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Protein

Pyrroline-5-carboxylate reductase

Gene

PROC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde.
Proteins known to be involved in this subpathway in this organism are:
  1. Pyrroline-5-carboxylate reductase (PROC1), Pyrroline-5-carboxylate reductase (AXX17_At5g14300)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

  • pyrroline-5-carboxylate reductase activity Source: TAIR

GO - Biological processi

  • L-proline biosynthetic process Source: UniProtKB-UniPathway
  • response to heat Source: TAIR
  • response to salt stress Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-ATH-70614. Amino acid synthesis and interconversion (transamination).
SABIO-RKP54904.
UniPathwayiUPA00098; UER00361.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroline-5-carboxylate reductase (EC:1.5.1.2)
Short name:
P5C reductase
Short name:
P5CR
Alternative name(s):
Protein EMBRYO DEFECTIVE 2772
Gene namesi
Name:PROC1
Synonyms:EMB2772
Ordered Locus Names:At5g14800
ORF Names:T9L3_100
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G14800.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: TAIR
  • cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2242730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001873231 – 276Pyrroline-5-carboxylate reductaseAdd BLAST276

Proteomic databases

PaxDbiP54904.

PTM databases

iPTMnetiP54904.

Expressioni

Gene expression databases

ExpressionAtlasiP54904. baseline and differential.
GenevisibleiP54904. AT.

Interactioni

Protein-protein interaction databases

BioGridi16609. 1 interactor.
MINTiMINT-8062239.
STRINGi3702.AT5G14800.1.

Structurei

3D structure databases

ProteinModelPortaliP54904.
SMRiP54904.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3124. Eukaryota.
COG0345. LUCA.
HOGENOMiHOG000230247.
InParanoidiP54904.
KOiK00286.
OMAiRTFNEHQ.
OrthoDBiEOG09360KVT.
PhylomeDBiP54904.

Family and domain databases

Gene3Di1.10.3730.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01925. P5C_reductase. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR029036. P5CR_dimer.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
PANTHERiPTHR11645. PTHR11645. 1 hit.
PfamiPF03807. F420_oxidored. 1 hit.
PF14748. P5CR_dimer. 1 hit.
[Graphical view]
PIRSFiPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00112. proC. 1 hit.
PROSITEiPS00521. P5CR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: P54904-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEILPIPAES FKVGFIGAGK MAESIARGVV ASGVLPPNRI CTAVHSNLNR
60 70 80 90 100
RDVFESFGVN VFSTSEEVVK ESDVVIFSVK PQVVKKAVTE LKSKLSKNKI
110 120 130 140 150
LVSVAAGIKL NDLQEWSGQD RFIRVMPNTP AAVGEAASVM SLGTGATEED
160 170 180 190 200
GAIVAMLFGA VGKILKADEK MFDAVTGLSG SGPAYIFLAI EALADGGVAA
210 220 230 240 250
GLPRELALSL ASQTVLGAAT MVSKTGKHPG VLKDDVTSPG GTTIAGVHEL
260 270
EKGSFRATLM NAVVAAAKRS RELSQS
Length:276
Mass (Da):28,624
Last modified:October 1, 1996 - v1
Checksum:iB577A01C92A3A28B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76538 Genomic DNA. Translation: AAA61346.1.
Y08951 Genomic DNA. Translation: CAA70148.1.
AL391149 Genomic DNA. Translation: CAC01879.1.
CP002688 Genomic DNA. Translation: AED92078.1.
AF410303 mRNA. Translation: AAK95289.1.
AY097368 mRNA. Translation: AAM19884.1.
AY087530 mRNA. Translation: AAM65072.1.
PIRiJQ2334.
RefSeqiNP_196984.1. NM_121484.5. [P54904-1]
UniGeneiAt.385.
At.75259.

Genome annotation databases

EnsemblPlantsiAT5G14800.1; AT5G14800.1; AT5G14800. [P54904-1]
GeneIDi831332.
GrameneiAT5G14800.1; AT5G14800.1; AT5G14800.
KEGGiath:AT5G14800.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76538 Genomic DNA. Translation: AAA61346.1.
Y08951 Genomic DNA. Translation: CAA70148.1.
AL391149 Genomic DNA. Translation: CAC01879.1.
CP002688 Genomic DNA. Translation: AED92078.1.
AF410303 mRNA. Translation: AAK95289.1.
AY097368 mRNA. Translation: AAM19884.1.
AY087530 mRNA. Translation: AAM65072.1.
PIRiJQ2334.
RefSeqiNP_196984.1. NM_121484.5. [P54904-1]
UniGeneiAt.385.
At.75259.

3D structure databases

ProteinModelPortaliP54904.
SMRiP54904.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16609. 1 interactor.
MINTiMINT-8062239.
STRINGi3702.AT5G14800.1.

Chemistry databases

ChEMBLiCHEMBL2242730.

PTM databases

iPTMnetiP54904.

Proteomic databases

PaxDbiP54904.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G14800.1; AT5G14800.1; AT5G14800. [P54904-1]
GeneIDi831332.
GrameneiAT5G14800.1; AT5G14800.1; AT5G14800.
KEGGiath:AT5G14800.

Organism-specific databases

TAIRiAT5G14800.

Phylogenomic databases

eggNOGiKOG3124. Eukaryota.
COG0345. LUCA.
HOGENOMiHOG000230247.
InParanoidiP54904.
KOiK00286.
OMAiRTFNEHQ.
OrthoDBiEOG09360KVT.
PhylomeDBiP54904.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00361.
ReactomeiR-ATH-70614. Amino acid synthesis and interconversion (transamination).
SABIO-RKP54904.

Miscellaneous databases

PROiP54904.

Gene expression databases

ExpressionAtlasiP54904. baseline and differential.
GenevisibleiP54904. AT.

Family and domain databases

Gene3Di1.10.3730.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01925. P5C_reductase. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR029036. P5CR_dimer.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
PANTHERiPTHR11645. PTHR11645. 1 hit.
PfamiPF03807. F420_oxidored. 1 hit.
PF14748. P5CR_dimer. 1 hit.
[Graphical view]
PIRSFiPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00112. proC. 1 hit.
PROSITEiPS00521. P5CR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP5CR1_ARATH
AccessioniPrimary (citable) accession number: P54904
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.