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Protein

[Protein ADP-ribosylarginine] hydrolase

Gene

Adprh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reverse reaction of mono-ADP-ribosylation.

Catalytic activityi

Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + protein-L-arginine.
N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine.

Enzyme regulationi

Synergistically stimulated by magnesium and dithiothreitol (DTT) in vitro.

GO - Molecular functioni

  • ADP-ribosylarginine hydrolase activity Source: UniProtKB
  • magnesium ion binding Source: InterPro

GO - Biological processi

  • cellular protein modification process Source: UniProtKB
  • protein de-ADP-ribosylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
[Protein ADP-ribosylarginine] hydrolase (EC:3.2.2.19)
Short name:
ADP-ribosylarginine hydrolase
Alternative name(s):
ADP-ribose-L-arginine cleaving enzyme
Gene namesi
Name:Adprh
Synonyms:Arh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1098234. Adprh.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362[Protein ADP-ribosylarginine] hydrolasePRO_0000157284Add
BLAST

Proteomic databases

EPDiP54923.
PaxDbiP54923.
PeptideAtlasiP54923.
PRIDEiP54923.

2D gel databases

REPRODUCTION-2DPAGEP54923.

PTM databases

iPTMnetiP54923.
PhosphoSiteiP54923.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002844.
CleanExiMM_ADPRH.
ExpressionAtlasiP54923. baseline and differential.
GenevisibleiP54923. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002923.

Structurei

3D structure databases

ProteinModelPortaliP54923.
SMRiP54923. Positions 6-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosylglycohydrolase family.Curated

Phylogenomic databases

eggNOGiENOG410IEA9. Eukaryota.
ENOG410XPXD. LUCA.
HOGENOMiHOG000007974.
HOVERGENiHBG050462.
InParanoidiP54923.
KOiK01245.
OMAiPPRQWGK.
OrthoDBiEOG091G0AJ4.
PhylomeDBiP54923.
TreeFamiTF329417.

Family and domain databases

InterProiIPR012108. ADP-ribosylarg_hydro.
IPR005502. Ribosyl_crysJ1.
[Graphical view]
PfamiPF03747. ADP_ribosyl_GH. 1 hit.
[Graphical view]
PIRSFiPIRSF016939. ADP_ribslarg_hdr. 1 hit.
SUPFAMiSSF101478. SSF101478. 1 hit.

Sequencei

Sequence statusi: Complete.

P54923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGLIERYV AAMVLSAAGD TLGYFNGKWE FIRDGETIHQ QLAQMGDLEA
60 70 80 90 100
IDVARWRVSD DTVMHLATAE ALMEAGQSPD LPRLYSLLAK HYRDCMGDMD
110 120 130 140 150
GRAPGGACMQ NAMLLQPNRA DGYRIPFNSH EGGCGAAMRA MCIGLRFPHP
160 170 180 190 200
SQLDLLIQVS IESGRMTHHH PTGYLGSLAS ALFTAYAVNG KSPWQWGKGL
210 220 230 240 250
MEVLPEAKKY ITQSGYFVKE NLQHWSYFEK EWEKYLELRG ILDGNSAPVF
260 270 280 290 300
PQPFGVKERD QFYIDVSYSG WGGSSGHDAP MIAYDALLAA GDSWKELAHR
310 320 330 340 350
AFFHGGDSDS TAAIAGCWWG VMYGFKGVNP ANYEKLEYRQ RLEEAGRALY
360
SLGSKEDPVL DP
Length:362
Mass (Da):40,068
Last modified:October 1, 1996 - v1
Checksum:iE06BCAEF69BA7C4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13290 mRNA. Translation: AAA37259.1.
AF244347 mRNA. Translation: AAF86223.1.
BC003437 mRNA. Translation: AAH03437.1.
CCDSiCCDS28167.1.
PIRiA47411.
RefSeqiNP_031440.1. NM_007414.3.
UniGeneiMm.20047.

Genome annotation databases

EnsembliENSMUST00000002923; ENSMUSP00000002923; ENSMUSG00000002844.
GeneIDi11544.
KEGGimmu:11544.
UCSCiuc007zex.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13290 mRNA. Translation: AAA37259.1.
AF244347 mRNA. Translation: AAF86223.1.
BC003437 mRNA. Translation: AAH03437.1.
CCDSiCCDS28167.1.
PIRiA47411.
RefSeqiNP_031440.1. NM_007414.3.
UniGeneiMm.20047.

3D structure databases

ProteinModelPortaliP54923.
SMRiP54923. Positions 6-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002923.

PTM databases

iPTMnetiP54923.
PhosphoSiteiP54923.

2D gel databases

REPRODUCTION-2DPAGEP54923.

Proteomic databases

EPDiP54923.
PaxDbiP54923.
PeptideAtlasiP54923.
PRIDEiP54923.

Protocols and materials databases

DNASUi11544.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002923; ENSMUSP00000002923; ENSMUSG00000002844.
GeneIDi11544.
KEGGimmu:11544.
UCSCiuc007zex.1. mouse.

Organism-specific databases

CTDi141.
MGIiMGI:1098234. Adprh.

Phylogenomic databases

eggNOGiENOG410IEA9. Eukaryota.
ENOG410XPXD. LUCA.
HOGENOMiHOG000007974.
HOVERGENiHBG050462.
InParanoidiP54923.
KOiK01245.
OMAiPPRQWGK.
OrthoDBiEOG091G0AJ4.
PhylomeDBiP54923.
TreeFamiTF329417.

Miscellaneous databases

ChiTaRSiAdprh. mouse.
PROiP54923.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002844.
CleanExiMM_ADPRH.
ExpressionAtlasiP54923. baseline and differential.
GenevisibleiP54923. MM.

Family and domain databases

InterProiIPR012108. ADP-ribosylarg_hydro.
IPR005502. Ribosyl_crysJ1.
[Graphical view]
PfamiPF03747. ADP_ribosyl_GH. 1 hit.
[Graphical view]
PIRSFiPIRSF016939. ADP_ribslarg_hdr. 1 hit.
SUPFAMiSSF101478. SSF101478. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADPRH_MOUSE
AccessioniPrimary (citable) accession number: P54923
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.