SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P54921

- SNAA_RAT

UniProt

P54921 - SNAA_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Alpha-soluble NSF attachment protein

Gene
Napa, Snap, Snapa
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus By similarity.

GO - Molecular functioni

  1. protein binding Source: BHF-UCL
  2. SNARE binding Source: MGI

GO - Biological processi

  1. apical protein localization Source: Ensembl
  2. brain development Source: Ensembl
  3. intracellular protein transport Source: Ensembl
  4. membrane fusion Source: RGD
  5. neuron differentiation Source: Ensembl
  6. regulation of synaptic vesicle priming Source: Ensembl
  7. SNARE complex disassembly Source: Ensembl
  8. synaptic transmission, glutamatergic Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-soluble NSF attachment protein
Short name:
SNAP-alpha
Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein alpha
Gene namesi
Name:Napa
Synonyms:Snap, Snapa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi620855. Napa.

Subcellular locationi

GO - Cellular componenti

  1. synaptobrevin 2-SNAP-25-syntaxin-1a complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Alpha-soluble NSF attachment proteinPRO_0000219058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP54921.
PRIDEiP54921.

PTM databases

PhosphoSiteiP54921.

Expressioni

Gene expression databases

GenevestigatoriP54921.

Interactioni

Subunit structurei

Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha By similarity. Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. Found in a complex with VAMP8. Interacts with VTI1A By similarity. Interacts with STX12.3 Publications

Protein-protein interaction databases

IntActiP54921. 1 interaction.
MINTiMINT-4542616.
STRINGi10116.ENSRNOP00000002044.

Structurei

3D structure databases

ProteinModelPortaliP54921.

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.

Phylogenomic databases

eggNOGiNOG245914.
GeneTreeiENSGT00390000005826.
HOGENOMiHOG000165015.
HOVERGENiHBG001325.
InParanoidiP54921.
KOiK15296.
OMAiIANFIHG.
OrthoDBiEOG7FNC80.
PhylomeDBiP54921.
TreeFamiTF316547.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR000744. NSF_attach.
IPR011990. TPR-like_helical.
[Graphical view]
PANTHERiPTHR13768. PTHR13768. 1 hit.
PRINTSiPR00448. NSFATTACHMNT.

Sequencei

Sequence statusi: Complete.

P54921-1 [UniParc]FASTAAdd to Basket

« Hide

MDTSGKQAEA MALLAEAERK VKNSQSFFSG LFGGSSKIEE ACEIYARAAN    50
MFKMAKNWSA AGNAFCQAAQ LHLQLQSKHD AATCFVDAGN AFKKADPQEA 100
INCLMRAIEI YTDMGRFTIA AKHHISIAEI YETELVDVEK AIAHYEQSAD 150
YYKGEESNSS ANKCLLKVAG YAAQLEQYQK AIDIYEQVGT SAMDSPLLKY 200
SAKDYFFKAA LCHFCIDMLN AKLAVQKYEE LFPAFSDSRE CKLMKKLLEA 250
HEEQNVDSYT ESVKEYDSIS RLDQWLTTML LRIKKTIQGD EEDLR 295
Length:295
Mass (Da):33,193
Last modified:July 15, 1999 - v2
Checksum:i662356859DF0BA3F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89968 mRNA. Translation: CAA62005.1.
BC063156 mRNA. Translation: AAH63156.1.
PIRiS58285.
RefSeqiNP_542152.1. NM_080585.1.
UniGeneiRn.31745.

Genome annotation databases

EnsembliENSRNOT00000002044; ENSRNOP00000002044; ENSRNOG00000001494.
GeneIDi140673.
KEGGirno:140673.
UCSCiRGD:620855. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89968 mRNA. Translation: CAA62005.1 .
BC063156 mRNA. Translation: AAH63156.1 .
PIRi S58285.
RefSeqi NP_542152.1. NM_080585.1.
UniGenei Rn.31745.

3D structure databases

ProteinModelPortali P54921.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P54921. 1 interaction.
MINTi MINT-4542616.
STRINGi 10116.ENSRNOP00000002044.

PTM databases

PhosphoSitei P54921.

Proteomic databases

PaxDbi P54921.
PRIDEi P54921.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000002044 ; ENSRNOP00000002044 ; ENSRNOG00000001494 .
GeneIDi 140673.
KEGGi rno:140673.
UCSCi RGD:620855. rat.

Organism-specific databases

CTDi 8775.
RGDi 620855. Napa.

Phylogenomic databases

eggNOGi NOG245914.
GeneTreei ENSGT00390000005826.
HOGENOMi HOG000165015.
HOVERGENi HBG001325.
InParanoidi P54921.
KOi K15296.
OMAi IANFIHG.
OrthoDBi EOG7FNC80.
PhylomeDBi P54921.
TreeFami TF316547.

Miscellaneous databases

NextBioi 620663.
PROi P54921.

Gene expression databases

Genevestigatori P54921.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR000744. NSF_attach.
IPR011990. TPR-like_helical.
[Graphical view ]
PANTHERi PTHR13768. PTHR13768. 1 hit.
PRINTSi PR00448. NSFATTACHMNT.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Mitchell J.R.D., Mitchell M., Holman D., Oldfield S.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: White adipose tissue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. "Syntaxin 12, a member of the syntaxin family localized to the endosome."
    Tang B.L., Tan A.E., Lim L.K., Lee S.S., Low D.Y., Hong W.
    J. Biol. Chem. 273:6944-6950(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STX12.
  4. "Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome."
    Wong S.H., Zhang T., Xu Y., Subramaniam V.N., Griffiths G., Hong W.
    Mol. Biol. Cell 9:1549-1563(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH VAMP8.
  5. "NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex."
    Hanley J.G., Khatri L., Hanson P.I., Ziff E.B.
    Neuron 34:53-67(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PRKCABP.

Entry informationi

Entry nameiSNAA_RAT
AccessioniPrimary (citable) accession number: P54921
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1999
Last modified: June 11, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi