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P54921

- SNAA_RAT

UniProt

P54921 - SNAA_RAT

Protein

Alpha-soluble NSF attachment protein

Gene

Napa

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.By similarity

    GO - Molecular functioni

    1. protein binding Source: BHF-UCL
    2. SNARE binding Source: MGI

    GO - Biological processi

    1. apical protein localization Source: Ensembl
    2. brain development Source: Ensembl
    3. intracellular protein transport Source: Ensembl
    4. membrane fusion Source: RGD
    5. neuron differentiation Source: Ensembl
    6. regulation of synaptic vesicle priming Source: Ensembl
    7. SNARE complex disassembly Source: Ensembl
    8. synaptic transmission, glutamatergic Source: Ensembl

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-soluble NSF attachment protein
    Short name:
    SNAP-alpha
    Alternative name(s):
    N-ethylmaleimide-sensitive factor attachment protein alpha
    Gene namesi
    Name:Napa
    Synonyms:Snap, Snapa
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi620855. Napa.

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. synaptobrevin 2-SNAP-25-syntaxin-1a complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Alpha-soluble NSF attachment proteinPRO_0000219058Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP54921.
    PRIDEiP54921.

    PTM databases

    PhosphoSiteiP54921.

    Expressioni

    Gene expression databases

    GenevestigatoriP54921.

    Interactioni

    Subunit structurei

    Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha By similarity. Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. Found in a complex with VAMP8. Interacts with VTI1A By similarity. Interacts with STX12.By similarity3 Publications

    Protein-protein interaction databases

    IntActiP54921. 1 interaction.
    MINTiMINT-4542616.
    STRINGi10116.ENSRNOP00000002044.

    Structurei

    3D structure databases

    ProteinModelPortaliP54921.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SNAP family.Curated

    Phylogenomic databases

    eggNOGiNOG245914.
    GeneTreeiENSGT00390000005826.
    HOGENOMiHOG000165015.
    HOVERGENiHBG001325.
    InParanoidiP54921.
    KOiK15296.
    OMAiIANFIHG.
    OrthoDBiEOG7FNC80.
    PhylomeDBiP54921.
    TreeFamiTF316547.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR000744. NSF_attach.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PANTHERiPTHR13768. PTHR13768. 1 hit.
    PRINTSiPR00448. NSFATTACHMNT.

    Sequencei

    Sequence statusi: Complete.

    P54921-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTSGKQAEA MALLAEAERK VKNSQSFFSG LFGGSSKIEE ACEIYARAAN    50
    MFKMAKNWSA AGNAFCQAAQ LHLQLQSKHD AATCFVDAGN AFKKADPQEA 100
    INCLMRAIEI YTDMGRFTIA AKHHISIAEI YETELVDVEK AIAHYEQSAD 150
    YYKGEESNSS ANKCLLKVAG YAAQLEQYQK AIDIYEQVGT SAMDSPLLKY 200
    SAKDYFFKAA LCHFCIDMLN AKLAVQKYEE LFPAFSDSRE CKLMKKLLEA 250
    HEEQNVDSYT ESVKEYDSIS RLDQWLTTML LRIKKTIQGD EEDLR 295
    Length:295
    Mass (Da):33,193
    Last modified:July 15, 1999 - v2
    Checksum:i662356859DF0BA3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89968 mRNA. Translation: CAA62005.1.
    BC063156 mRNA. Translation: AAH63156.1.
    PIRiS58285.
    RefSeqiNP_542152.1. NM_080585.1.
    UniGeneiRn.31745.

    Genome annotation databases

    EnsembliENSRNOT00000002044; ENSRNOP00000002044; ENSRNOG00000001494.
    GeneIDi140673.
    KEGGirno:140673.
    UCSCiRGD:620855. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89968 mRNA. Translation: CAA62005.1 .
    BC063156 mRNA. Translation: AAH63156.1 .
    PIRi S58285.
    RefSeqi NP_542152.1. NM_080585.1.
    UniGenei Rn.31745.

    3D structure databases

    ProteinModelPortali P54921.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P54921. 1 interaction.
    MINTi MINT-4542616.
    STRINGi 10116.ENSRNOP00000002044.

    PTM databases

    PhosphoSitei P54921.

    Proteomic databases

    PaxDbi P54921.
    PRIDEi P54921.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000002044 ; ENSRNOP00000002044 ; ENSRNOG00000001494 .
    GeneIDi 140673.
    KEGGi rno:140673.
    UCSCi RGD:620855. rat.

    Organism-specific databases

    CTDi 8775.
    RGDi 620855. Napa.

    Phylogenomic databases

    eggNOGi NOG245914.
    GeneTreei ENSGT00390000005826.
    HOGENOMi HOG000165015.
    HOVERGENi HBG001325.
    InParanoidi P54921.
    KOi K15296.
    OMAi IANFIHG.
    OrthoDBi EOG7FNC80.
    PhylomeDBi P54921.
    TreeFami TF316547.

    Miscellaneous databases

    NextBioi 620663.
    PROi P54921.

    Gene expression databases

    Genevestigatori P54921.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR000744. NSF_attach.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    PANTHERi PTHR13768. PTHR13768. 1 hit.
    PRINTSi PR00448. NSFATTACHMNT.
    ProtoNeti Search...

    Publicationsi

    1. Mitchell J.R.D., Mitchell M., Holman D., Oldfield S.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: White adipose tissue.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    3. "Syntaxin 12, a member of the syntaxin family localized to the endosome."
      Tang B.L., Tan A.E., Lim L.K., Lee S.S., Low D.Y., Hong W.
      J. Biol. Chem. 273:6944-6950(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STX12.
    4. "Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome."
      Wong S.H., Zhang T., Xu Y., Subramaniam V.N., Griffiths G., Hong W.
      Mol. Biol. Cell 9:1549-1563(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH VAMP8.
    5. "NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex."
      Hanley J.G., Khatri L., Hanson P.I., Ziff E.B.
      Neuron 34:53-67(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PRKCABP.

    Entry informationi

    Entry nameiSNAA_RAT
    AccessioniPrimary (citable) accession number: P54921
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3