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Protein

Oligoribonuclease, mitochondrial

Gene

REX2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

3'-to-5' exoribonuclease specific for small oligoribonucleotides.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei184Sequence analysis1

GO - Molecular functioni

  • 3'-5' exonuclease activity Source: SGD
  • 3'-5'-exoribonuclease activity Source: SGD
  • nucleic acid binding Source: InterPro

GO - Biological processi

  • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • mitochondrial genome maintenance Source: SGD
  • U4 snRNA 3'-end processing Source: SGD
  • U5 snRNA 3'-end processing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciYEAST:G3O-32213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Oligoribonuclease, mitochondrial (EC:3.1.-.-)
Gene namesi
Name:REX2
Synonyms:YNT20
Ordered Locus Names:YLR059C
ORF Names:L2159
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR059C.
SGDiS000004049. REX2.

Subcellular locationi

  • Mitochondrion 1 Publication

GO - Cellular componenti

  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000020274? – 269Oligoribonuclease, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP54964.
PRIDEiP54964.

PTM databases

iPTMnetiP54964.

Interactioni

Protein-protein interaction databases

BioGridi31334. 43 interactors.
DIPiDIP-5084N.
IntActiP54964. 1 interactor.
MINTiMINT-549084.

Structurei

3D structure databases

ProteinModelPortaliP54964.
SMRiP54964.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 227ExonucleaseAdd BLAST173

Sequence similaritiesi

Belongs to the oligoribonuclease family.Curated
Contains 1 exonuclease domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000009255.
HOGENOMiHOG000246596.
InParanoidiP54964.
KOiK13288.
OMAiEICESKT.
OrthoDBiEOG092C4ZN4.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWLLFPARI VARTRPNLFS LYRRSVSQYL RPRTIQNLQS MAQTPELKTK
60 70 80 90 100
LFKPLVWIDC EMTGLDHVND RIIEICCIIT DGHLAPVKAA DGQGDSHYES
110 120 130 140 150
VIHYGPEVMN KMNEWCIEHH GNSGLTAKVL ASEKTLAQVE DELLEYIQRY
160 170 180 190 200
IPDKNVGVLA GNSVHMDRLF MVREFPKVID HLFYRIVDVS SIMEVARRHN
210 220 230 240 250
PALQARNPKK EAAHTAYSDI KESIAQLQWY MDNYLKPPQE TESVESIGSE
260
QPESPSSSTS SLKRQRTDF
Length:269
Mass (Da):30,870
Last modified:October 1, 1996 - v1
Checksum:iC942C823691E9815
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100S → T in AAA98633 (Ref. 1) Curated1
Sequence conflicti124 – 127GLTA → ESHP in AAA98633 (Ref. 1) Curated4
Sequence conflicti181H → R in AAT93024 (PubMed:17322287).Curated1
Sequence conflicti223 – 269SIAQL…QRTDF → HSSIAMVHGQLLEATTGNRV GRVNRI (Ref. 1) CuratedAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47977 Genomic DNA. Translation: AAA98633.1.
X94607 Genomic DNA. Translation: CAA64306.1.
Z73231 Genomic DNA. Translation: CAA97590.1.
AY693005 Genomic DNA. Translation: AAT93024.1.
BK006945 Genomic DNA. Translation: DAA09377.1.
PIRiS61633.
RefSeqiNP_013160.1. NM_001181946.1.

Genome annotation databases

EnsemblFungiiYLR059C; YLR059C; YLR059C.
GeneIDi850748.
KEGGisce:YLR059C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47977 Genomic DNA. Translation: AAA98633.1.
X94607 Genomic DNA. Translation: CAA64306.1.
Z73231 Genomic DNA. Translation: CAA97590.1.
AY693005 Genomic DNA. Translation: AAT93024.1.
BK006945 Genomic DNA. Translation: DAA09377.1.
PIRiS61633.
RefSeqiNP_013160.1. NM_001181946.1.

3D structure databases

ProteinModelPortaliP54964.
SMRiP54964.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31334. 43 interactors.
DIPiDIP-5084N.
IntActiP54964. 1 interactor.
MINTiMINT-549084.

PTM databases

iPTMnetiP54964.

Proteomic databases

MaxQBiP54964.
PRIDEiP54964.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR059C; YLR059C; YLR059C.
GeneIDi850748.
KEGGisce:YLR059C.

Organism-specific databases

EuPathDBiFungiDB:YLR059C.
SGDiS000004049. REX2.

Phylogenomic databases

GeneTreeiENSGT00390000009255.
HOGENOMiHOG000246596.
InParanoidiP54964.
KOiK13288.
OMAiEICESKT.
OrthoDBiEOG092C4ZN4.

Enzyme and pathway databases

BioCyciYEAST:G3O-32213-MONOMER.

Miscellaneous databases

PROiP54964.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiORN_YEAST
AccessioniPrimary (citable) accession number: P54964
Secondary accession number(s): D6VY61, E9P909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1730 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.