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Protein

Squalene--hopene cyclase

Gene

shc

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cyclization of squalene into hopene.

Catalytic activityi

Squalene = hop-22(29)-ene.
Hopan-22-ol = squalene + H2O.

Pathwayi: hopanoid biosynthesis

This protein is involved in the pathway hopanoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway hopanoid biosynthesis and in Secondary metabolite biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Lyase

Enzyme and pathway databases

BioCyciBDIA224911:G1G3J-3028-MONOMER
UniPathwayiUPA00337

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene--hopene cyclase (EC:4.2.1.129, EC:5.4.99.17)
Alternative name(s):
Squalene--hopanol cyclase
Gene namesi
Name:shc
Ordered Locus Names:blr3004
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726511 – 660Squalene--hopene cyclaseAdd BLAST660

Proteomic databases

PRIDEiP54924

Interactioni

Protein-protein interaction databases

STRINGi224911.blr3004

Structurei

3D structure databases

ProteinModelPortaliP54924
SMRiP54924
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati73 – 114PFTB 1Add BLAST42
Repeati419 – 460PFTB 2Add BLAST42
Repeati536 – 586PFTB 3Add BLAST51

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105EWU Bacteria
COG1657 LUCA
HOGENOMiHOG000220823
InParanoidiP54924
KOiK06045
OMAiGRQTWTY
OrthoDBiPOG091H0DNT
PhylomeDBiP54924

Family and domain databases

CDDicd02892 SQCY_1, 1 hit
InterProiView protein in InterPro
IPR006400 Hopene-cyclase
IPR032696 SQ_cyclase_C
IPR032697 SQ_cyclase_N
IPR018333 Squalene_cyclase
IPR002365 Terpene_synthase_CS
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF13243 SQHop_cyclase_C, 1 hit
PF13249 SQHop_cyclase_N, 1 hit
SUPFAMiSSF48239 SSF48239, 2 hits
TIGRFAMsiTIGR01507 hopene_cyclase, 1 hit
TIGR01787 squalene_cyclas, 1 hit
PROSITEiView protein in PROSITE
PS01074 TERPENE_SYNTHASES, 1 hit

Sequencei

Sequence statusi: Complete.

P54924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVNATARE AKESKISESE ILESSIASAT QGVLGFQQSD GHWVFELEAD
60 70 80 90 100
CTIPAEYVLL RHYLAEPVDT VLEAKIGNYL RRVQGAHGGW PLVHDGEFDM
110 120 130 140 150
SASVKAYFAL KMIGDSIDAP HMVRAREAIH ARGGAIHSNV FTRFMLAMFG
160 170 180 190 200
IVTWRAVPVL PIEIMLLPFW SPFHINKISY WARTTMVPLM VIAALKPRAK
210 220 230 240 250
NPKGVGIDEL FLQDPRSIGM TAKAPHQSMA WFLLFRSLDA ILRVIEPLFP
260 270 280 290 300
KSLRKRAIDT ALAFSEERLN GEDGMGAIYP PMANLVMMYD ALGKDENYPP
310 320 330 340 350
RAVTRRGIDK LLVIGDDEAY CQPCVSPVWD TTLTAHALLE AGGDKAVPAA
360 370 380 390 400
KHGLDWLIPK QELEVKGDWA VKRPDVRPGG WAFQYNNAYY PDLDDTAVVV
410 420 430 440 450
MSMDRMRREH GVTGYDSAID RGREWIEGMQ SDDGGWAAFD VNNLEYYLNN
460 470 480 490 500
IPFSDHGALL DPPTEDVTAR CVSMLAQLGE TAKTSKHVAD GVAYLRKTQH
510 520 530 540 550
PEGSWYGRWG MNFIYGTWSV LCALNMAGVR HDDPMIRKAA DWLASIQNKD
560 570 580 590 600
GGWGEDAVSY RLDYKGWEAA PSTASQTAWA LLALMAAGEV DHPAVARGVE
610 620 630 640 650
YLIATQNEKG LWDEQRYTAT GFPRVFYLRY HGYSKFFPLW ALARYRNLRN
660
TNSRVVGVGM
Length:660
Mass (Da):73,702
Last modified:February 28, 2003 - v2
Checksum:iFC3BBC9903959F66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7 – 10TARE → PP (Ref. 1) Curated4
Sequence conflicti347V → G in CAA60250 (Ref. 1) Curated1
Sequence conflicti557A → T in CAA60250 (Ref. 1) Curated1
Sequence conflicti641A → G in CAA60250 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86552 Genomic DNA Translation: CAA60250.1
BA000040 Genomic DNA Translation: BAC48269.1
RefSeqiNP_769644.1, NC_004463.1
WP_011085788.1, NZ_CP011360.1

Genome annotation databases

EnsemblBacteriaiBAC48269; BAC48269; BAC48269
GeneIDi1053386
KEGGibja:blr3004
PATRICifig|224911.44.peg.2630

Similar proteinsi

Entry informationi

Entry nameiSQHC_BRADU
AccessioniPrimary (citable) accession number: P54924
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 28, 2003
Last modified: May 23, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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