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P54970

- ILL2_ARATH

UniProt

P54970 - ILL2_ARATH

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Protein

IAA-amino acid hydrolase ILR1-like 2

Gene
ILL2, At5g56660, MIK19.11
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes certain amino acid conjugates of the plant growth regulator indole-3-acetic acid (IAA), including IAA-Ala.

Cofactori

Manganese. The ion enhances activity.

GO - Molecular functioni

  1. IAA-Ala conjugate hydrolase activity Source: TAIR
  2. IAA-amino acid conjugate hydrolase activity Source: TAIR

GO - Biological processi

  1. auxin metabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese

Protein family/group databases

MEROPSiM20.014.

Names & Taxonomyi

Protein namesi
Recommended name:
IAA-amino acid hydrolase ILR1-like 2 (EC:3.5.1.-)
Gene namesi
Name:ILL2
Ordered Locus Names:At5g56660
ORF Names:MIK19.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G56660.

Subcellular locationi

Endoplasmic reticulum lumen Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum Source: TAIR
  2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 439418IAA-amino acid hydrolase ILR1-like 2PRO_0000001190Add
BLAST

Proteomic databases

PaxDbiP54970.
PRIDEiP54970.

Expressioni

Gene expression databases

GenevestigatoriP54970.

Structurei

Secondary structure

1
439
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi38 – 436
Helixi45 – 6016
Helixi69 – 8214
Beta strandi86 – 905
Turni91 – 933
Beta strandi94 – 10411
Beta strandi106 – 1127
Helixi139 – 15517
Helixi157 – 1593
Beta strandi161 – 1699
Turni172 – 1754
Helixi177 – 1837
Turni184 – 1896
Beta strandi190 – 20314
Beta strandi207 – 2093
Beta strandi211 – 2155
Beta strandi217 – 22711
Helixi240 – 25314
Helixi262 – 2643
Beta strandi266 – 2749
Beta strandi285 – 29612
Helixi298 – 31518
Beta strandi318 – 3258
Helixi326 – 3283
Beta strandi335 – 3373
Helixi339 – 35315
Helixi355 – 3573
Beta strandi358 – 3603
Helixi370 – 3745
Turni375 – 3784
Beta strandi379 – 3879
Beta strandi396 – 3983
Helixi405 – 4073
Helixi408 – 42720

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XMBX-ray2.00A22-439[»]
2Q43X-ray2.00A22-439[»]
ProteinModelPortaliP54970.
SMRiP54970. Positions 37-428.

Miscellaneous databases

EvolutionaryTraceiP54970.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi436 – 4394Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the peptidase M20 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1473.
HOGENOMiHOG000241403.
InParanoidiP54970.
KOiK14664.
OMAiRRNLHEH.
PhylomeDBiP54970.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
InterProiIPR017439. Amidohydrolase.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF005962. Pept_M20D_amidohydro. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01891. amidohydrolases. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54970-1 [UniParc]FASTAAdd to Basket

« Hide

MALNKLLSLT FQLLLFLLSV SSESPWIAED TSQIQTKLLE FAKSPEVFDW    50
MVKIRRKIHE NPELGYEELE TSKLIRSELE LIGIKYRYPV AITGVIGYIG 100
TGEPPFVALR ADMDALPIQE GVEWEHKSKI AGKMHACGHD GHVTMLLGAA 150
KILHEHRHHL QGTVVLIFQP AEEGLSGAKK MREEGALKNV EAIFGIHLSA 200
RIPFGKAASR AGSFLAGAGV FEAVITGKGG HAAIPQHTID PVVAASSIVL 250
SLQQLVSRET DPLDSKVVTV SKVNGGNAFN VIPDSITIGG TLRAFTGFTQ 300
LQQRVKEVIT KQAAVHRCNA SVNLTPNGRE PMPPTVNNKD LYKQFKKVVR 350
DLLGQEAFVE AAPVMGSEDF SYFAETIPGH FSLLGMQDET NGYASSHSPL 400
YRINEDVLPY GAAIHASMAV QYLKEKASKG SVSGFHEEL 439
Length:439
Mass (Da):47,856
Last modified:May 27, 2002 - v2
Checksum:iBFA5F35AF4C4F508
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti131 – 1311A → P in AAC49016. 1 Publication
Sequence conflicti236 – 2361Q → H in AAC49016. 1 Publication
Sequence conflicti240 – 2401D → G in AAL59907. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23796 mRNA. Translation: AAC49016.1.
AF047031 Genomic DNA. Translation: AAC04866.1.
AB013392 Genomic DNA. Translation: BAB09884.1.
CP002688 Genomic DNA. Translation: AED96793.1.
AY072084 mRNA. Translation: AAL59907.1.
RefSeqiNP_200477.1. NM_125049.3.
UniGeneiAt.46738.
At.66661.
At.66838.

