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P54920 (SNAA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-soluble NSF attachment protein

Short name=SNAP-alpha
Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein alpha
Gene names
Name:NAPA
Synonyms:SNAPA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Subunit structure

Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. Found in a complex with VAMP8 By similarity. Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha. Interacts with VTI1A. Interacts with STX12 By similarity. Ref.7

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the SNAP family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Alpha-soluble NSF attachment protein
PRO_0000219056

Amino acid modifications

Modified residue11N-acetylmethionine Ref.9

Experimental info

Sequence conflict1951S → T in AAC80170. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P54920 [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: 7704A619A441E609

FASTA29533,233
        10         20         30         40         50         60 
MDNSGKEAEA MALLAEAERK VKNSQSFFSG LFGGSSKIEE ACEIYARAAN MFKMAKNWSA 

        70         80         90        100        110        120 
AGNAFCQAAQ LHLQLQSKHD AATCFVDAGN AFKKADPQEA INCLMRAIEI YTDMGRFTIA 

       130        140        150        160        170        180 
AKHHISIAEI YETELVDIEK AIAHYEQSAD YYKGEESNSS ANKCLLKVAG YAALLEQYQK 

       190        200        210        220        230        240 
AIDIYEQVGT NAMDSPLLKY SAKDYFFKAA LCHFCIDMLN AKLAVQKYEE LFPAFSDSRE 

       250        260        270        280        290 
CKLMKKLLEA HEEQNVDSYT ESVKEYDSIS RLDQWLTTML LRIKKTIQGD EEDLR 

« Hide

References

« Hide 'large scale' references
[1]"Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery."
Lemons P.P., Chen D., Bernstein A.M., Bennett M.K., Whiteheart S.W.
Blood 90:1490-1500(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Platelet.
[2]Chen D., Shao H.P., Whiteheart S.W.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 91; 133 AND 289.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Lung and Placenta.
[7]"Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi."
Hirose H., Arasaki K., Dohmae N., Takio K., Hatsuzawa K., Nagahama M., Tani K., Yamamoto A., Tohyama M., Tagaya M.
EMBO J. 23:1267-1278(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH RINT1; USE1L; NAPA AND ZW10.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U39412 mRNA. Translation: AAC80170.1.
BT019568 mRNA. Translation: AAV38375.1.
AK292244 mRNA. Translation: BAF84933.1.
CH471126 Genomic DNA. Translation: EAW57491.1.
BC001165 mRNA. Translation: AAH01165.1.
BC007432 mRNA. Translation: AAH07432.1.
BC028234 mRNA. Translation: AAH28234.1.
BC091511 mRNA. Translation: AAH91511.1.
PIRG02238.
RefSeqNP_003818.2. NM_003827.3.
UniGeneHs.730799.
Hs.744881.

3D structure databases

ProteinModelPortalP54920.
SMRP54920. Positions 8-293.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114305. 24 interactions.
DIPDIP-393N.
IntActP54920. 7 interactions.
MINTMINT-3020680.
STRING9606.ENSP00000263354.

PTM databases

PhosphoSiteP54920.

Polymorphism databases

DMDM116242794.

2D gel databases

OGPP54920.

Proteomic databases

PaxDbP54920.
PeptideAtlasP54920.
PRIDEP54920.

Protocols and materials databases

DNASU8775.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263354; ENSP00000263354; ENSG00000105402.
GeneID8775.
KEGGhsa:8775.
UCSCuc002pha.2. human.

Organism-specific databases

CTD8775.
GeneCardsGC19M047990.
H-InvDBHIX0137469.
HGNCHGNC:7641. NAPA.
HPACAB010100.
HPA046149.
HPA050196.
MIM603215. gene.
neXtProtNX_P54920.
PharmGKBPA31443.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245914.
HOGENOMHOG000165015.
HOVERGENHBG001325.
InParanoidP54920.
KOK15296.
OMAINCLNRA.
OrthoDBEOG7FNC80.
PhylomeDBP54920.
TreeFamTF316547.

Enzyme and pathway databases

ReactomeREACT_11123. Membrane Trafficking.

Gene expression databases

ArrayExpressP54920.
BgeeP54920.
CleanExHS_NAPA.
GenevestigatorP54920.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR000744. NSF_attach.
IPR011990. TPR-like_helical.
[Graphical view]
PANTHERPTHR13768. PTHR13768. 1 hit.
PRINTSPR00448. NSFATTACHMNT.
ProtoNetSearch...

Other

GeneWikiNAPA_(gene).
GenomeRNAi8775.
NextBio32904.
PMAP-CutDBP54920.
PROP54920.
SOURCESearch...

Entry information

Entry nameSNAA_HUMAN
AccessionPrimary (citable) accession number: P54920
Secondary accession number(s): A8K879, Q96IK3, Q9BVJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM