Reviewed, UniProtKB/Swiss-Prot P54927 (IMP2_SOLLC)

Names and origin

Protein names

Recommended name:
    Inositol monophosphatase 2
    EC=3.1.3.25
Alternative name(s):
    Inositol-1(or 4)-monophosphatase 2
      Short name=IMPase 2
      Short name=IMP 2

Gene names

Name:

IMP2

Organism

Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

Taxonomic identifier

4081 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum › Lycopersicon

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides.
Catalytic activity	Myo-inositol phosphate + H2O = myo-inositol + phosphate.
Cofactor	Magnesium By similarity.
Enzyme regulation	Inhibited by Li+.
Pathway	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Ligand	Lithium Magnesium Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Molecular function	inositol-1(or 4)-monophosphatase activity Inferred from electronic annotation. Source: EC lithium ion binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Inositol monophosphatase 2		PRO_0000142524
Regions
	Region	88 – 91	4	Substrate binding By similarity
	Region	189 – 191	3	Substrate binding By similarity
Sites
	Metal binding	65	1	Magnesium 1 By similarity
	Metal binding	86	1	Magnesium 1 By similarity
	Metal binding	86	1	Magnesium 2 By similarity
	Metal binding	88	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	89	1	Magnesium 2 By similarity
	Metal binding	216	1	Magnesium 2 By similarity
	Binding site	65	1	Substrate By similarity
	Binding site	208	1	Substrate By similarity
	Binding site	216	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54927-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 5369735F30FC884B	FASTA	265	28,705
	10 20 30 40 50 60 MEEFVDVAIE AAKKAGEIIR HGFYKSKHIE HKGVVDLVTE TDKACEVLIF NHLKQCFPSH 70 80 90 100 110 120 KFIGEETTAA ASGNFELTDE PTWIVDPLDG TTNFVHGFPF VCVSIGLTIE KKPVVGVVYN 130 140 150 160 170 180 PIIDELFTAI YGRGAFLNGK SIRVSSESQL VKALVATEVG TNRDKAIVDA TTGRINRVIF 190 200 210 220 230 240 KVRSLRMSGS CALNLCGVAC GRLDLFYEIE FGGPWDVAAG ALIVIEAGGL VLDPSGSEFD 250 260 LTARRVAATN AHLKDAFINA LNESE

References

[1]	"Plant inositol monophosphatase is a lithium-sensitive enzyme encoded by a multigene family." Gillaspy G.E., Keddie J.S., Oda K., Gruissem W. Plant Cell 7:2175-2185(1995) [PubMed: 8718627] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. VFNT Cherry.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U39443 mRNA. Translation: AAB19029.1.
PIR	T07800.
UniGene	Les.3600
3D structure databases
HSSP	HSSP built from PDB template 1IMF based on UniProtKB P29218.
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.1.3.25. 281054.
Family and domain databases
InterPro	IPR020583. Inositol_monoP_metal-BS. IPR020552. Inositol_monoPase_Li-sen. IPR000760. Inositol_monophosphatase. IPR020550. Inositol_monophosphatase_CS. [Graphical view]
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PRINTS	PR00377. IMPHPHTASES. PR00378. LIIMPHPHTASE.
ProDom	PD023420. Inositol_P. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00629. IMP_1. 1 hit. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IMP2_SOLLC

Accession

Primary (citable) accession number: P54927

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	September 22, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)