Genome annotation databases

EnsemblPlantsiAT5G56660.1; AT5G56660.1; AT5G56660.
GeneIDi835767.
KEGGiath:AT5G56660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23796 mRNA. Translation: AAC49016.1 .
AF047031 Genomic DNA. Translation: AAC04866.1 .
AB013392 Genomic DNA. Translation: BAB09884.1 .
CP002688 Genomic DNA. Translation: AED96793.1 .
AY072084 mRNA. Translation: AAL59907.1 .
RefSeqi NP_200477.1. NM_125049.3.
UniGenei At.46738.
At.66661.
At.66838.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XMB X-ray 2.00 A 22-439 [» ]
2Q43 X-ray 2.00 A 22-439 [» ]
ProteinModelPortali P54970.
SMRi P54970. Positions 37-428.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M20.014.

Proteomic databases

PaxDbi P54970.
PRIDEi P54970.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G56660.1 ; AT5G56660.1 ; AT5G56660 .
GeneIDi 835767.
KEGGi ath:AT5G56660.

Organism-specific databases

GeneFarmi 1960. 187.
TAIRi AT5G56660.

Phylogenomic databases

eggNOGi COG1473.
HOGENOMi HOG000241403.
InParanoidi P54970.
KOi K14664.
OMAi RRNLHEH.
PhylomeDBi P54970.

Miscellaneous databases

EvolutionaryTracei P54970.

Gene expression databases

Genevestigatori P54970.

Family and domain databases

Gene3Di 3.30.70.360. 1 hit.
InterProi IPR017439. Amidohydrolase.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view ]
Pfami PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view ]
PIRSFi PIRSF005962. Pept_M20D_amidohydro. 1 hit.
SUPFAMi SSF55031. SSF55031. 1 hit.
TIGRFAMsi TIGR01891. amidohydrolases. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ILR1, an amidohydrolase that releases active indole-3-acetic acid from conjugates."
    Bartel B., Fink G.R.
    Science 268:1745-1748(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Landsberg erecta.
  2. "IAR3 encodes an auxin conjugate hydrolase from Arabidopsis."
    Davies R.T., Goetz D.H., Lasswell J.E., Anderson M.N., Bartel B.
    Plant Cell 11:365-376(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Columbia.
  3. "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence features of the regions of 1,367,185 bp covered by 19 physically assigned P1 and TAC clones."
    Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N., Tabata S.
    DNA Res. 5:203-216(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Characterization of a family of IAA-amino acid conjugate hydrolases from Arabidopsis."
    LeClere S., Tellez R., Rampey R.A., Matsuda S.P.T., Bartel B.
    J. Biol. Chem. 277:20446-20452(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  7. "X-ray structure of IAA-aminoacid hydrolase from Arabidopsis thaliana gene At5g56660."
    Wesenberg G.E., Smith D.W., Phillips G.N. Jr., Bitto E., Bingman C.A., Allard S.T.M.
    Submitted (OCT-2004) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 22-439.

Entry informationi

Entry nameiILL2_ARATH
AccessioniPrimary (citable) accession number: P54970
Secondary accession number(s): O49221
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 27, 2002
Last modified: May 14, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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