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P54921 (SNAA_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-soluble NSF attachment protein

Short name=SNAP-alpha
Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein alpha
Gene names
Name:Napa
Synonyms:Snap, Snapa
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus By similarity.

Subunit structure

Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha By similarity. Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. Found in a complex with VAMP8. Interacts with VTI1A By similarity. Interacts with STX12. Ref.3 Ref.4 Ref.5

Subcellular location

Membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the SNAP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Alpha-soluble NSF attachment protein
PRO_0000219058

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
P54921 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 662356859DF0BA3F

FASTA29533,193
        10         20         30         40         50         60 
MDTSGKQAEA MALLAEAERK VKNSQSFFSG LFGGSSKIEE ACEIYARAAN MFKMAKNWSA 

        70         80         90        100        110        120 
AGNAFCQAAQ LHLQLQSKHD AATCFVDAGN AFKKADPQEA INCLMRAIEI YTDMGRFTIA 

       130        140        150        160        170        180 
AKHHISIAEI YETELVDVEK AIAHYEQSAD YYKGEESNSS ANKCLLKVAG YAAQLEQYQK 

       190        200        210        220        230        240 
AIDIYEQVGT SAMDSPLLKY SAKDYFFKAA LCHFCIDMLN AKLAVQKYEE LFPAFSDSRE 

       250        260        270        280        290 
CKLMKKLLEA HEEQNVDSYT ESVKEYDSIS RLDQWLTTML LRIKKTIQGD EEDLR 

« Hide

References

« Hide 'large scale' references
[1]Mitchell J.R.D., Mitchell M., Holman D., Oldfield S.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: White adipose tissue.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[3]"Syntaxin 12, a member of the syntaxin family localized to the endosome."
Tang B.L., Tan A.E., Lim L.K., Lee S.S., Low D.Y., Hong W.
J. Biol. Chem. 273:6944-6950(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH STX12.
[4]"Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome."
Wong S.H., Zhang T., Xu Y., Subramaniam V.N., Griffiths G., Hong W.
Mol. Biol. Cell 9:1549-1563(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A COMPLEX WITH VAMP8.
[5]"NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex."
Hanley J.G., Khatri L., Hanson P.I., Ziff E.B.
Neuron 34:53-67(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PRKCABP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X89968 mRNA. Translation: CAA62005.1.
BC063156 mRNA. Translation: AAH63156.1.
PIRS58285.
RefSeqNP_542152.1. NM_080585.1.
UniGeneRn.31745.

3D structure databases

ProteinModelPortalP54921.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP54921. 1 interaction.
MINTMINT-4542616.
STRING10116.ENSRNOP00000002044.

PTM databases

PhosphoSiteP54921.

Proteomic databases

PaxDbP54921.
PRIDEP54921.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000002044; ENSRNOP00000002044; ENSRNOG00000001494.
GeneID140673.
KEGGrno:140673.
UCSCRGD:620855. rat.

Organism-specific databases

CTD8775.
RGD620855. Napa.

Phylogenomic databases

eggNOGNOG245914.
GeneTreeENSGT00390000005826.
HOGENOMHOG000165015.
HOVERGENHBG001325.
InParanoidP54921.
KOK15296.
OMAINCLNRA.
OrthoDBEOG7FNC80.
PhylomeDBP54921.
TreeFamTF316547.

Gene expression databases

GenevestigatorP54921.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR000744. NSF_attach.
IPR011990. TPR-like_helical.
[Graphical view]
PANTHERPTHR13768. PTHR13768. 1 hit.
PRINTSPR00448. NSFATTACHMNT.
ProtoNetSearch...

Other

NextBio620663.
PROP54921.

Entry information

Entry nameSNAA_RAT
AccessionPrimary (citable) accession number: P54921
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1999
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families