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P54961

- HMCS1_BLAGE

UniProt

P54961 - HMCS1_BLAGE

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Protein
Hydroxymethylglutaryl-CoA synthase 1
Gene
HMGCS-1
Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase By similarity.

Catalytic activityi

Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Proton donor/acceptor By similarity
Active sitei116 – 1161Acyl-thioester intermediate By similarity
Active sitei246 – 2461Proton donor/acceptor By similarity

GO - Molecular functioni

  1. hydroxymethylglutaryl-CoA synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoprenoid biosynthetic process Source: InterPro
  2. sterol biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Enzyme and pathway databases

BRENDAi2.3.3.10. 875.
UniPathwayiUPA00058; UER00102.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylglutaryl-CoA synthase 1 (EC:2.3.3.10)
Short name:
HMG-CoA synthase 1
Alternative name(s):
3-hydroxy-3-methylglutaryl coenzyme A synthase 1
Gene namesi
Name:HMGCS-1
OrganismiBlattella germanica (German cockroach) (Blatta germanica)
Taxonomic identifieri6973 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Hydroxymethylglutaryl-CoA synthase 1
PRO_0000213752Add
BLAST

Proteomic databases

PRIDEiP54961.

Structurei

3D structure databases

ProteinModelPortaliP54961.
SMRiP54961. Positions 5-452.

Family & Domainsi

Sequence similaritiesi

Belongs to the HMG-CoA synthase family.

Family and domain databases

Gene3Di3.40.47.10. 1 hit.
InterProiIPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 3 hits.
TIGRFAMsiTIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEiPS01226. HMG_COA_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54961-1 [UniParc]FASTAAdd to Basket

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MWPSDVGIVA LELIFPSQYV DQVDLEVYDN VSAGKYTVGL GQARMGFCTD    50
REDINSLCLT VVSRLMERWS IPYSQIGRLE VGTETLLDKS KSVKTVLMQL 100
FKDNTDIEGV DTVNACYGGT SALFNAISWV ESSSWDGRYA LVVAGDIAVY 150
AKGSARPTGG AGAVAMLVGA NAPLVFDRGV RSSHMQHAYD FYKPDLSSLY 200
PTVDGKLSIQ CYLSALDHCY QLYCSKIQKQ LGEKFDIERL DAVLFHAPYC 250
KLVQKSLARL VLNDFVRASE EERTTKYSSL EALKGVKLED TYFDREVEKA 300
VMTYSKNMFE EKTKPSLLLA NQVGNMYTPS LYGGLVSLLV SKSAQELAGK 350
RVALFSYGSG LASSMFSLRI SSDASAKSSL QRLVSNLSHI KPQLDLRHKV 400
SPEEFAQTME TREHNHHKAP YTPEGSIDVL FPGTWYLESV DSLYRRSYKQ 450
VPG 453
Length:453
Mass (Da):50,332
Last modified:October 1, 1996 - v1
Checksum:iC79EB2376270F348
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73679 mRNA. Translation: CAA52032.1.
PIRiS38986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73679 mRNA. Translation: CAA52032.1 .
PIRi S38986.

3D structure databases

ProteinModelPortali P54961.
SMRi P54961. Positions 5-452.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P54961.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00058 ; UER00102 .
BRENDAi 2.3.3.10. 875.

Family and domain databases

Gene3Di 3.40.47.10. 1 hit.
InterProi IPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 3 hits.
TIGRFAMsi TIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEi PS01226. HMG_COA_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "3-hydroxy-3-methylglutaryl-coenzyme-A synthase from Blattella germanica. Cloning, expression, developmental pattern and tissue expression."
    Martinez-Gonzalez J., Buesa C., Piulachs M.D., Belles X., Hegardt F.G.
    Eur. J. Biochem. 217:691-699(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHMCS1_BLAGE
AccessioniPrimary (citable) accession number: P54961
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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