Reviewed, UniProtKB/Swiss-Prot P54923 (ADPRH_MOUSE)

Names and origin

Protein names

Recommended name:
    [Protein ADP-ribosylarginine] hydrolase
      Short name=ADP-ribosylarginine hydrolase
    EC=3.2.2.19
Alternative name(s):
    ADP-ribose-L-arginine cleaving enzyme

Gene names

Name:	Adprh
Synonyms:	Arh1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the reverse reaction of mono-ADP-ribosylation.
Catalytic activity	Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-ribose + protein-L-arginine. N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-ribose + L-arginine.
Enzyme regulation	Synergistically stimulated by magnesium and dithiothreitol (DTT) in vitro.
Sequence similarities	Belongs to the ADP-ribosylglycohydrolase family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	protein amino acid de-ADP-ribosylation Inferred from electronic annotation. Source: InterPro
Molecular function	ADP-ribosylarginine hydrolase activity Ref.1 Inferred from mutant phenotype. Source: UniProtKB magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	[Protein ADP-ribosylarginine] hydrolase		PRO_0000157284

Sequences

	Sequence		Length	Mass (Da)
	P54923-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: E06BCAEF69BA7C4E	FASTA	362	40,068
	10 20 30 40 50 60 MGGGLIERYV AAMVLSAAGD TLGYFNGKWE FIRDGETIHQ QLAQMGDLEA IDVARWRVSD 70 80 90 100 110 120 DTVMHLATAE ALMEAGQSPD LPRLYSLLAK HYRDCMGDMD GRAPGGACMQ NAMLLQPNRA 130 140 150 160 170 180 DGYRIPFNSH EGGCGAAMRA MCIGLRFPHP SQLDLLIQVS IESGRMTHHH PTGYLGSLAS 190 200 210 220 230 240 ALFTAYAVNG KSPWQWGKGL MEVLPEAKKY ITQSGYFVKE NLQHWSYFEK EWEKYLELRG 250 260 270 280 290 300 ILDGNSAPVF PQPFGVKERD QFYIDVSYSG WGGSSGHDAP MIAYDALLAA GDSWKELAHR 310 320 330 340 350 360 AFFHGGDSDS TAAIAGCWWG VMYGFKGVNP ANYEKLEYRQ RLEEAGRALY SLGSKEDPVL DP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase." Takada T., Iida K., Moss J. J. Biol. Chem. 268:17837-17843(1993) [PubMed: 8349667] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genomic organization and promoter analysis of the mouse ADP-ribosylarginine hydrolase gene." Aoki K., Kato J., Shoemaker M.T., Moss J. Gene 351:83-95(2005) [PubMed: 15893437] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L13290 mRNA. Translation: AAA37259.1. AF244347 mRNA. Translation: AAF86223.1. BC003437 mRNA. Translation: AAH03437.1.
IPI	IPI00111149.
PIR	A47411.
RefSeq	NP_031440.1.
UniGene	Mm.20047
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P54923.
PTM databases
PhosphoSite	P54923.
2-D gel databases
REPRODUCTION-2DPAGE	P54923.
Proteomic databases
PRIDE	P54923.
Genome annotation databases
Ensembl	ENSMUST00000002923; ENSMUSP00000002923; ENSMUSG00000002844; Mus musculus. [Genome view]
GeneID	11544.
KEGG	mmu:11544.
UCSC	uc007zex.1. mouse.
Organism-specific databases
CTD	11544.
MGI	MGI:1098234. Adprh.
Phylogenomic databases
eggNOG	roNOG09199.
HOGENOM	HBG715225.
HOVERGEN	P54923.
InParanoid	P54923.
OMA	HWSYFQD.
OrthoDB	EOG9284N7.
PhylomeDB	P54923.
Enzyme and pathway databases
BRENDA	3.2.2.19. 244.
Gene expression databases
ArrayExpress	P54923.
Bgee	P54923.
CleanEx	MM_ADPRH.
Genevestigator	P54923.
GermOnline	ENSMUSG00000002844. Mus musculus.
Family and domain databases
InterPro	IPR012108. ADP-ribosylarg_hydro. IPR005502. Ribosyl_crysJ1. [Graphical view]
PANTHER	PTHR22957:SF7. ADP-ribosylarg_hydro. 1 hit.
Pfam	PF03747. ADP_ribosyl_GH. 1 hit. [Graphical view]
PIRSF	PIRSF016939. ADP_ribslarg_hdr. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	279014.
SOURCE	Search...

Entry information

Entry name

ADPRH_MOUSE

Accession

Primary (citable) accession number: P54923

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 19, 2010
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)