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Protein

Aspartic protease Bla g 2

Gene
N/A
Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a digestive enzyme in the cockroach.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551By similarity
Metal bindingi178 – 1781Zinc
Metal bindingi186 – 1861Zinc
Active sitei239 – 2391By similarity
Metal bindingi326 – 3261Zinc
Metal bindingi330 – 3301Zinc

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiA01.950.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic protease Bla g 2 (EC:3.4.23.-)
Alternative name(s):
Allergen Bla g II
Allergen: Bla g 2
OrganismiBlattella germanica (German cockroach) (Blatta germanica)
Taxonomic identifieri6973 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei141. Bla g 2.
3140. Bla g 2.0101.
4012. Bla g 2.0201.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 245Removed in mature formPRO_0000025935
Chaini25 – 352328Aspartic protease Bla g 2PRO_0000025936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 151
Disulfide bondi68 ↔ 73
Disulfide bondi75 ↔ 136
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi261 ↔ 272
Disulfide bondi276 ↔ 309
Glycosylationi295 – 2951N-linked (GlcNAc...)2 Publications
Glycosylationi340 – 3401N-linked (GlcNAc...)2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1
352
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi31 – 355Combined sources
Beta strandi39 – 457Combined sources
Beta strandi48 – 558Combined sources
Beta strandi61 – 644Combined sources
Helixi71 – 744Combined sources
Beta strandi87 – 893Combined sources
Beta strandi94 – 985Combined sources
Turni99 – 1013Combined sources
Beta strandi102 – 11514Combined sources
Beta strandi118 – 13114Combined sources
Helixi134 – 1374Combined sources
Beta strandi141 – 1455Combined sources
Beta strandi154 – 1574Combined sources
Helixi160 – 1667Combined sources
Beta strandi172 – 1809Combined sources
Beta strandi186 – 1927Combined sources
Helixi197 – 1993Combined sources
Beta strandi200 – 21011Combined sources
Beta strandi212 – 2154Combined sources
Beta strandi220 – 2245Combined sources
Beta strandi227 – 2304Combined sources
Beta strandi235 – 2384Combined sources
Beta strandi243 – 2486Combined sources
Helixi249 – 25911Combined sources
Beta strandi262 – 2654Combined sources
Beta strandi270 – 2745Combined sources
Helixi276 – 2816Combined sources
Beta strandi285 – 2895Combined sources
Beta strandi292 – 2965Combined sources
Helixi298 – 3014Combined sources
Beta strandi302 – 3054Combined sources
Beta strandi308 – 3169Combined sources
Beta strandi320 – 3245Combined sources
Helixi326 – 3294Combined sources
Beta strandi332 – 3376Combined sources
Turni338 – 3414Combined sources
Beta strandi342 – 3487Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YG9X-ray1.30A25-348[»]
2NR6X-ray2.81A/B25-343[»]
3LIZX-ray1.80A25-352[»]
4RLDX-ray2.90A/B/C/D25-350[»]
ProteinModelPortaliP54958.
SMRiP54958. Positions 25-350.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54958.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 346308Peptidase A1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGLKLVTVL FAVATITHAA ELQRVPLYKL VHVFINTQYA GITKIGNQNF
60 70 80 90 100
LTVFDSTSCN VVVASQECVG GACVCPNLQK YEKLKPKYIS DGNVQVKFFD
110 120 130 140 150
TGSAVGRGIE DSLTISNLTT SQQDIVLADE LSQEVCILSA DVVVGIAAPG
160 170 180 190 200
CPNALKGKTV LENFVEENLI APVFSIHHAR FQDGEHFGEI IFGGSDWKYV
210 220 230 240 250
DGEFTYVPLV GDDSWKFRLD GVKIGDTTVA PAGTQAIIDT SKAIIVGPKA
260 270 280 290 300
YVNPINEAIG CVVEKTTTRR ICKLDCSKIP SLPDVTFVIN GRNFNISSQY
310 320 330 340 350
YIQQNGNLCY SGFQPCGHSD HFFIGDFFVD HYYSEFNWEN KTMGFGRSVE

SV
Length:352
Mass (Da):38,558
Last modified:October 1, 1996 - v1
Checksum:iEA334CEB5D060A81
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61L → I in ABP35603 (Ref. 2) Curated
Sequence conflicti87 – 871K → R in ABP35603 (Ref. 2) Curated
Sequence conflicti116 – 1161S → F in ABP35603 (Ref. 2) Curated
Sequence conflicti142 – 1421V → G in ABP35603 (Ref. 2) Curated
Sequence conflicti342 – 3421T → A in ABP35603 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28863 mRNA. Translation: AAA86744.1.
EF203068 mRNA. Translation: ABP35603.1.
PIRiA57164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28863 mRNA. Translation: AAA86744.1.
EF203068 mRNA. Translation: ABP35603.1.
PIRiA57164.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YG9X-ray1.30A25-348[»]
2NR6X-ray2.81A/B25-343[»]
3LIZX-ray1.80A25-352[»]
4RLDX-ray2.90A/B/C/D25-350[»]
ProteinModelPortaliP54958.
SMRiP54958. Positions 25-350.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei141. Bla g 2.
3140. Bla g 2.0101.
4012. Bla g 2.0201.
MEROPSiA01.950.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP54958.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASP2_BLAGE
AccessioniPrimary (citable) accession number: P54958
Secondary accession number(s): B0L0M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 13, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.