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P54928 (IMP3_SOLLC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Inositol monophosphatase 3
Short name=IMP 3
Short name=IMPase 3
EC=3.1.3.25
Alternative name(s):
Inositol-1(or 4)-monophosphatase 3
Gene names
Name:IMP3
OrganismSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifier4081 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum › Lycopersicon

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides.

Catalytic activity

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactor

Magnesium By similarity.

Enzyme regulation

Inhibited by Li+.

Pathway

Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Sequence similarities

Belongs to the inositol monophosphatase family.

Ontologies

Keywords
   LigandLithium
Magnesium
Metal-binding
   Molecular functionHydrolase
Gene Ontology (GO)
   Molecular functioninositol monophosphate 1-phosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Inositol monophosphatase 3
PRO_0000142525

Regions

Region93 – 964Substrate binding By similarity
Region194 – 1963Substrate binding By similarity

Sites

Metal binding711Magnesium 1 By similarity
Metal binding911Magnesium 1 By similarity
Metal binding911Magnesium 2 By similarity
Metal binding931Magnesium 1; via carbonyl oxygen By similarity
Metal binding941Magnesium 2 By similarity
Metal binding2211Magnesium 2 By similarity
Binding site711Substrate By similarity
Binding site2131Substrate By similarity
Binding site2211Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P54928 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: BCB635A029804901

FASTA26829,054
        10         20         30         40         50         60 
MAQNGSVEQF LDVAVEAAKK AGEIIREGFY KTKHVEHKGM VDLVTETDKA CEDFIFNHLK 

        70         80         90        100        110        120 
QRFPSHKFIG EETTAACGNF ELTDEPTWIV DPLDGTTNFV HGFPFVCVSI GLTIEKKPTV 

       130        140        150        160        170        180 
GVVYNPIIDE LFTGIDGKGA FLNGKPIKVS SQSELVKALL ATEAGTNRDK LVVDATTGRI 

       190        200        210        220        230        240 
NSLLFKVRSL RMCGSCALNL CGVACGRLDL FYELEFGGPW DVAGGAVIVK EAGGFVFDPS 

       250        260 
GSEFDLTARR VAATNAHLKD AFIKALNE

« Hide

References

[1]"Plant inositol monophosphatase is a lithium-sensitive enzyme encoded by a multigene family."
Gillaspy G.E., Keddie J.S., Oda K., Gruissem W.
Plant Cell 7:2175-2185(1995) [PubMed: 8718627] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. VFNT Cherry.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U39059 mRNA. Translation: AAB19031.1.
PIRT07795.
RefSeqNP_001233837.1. NM_001246908.1.
UniGeneLes.3598.

3D structure databases

ProteinModelPortalP54928.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID544013.

Family and domain databases

InterProIPR020583. Inositol_monoP_metal-BS.
IPR020552. Inositol_monoPase_Li-sen.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERPTHR20854. Inositol_P. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSPR00377. IMPHPHTASES.
PR00378. LIIMPHPHTASE.
PROSITEPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIMP3_SOLLC
AccessionPrimary (citable) accession number: P54928
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 14, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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