P54919Q9S2E6HEM2_STRCODelta-aminolevulinic acid dehydrataseALADALADH4.2.1.24Porphobilinogen synthasehemBSCO3311SCE68.09cStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus groupCloning and characterisation of the genes that encode enzymes for first steps of tetrapyrrole biosynthesis in Streptomyces coelicolor A3(2).NUCLEOTIDE SEQUENCE [GENOMIC DNA]Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogenPorphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.Homooctamer.Belongs to the ALAD family.Heme biosynthesisLyaseMagnesiumMetal-bindingPorphyrin biosynthesisReference proteome5-aminolevulinate5-aminolevulinateMg(2+)5-aminolevulinate5-aminolevulinateDVMTTYGSFPGARPRRLRTTPVMRRMVAETRLHPADFILPAFVREGVSEPVPIAAMPGVVQHTRDTLKKAAAEAVEAGVSGIMLFGVPEDGKKDAAGTAGTDPDGILQVALRDVRAEVGDELLVMSDLCLDEFTDHGHCGVLDGQGRVDNDATLERYAEMAQVQADAGAHVVGPSGMMDGQIGVIRDALDQIGREDVAILAYTAKYASAFYGPFREAVGSSLKGDRKTYQQDSANARESLRELALDLEEGADMVMVKPAGPYLDILAKVAEASDVPVAAYQISGEYSMIEAAAEKGWIDRDRAILESLTGIKRAGARNILTYWATEVARTLR
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