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P54975

- CRTB_PARSN

UniProt

P54975 - CRTB_PARSN

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Protein
15-cis-phytoene synthase
Gene
crtB
Organism
Paracoccus sp. (strain N81106 / MBIC 01143) (Agrobacterium aurantiacum)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of carotenoids for the production of astaxanthin. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield 15-cis phytoene.1 Publication

Catalytic activityi

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.1 Publication

Cofactori

ATP. ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction By similarity.
Manganese or magnesium By similarity.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00387.
UPA00799.

Names & Taxonomyi

Protein namesi
Recommended name:
15-cis-phytoene synthase (EC:2.5.1.32)
Short name:
PSase
Gene namesi
Name:crtB
OrganismiParacoccus sp. (strain N81106 / MBIC 01143) (Agrobacterium aurantiacum)
Taxonomic identifieri81397 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 30430415-cis-phytoene synthase
PRO_0000067430Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP54975.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54975-1 [UniParc]FASTAAdd to Basket

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MSDLVLTSTE AITQGSQSFA TAAKLMPPGI RDDTVMLYAW CRHADDVIDG    50
QALGSRPEAV NDPQARLDGL RADTLAALQG DGPVTPPFAA LRAVARRHDF 100
PQAWPMDLIE GFAMDVEARD YRTLDDVLEY SYHVAGIVGV MMARVMGVRD 150
DPVLDRACDL GLAFQLTNIA RDVIDDARIG RCYLPGDWLD QAGARVDGPV 200
PSPELYTVIL RLLDAAELYY ASARVGLADL PPRCAWSIAA ALRIYRAIGL 250
RIRKGGPEAY RQRISTSKAA KIGLLGIGGW DVARSRLPGA GVSRQGLWTR 300
PHHA 304
Length:304
Mass (Da):33,030
Last modified:January 24, 2006 - v2
Checksum:iA9C253BED2B90E00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D58420 Genomic DNA. Translation: BAA09595.2.
AB206672 Genomic DNA. Translation: BAE47469.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D58420 Genomic DNA. Translation: BAA09595.2 .
AB206672 Genomic DNA. Translation: BAE47469.1 .

3D structure databases

ProteinModelPortali P54975.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00387 .
UPA00799 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level."
    Misawa N., Satomi Y., Kondo K., Yokoyama A., Kajiwara S., Saito T., Ohtani T., Miki W.
    J. Bacteriol. 177:6575-6584(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY.
  2. Misawa N.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 56; 90-92 AND 284-295.
  3. "Structure of the complete carotenoid biosynthesis gene cluster of Paracoccus sp. strain N81106."
    Maruyama T., Inomata Y., Haga M., Ide T., Misawa N.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCRTB_PARSN
AccessioniPrimary (citable) accession number: P54975
Secondary accession number(s): Q33DT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 24, 2006
Last modified: October 16, 2013
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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