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Protein

Squalene--hopene cyclase

Gene

shc

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cyclization of squalene into hopene.

Catalytic activityi

Squalene = hop-22(29)-ene.
Hopan-22-ol = squalene + H2O.

Pathwayi: hopanoid biosynthesis

This protein is involved in the pathway hopanoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway hopanoid biosynthesis and in Secondary metabolite biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase

Enzyme and pathway databases

UniPathwayiUPA00337.

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene--hopene cyclase (EC:4.2.1.129, EC:5.4.99.17)
Alternative name(s):
Squalene--hopanol cyclase
Gene namesi
Name:shc
Ordered Locus Names:blr3004
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726511 – 660Squalene--hopene cyclaseAdd BLAST660

Interactioni

Protein-protein interaction databases

STRINGi224911.blr3004.

Structurei

3D structure databases

ProteinModelPortaliP54924.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati73 – 114PFTB 1Add BLAST42
Repeati419 – 460PFTB 2Add BLAST42
Repeati536 – 586PFTB 3Add BLAST51

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 3 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105EWU. Bacteria.
COG1657. LUCA.
HOGENOMiHOG000220823.
InParanoidiP54924.
KOiK06045.
OMAiREWIEGM.
OrthoDBiPOG091H0DNT.
PhylomeDBiP54924.

Family and domain databases

CDDicd02892. SQCY_1. 1 hit.
Gene3Di1.50.10.20. 2 hits.
InterProiIPR006400. Hopene-cyclase.
IPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01507. hopene_cyclase. 1 hit.
TIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVNATARE AKESKISESE ILESSIASAT QGVLGFQQSD GHWVFELEAD
60 70 80 90 100
CTIPAEYVLL RHYLAEPVDT VLEAKIGNYL RRVQGAHGGW PLVHDGEFDM
110 120 130 140 150
SASVKAYFAL KMIGDSIDAP HMVRAREAIH ARGGAIHSNV FTRFMLAMFG
160 170 180 190 200
IVTWRAVPVL PIEIMLLPFW SPFHINKISY WARTTMVPLM VIAALKPRAK
210 220 230 240 250
NPKGVGIDEL FLQDPRSIGM TAKAPHQSMA WFLLFRSLDA ILRVIEPLFP
260 270 280 290 300
KSLRKRAIDT ALAFSEERLN GEDGMGAIYP PMANLVMMYD ALGKDENYPP
310 320 330 340 350
RAVTRRGIDK LLVIGDDEAY CQPCVSPVWD TTLTAHALLE AGGDKAVPAA
360 370 380 390 400
KHGLDWLIPK QELEVKGDWA VKRPDVRPGG WAFQYNNAYY PDLDDTAVVV
410 420 430 440 450
MSMDRMRREH GVTGYDSAID RGREWIEGMQ SDDGGWAAFD VNNLEYYLNN
460 470 480 490 500
IPFSDHGALL DPPTEDVTAR CVSMLAQLGE TAKTSKHVAD GVAYLRKTQH
510 520 530 540 550
PEGSWYGRWG MNFIYGTWSV LCALNMAGVR HDDPMIRKAA DWLASIQNKD
560 570 580 590 600
GGWGEDAVSY RLDYKGWEAA PSTASQTAWA LLALMAAGEV DHPAVARGVE
610 620 630 640 650
YLIATQNEKG LWDEQRYTAT GFPRVFYLRY HGYSKFFPLW ALARYRNLRN
660
TNSRVVGVGM
Length:660
Mass (Da):73,702
Last modified:February 28, 2003 - v2
Checksum:iFC3BBC9903959F66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7 – 10TARE → PP (Ref. 1) Curated4
Sequence conflicti347V → G in CAA60250 (Ref. 1) Curated1
Sequence conflicti557A → T in CAA60250 (Ref. 1) Curated1
Sequence conflicti641A → G in CAA60250 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86552 Genomic DNA. Translation: CAA60250.1.
BA000040 Genomic DNA. Translation: BAC48269.1.
RefSeqiNP_769644.1. NC_004463.1.
WP_011085788.1. NZ_CP011360.1.

Genome annotation databases

EnsemblBacteriaiBAC48269; BAC48269; BAC48269.
GeneIDi1053386.
KEGGibja:blr3004.
PATRICi21189458. VBIBraJap65052_2987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86552 Genomic DNA. Translation: CAA60250.1.
BA000040 Genomic DNA. Translation: BAC48269.1.
RefSeqiNP_769644.1. NC_004463.1.
WP_011085788.1. NZ_CP011360.1.

3D structure databases

ProteinModelPortaliP54924.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224911.blr3004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC48269; BAC48269; BAC48269.
GeneIDi1053386.
KEGGibja:blr3004.
PATRICi21189458. VBIBraJap65052_2987.

Phylogenomic databases

eggNOGiENOG4105EWU. Bacteria.
COG1657. LUCA.
HOGENOMiHOG000220823.
InParanoidiP54924.
KOiK06045.
OMAiREWIEGM.
OrthoDBiPOG091H0DNT.
PhylomeDBiP54924.

Enzyme and pathway databases

UniPathwayiUPA00337.

Family and domain databases

CDDicd02892. SQCY_1. 1 hit.
Gene3Di1.50.10.20. 2 hits.
InterProiIPR006400. Hopene-cyclase.
IPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01507. hopene_cyclase. 1 hit.
TIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSQHC_BRADU
AccessioniPrimary (citable) accession number: P54924
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 28, 2003
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.