P54975 (CRTB_PARSN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phytoene synthase
EC=2.5.1.32

Gene names

Name:

crtB

Organism

Paracoccus sp. (strain N81106 / MBIC 01143) (Agrobacterium aurantiacum)

Taxonomic identifier

81397 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Paracoccus

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reaction from prephytoene diphosphate to phytoene.
Catalytic activity	2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.
Pathway	Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.
Sequence similarities	Belongs to the phytoene/squalene synthase family.

Ontologies

Keywords
Biological process	Carotenoid biosynthesis
Molecular function	Transferase
Technical term	Multifunctional enzyme
Gene Ontology (GO)
Biological_process	carotenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	geranylgeranyl-diphosphate geranylgeranyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Phytoene synthase		PRO_0000067430

Sequences

	Sequence		Length	Mass (Da)
	P54975 [UniParc]. Last modified January 24, 2006. Version 2. Checksum: A9C253BED2B90E00	FASTA	304	33,030
	10 20 30 40 50 60 MSDLVLTSTE AITQGSQSFA TAAKLMPPGI RDDTVMLYAW CRHADDVIDG QALGSRPEAV 70 80 90 100 110 120 NDPQARLDGL RADTLAALQG DGPVTPPFAA LRAVARRHDF PQAWPMDLIE GFAMDVEARD 130 140 150 160 170 180 YRTLDDVLEY SYHVAGIVGV MMARVMGVRD DPVLDRACDL GLAFQLTNIA RDVIDDARIG 190 200 210 220 230 240 RCYLPGDWLD QAGARVDGPV PSPELYTVIL RLLDAAELYY ASARVGLADL PPRCAWSIAA 250 260 270 280 290 300 ALRIYRAIGL RIRKGGPEAY RQRISTSKAA KIGLLGIGGW DVARSRLPGA GVSRQGLWTR PHHA

References

[1]	"Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level." Misawa N., Satomi Y., Kondo K., Yokoyama A., Kajiwara S., Saito T., Ohtani T., Miki W. J. Bacteriol. 177:6575-6584(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Misawa N. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 56; 90-92 AND 284-295.
[3]	"Structure of the complete carotenoid biosynthesis gene cluster of Paracoccus sp. strain N81106." Maruyama T., Inomata Y., Haga M., Ide T., Misawa N. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D58420 Genomic DNA. Translation: BAA09595.2. AB206672 Genomic DNA. Translation: BAE47469.1.
3D structure databases
ProteinModelPortal	P54975.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00799; UER00773.
Family and domain databases
Gene3D	1.10.600.10. 1 hit.
InterPro	IPR002060. Squ/phyt_synthse. IPR019845. Squalene/phytoene_synthase_CS. IPR008949. Terpenoid_synth. [Graphical view]
Pfam	PF00494. SQS_PSY. 1 hit. [Graphical view]
SUPFAM	SSF48576. Terpenoid_synth. 1 hit.
PROSITE	PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit. PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CRTB_PARSN

Accession

Primary (citable) accession number: P54975
Secondary accession number(s): Q33DT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 24, 2006
Last modified:	April 3, 2013
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program