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P54961 (HMCS1_BLAGE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxymethylglutaryl-CoA synthase 1

Short name=HMG-CoA synthase 1
EC=2.3.3.10
Alternative name(s):
3-hydroxy-3-methylglutaryl coenzyme A synthase 1
Gene names
Name:HMGCS-1
OrganismBlattella germanica (German cockroach) (Blatta germanica)
Taxonomic identifier6973 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase By similarity.

Catalytic activity

Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.

Sequence similarities

Belongs to the HMG-CoA synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Hydroxymethylglutaryl-CoA synthase 1
PRO_0000213752

Sites

Active site841Proton donor/acceptor By similarity
Active site1161Acyl-thioester intermediate By similarity
Active site2461Proton donor/acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
P54961 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: C79EB2376270F348

FASTA45350,332
        10         20         30         40         50         60 
MWPSDVGIVA LELIFPSQYV DQVDLEVYDN VSAGKYTVGL GQARMGFCTD REDINSLCLT 

        70         80         90        100        110        120 
VVSRLMERWS IPYSQIGRLE VGTETLLDKS KSVKTVLMQL FKDNTDIEGV DTVNACYGGT 

       130        140        150        160        170        180 
SALFNAISWV ESSSWDGRYA LVVAGDIAVY AKGSARPTGG AGAVAMLVGA NAPLVFDRGV 

       190        200        210        220        230        240 
RSSHMQHAYD FYKPDLSSLY PTVDGKLSIQ CYLSALDHCY QLYCSKIQKQ LGEKFDIERL 

       250        260        270        280        290        300 
DAVLFHAPYC KLVQKSLARL VLNDFVRASE EERTTKYSSL EALKGVKLED TYFDREVEKA 

       310        320        330        340        350        360 
VMTYSKNMFE EKTKPSLLLA NQVGNMYTPS LYGGLVSLLV SKSAQELAGK RVALFSYGSG 

       370        380        390        400        410        420 
LASSMFSLRI SSDASAKSSL QRLVSNLSHI KPQLDLRHKV SPEEFAQTME TREHNHHKAP 

       430        440        450 
YTPEGSIDVL FPGTWYLESV DSLYRRSYKQ VPG 

« Hide

References

[1]"3-hydroxy-3-methylglutaryl-coenzyme-A synthase from Blattella germanica. Cloning, expression, developmental pattern and tissue expression."
Martinez-Gonzalez J., Buesa C., Piulachs M.D., Belles X., Hegardt F.G.
Eur. J. Biochem. 217:691-699(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X73679 mRNA. Translation: CAA52032.1.
PIRS38986.

3D structure databases

ProteinModelPortalP54961.
SMRP54961. Positions 5-452.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP54961.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.3.3.10. 875.
UniPathwayUPA00058; UER00102.

Family and domain databases

Gene3D3.40.47.10. 1 hit.
InterProIPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view]
SUPFAMSSF53901. SSF53901. 3 hits.
TIGRFAMsTIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEPS01226. HMG_COA_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHMCS1_BLAGE
AccessionPrimary (citable) accession number: P54961
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways