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P54920

- SNAA_HUMAN

UniProt

P54920 - SNAA_HUMAN

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Protein

Alpha-soluble NSF attachment protein

Gene

NAPA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

GO - Biological processi

  1. apical protein localization Source: Ensembl
  2. brain development Source: Ensembl
  3. intracellular protein transport Source: Ensembl
  4. intra-Golgi vesicle-mediated transport Source: ProtInc
  5. membrane fusion Source: ProtInc
  6. membrane organization Source: Reactome
  7. neuron differentiation Source: Ensembl
  8. post-Golgi vesicle-mediated transport Source: Reactome
  9. regulation of synaptic vesicle priming Source: Ensembl
  10. SNARE complex disassembly Source: Ensembl
  11. synaptic transmission, glutamatergic Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_19400. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-soluble NSF attachment protein
Short name:
SNAP-alpha
Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein alpha
Gene namesi
Name:NAPA
Synonyms:SNAPA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:7641. NAPA.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. extracellular vesicular exosome Source: UniProtKB
  3. membrane Source: UniProtKB
  4. synaptobrevin 2-SNAP-25-syntaxin-1a complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Alpha-soluble NSF attachment proteinPRO_0000219056Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP54920.
PaxDbiP54920.
PeptideAtlasiP54920.
PRIDEiP54920.

2D gel databases

OGPiP54920.

PTM databases

PhosphoSiteiP54920.

Miscellaneous databases

PMAP-CutDBP54920.

Expressioni

Gene expression databases

BgeeiP54920.
CleanExiHS_NAPA.
ExpressionAtlasiP54920. baseline and differential.
GenevestigatoriP54920.

Organism-specific databases

HPAiCAB010100.
HPA046149.
HPA050196.

Interactioni

Subunit structurei

Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. Found in a complex with VAMP8 (By similarity). Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha. Interacts with VTI1A. Interacts with STX12 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NSFP464592EBI-749652,EBI-712251
SNAP23O001612EBI-749652,EBI-745000
STX4Q128462EBI-749652,EBI-744942

Protein-protein interaction databases

BioGridi114305. 34 interactions.
DIPiDIP-393N.
IntActiP54920. 8 interactions.
MINTiMINT-3020680.
STRINGi9606.ENSP00000263354.

Structurei

3D structure databases

ProteinModelPortaliP54920.
SMRiP54920. Positions 8-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.Curated

Phylogenomic databases

eggNOGiNOG245914.
GeneTreeiENSGT00390000005826.
HOGENOMiHOG000165015.
HOVERGENiHBG001325.
InParanoidiP54920.
KOiK15296.
OMAiHAREAEC.
OrthoDBiEOG7FNC80.
PhylomeDBiP54920.
TreeFamiTF316547.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR000744. NSF_attach.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR13768. PTHR13768. 1 hit.
PRINTSiPR00448. NSFATTACHMNT.

Sequencei

Sequence statusi: Complete.

P54920-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNSGKEAEA MALLAEAERK VKNSQSFFSG LFGGSSKIEE ACEIYARAAN
60 70 80 90 100
MFKMAKNWSA AGNAFCQAAQ LHLQLQSKHD AATCFVDAGN AFKKADPQEA
110 120 130 140 150
INCLMRAIEI YTDMGRFTIA AKHHISIAEI YETELVDIEK AIAHYEQSAD
160 170 180 190 200
YYKGEESNSS ANKCLLKVAG YAALLEQYQK AIDIYEQVGT NAMDSPLLKY
210 220 230 240 250
SAKDYFFKAA LCHFCIDMLN AKLAVQKYEE LFPAFSDSRE CKLMKKLLEA
260 270 280 290
HEEQNVDSYT ESVKEYDSIS RLDQWLTTML LRIKKTIQGD EEDLR
Length:295
Mass (Da):33,233
Last modified:October 17, 2006 - v3
Checksum:i7704A619A441E609
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951S → T in AAC80170. (PubMed:9269766)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39412 mRNA. Translation: AAC80170.1.
BT019568 mRNA. Translation: AAV38375.1.
AK292244 mRNA. Translation: BAF84933.1.
CH471126 Genomic DNA. Translation: EAW57491.1.
BC001165 mRNA. Translation: AAH01165.1.
BC007432 mRNA. Translation: AAH07432.1.
BC028234 mRNA. Translation: AAH28234.1.
BC091511 mRNA. Translation: AAH91511.1.
CCDSiCCDS12702.1.
PIRiG02238.
RefSeqiNP_003818.2. NM_003827.3.
UniGeneiHs.730799.
Hs.744881.

Genome annotation databases

EnsembliENST00000263354; ENSP00000263354; ENSG00000105402.
GeneIDi8775.
KEGGihsa:8775.
UCSCiuc002pha.2. human.

Polymorphism databases

DMDMi116242794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39412 mRNA. Translation: AAC80170.1 .
BT019568 mRNA. Translation: AAV38375.1 .
AK292244 mRNA. Translation: BAF84933.1 .
CH471126 Genomic DNA. Translation: EAW57491.1 .
BC001165 mRNA. Translation: AAH01165.1 .
BC007432 mRNA. Translation: AAH07432.1 .
BC028234 mRNA. Translation: AAH28234.1 .
BC091511 mRNA. Translation: AAH91511.1 .
CCDSi CCDS12702.1.
PIRi G02238.
RefSeqi NP_003818.2. NM_003827.3.
UniGenei Hs.730799.
Hs.744881.

3D structure databases

ProteinModelPortali P54920.
SMRi P54920. Positions 8-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114305. 34 interactions.
DIPi DIP-393N.
IntActi P54920. 8 interactions.
MINTi MINT-3020680.
STRINGi 9606.ENSP00000263354.

PTM databases

PhosphoSitei P54920.

Polymorphism databases

DMDMi 116242794.

2D gel databases

OGPi P54920.

Proteomic databases

MaxQBi P54920.
PaxDbi P54920.
PeptideAtlasi P54920.
PRIDEi P54920.

Protocols and materials databases

DNASUi 8775.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263354 ; ENSP00000263354 ; ENSG00000105402 .
GeneIDi 8775.
KEGGi hsa:8775.
UCSCi uc002pha.2. human.

Organism-specific databases

CTDi 8775.
GeneCardsi GC19M047990.
H-InvDB HIX0137469.
HGNCi HGNC:7641. NAPA.
HPAi CAB010100.
HPA046149.
HPA050196.
MIMi 603215. gene.
neXtProti NX_P54920.
PharmGKBi PA31443.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG245914.
GeneTreei ENSGT00390000005826.
HOGENOMi HOG000165015.
HOVERGENi HBG001325.
InParanoidi P54920.
KOi K15296.
OMAi HAREAEC.
OrthoDBi EOG7FNC80.
PhylomeDBi P54920.
TreeFami TF316547.

Enzyme and pathway databases

Reactomei REACT_19400. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

ChiTaRSi NAPA. human.
GeneWikii NAPA_(gene).
GenomeRNAii 8775.
NextBioi 32904.
PMAP-CutDB P54920.
PROi P54920.
SOURCEi Search...

Gene expression databases

Bgeei P54920.
CleanExi HS_NAPA.
ExpressionAtlasi P54920. baseline and differential.
Genevestigatori P54920.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR000744. NSF_attach.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
PANTHERi PTHR13768. PTHR13768. 1 hit.
PRINTSi PR00448. NSFATTACHMNT.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery."
    Lemons P.P., Chen D., Bernstein A.M., Bennett M.K., Whiteheart S.W.
    Blood 90:1490-1500(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Platelet.
  2. Chen D., Shao H.P., Whiteheart S.W.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 91; 133 AND 289.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lung and Placenta.
  7. "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi."
    Hirose H., Arasaki K., Dohmae N., Takio K., Hatsuzawa K., Nagahama M., Tani K., Yamamoto A., Tohyama M., Tagaya M.
    EMBO J. 23:1267-1278(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH RINT1; USE1L; NAPA AND ZW10.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNAA_HUMAN
AccessioniPrimary (citable) accession number: P54920
Secondary accession number(s): A8K879, Q96IK3, Q9BVJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: November 26, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3