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Protein

[Protein ADP-ribosylarginine] hydrolase

Gene

Adprh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reverse reaction of mono-ADP-ribosylation.

Catalytic activityi

Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + protein-L-arginine.
N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine.

Enzyme regulationi

Synergistically stimulated by magnesium and dithiothreitol (DTT) in vitro.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Potassium; via carbonyl oxygenBy similarity1
Metal bindingi30Potassium; via carbonyl oxygenBy similarity1
Metal bindingi32Potassium; via carbonyl oxygenBy similarity1
Metal bindingi59MagnesiumBy similarity1
Metal bindingi60MagnesiumBy similarity1
Metal bindingi61MagnesiumBy similarity1
Binding sitei90ADP-D-riboseBy similarity1
Binding sitei129ADP-D-ribose; via carbonyl oxygenBy similarity1
Binding sitei135ADP-D-ribose; via amide nitrogenBy similarity1
Metal bindingi308PotassiumBy similarity1
Metal bindingi309MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi106 – 108ADP-D-riboseBy similarity3
Nucleotide bindingi168 – 170ADP-D-riboseBy similarity3
Nucleotide bindingi268 – 269ADP-D-riboseBy similarity2
Nucleotide bindingi274 – 275ADP-D-riboseBy similarity2

GO - Molecular functioni

  • ADP-ribosylarginine hydrolase activity Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • potassium ion binding Source: UniProtKB

GO - Biological processi

  • cellular protein modification process Source: UniProtKB
  • protein de-ADP-ribosylation Source: InterPro

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
[Protein ADP-ribosylarginine] hydrolase (EC:3.2.2.19)
Short name:
ADP-ribosylarginine hydrolase
Alternative name(s):
ADP-ribose-L-arginine cleaving enzyme
Gene namesi
Name:Adprh
Synonyms:Arh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1098234. Adprh.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001572841 – 362[Protein ADP-ribosylarginine] hydrolaseAdd BLAST362

Proteomic databases

EPDiP54923.
PaxDbiP54923.
PeptideAtlasiP54923.
PRIDEiP54923.

2D gel databases

REPRODUCTION-2DPAGEiP54923.

PTM databases

iPTMnetiP54923.
PhosphoSitePlusiP54923.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002844.
CleanExiMM_ADPRH.
ExpressionAtlasiP54923. baseline and differential.
GenevisibleiP54923. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002923.

Structurei

3D structure databases

ProteinModelPortaliP54923.
SMRiP54923.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosylglycohydrolase family.Curated

Phylogenomic databases

eggNOGiENOG410IEA9. Eukaryota.
ENOG410XPXD. LUCA.
GeneTreeiENSGT00530000063627.
HOGENOMiHOG000007974.
HOVERGENiHBG050462.
InParanoidiP54923.
KOiK01245.
OMAiPPRQWGK.
OrthoDBiEOG091G0AJ4.
PhylomeDBiP54923.
TreeFamiTF329417.

Family and domain databases

Gene3Di1.10.4080.10. 1 hit.
InterProiView protein in InterPro
IPR012108. ADP-ribosylarg_hydro.
IPR005502. Ribosyl_crysJ1.
IPR036705. Ribosyl_crysJ1_sf.
PfamiView protein in Pfam
PF03747. ADP_ribosyl_GH. 1 hit.
PIRSFiPIRSF016939. ADP_ribslarg_hdr. 1 hit.
SUPFAMiSSF101478. SSF101478. 1 hit.

Sequencei

Sequence statusi: Complete.

P54923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGLIERYV AAMVLSAAGD TLGYFNGKWE FIRDGETIHQ QLAQMGDLEA
60 70 80 90 100
IDVARWRVSD DTVMHLATAE ALMEAGQSPD LPRLYSLLAK HYRDCMGDMD
110 120 130 140 150
GRAPGGACMQ NAMLLQPNRA DGYRIPFNSH EGGCGAAMRA MCIGLRFPHP
160 170 180 190 200
SQLDLLIQVS IESGRMTHHH PTGYLGSLAS ALFTAYAVNG KSPWQWGKGL
210 220 230 240 250
MEVLPEAKKY ITQSGYFVKE NLQHWSYFEK EWEKYLELRG ILDGNSAPVF
260 270 280 290 300
PQPFGVKERD QFYIDVSYSG WGGSSGHDAP MIAYDALLAA GDSWKELAHR
310 320 330 340 350
AFFHGGDSDS TAAIAGCWWG VMYGFKGVNP ANYEKLEYRQ RLEEAGRALY
360
SLGSKEDPVL DP
Length:362
Mass (Da):40,068
Last modified:October 1, 1996 - v1
Checksum:iE06BCAEF69BA7C4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13290 mRNA. Translation: AAA37259.1.
AF244347 mRNA. Translation: AAF86223.1.
BC003437 mRNA. Translation: AAH03437.1.
CCDSiCCDS28167.1.
PIRiA47411.
RefSeqiNP_031440.1. NM_007414.3.
UniGeneiMm.20047.

Genome annotation databases

EnsembliENSMUST00000002923; ENSMUSP00000002923; ENSMUSG00000002844.
GeneIDi11544.
KEGGimmu:11544.
UCSCiuc007zex.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiADPRH_MOUSE
AccessioniPrimary (citable) accession number: P54923
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families