P54926 (IMP1_SOLLC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol monophosphatase 1
Short name=IMP 1
Short name=IMPase 1
EC=3.1.3.25

Alternative name(s):
Inositol-1(or 4)-monophosphatase 1

Gene names

Name:

IMP1

Organism

Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

Taxonomic identifier

4081 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum › Lycopersicon

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides.
Catalytic activity	Myo-inositol phosphate + H2O = myo-inositol + phosphate.
Cofactor	Magnesium By similarity.
Enzyme regulation	Inhibited by Li+.
Pathway	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Ligand	Lithium Magnesium Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Molecular function	inositol monophosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Inositol monophosphatase 1		PRO_0000142523
Regions
	Region	93 – 96	4	Substrate binding By similarity
	Region	194 – 196	3	Substrate binding By similarity
Sites
	Metal binding	71	1	Magnesium 1 By similarity
	Metal binding	91	1	Magnesium 1 By similarity
	Metal binding	91	1	Magnesium 2 By similarity
	Metal binding	93	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	94	1	Magnesium 2 By similarity
	Metal binding	221	1	Magnesium 2 By similarity
	Binding site	71	1	Substrate By similarity
	Binding site	221	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54926 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 92D1D532E359E0FD	FASTA	273	29,559
	10 20 30 40 50 60 MARNGSLEEF LGVAVDAAKR AGEIIRKGFH ETKHVVHKGQ VDLVTETDKA CEDLIFNHLK 70 80 90 100 110 120 QHFPSHKFIG EETSAATGDF DLTDEPTWIV DPVDGTTNFV HGFPSVCVSI GLTIGKIPTV 130 140 150 160 170 180 GVVYDPIIDE LFTGINGKGA YLNGKPIKVS SQSELVKSLL GTEVGTTRDN LTVETTTRRI 190 200 210 220 230 240 NNLLFKVRSL RMCGSCALDL CWVACGRLEL FYLIGYGGPW DVAGGAVIVK EAGGVLFDPS 250 260 270 GSEFDITSQR VAATNPHLKE AFVEALQLSE YVS

References

[1]	"Plant inositol monophosphatase is a lithium-sensitive enzyme encoded by a multigene family." Gillaspy G.E., Keddie J.S., Oda K., Gruissem W. Plant Cell 7:2175-2185(1995) [PubMed: 8718627] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. VFNT Cherry.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U39444 mRNA. Translation: AAB19030.1.
RefSeq	NP_001233901.1. NM_001246972.1.
UniGene	Les.3599.
3D structure databases
ProteinModelPortal	P54926.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	544280.
Family and domain databases
InterPro	IPR020583. Inositol_monoP_metal-BS. IPR020552. Inositol_monoPase_Li-sen. IPR000760. Inositol_monophosphatase. IPR020550. Inositol_monophosphatase_CS. [Graphical view]
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PRINTS	PR00377. IMPHPHTASES. PR00378. LIIMPHPHTASE.
PROSITE	PS00629. IMP_1. 1 hit. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IMP1_SOLLC

Accession

Primary (citable) accession number: P54926

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program