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Protein

Allergen Bla g 4

Gene
N/A
Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable ligand-binding protein.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Allergen Bla g 4
Alternative name(s):
Allergen Bla g IV
Allergen: Bla g 4
OrganismiBlattella germanica (German cockroach) (Blatta germanica)
Taxonomic identifieri6973 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei143. Bla g 4.
3141. Bla g 4.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 12›12Sequence analysisAdd
BLAST
Chaini13 – 182170Allergen Bla g 4PRO_0000017984Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Structurei

Secondary structure

1
182
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni14 – 163Combined sources
Helixi28 – 314Combined sources
Beta strandi33 – 419Combined sources
Helixi44 – 474Combined sources
Beta strandi48 – 569Combined sources
Turni57 – 593Combined sources
Beta strandi60 – 667Combined sources
Beta strandi74 – 8310Combined sources
Beta strandi86 – 916Combined sources
Helixi96 – 983Combined sources
Beta strandi100 – 1078Combined sources
Beta strandi109 – 1179Combined sources
Helixi120 – 1223Combined sources
Beta strandi126 – 1338Combined sources
Turni135 – 1373Combined sources
Helixi148 – 16922Combined sources
Helixi174 – 1763Combined sources
Beta strandi177 – 1793Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EBKX-ray1.90A/B7-182[»]
ProteinModelPortaliP54962.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54962.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR005657. Triabi/Procalin.
[Graphical view]
PfamiPF03973. Triabin. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AVLALCATDT LANEDCFRHE SLVPNLDYER FRGSWIIAAG TSEALTQYKC
60 70 80 90 100
WIDRFSYDDA LVSKYTDSQG KNRTTIRGRT KFEGNKFTID YNDKGKAFSA
110 120 130 140 150
PYSVLATDYE NYAIVEGCPA AANGHVIYVQ IRFSVRRFHP KLGDKEMIQH
160 170 180
YTLDQVNQHK KAIEEDLKHF NLKYEDLHST CH
Length:182
Mass (Da):20,927
Last modified:October 1, 1996 - v1
Checksum:i54B5C17485BEDF89
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40767 mRNA. Translation: AAA87851.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40767 mRNA. Translation: AAA87851.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EBKX-ray1.90A/B7-182[»]
ProteinModelPortaliP54962.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei143. Bla g 4.
3141. Bla g 4.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP54962.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR005657. Triabi/Procalin.
[Graphical view]
PfamiPF03973. Triabin. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of cockroach allergen, Bla g 4, identifies ligand binding proteins (or calycins) as a cause of IgE antibody responses."
    Arruda L.K., Vailes L.D., Hayden M.L., Benjamin D.C., Chapman M.D.
    J. Biol. Chem. 270:31196-31201(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.

Entry informationi

Entry nameiBLG4_BLAGE
AccessioniPrimary (citable) accession number: P54962
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 11, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.