathway	Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

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Ontologies

Keywords
Biological process	Carotenoid biosynthesis Chlorophyll biosynthesis Isoprene biosynthesis Photosynthesis
Ligand	Magnesium Metal-binding
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carotenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW photosynthesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	farnesyltranstransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 288

288

Geranylgeranyl pyrophosphate synthetase

PRO_0000123995

Sites

Metal binding

Magnesium 1 By similarity

Metal binding

Magnesium 2 By similarity

Metal binding

Magnesium 1 By similarity

Metal binding

Magnesium 2 By similarity

Metal binding

208

Magnesium 3 By similarity

Binding site

Isopentenyl diphosphate By similarity

Binding site

Isopentenyl diphosphate By similarity

Binding site

Farnesyl diphosphate By similarity

Binding site

Isopentenyl diphosphate By similarity

Binding site

170

Farnesyl diphosphate By similarity

Binding site

171

Farnesyl diphosphate By similarity

Binding site

205

Farnesyl diphosphate By similarity

Experimental info

Sequence conflict

A → R in CAB38744. Ref.1

Sequence conflict

D → S in CAB38744. Ref.1

Sequence conflict

A → V in AAF24294. Ref.2

Sequence conflict

123

R → G in CAB38744. Ref.1

Sequence conflict

128

Q → R in CAB38744. Ref.1

Sequence conflict

234

N → S in CAB38744. Ref.1

Sequence conflict

247

R → G in CAB38744. Ref.1

Sequence conflict

264

G → A in CAB38744. Ref.1

Sequence conflict

277

E → D in CAB38744. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

P54976-1 [UniParc].

Last modified January 24, 2006. Version 3.
Checksum: FAB8D98C8557A8A2
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FASTA

288

30,229

        10         20         30         40         50         60 
MAFEQRIEAA MAAAIARGQG SEAPSKLATA LDYAVTPGGA RIRPTLLLSV ATACGDDRPA 

        70         80         90        100        110        120 
LSDAAAVALE LIHCASLVHD DLPCFDDAEI RRGKPTVHRA YSEPLAILTG DSLIVMGFEV 

       130        140        150        160        170        180 
LARAAADQPQ RALQLVTALA VRTGMPMGIC AGQGWESESQ INLSAYHRAK TGALFIAATQ 

       190        200        210        220        230        240 
MGAIAAGYEA EPWEELGARI GEAFQVADDL RDALCDAETL GKPAGQDEIH ARPNAVREYG 

       250        260        270        280 
VEGAAKRLKD ILGGAIASIP SCPGEAMLAE MVRRYAEKIV PAQVAARV

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete DNA sequence, specific Tn5 insertion map, and gene assignment of the carotenoid biosynthesis pathway of Rhodobacter sphaeroides." Lang H.P., Cogdell R.J., Takaichi S., Hunter C.N. J. Bacteriol. 177:2064-2073(1995) [PubMed: 7721699] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DNA sequence analysis of the photosynthesis region of Rhodobacter sphaeroides 2.4.1." Choudhary M., Kaplan S. Nucleic Acids Res. 28:862-867(2000) [PubMed: 10648776] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases
	AJ010302 Genomic DNA. Translation: CAB38744.1. AF195122 Genomic DNA. Translation: AAF24294.1. CP000143 Genomic DNA. Translation: ABA79439.1.
PIR	S49625. T50750.
RefSeq	YP_353340.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P54976.
Genome annotation databases
GeneID	3719275.
GenomeReviews	Gene locus RHOS4_18710 in contig CP000143_GR.
KEGG	rsp:RSP_0265.
NMPDR	fig\|272943.3.peg.1570.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P54976.
OMA	HCASLVH.
Enzyme and pathway databases
BioCyc	RSPH272943:RSP_0265-MON.
Family and domain databases
InterPro	IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHER	PTHR12001. Polyprenyl_synt. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

CRTE_RHOS4

Accession

Primary (citable) accession number: P54976
Secondary accession number(s): Q3J195, Q9RFC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 24, 2006
Last modified:	November 3, 2009
This is version 55 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents