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P54961

- HMCS1_BLAGE

UniProt

P54961 - HMCS1_BLAGE

Protein

Hydroxymethylglutaryl-CoA synthase 1

Gene

HMGCS-1

Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.By similarity

    Catalytic activityi

    Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei84 – 841Proton donor/acceptorPROSITE-ProRule annotation
    Active sitei116 – 1161Acyl-thioester intermediatePROSITE-ProRule annotation
    Active sitei246 – 2461Proton donor/acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. hydroxymethylglutaryl-CoA synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: InterPro
    2. sterol biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Enzyme and pathway databases

    BRENDAi2.3.3.10. 875.
    UniPathwayiUPA00058; UER00102.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxymethylglutaryl-CoA synthase 1 (EC:2.3.3.10)
    Short name:
    HMG-CoA synthase 1
    Alternative name(s):
    3-hydroxy-3-methylglutaryl coenzyme A synthase 1
    Gene namesi
    Name:HMGCS-1
    OrganismiBlattella germanica (German cockroach) (Blatta germanica)
    Taxonomic identifieri6973 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 453453Hydroxymethylglutaryl-CoA synthase 1PRO_0000213752Add
    BLAST

    Proteomic databases

    PRIDEiP54961.

    Structurei

    3D structure databases

    ProteinModelPortaliP54961.
    SMRiP54961. Positions 5-452.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMG-CoA synthase family.Curated

    Family and domain databases

    Gene3Di3.40.47.10. 1 hit.
    InterProiIPR000590. HMG_CoA_synt_AS.
    IPR013746. HMG_CoA_synt_C_dom.
    IPR013528. HMG_CoA_synth_N.
    IPR010122. HMG_CoA_synthase_euk.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF08540. HMG_CoA_synt_C. 1 hit.
    PF01154. HMG_CoA_synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 3 hits.
    TIGRFAMsiTIGR01833. HMG-CoA-S_euk. 1 hit.
    PROSITEiPS01226. HMG_COA_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54961-1 [UniParc]FASTAAdd to Basket

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    MWPSDVGIVA LELIFPSQYV DQVDLEVYDN VSAGKYTVGL GQARMGFCTD    50
    REDINSLCLT VVSRLMERWS IPYSQIGRLE VGTETLLDKS KSVKTVLMQL 100
    FKDNTDIEGV DTVNACYGGT SALFNAISWV ESSSWDGRYA LVVAGDIAVY 150
    AKGSARPTGG AGAVAMLVGA NAPLVFDRGV RSSHMQHAYD FYKPDLSSLY 200
    PTVDGKLSIQ CYLSALDHCY QLYCSKIQKQ LGEKFDIERL DAVLFHAPYC 250
    KLVQKSLARL VLNDFVRASE EERTTKYSSL EALKGVKLED TYFDREVEKA 300
    VMTYSKNMFE EKTKPSLLLA NQVGNMYTPS LYGGLVSLLV SKSAQELAGK 350
    RVALFSYGSG LASSMFSLRI SSDASAKSSL QRLVSNLSHI KPQLDLRHKV 400
    SPEEFAQTME TREHNHHKAP YTPEGSIDVL FPGTWYLESV DSLYRRSYKQ 450
    VPG 453
    Length:453
    Mass (Da):50,332
    Last modified:October 1, 1996 - v1
    Checksum:iC79EB2376270F348
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73679 mRNA. Translation: CAA52032.1.
    PIRiS38986.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73679 mRNA. Translation: CAA52032.1 .
    PIRi S38986.

    3D structure databases

    ProteinModelPortali P54961.
    SMRi P54961. Positions 5-452.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P54961.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00058 ; UER00102 .
    BRENDAi 2.3.3.10. 875.

    Family and domain databases

    Gene3Di 3.40.47.10. 1 hit.
    InterProi IPR000590. HMG_CoA_synt_AS.
    IPR013746. HMG_CoA_synt_C_dom.
    IPR013528. HMG_CoA_synth_N.
    IPR010122. HMG_CoA_synthase_euk.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF08540. HMG_CoA_synt_C. 1 hit.
    PF01154. HMG_CoA_synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 3 hits.
    TIGRFAMsi TIGR01833. HMG-CoA-S_euk. 1 hit.
    PROSITEi PS01226. HMG_COA_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "3-hydroxy-3-methylglutaryl-coenzyme-A synthase from Blattella germanica. Cloning, expression, developmental pattern and tissue expression."
      Martinez-Gonzalez J., Buesa C., Piulachs M.D., Belles X., Hegardt F.G.
      Eur. J. Biochem. 217:691-699(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHMCS1_BLAGE
    AccessioniPrimary (citable) accession number: P54961
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3